Bioorg. Med. Chem.

Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point.

FitzGerald EA, Rachman MM, Cederfelt D, ..., Koehler K, Danielson UH

Bioorg. Med. Chem. 121 (-) 118134 [2025-04-15; online 2025-02-25]

Discovery and biological evaluation of novel dual PTP1B and ACP1 inhibitors for the treatment of insulin resistance.

Feng B, Zhang J, Liu Z, Xu Y, Hu H

Bioorg. Med. Chem. 97 (-) 117545 [2024-01-01; online 2023-12-06]

2-Alkyl substituted benzimidazoles as a new class of selective AT2 receptor ligands.

Roy T, Petersen NN, Gopalan G, ..., Hallberg M, Larhed M

Bioorg. Med. Chem. 66 (-) 116804 [2022-07-15; online 2022-05-07]

Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds.

Gopalan G, Palo-Nieto C, Petersen NN, Hallberg M, Larhed M

Bioorg. Med. Chem. 65 (-) 116790 [2022-07-01; online 2022-05-04]

A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.

Vella P, Rudraraju RS, Lundbäck T, ..., Schneider G, Schnell R

Bioorg. Med. Chem. 30 (-) 115898 [2021-01-15; online 2020-12-05]

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands.

Wannberg J, Gising J, Lindman J, ..., Hallberg M, Larhed M

Bioorg. Med. Chem. 29 (-) 115859 [2021-01-01; online 2020-11-07]

Comprehensive kinetic and substrate specificity analysis of an arylsulfatase from Helix pomatia using mass spectrometry.

Correia MSP, Ballet C, Meistermann H, Conway LP, Globisch D

Bioorg. Med. Chem. 27 (6) 955-962 [2019-03-15; online 2019-01-30]

Daniel Globisch SciLifeLab Fellow

Synthesis and in vitro evaluation of 5-substituted benzovesamicol analogs containing N-substituted amides as potential positron emission tomography tracers for the vesicular acetylcholine transporter.

Roslin S, De Rosa M, Deuther-Conrad W, ..., Brust P, Larhed M

Bioorg. Med. Chem. 25 (19) 5095-5106 [2017-10-01; online 2017-01-25]

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB).

De Rosa M, Lu L, Zamaratski E, ..., Mowbray SL, Karlén A

Bioorg. Med. Chem. 25 (3) 897-911 [2017-02-01; online 2016-12-07]