Cancer Res.

Abstract 5300: Spatially resolved integrated omics profiling for ADC targets in urothelial carcinoma

Panshikar P, O´Roberts E, Krantz D, ..., Ullén A, Stadler C

Cancer Res. 85 (8_Supplement_1) 5300-5300 [2025-04-21; online 2025-04-21]

Abstract 176: Simultaneous spatial characterisation of copy number change and immune cell profiling using DNA FISH and multiplexed immunofluorescence

O'Roberts EM, Panshikar P, Li-Wang X, ..., Bienko M, Stadler C

Cancer Res. 85 (8_Supplement_1) 176-176 [2025-04-21; online 2025-04-21]

Abstract A017: Enhanced efficacy of anti-mesothelin CAR T cells in ovarian cancer through drug combinations: Impact of treatment kinetics, co-stimulatory domain, and donor variability

Pizarro LR, Poiret T, Gudoitytė G, ..., Magalhaes I, Erkers T

Cancer Res. 85 (5_Supplement) A017-A017 [2025-03-11; online 2025-03-11]

Year 2024

An Atlas of Accessible Chromatin in Advanced Prostate Cancer Reveals the Epigenetic Evolution during Tumor Progression.

Shrestha R, Chesner LN, Zhang M, ..., Quigley DA, Feng FY

Cancer Res. 84 (18) 3086-3100 [2024-09-16; online 2024-07-11]

Arian Lundberg DDLS Fellow

Abstract PO3-25-07: Characterization of tertiary lymphoid structures and its association with response to immune checkpoint inhibitors in triple negative breast cancer using spatial transcriptomics

Wang X, Venet D, Lifrange F, ..., Rothé F, Sotiriou C

Cancer Res. 84 (9_Supplement) PO3-25-07-PO3-25-07 [2024-05-02; online 2024-05-02]

Abstract 3100: Interactive analysis of drug testing data for functional precision oncology with Breeze 2.0

Potdar S, Ianevski F, Ianevski A, ..., Aittokallio T, Saarela J

Cancer Res. 84 (6_Supplement) 3100-3100 [2024-03-22; online 2024-03-22]

Abstract 7287: High-grade serous ovarian carcinoma detected with TP53 mutation panel and SiMSen-Seq

Widjaja AO, Micallef P, Ulfenborg B, ..., Linder A, Sundfeldt K

Cancer Res. 84 (6_Supplement) 7287-7287 [2024-03-22; online 2024-03-22]

Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response.

Ramos L, Henriksson M, Helleday T, Green AC

Cancer Res. 84 (1) 9-16 [2024-01-02; online 2023-11-03]

Year 2023

The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer.

Lundberg A, Zhang M, Aggarwal R, ..., Small EJ, Quigley DA

Cancer Res. 83 (16) 2763-2774 [2023-08-15; online 2023-06-08]

Arian Lundberg DDLS Fellow

Abstract A051: The spatial landscape of clonal somatic copy number alterations in benign and malignant prostate epithelia

Erickson A, He M, Berglund E, ..., Lamb AD, Lundeberg J

Cancer Res. 83 (11_Supplement) A051-A051 [2023-06-02; online 2023-06-02]

Abstract LB362: Epigenome-wide DNA methylation alterations precede diagnosis since birth and affect prognosis of pediatric B-cell acute lymphoblastic leukemia

Ghantous A, Nusslé SG, Nassar F, ..., Munthe-Kaas MC, Herceg Z

Cancer Res. 83 (8_Supplement) LB362-LB362 [2023-04-14; online 2023-04-14]

Abstract 1793: Single-cell RNA analysis reveal effector-like CD8+ CAR-T cell subpopulations associated with response in lymphoma patients

Sarén T, Ramachandran M, Gammelgård G, ..., Enblad G, Essand M

Cancer Res. 83 (7_Supplement) 1793-1793 [2023-04-04; online 2023-04-04]

Abstract 705: Potentiation of immunotherapy by LSD1 modulation

Emond WB, Sawant R, Geitmann M, ..., Hellström M, Koehler KF

Cancer Res. 83 (7_Supplement) 705-705 [2023-04-04; online 2023-04-04]

Abstract 2929: Modular peptide cargo delivery by targeting CD40 enables ligandome driven, precision immunotherapy via the Adaptable Drug Affinity Conjugate (ADAC™) technology

Mebrahtu A, Lauren I, Veerman R, ..., Rockberg J, Mangsbo S

Cancer Res. 83 (7_Supplement) 2929-2929 [2023-04-04; online 2023-04-04]

Abstract PD4-01: PD4-01 Spatial transcriptomics reveals a substantial heterogeneity in TNBC tumor and stroma compartments with potential clinical implications

Wang X, Venet D, Lifrange F, ..., Rothé F, Sotiriou C

Cancer Res. 83 (5_Supplement) PD4-01-PD4-01 [2023-03-01; online 2023-03-01]

Year 2022

Dormant SOX9-Positive Cells Facilitate MYC-Driven Recurrence of Medulloblastoma.

Borgenvik A, Holmberg KO, Bolin S, ..., Weishaupt H, Swartling FJ

Cancer Res. 82 (24) 4586-4603 [2022-12-16; online 2022-10-12]

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.

Sjöström M, Zhao SG, Levy S, ..., Quigley DA, Feng FY

Cancer Res. 82 (21) 3888-3902 [2022-11-02; online 2022-10-18]

Arian Lundberg DDLS Fellow

MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET.

Srivastava A, Tommasi C, Sessions D, ..., Lopez-Pajares V, Lee CS

Cancer Res. 82 (17) 3143-3157 [2022-09-02; online 2022-06-16]

Abstract 1890: Development of the drug efficacy testing in ex vivo 3D cultures (DETECT) platform and its application to functional precision medicine in ovarian cancer

Åkerlund E, Gudoityte G, Lamodiere EM, ..., Joneborg U, Seashore-Ludlow B

Cancer Res. 82 (12_Supplement) 1890-1890 [2022-06-15; online 2022-06-15]

Abstract 2171: The spatial landscape of clonal somatic mutations in benign and malignant tissue

Erickson A, Berglund E, He M, ..., Lamb AD, Lundenberg J

Cancer Res. 82 (12_Supplement) 2171-2171 [2022-06-15; online 2022-06-15]

Abstract PR016: The spatial landscape of clonal somatic mutations in benign and malignant tissue

Erickson A, Berglund E, He M, ..., Lamb AD, Lundeberg J

Cancer Res. 82 (10_Supplement) PR016-PR016 [2022-05-15; online 2022-05-15]

Abstract P1-07-07: Endoresist: Prognostic and predictive gene profiles in endocrine-resistant breast cancers

Schagerholm C, Robertson S, Holm B, ..., Williams C, Hartman J

Cancer Res. 82 (4_Supplement) P1-07-07-P1-07-07 [2022-02-15; online 2022-02-15]

Year 2021

Predicting Molecular Phenotypes from Histopathology Images: A Transcriptome-Wide Expression-Morphology Analysis in Breast Cancer.

Wang Y, Kartasalo K, Weitz P, ..., Hartman J, Rantalainen M

Cancer Res. 81 (19) 5115-5126 [2021-10-01; online 2021-08-02]

DDLS Fellow Kimmo Kartasalo

NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis.

Zhao Z, Gad H, Benitez-Buelga C, ..., Xia Q, Helleday T

Cancer Res. 81 (15) 4079-4093 [2021-08-01; online 2021-05-27]

Inflammation and Apolipoproteins Are Potential Biomarkers for Stratification of Cutaneous Melanoma Patients for Immunotherapy and Targeted Therapy.

Karlsson MJ, Costa Svedman F, Tebani A, ..., Egyhazi Brage S, Maddalo G

Cancer Res. 81 (9) 2545-2555 [2021-05-01; online 2021-02-11]

The Irradiated Brain Microenvironment Supports Glioma Stemness and Survival via Astrocyte-Derived Transglutaminase 2.

Berg TJ, Marques C, Pantazopoulou V, ..., Squatrito M, Pietras A

Cancer Res. 81 (8) 2101-2115 [2021-04-15; online 2021-01-22]

Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.

La Fleur L, Botling J, He F, ..., Karlsson MCI, Sarhan D

Cancer Res. 81 (4) 956-967 [2021-02-15; online 2020-12-08]

Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer.

Liu Z, Derkach A, Yu KJ, ..., Hildesheim A, Pfeiffer RM

Cancer Res. 81 (4) 1148-1152 [2021-02-15; online 2020-12-03]

Time-Dependent Effects of Oral Contraceptive Use on Breast, Ovarian, and Endometrial Cancers.

Karlsson T, Johansson T, Höglund J, Ek WE, Johansson Å

Cancer Res. 81 (4) 1153-1162 [2021-02-15; online 2020-12-17]

Year 2020

MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG.

Rudd SG, Gad H, Sanjiv K, ..., Berglund UW, Helleday T

Cancer Res. 80 (17) 3530-3541 [2020-09-01; online 2020-04-20]

Abstract 2081: Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes

Hases L, Indukuri R, Birgersson M, ..., Archer A, Williams C

Cancer Res. 80 (16_Supplement) 2081-2081 [2020-08-15; online 2020-08-15]

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis.

Zhang Y, Cedervall J, Hamidi A, ..., Dimberg A, Olsson AK

Cancer Res. 80 (16) 3345-3358 [2020-08-15; online 2020-06-25]

Abstract 2371: FBXL12 modulates Fanconi anaemia-BRCA signaling under conditions of oncogene-induced replication stress

Brunner A, Johansson H, Kourtesakis A, ..., Lehtiö J, Sangfelt O

Cancer Res. 80 (16_Supplement) 2371-2371 [2020-08-15; online 2020-08-15]

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds.

Peuget S, Zhu J, Sanz G, ..., Zubarev R, Selivanova G

Cancer Res. 80 (7) 1538-1550 [2020-04-01; online 2020-02-04]

Year 2019

Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress.

Young LA, O'Connor LO, de Renty C, ..., Lau A, O'Connor MJ

Cancer Res. 79 (14) 3762-3775 [2019-07-15; online 2019-05-23]

Abstract 3843: LSD1 modulation by allosteric ligands

Emond WB, Geitmann M, Jarvius M, ..., Segerman A, Bremberg U

Cancer Res. 79 (13_Supplement) 3843-3843 [2019-07-01; online 2019-07-01]

Year 2018

Spatially Resolved Transcriptomics Enables Dissection of Genetic Heterogeneity in Stage III Cutaneous Malignant Melanoma.

Thrane K, Eriksson H, Maaskola J, Hansson J, Lundeberg J

Cancer Res. 78 (20) 5970-5979 [2018-10-15; online 2018-08-28]

Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype.

Goudarzi KM, Espinoza JA, Guo M, ..., Lindström MS, Hägerstrand D

Cancer Res. 78 (20) 5901-5916 [2018-10-15; online 2018-08-22]

The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors.

Spiegelberg D, Mortensen AC, Lundsten S, ..., Lane DP, Nestor M

Cancer Res. 78 (17) 5084-5093 [2018-09-01; online 2018-07-19]

SETD2 Is Recurrently Mutated in Whole-Exome Sequenced Canine Osteosarcoma.

Sakthikumar S, Elvers I, Kim J, ..., Marinescu VD, Lindblad-Toh K

Cancer Res. 78 (13) 3421-3431 [2018-07-01; online 2018-05-03]

Abstract 2199: Establishment and high-throughput drug testing of multiple patient-derived cells from each renal cancer; intratumor heterogeneity of drug response and implications for precision medicine

Saeed K, Ojamies P, Pellinen T, ..., Kallioniemi O, Östling P

Cancer Res. 78 (13_Supplement) 2199-2199 [2018-07-01; online 2018-07-01]

Abstract 5302: Phenotypic heterogeneity of patient-derived tumor cells visualized by unsupervised analysis in cell-based personalized drug testing

Turkki R, Paavolainen L, Mikkonen P, ..., Pietiäinen V, Kallioniemi O

Cancer Res. 78 (13_Supplement) 5302-5302 [2018-07-01; online 2018-07-01]

Year 2017

Abstract 3854: Precision medicine approach: analysis of renal cancer patient-derived cells with phenomics, genomics and drug sensitivity profiling

Pietiäinen VM, Mikkonen P, Saeed K, ..., Östling P, Kallioniemi O

Cancer Res. 77 (13_Supplement) 3854-3854 [2017-07-01; online 2017-07-01]

Abstract 4401: Role of estrogen signaling in colon microenvironment during obesity

Archer A, Pettersson L, González-Granillo M, ..., Korach-André M, Williams C

Cancer Res. 77 (13_Supplement) 4401-4401 [2017-07-01; online 2017-07-01]

Abstract 5026: Association to drug-induced leukopenia using whole-exome sequencing of non-small cell lung cancer patients on gemcitabine/carboplatin regimen

Svedberg A, Sigurgeirsson B, Björn N, ..., Lundeberg J, Gréen H

Cancer Res. 77 (13_Supplement) 5026-5026 [2017-07-01; online 2017-07-01]

Abstract 5493: The cistrome of estrogen receptor beta in colorectal cancer cells

Indukuri R, Wang J, Mesmar F, Williams C

Cancer Res. 77 (13_Supplement) 5493-5493 [2017-07-01; online 2017-07-01]

Abstract 5028: Whole exome sequencing and genetic association of gemcitabine/carboplatin induced thrombocytopenia in non-small cell lung cancer patients

Björn N, Svedberg A, Sigurgeirsson B, ..., Lundeberg J, Gréen H

Cancer Res. 77 (13_Supplement) 5028-5028 [2017-07-01; online 2017-07-01]

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses.

Niklasson M, Maddalo G, Sramkova Z, ..., Enger PØ, Andäng M

Cancer Res. 77 (7) 1741-1752 [2017-04-01; online 2017-01-13]

Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer.

Mathot L, Kundu S, Ljungström V, ..., Nilsson M, Sjöblom T

Cancer Res. 77 (7) 1730-1740 [2017-04-01; online 2017-01-20]

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.

Gustafsson R, Jemth AS, Gustafsson NM, ..., Helleday T, Stenmark P

Cancer Res. 77 (4) 937-948 [2017-02-15; online 2016-11-29]

Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype.

Sreedharan S, Maturi NP, Xie Y, ..., Swartling FJ, Uhrbom L

Cancer Res. 77 (3) 802-812 [2017-02-01; online 2016-11-15]

Year 2016

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.

Valerie NC, Hagenkort A, Page BD, ..., Jemth AS, Helleday T

Cancer Res. 76 (18) 5501-5511 [2016-09-15; online 2016-08-16]

Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis.

Menard JA, Christianson HC, Kucharzewska P, ..., Johansson MC, Belting M

Cancer Res. 76 (16) 4828-4840 [2016-08-15; online 2016-05-19]

Tumor-Induced NETosis as a Risk Factor for Metastasis and Organ Failure.

Cedervall J, Zhang Y, Olsson AK

Cancer Res. 76 (15) 4311-4315 [2016-08-01; online 2016-07-11]

Abstract 1260: Polymerase kappa determines the sensitivity of MTH1 inhibitors to cisplatin-resistant cell

Sanjiv K, Gad H, Rudd S, ..., Hendrickson AW, Helleday T

Cancer Res. 76 (14_Supplement) 1260-1260 [2016-07-15; online 2016-07-15]

Abstract 1109: AAGUGC-microRNAs are an integral part of an oncogenic signaling network driving non-small cell lung cancer proliferation

Zhou Y, Frings O, Fredlund E, ..., Branca RM, Orre LM

Cancer Res. 76 (14_Supplement) 1109-1109 [2016-07-15; online 2016-07-15]

Abstract LB-176: The human androgen receptor regulates DNA damage response (DDR) in prostate cancer

Asim M, Zecchini H, Tarish F, ..., Helleday T, Neal D

Cancer Res. 76 (14_Supplement) LB-176-LB-176 [2016-07-15; online 2016-07-15]

Abstract 3881: Breast cancer proteogenomics landscape defines subtype specific protein level regulations and reveals proteins coded by pseudogenic loci

Johansson H, Zhu Y, Haugland M, ..., Borresen-Dale AL, Lehtio J

Cancer Res. 76 (14_Supplement) 3881-3881 [2016-07-15; online 2016-07-15]

Abstract 2385: Understanding the dynamic interplay between genetically different cancer cell clones in glioblastoma

Guo M, Heller S, Thorslund J, ..., Nistér M, Hägerstrand D

Cancer Res. 76 (14_Supplement) 2385-2385 [2016-07-15; online 2016-07-15]

c-Myb Enhances Breast Cancer Invasion and Metastasis through the Wnt/β-Catenin/Axin2 Pathway.

Li Y, Jin K, van Pelt GW, ..., Zhou F, Zhang L

Cancer Res. 76 (11) 3364-3375 [2016-06-01; online 2016-04-05]

Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages.

Wallerius M, Wallmann T, Bartish M, ..., Andersson J, Rolny C

Cancer Res. 76 (11) 3166-3178 [2016-06-01; online 2016-04-06]

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition.

Bräutigam L, Pudelko L, Jemth AS, ..., Stenmark P, Helleday T

Cancer Res. 76 (8) 2366-2375 [2016-04-15; online 2016-02-09]

DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair.

Ying S, Chen Z, Medhurst AL, ..., Meek K, Helleday T

Cancer Res. 76 (5) 1078-1088 [2016-03-01; online 2015-11-24]

Year 2015

Elevated expression of the C-type lectin CD93 in the glioblastoma vasculature regulates cytoskeletal rearrangements that enhance vessel function and reduce host survival.

Langenkamp E, Zhang L, Lugano R, ..., Smits A, Dimberg A

Cancer Res. 75 (21) 4504-4516 [2015-11-01; online 2015-09-11]

Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer.

Ylipää A, Kivinummi K, Kohvakka A, ..., Visakorpi T, Nykter M

Cancer Res. 75 (19) 4026-4031 [2015-10-01; online 2015-08-17]

DDLS Fellow Kimmo Kartasalo

Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals.

Cedervall J, Zhang Y, Huang H, ..., Dimberg A, Olsson AK

Cancer Res. 75 (13) 2653-2662 [2015-07-01; online 2015-06-12]

Year 2014

TGFβ receptor 1: an immune susceptibility gene in HPV-associated cancer.

Levovitz C, Chen D, Ivansson E, ..., Boffetta P, Sikora AG

Cancer Res. 74 (23) 6833-6844 [2014-12-01; online 2014-10-01]

Abstract 5476: Simultaneous targeting of multiple cancer-related pathways in HPV-positive head and neck cancer with demethylating agents

Biktasova A, Gubanova E, Zou M, Yarbrough WG, Issaeva N

Cancer Res. 74 (19_Supplement) 5476-5476 [2014-10-01; online 2014-10-01]

Immunogenetic studies of chronic lymphocytic leukemia: revelations and speculations about ontogeny and clinical evolution.

Vardi A, Agathangelidis A, Sutton LA, ..., Rosenquist R, Stamatopoulos K

Cancer Res. 74 (16) 4211-4216 [2014-08-15; online 2014-07-29]

Genome-wide profiling of AP-1-regulated transcription provides insights into the invasiveness of triple-negative breast cancer.

Zhao C, Qiao Y, Jonsson P, ..., Williams C, Dahlman-Wright K

Cancer Res. 74 (14) 3983-3994 [2014-07-15; online 2014-05-15]

Year 2013

Lessons from functional analysis of genome-wide association studies.

Sur I, Tuupanen S, Whitington T, Aaltonen LA, Taipale J

Cancer Res. 73 (14) 4180-4184 [2013-07-15; online 2013-07-05]

Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2-dependent mechanisms.

Mao Y, Poschke I, Wennerberg E, ..., Lundqvist A, Kiessling R

Cancer Res. 73 (13) 3877-3887 [2013-07-01; online 2013-04-30]

SciLifeLab Fellow Yumeng Mao

Abstract B70: Generation of MAGE-A4 230-239 peptide-specific cytotoxic T lymphocytes using an alloreactive approach.

Lövgren T, Mao Y, Böschen ML, ..., Poschke I, Kiessling R

Cancer Res. 73 (1_Supplement) B70-B70 [2013-01-01; online 2014-04-02]

Year 2012

Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1.

Ying S, Hamdy FC, Helleday T

Cancer Res. 72 (11) 2814-2821 [2012-06-01; online 2012-03-23]

Year 2010