Mardinoglu A

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Family name Mardinoglu
Given name Adil
Initials A
ORCID

ORCID 0000-0002-4254-6090
Affiliations Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden.
Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.

121 publications

DOI Crossref
Targeting PKLR and lipogenic enzymes through JNK inhibition to develop a therapeutic strategy for MASLD and MASH
Mardinoglu A, Kim W, Li M, ..., Zhang C, Turkez H
- - (-) - [2025-09-25; online 2025-09-25]
PubMed DOI Crossref
Unravelling the Complexity of Sarcopenia Through a Systems Biology Approach.
Ceyhan AB, Altay O, Zhang C, ..., Turkez H, Mardinoglu A
Int J Mol Sci 26 (17) - [2025-09-02; online 2025-09-02]
PubMed DOI Crossref
Longitudinal big biological data in the AI era.
Mardinoglu A, Turkez H, Shong M, ..., Hood L, Uhlen M
Mol Syst Biol 21 (9) 1147-1165 [2025-09-00; online 2025-08-05]
PubMed DOI Crossref
Noscapine-bile acid hybrids as novel anticancer agents.
Babanezhad Harikandei K, Salehi P, Hasanpour Z, ..., Asghari SM, Mardinoglu A
RSC Med Chem 16 (11) 5511-5533 [2025-08-29; online 2025-08-29]
DOI Crossref
Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats
Yang H, Zhang C, Kim W, ..., Turkez H, Mardinoglu A
Elife 13 (-) - [2025-02-11; online 2025-02-11]
PubMed DOI Crossref
Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats.
Yang H, Zhang C, Kim W, ..., Turkez H, Mardinoglu A
Elife 13 (-) - [2025-02-11; online 2025-02-11]
PubMed DOI Crossref
Design, Synthesis, and Computational Evaluation of 3,4-Dihydroquinolin-2(1H)-One Analogues as Potential VEGFR2 Inhibitors in Glioblastoma Multiforme.
Buhlak S, Abad N, Akachar J, ..., Türkez H, Mardinoglu A
Pharmaceuticals (Basel, Switzerland) 18 (2) - [2025-02-08; online 2025-02-08]
PubMed DOI Crossref
Genome-scale models in human metabologenomics.
Mardinoglu A, Palsson BØ
Nat. Rev. Genet. 26 (2) 123-140 [2025-02-00; online 2024-09-19]
DOI Crossref
Advancing Chronic Liver Disease Diagnoses: Targeted Proteomics for the Non-Invasive Detection of Fibrosis
Villanueva Raisman A, Kotol D, Altay O, ..., Zeybel M, Edfors F
Livers 5 (1) 2 [2025-01-14; online 2025-01-14]
PubMed DOI Crossref
Multi-omics characterization of lymphedema-induced adipose tissue resulting from breast cancer-related surgery.
Karaman S, Lehti S, Zhang C, ..., Alitalo K, Kivelä R
FASEB J. 38 (20) e70097 [2024-10-31; online 2024-10-12]
DOI Crossref
PKLR-modulating compounds show promising effects for the treatment of hepatocellular carcinoma
Mardinoglu A, Kim W, Jin H, ..., Shi X, Zhang C
- - (-) - [2024-10-30; online 2024-10-30]
PubMed DOI Crossref
Identifying Hub Genes and Metabolic Pathways in Collagen VI-Related Dystrophies: A Roadmap to Therapeutic Intervention.
Ceyhan AB, Kaynar A, Altay O, ..., Turkez H, Mardinoglu A
Biomolecules 14 (11) - [2024-10-29; online 2024-10-29]
DOI Crossref
Synthesis, Characterization, Theoretical Studies and in Vitro Embriyotoxic, Genotoxic and Anticancer Effects of Novel Phenyl(1,4,6-Triphenyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidin-5-yl)Methanone
Akbas E, Othman KA, Çelikezen FÇ, ..., Yapca OE, Mardinoglu A
Polycyclic Aromatic Compounds 44 (9) 6284-6301 [2024-10-20; online 2023-11-03]
PubMed DOI Crossref
Unveiling the Molecular Mechanisms of Glioblastoma through an Integrated Network-Based Approach.
Kaynar A, Kim W, Ceyhan AB, ..., Shoaie S, Mardinoglu A
Biomedicines 12 (10) - [2024-10-01; online 2024-10-01]
PubMed DOI Crossref
Discovery of Cell-Permeable Allosteric Inhibitors of Liver Pyruvate Kinase: Design and Synthesis of Sulfone-Based Urolithins.
Iqbal S, Islam MZ, Ashraf S, ..., Turkez H, Mardinoglu A
Int J Mol Sci 25 (14) - [2024-07-22; online 2024-07-22]
PubMed DOI Crossref
Discovery of a Therapeutic Agent for Glioblastoma Using a Systems Biology-Based Drug Repositioning Approach.
Kaynar A, Ozcan M, Li X, ..., Shoaie S, Mardinoglu A
Int J Mol Sci 25 (14) - [2024-07-18; online 2024-07-18]
DOI Crossref
High Resolution Crystal Structure of the Pyruvate Kinase Tetramer in Complex with the Allosteric Activator Mitapivat/AG-348
Han X, Sandalova T, Zhang C, ..., Achour A, Sun R
Crystals 14 (5) 441 [2024-05-05; online 2024-05-05]
PubMed DOI Crossref
Drug repositioning for immunotherapy in breast cancer using single-cell analysis.
Mohammadi E, Dashti S, Shafizade N, ..., Mardinoglu A, Sekhavati MH
NPJ Syst Biol Appl 10 (1) 37 [2024-04-08; online 2024-04-08]
PubMed DOI Crossref
Drug Synergism of Anticancer Action in Combination with Favipiravir and Paclitaxel on Neuroblastoma Cells.
Turkez H, Arslan ME, Selvitopi H, ..., Oner S, Mardinoglu A
Medicina (Kaunas) 60 (1) - [2023-12-30; online 2023-12-30]
PubMed DOI Crossref
Novel styryl-thiazole hybrids as potential anti-Alzheimer's agents.
Gouleni N, Di Rienzo A, Yılmaz A, ..., Vassiliou S, Cacciatore I
RSC Med Chem 14 (11) 2315-2326 [2023-11-15; online 2023-09-21]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Open MoA: revealing the mechanism of action (MoA) based on network topology and hierarchy.
Liao X, Ozcan M, Shi M, ..., Mardinoglu A, Zhang C
Bioinformatics 39 (11) - [2023-11-01; online 2023-11-06]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Characterization of an in vitro steatosis model simulating activated de novo lipogenesis in MAFLD patients.
Kim W, Li M, Jin H, ..., Zhang C, Mardinoglu A
iScience 26 (10) 107727 [2023-10-20; online 2023-08-25]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Systems-level temporal immune-metabolic profile in Crimean-Congo hemorrhagic fever virus infection.
Ambikan AT, Elaldi N, Svensson-Akusjärvi S, ..., Mirazimi A, Neogi U
Proc. Natl. Acad. Sci. U.S.A. 120 (37) e2304722120 [2023-09-12; online 2023-09-05]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation.
Jin H, Zhang C, Zwahlen M, ..., Uhlén M, Mardinoglu A
Nat Commun 14 (1) 5417 [2023-09-05; online 2023-09-05]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Infection with COVID-19 is no longer a public emergency: But what about degenerative dementia?
Yulug B, Ayyıldız B, Ayyıldız S, ..., Velioglu HA, Mardinoglu A
J Med Virol 95 (9) e29072 [2023-09-00; online 2023-09-19]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
The acute effect of different NAD+ precursors included in the combined metabolic activators.
Li X, Yang H, Jin H, ..., Borén J, Mardinoglu A
Free Radic. Biol. Med. 205 (-) 77-89 [2023-08-20; online 2023-06-02]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
Oxidative, Genotoxic and Cytotoxic Damage Potential of Novel Borenium and Borinium Compounds
Oguzkan SB, Turkez H, Ugras HI, Tatar A, Mardinoglu A
Inorganics 11 (8) 324 [2023-07-31; online 2023-07-31]
PubMed DOI Crossref
Next generation pan-cancer blood proteome profiling using proximity extension assay.
Álvez MB, Edfors F, von Feilitzen K, ..., Fagerberg L, Uhlén M
Nat Commun 14 (1) 4308 [2023-07-18; online 2023-07-18]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients.
Bayraktar A, Li X, Kim W, ..., Shoaie S, Mardinoglu A
J Transl Med 21 (1) 332 [2023-05-20; online 2023-05-20]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Revisiting the role of serine metabolism in hepatic lipogenesis.
Yang H, Zhang C, Turkez H, ..., Boren J, Mardinoglu A
Nat Metab 5 (5) 760-761 [2023-05-00; online 2023-05-11]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase.
Battisti UM, Monjas L, Akladios F, ..., Mardinoğlu A, Grøtli M
Pharmaceuticals (Basel, Switzerland) 16 (5) - [2023-04-28; online 2023-04-28]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
Molecular profiling of high-level athlete skeletal muscle after acute exercise – a systems biology approach
Reitzner SM, Emanuelsson EB, Arif M, ..., Chapman MA, Sundberg CJ
- - (-) - [2023-04-11; online 2023-04-11]
PubMed DOI Crossref
Costunolide and Parthenolide Ameliorate MPP+ Induced Apoptosis in the Cellular Parkinson's Disease Model.
Arslan ME, Türkez H, Sevim Y, ..., Öner S, Mardinoğlu A
Cells 12 (7) - [2023-03-24; online 2023-03-24]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
standard-GEM: standardization of open-source genome-scale metabolic models
Anton M, Almaas E, Benfeitas R, ..., Zeidan AA, Kerkhoven EJ
- - (-) - [2023-03-23; online 2023-03-23]
PubMed DOI Crossref
Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase.
Battisti UM, Gao C, Akladios F, ..., Mardinoglu A, Grøtli M
Nutrients 15 (3) - [2023-01-22; online 2023-01-22]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
Cover Feature: Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase (ChemBioChem 1/2023)
Battisti UM, Gao C, Nilsson O, ..., Mardinoglu A, Grøtli M
Chembiochem 24 (1) - [2023-01-03; online 2022-12-14]
PubMed DOI Crossref
Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase.
Battisti UM, Gao C, Nilsson O, ..., Mardinoglu A, Grøtli M
Chembiochem 24 (1) e202200339 [2023-01-03; online 2022-11-09]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Lipoic Acid Conjugated Boron Hybrids Enhance Wound Healing and Antimicrobial Processes.
Türkez H, Yıldırım ÖÇ, Öner S, ..., Yapça ÖE, Mardinoğlu A
Pharmaceutics 15 (1) - [2022-12-31; online 2022-12-31]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
In Vitro Transcriptome Analysis of Cobalt Boride Nanoparticles on Human Pulmonary Alveolar Cells.
Arslan ME, Tatar A, Yıldırım ÖÇ, ..., Mardinoğlu A, Türkez H
Materials (Basel) 15 (23) - [2022-12-06; online 2022-12-06]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Development of l-Dopa-containing diketopiperazines as blood-brain barrier shuttle.
Cornacchia C, Marinelli L, Di Rienzo A, ..., Di Stefano A, Cacciatore I
Eur J Med Chem 243 (-) 114746 [2022-12-05; online 2022-09-08]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Editorial: Application of systems biology in molecular characterization and diagnosis of cancer, Volume II.
Wei Y, Zhang C, Mardinoglu A, Zhang P
Front Mol Biosci 9 (-) 1089463 [2022-11-25; online 2022-11-25]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Toxicity of Glycyl-l-Prolyl-l-Glutamate Pseudotripeptides: Cytotoxic, Oxidative, Genotoxic, and Embryotoxic Perspectives.
Turkez H, Ozdemir Tozlu O, Tatar A, ..., Di Stefano A, Mardinoglu A
J Toxicol 2022 (-) 3775194 [2022-11-19; online 2022-11-19]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
In Vitro and In Vivo Neuroprotective Effects of Sarcosine.
Tanas A, Tozlu ÖÖ, Gezmiş T, ..., Mardinoğlu A, Türkez H
Biomed Res Int 2022 (-) 5467498 [2022-10-15; online 2022-10-15]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Chronic hyperinsulinemia promotes human hepatocyte senescence.
Baboota RK, Spinelli R, Erlandsson MC, ..., Kahn CR, Smith U
Mol Metab 64 (-) 101558 [2022-10-00; online 2022-07-21]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Ameliorative Effects by Hexagonal Boron Nitride Nanoparticles against Beta Amyloid Induced Neurotoxicity.
Aydin N, Turkez H, Tozlu OO, ..., Di Stefano A, Mardinoglu A
Nanomaterials (Basel) 12 (15) - [2022-08-05; online 2022-08-05]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
Genome-wide single cell annotation of the human protein-coding genes
Karlsson M, Álvez MB, Shi M, ..., Fagerberg L, Uhlén M
- - (-) - [2022-08-04; online 2022-08-04]
PubMed DOI Crossref
Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study.
Turkez H, Yıldırım S, Sahin E, ..., Saruhan F, Mardinoglu A
Toxics 10 (8) - [2022-07-28; online 2022-07-28]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Boron Nitride Nanoparticles Loaded with a Boron-Based Hybrid as a Promising Drug Carrier System for Alzheimer's Disease Treatment.
Yıldırım ÖÇ, Arslan ME, Öner S, ..., Mardinoglu A, Turkez H
Int J Mol Sci 23 (15) - [2022-07-26; online 2022-07-26]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection
Mikaeloff F, Gelpi M, Benfeitas R, ..., Nielsen SD, Neogi U
- - (-) - [2022-06-13; online 2022-06-13]
PubMed DOI Crossref
Recent Progress and Future Direction for the Application of Multiomics Data in Clinical Liver Transplantation.
Liu Z, Xu J, Que S, ..., Mardinoglu A, Zheng S
J Clin Transl Hepatol 10 (2) 363-373 [2022-04-28; online 2022-01-04]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach.
Li X, Shong K, Kim W, ..., Zhang C, Mardinoglu A
EBioMedicine 78 (-) 103963 [2022-04-00; online 2022-03-25]
Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis.
Zeybel M, Arif M, Li X, ..., Borén J, Mardinoglu A
Adv Sci (Weinh) 9 (11) e2104373 [2022-04-00; online 2022-02-07]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Molecular Genetics and Cytotoxic Responses to Titanium Diboride and Zinc Borate Nanoparticles on Cultured Human Primary Alveolar Epithelial Cells.
Türkez H, Arslan ME, Tatar A, ..., Tatar A, Mardinoglu A
Materials (Basel) 15 (7) - [2022-03-22; online 2022-03-22]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
A Gene Co-Expression Network-Based Drug Repositioning Approach Identifies Candidates for Treatment of Hepatocellular Carcinoma.
Yuan M, Shong K, Li X, ..., Zhang C, Mardinoglu A
Cancers (Basel) 14 (6) - [2022-03-19; online 2022-03-19]
Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow
DOI Crossref
Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning
Zhang C, Shi M, Kim W, ..., Boren J, Mardinoglu A
- - (-) - [2022-02-17; online 2022-02-17]
DOI Crossref
Synthesis and in Vitro Toxicity Assessment of Different Nano-Calcium Phosphate Nanoparticles
Başak T, Hasan T, Feray B, ..., Di SA, Adil M
Braz. arch. biol. technol. 65 (-) - [2022-00-00; online 2022-00-00]
DOI Crossref
Transient Colonising Microbes Promote Gut Dysbiosis and Disease Pathology
Lee S, Meslier V, Bidkhori G, ..., Uhlen M, Shoaie S
- - (-) - [2022-00-00; online 2022-00-00]
DOI Crossref
Development of L-Dopa-Containing Diketopiperazines as Blood-Brain Barrier Shuttle
Cornacchia C, Marinelli L, Di Rienzo A, ..., Di Stefano A, Cacciatore I
- - (-) - [2022-00-00; online 2022-00-00]
PubMed DOI Crossref
Therapeutic Potential of Ferulic Acid in Alzheimer's Disease.
Turkez H, Arslan ME, Barboza JN, ..., de Sousa DP, Mardinoğlu A
Curr Drug Deliv 19 (8) 860-873 [2021-12-30; online 2021-12-30]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Systems Biology Approaches to Decipher the Underlying Molecular Mechanisms of Glioblastoma Multiforme.
Kaynar A, Altay O, Li X, ..., Shoaie S, Mardinoglu A
Int J Mol Sci 22 (24) 13213 [2021-12-08; online 2021-12-08]
Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
Revealing the Molecular Mechanisms of Alzheimer's Disease Based on Network Analysis.
Bayraktar A, Lam S, Altay O, ..., Shoaie S, Mardinoglu A
Int J Mol Sci 22 (21) 11556 [2021-10-26; online 2021-10-26]
Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
The Assessment of Selected miRNA Profile in Familial Mediterranean Fever.
Kahraman CY, Egin ME, Tatar A, Turkez H, Mardinoglu A
Biomed Res Int 2021 (-) 6495700 [2021-10-13; online 2021-10-13]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet.
Yang H, Mayneris-Perxachs J, Boqué N, ..., Mardinoglu A, Caimari A
Biomedicines 9 (10) - [2021-10-11; online 2021-10-11]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients.
Zeybel M, Altay O, Arif M, ..., Borén J, Mardinoglu A
Mol Syst Biol 17 (10) e10459 [2021-10-00; online 2021-10-26]
Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases.
Lam S, Hartmann N, Benfeitas R, ..., Knight R, Mardinoglu A
Biomedicines 9 (10) - [2021-09-24; online 2021-09-24]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19.
Altay O, Arif M, Li X, ..., Uhlén M, Mardinoglu A
Adv Sci (Weinh) 8 (17) e2101222 [2021-09-00; online 2021-06-28]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness.
Zhao LJ, Li YY, Zhang YT, ..., Zheng YC, Liu HM
EMBO Rep. 22 (8) e50922 [2021-08-04; online 2021-05-31]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
iNetModels 2.0: an interactive visualization and database of multi-omics data.
Arif M, Zhang C, Li X, ..., Uhlen M, Mardinoglu A
Nucleic Acids Res. 49 (W1) W271-W276 [2021-07-02; online 2021-04-14]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
A single-cell type transcriptomics map of human tissues.
Karlsson M, Zhang C, Méar L, ..., Uhlén M, Lindskog C
Sci Adv 7 (31) - [2021-07-00; online 2021-07-28]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
Systems analysis reveals ageing-related perturbations in retinoids and sex hormones in Alzheimer’s and Parkinson’s diseases
Lam S, Hartmann N, Benfeitas R, ..., Knight R, Mardinoglu A
- - (-) - [2021-06-10; online 2021-06-10]
PubMed DOI Crossref
Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction.
Arif M, Klevstig M, Benfeitas R, ..., Mardinoglu A, Boren J
Elife 10 (-) - [2021-05-11; online 2021-05-11]
DOI Crossref
Author response: Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction
Arif M, Klevstig M, Benfeitas R, ..., Mardinoglu A, Boren J
- - (-) - [2021-04-21; online 2021-04-21]
PubMed DOI Crossref
Revealing the Metabolic Alterations during Biofilm Development of Burkholderia cenocepacia Based on Genome-Scale Metabolic Modeling.
Altay O, Zhang C, Turkez H, ..., Uhlén M, Mardinoglu A
Metabolites 11 (4) - [2021-04-05; online 2021-04-05]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson’s disease
Rosario D, Bidkhori G, Lee S, ..., Mardinoglu A, Shoaie S
Cell Reports 34 (9) 108807 [2021-03-00; online 2021-03-00]
Saeed Shoaie SciLifeLab Fellow
DOI Crossref
Combined Metabolic Activators decrease liver steatosis by activating mitochondrial metabolism in a Golden Syrian hamster study
Yang H, Mayneris-Perxachs J, Boqué N, ..., Mardinoglu A, Caimari A
- - (-) - [2021-02-19; online 2021-02-19]
PubMed DOI Crossref
Targeted Gene Candidates for Treatment and Early Diagnosis of Age-Related Macular Degeneration.
Cinici E, Caglar O, Arslan ME, ..., Mardinoglu A, Turkez H
Biomed Res Int 2021 (-) 6620900 [2021-02-02; online 2021-02-02]
PubMed DOI Crossref
Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia
Harzandi A, Lee S, Bidkhori G, ..., Shoaie S, Sharpe CC
iScience 24 (2) 102046 [2021-02-00; online 2021-02-00]
Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
A Novel Mutation of ATP7B Gene in a Case of Wilson Disease.
Kahraman CY, Islek A, Tatar A, ..., Mardinglu A, Turkez H
Medicina (Kaunas) 57 (2) - [2021-01-29; online 2021-01-29]
PubMed DOI Crossref
Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers.
Li X, Kim W, Arif M, ..., Zhang C, Mardinoglu A
Cancers (Basel) 13 (2) - [2021-01-19; online 2021-01-19]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer's Disease.
Turkez H, Cacciatore I, Marinelli L, ..., Di Stefano A, Mardinoglu A
Biomolecules 11 (1) - [2021-01-19; online 2021-01-19]
DOI Crossref
Multiomics Personalized Network Analyses Highlight Progressive Immune Disruption of Central Metabolism Associated with COVID-19 Severity
Ambikan AT, Yang H, Krishnan S, ..., Benfeitas R, Neogi U
- - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in a Golden Syrian Hamster Study
Yang H, Mayneris-Perxachs J, Boqué N, ..., Mardinoglu A, Caimari A
- - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
A Network-Based Approach Reveals the Dysregulated Transcriptional Regulation in Non- Alcohol Fatty Liver Disease
Yang H, Arif M, Yuan M, ..., Zhang C, Mardinoglu A
- - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Network Analyses Links Epicardial Fat Metabolism to Human Coronary Heart Disease
Doran S, Arif M, Clausen M, ..., Mardinoglu A, Boren J
- - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Drug Repositioning for Clear Cell Renal Cell Carcinoma Based on Stratification of Patients
Li X, Kim W, Juszczak K, ..., Zhang C, Mardinoglu A
- - (-) - [2021-00-00; online 2021-00-00]
PubMed DOI Crossref
Editorial: Redox Homeostasis and Cancer.
Sinha M, Mardinoglu A, Ghose J, Singh K
Oxid Med Cell Longev 2020 (-) 5487381 [2020-12-18; online 2020-12-18]
PubMed DOI Crossref
Integration of molecular profiles in a longitudinal wellness profiling cohort.
Tebani A, Gummesson A, Zhong W, ..., Uhlen M, Fagerberg L
Nat Commun 11 (1) 4487 [2020-09-08; online 2020-09-08]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Current Status of COVID-19 Therapies and Drug Repositioning Applications.
Altay O, Mohammadi E, Lam S, ..., Uhlen M, Mardinoglu A
iScience 23 (7) 101303 [2020-07-24; online 2020-06-20]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
A systems biology approach for studying neurodegenerative diseases.
Lam S, Bayraktar A, Zhang C, ..., Uhlen M, Mardinoglu A
Drug Discov. Today 25 (7) 1146-1159 [2020-07-00; online 2020-05-19]
Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
Adipose tissue morphology, imaging and metabolomics predicting cardiometabolic risk and family history of type 2 diabetes in non-obese men.
Rawshani A, Eliasson B, Rawshani A, ..., Rosengren A, Smith U
Sci Rep 10 (1) 9973 [2020-06-19; online 2020-06-19]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Improvement in the Current Therapies for Hepatocellular Carcinoma Using a Systems Medicine Approach.
Ozcan M, Altay O, Lam S, ..., Boren J, Mardinoglu A
Adv Biosyst 4 (6) e2000030 [2020-06-00; online 2020-04-08]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Publisher Correction: MEMOTE for standardized genome-scale metabolic model testing.
Lieven C, Beber ME, Olivier BG, ..., Zakhartsev M, Zhang C
Nat. Biotechnol. 38 (4) 504 [2020-04-00; online 2020-04-09]
PubMed DOI Crossref
The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease.
Zhang C, Bjornson E, Arif M, ..., Borén J, Mardinoglu A
Mol Syst Biol 16 (4) e9495 [2020-04-00; online 2020-04-28]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
An atlas of human metabolism.
Robinson JL, Kocabaş P, Wang H, ..., Uhlén M, Nielsen J
Sci Signal 13 (624) eaaz1482 [2020-03-24; online 2020-03-24]
Adil Mardinoglu Avlant Nilsson SciLifeLab Fellow
PubMed DOI Crossref
An atlas of the protein-coding genes in the human, pig, and mouse brain.
Sjöstedt E, Zhong W, Fagerberg L, ..., Uhlén M, Mulder J
Science (New York, N.Y.) 367 (6482) eaay5947 [2020-03-06; online 2020-03-07]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
Nonpharmacological treatment options for Alzheimer’s disease: from animal testing to clinical studies
TÜRKEZ H, ARSLAN ME, STEFANO AD, CACCIATORE I, MARDİNOĞLU A
Turk J Zool 44 (2) 81-89 [2020-03-04; online 2020-03-04]
PubMed DOI Crossref
MEMOTE for standardized genome-scale metabolic model testing.
Lieven C, Beber ME, Olivier BG, ..., Zakhartsev M, Zhang C
Nat. Biotechnol. 38 (3) 272-276 [2020-03-00; online 2020-03-04]
Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow
DOI Crossref
Discovery of Functional Alternatively Spliced <i>PKM</i> Transcripts in Human Cancers
Li X, Zhang C, Kim W, ..., Uhlen M, Mardinoglu A
- - (-) - [2020-00-00; online 2020-00-00]
PubMed DOI Crossref
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.
Uhlen M, Karlsson MJ, Zhong W, ..., Fagerberg L, Brodin P
Science (New York, N.Y.) 366 (6472) eaax9198 [2019-12-20; online 2019-12-21]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
The human secretome.
Uhlén M, Karlsson MJ, Hober A, ..., Fagerberg L, Sivertsson Å
Sci Signal 12 (609) eaaz0274 [2019-11-26; online 2019-11-26]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Systems biology perspective for studying the gut microbiota in human physiology and liver diseases.
Altay O, Nielsen J, Uhlen M, Boren J, Mardinoglu A
EBioMedicine 49 (-) 364-373 [2019-11-00; online 2019-10-18]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis.
Benfeitas R, Bidkhori G, Mukhopadhyay B, ..., Kunos G, Mardinoglu A
EBioMedicine 40 (-) 471-487 [2019-02-00; online 2018-12-31]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes.
Bidkhori G, Benfeitas R, Klevstig M, ..., Boren J, Mardinoglu A
Proc. Natl. Acad. Sci. U.S.A. 115 (50) E11874-E11883 [2018-12-11; online 2018-11-27]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice.
Håversen L, Sundelin JP, Mardinoglu A, ..., Levin M, Borén J
Sci Rep 8 (1) 16973 [2018-11-19; online 2018-11-19]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Systems biology in hepatology: approaches and applications.
Mardinoglu A, Boren J, Smith U, Uhlen M, Nielsen J
Nat Rev Gastroenterol Hepatol 15 (6) 365-377 [2018-06-00; online 2018-04-25]
Adil Mardinoglu Affiliated researcher SciLifeLab Fellow
PubMed DOI Crossref
An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans
Mardinoglu A, Wu H, Bjornson E, ..., Taskinen MR, Borén J
Cell Metabolism 27 (3) 559-571.e5 [2018-03-00; online 2018-03-00]
Adil Mardinoglu Affiliated researcher SciLifeLab Fellow
PubMed DOI Crossref
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes.
Mardinoglu A, Gogg S, Lotta LA, ..., Laakso M, Smith U
EBioMedicine 27 (-) 151-155 [2018-01-00; online 2017-12-07]
Adil Mardinoglu Affiliated researcher SciLifeLab Fellow
PubMed DOI Crossref
The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis.
Liu Z, Que S, Zhou L, ..., Mardinoglu A, Valenti L
Sci Rep 7 (1) 9273 [2017-08-24; online 2017-08-24]
Adil Mardinoglu Affiliated researcher SciLifeLab Fellow
PubMed DOI Crossref
Network analyses identify liver-specific targets for treating liver diseases.
Lee S, Zhang C, Liu Z, ..., Boren J, Mardinoglu A
Mol Syst Biol 13 (8) 938 [2017-08-21; online 2017-08-21]
Adil Mardinoglu Affiliated researcher SciLifeLab Fellow Simon Elsässer
PubMed DOI Crossref
A pathology atlas of the human cancer transcriptome.
Uhlen M, Zhang C, Lee S, ..., Mardinoglu A, Ponten F
Science (New York, N.Y.) 357 (6352) eaan2507 [2017-08-18; online 2017-08-19]
Adil Mardinoglu Affiliated researcher SciLifeLab Fellow
PubMed DOI Crossref
Selection of complementary foods based on optimal nutritional values.
Sen P, Mardinogulu A, Nielsen J
Sci Rep 7 (1) 5413 [2017-07-14; online 2017-07-14]
Adil Mardinoglu Affiliated researcher SciLifeLab Fellow
PubMed DOI Crossref
A subcellular map of the human proteome.
Thul PJ, Åkesson L, Wiking M, ..., Uhlén M, Lundberg E
Science (New York, N.Y.) 356 (6340) eaal3321 [2017-05-26; online 2017-05-11]
Adil Mardinoglu Affiliated researcher SciLifeLab Fellow
PubMed DOI Crossref
Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD.
Mardinoglu A, Bjornson E, Zhang C, ..., Taskinen MR, Boren J
Mol Syst Biol 13 (3) 916 [2017-03-02; online 2017-03-02]
Adil Mardinoglu Affiliated researcher SciLifeLab Fellow
PubMed DOI Crossref
Predicting growth of the healthy infant using a genome scale metabolic model.
Nilsson A, Mardinoglu A, Nielsen J
NPJ Syst Biol Appl 3 (1) 3 [2017-01-31; online 2017-01-31]
Adil Mardinoglu Avlant Nilsson SciLifeLab Fellow
PubMed DOI Crossref
ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism.
Chaudhari A, Håversen L, Mobini R, ..., Perkins R, Borén J
Biochim. Biophys. Acta 1861 (11) 1643-1651 [2016-11-00; online 2016-07-27]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Transcriptomics resources of human tissues and organs.
Uhlén M, Hallström BM, Lindskog C, ..., Pontén F, Nielsen J
Mol Syst Biol 12 (4) 862 [2016-04-04; online 2016-04-04]
Adil Mardinoglu Affiliated researcher SciLifeLab Fellow
PubMed DOI Crossref
The gut microbiota modulates host amino acid and glutathione metabolism in mice
Mardinoglu A, Shoaie S, Bergentall M, ..., Bäckhed F, Nielsen J
Mol Syst Biol 11 (10) 834 [2015-10-00; online 2015-10-16]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome.
Shoaie S, Ghaffari P, Kovatcheva-Datchary P, ..., Bäckhed F, Nielsen J
Cell Metab. 22 (2) 320-331 [2015-08-04; online 2015-08-06]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
New paradigms for metabolic modeling of human cells.
Mardinoglu A, Nielsen J
Curr. Opin. Biotechnol. 34 (-) 91-97 [2015-08-00; online 2015-01-02]
DOI Crossref
Inclusion of interactions in mathematical modelling of implant assisted magnetic drug targeting
Cregg PJ, Murphy K, Mardinoglu A
Applied Mathematical Modelling 36 (1) 1-34 [2012-01-00; online 2012-01-00]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targeting application
Mardinoglu A, Cregg PJ, Murphy K, Curtin M, Prina-Mello A
Journal of Magnetism and Magnetic Materials 323 (3-4) 324-329 [2011-02-00; online 2011-02-00]
Adil Mardinoglu SciLifeLab Fellow
SciLifeLab Data Centre
Publications 9.5.1