Genomic consequences of intensive inbreeding in an isolated wolf population.

Kardos M, Åkesson M, Fountain T, Flagstad Ø, Liberg O, Olason P, Sand H, Wabakken P, Wikenros C, Ellegren H

Nat Ecol Evol 2 (1) 124-131 [2018-01-00; online 2017-11-20]

Inbreeding (mating between relatives) is a major concern for conservation as it decreases individual fitness and can increase the risk of population extinction. We used whole-genome resequencing of 97 grey wolves (Canis lupus) from the highly inbred Scandinavian wolf population to identify 'identical-by-descent' (IBD) chromosome segments as runs of homozygosity (ROH). This gave the high resolution required to precisely measure realized inbreeding as the IBD fraction of the genome in ROH (F

Affiliated researcher

PubMed 29158554

DOI 10.1038/s41559-017-0375-4

Crossref 10.1038/s41559-017-0375-4

pii: 10.1038/s41559-017-0375-4

Publications 9.5.0