The glioblastoma vasculature as a target for cancer therapy.

Dimberg A

Biochem. Soc. Trans. 42 (6) 1647-1652 [2014-12-00; online 2014-11-18]

Glioblastoma is characterized by microvascular proliferation and a highly abnormal dysfunctional vasculature. The glioblastoma vessels differ significantly from normal brain vessels morphologically, functionally and molecularly. The present review provides a brief overview of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment.

Affiliated researcher

PubMed 25399584

DOI 10.1042/BST20140278

Crossref 10.1042/BST20140278

pii: BST20140278