Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0).

Llona-Minguez S, Mackay SP

Beilstein J Org Chem 10 (-) 1333-1338 [2014-06-11; online 2014-06-11]

A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with interesting three-dimensional character, including chiral cyclopentane-1,2-diol and -1,2,3-triol derivatives. This unusual substitution pattern provides a useful starting point for the discovery of novel bioactive molecules.

Affiliated researcher

PubMed 24991286

DOI 10.3762/bjoc.10.135

Crossref 10.3762/bjoc.10.135

pmc: PMC4077357