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Eriksson A, Kürten C, Syrén PO
Chembiochem 18 (23) 2301-2305 [2017-12-05; online 2017-11-03]
Terpenes represent one of the most diversified classes of natural products with potent biological activities. The key to the myriad of polycyclic terpene skeletons with crucial functions in organisms from all kingdoms of life are terpene cyclase enzymes. These biocatalysts enable stereospecific cyclization of relatively simple, linear, prefolded polyisoprenes by highly complex, partially concerted, electrophilic cyclization cascades that remain incompletely understood. Herein, additional mechanistic light is shed on terpene biosynthesis by kinetic studies in mixed H
PubMed 28980755
DOI 10.1002/cbic.201700443
Crossref 10.1002/cbic.201700443