Protonation-Initiated Cyclization by a Class II Terpene Cyclase Assisted by Tunneling.

Eriksson A, Kürten C, Syrén PO

Chembiochem 18 (23) 2301-2305 [2017-12-05; online 2017-11-03]

Terpenes represent one of the most diversified classes of natural products with potent biological activities. The key to the myriad of polycyclic terpene skeletons with crucial functions in organisms from all kingdoms of life are terpene cyclase enzymes. These biocatalysts enable stereospecific cyclization of relatively simple, linear, prefolded polyisoprenes by highly complex, partially concerted, electrophilic cyclization cascades that remain incompletely understood. Herein, additional mechanistic light is shed on terpene biosynthesis by kinetic studies in mixed H

Affiliated researcher

PubMed 28980755

DOI 10.1002/cbic.201700443

Crossref 10.1002/cbic.201700443

pmc: PMC5725671


Publications 7.1.2