Delemotte L

Family name	Delemotte
Given name	Lucie
Initials	L
ORCID	ORCID 0000-0002-0828-3899
Affiliations

An intracellular hydrophobic nexus critical for hERG1 channel slow deactivation.

Stevens-Sostre WA, Flores-Aldama L, Bustos D, ..., Delemotte L, Robertson GA

Biophys. J. 123 (14) 2024-2037 [2024-07-16; online 2024-01-12]

The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics.

Yee SW, Macdonald CB, Mitrovic D, ..., Giacomini KM, Coyote-Maestas W

Mol. Cell 84 (10) 1932-1947.e10 [2024-05-16; online 2024-05-03]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction.

Clatot J, Currin CB, Liang Q, ..., Covarrubias M, Goldberg EM

Proc. Natl. Acad. Sci. U.S.A. 121 (3) e2307776121 [2024-01-16; online 2024-01-09]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Subtype-specific modulation of human KV 7 channels by the anticonvulsant cannabidiol through a lipid-exposed pore-domain site.

Pökl M, Sridhar A, Frampton DJA, ..., Delemotte L, Liin SI

Br J Pharmacol 180 (23) 2956-2972 [2023-12-00; online 2023-07-27]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Coevolution-Driven Method for Efficiently Simulating Conformational Changes in Proteins Reveals Molecular Details of Ligand Effects in the β2AR Receptor.

Mitrovic D, Chen Y, Marciniak A, Delemotte L

J Phys Chem B 127 (46) 9891-9904 [2023-11-23; online 2023-11-10]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Reconstructing the transport cycle in the sugar porter superfamily using coevolution-powered machine learning.

Mitrovic D, McComas SE, Alleva C, ..., Drew D, Delemotte L

Elife 12 (-) - [2023-07-05; online 2023-07-05]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Determinants of sugar-induced influx in the mammalian fructose transporter GLUT5.

McComas SE, Reichenbach T, Mitrovic D, ..., Delemotte L, Drew D

Elife 12 (-) - [2023-07-05; online 2023-07-05]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Modulation of Pore Opening of Eukaryotic Sodium Channels by π-Helices in S6.

Choudhury K, Delemotte L

J Phys Chem Lett 14 (25) 5876-5881 [2023-06-29; online 2023-06-21]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Interplay between VSD, pore, and membrane lipids in electromechanical coupling in HCN channels.

Elbahnsi A, Cowgill J, Burtscher V, ..., Chanda B, Delemotte L

Elife 12 (-) - [2023-06-21; online 2023-06-21]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

An α-π transition in S6 shapes the conformational cycle of the bacterial sodium channel NavAb.

Choudhury K, Howard RJ, Delemotte L

J. Gen. Physiol. 155 (2) - [2023-02-06; online 2022-12-14]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium.

Mehregan A, Pérez-Conesa S, Zhuang Y, ..., Ulens C, Delemotte L

Biochim Biophys Acta Biomembr 1864 (10) 183994 [2022-10-01; online 2022-06-18]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Markov state modelling reveals heterogeneous drug-inhibition mechanism of Calmodulin.

Westerlund AM, Sridhar A, Dahl L, ..., Bodnar AY, Delemotte L

PLoS Comput Biol 18 (10) e1010583 [2022-10-00; online 2022-10-07]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.

Chi G, Liang Q, Sridhar A, ..., Covarrubias M, Dürr KL

Nat Commun 13 (1) 4087 [2022-07-15; online 2022-07-15]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism.

Frampton DJA, Choudhury K, Nikesjö J, Delemotte L, Liin SI

Elife 11 (-) - [2022-06-01; online 2022-06-01]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Identification of electroporation sites in the complex lipid organization of the plasma membrane.

Rems L, Tang X, Zhao F, ..., Testa I, Delemotte L

Elife 11 (-) - [2022-02-23; online 2022-02-23]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine.

Choudhury K, Kasimova MA, McComas S, Howard RJ, Delemotte L

Biophys. J. 121 (1) 11-22 [2022-01-04; online 2021-12-08]

Lucie Delemotte SciLifeLab Fellow

DOI Crossref

Enhanced Sampling Methods for Molecular Dynamics Simulations [Article v1.0]

Hénin J, Lelièvre T, Shirts MR, Valsson O, Delemotte L

LiveCoMS 4 (1) - [2022-00-00; online 2022-00-00]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor.

Chen Y, Fleetwood O, Pérez-Conesa S, Delemotte L

J Chem Inf Model - (-) - [2021-11-15; online 2021-11-15]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5.

Galleano I, Harms H, Choudhury K, ..., Delemotte L, Pless SA

Proc. Natl. Acad. Sci. U.S.A. 118 (33) - [2021-08-17; online 2021-08-11]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Informing NMR experiments with molecular dynamics simulations to characterize the dominant activated state of the KcsA ion channel.

Pérez-Conesa S, Keeler EG, Zhang D, Delemotte L, McDermott AE

J Chem Phys 154 (16) 165102 [2021-04-28; online 2021-05-05]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Identification of ligand-specific G protein-coupled receptor states and prediction of downstream efficacy via data-driven modeling.

Fleetwood O, Carlsson J, Delemotte L

Elife 10 (-) - [2021-01-28; online 2021-01-28]

Jens Carlsson Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening.

Kang PW, Westerlund AM, Shi J, ..., Delemotte L, Cui J

Sci Adv 6 (50) - [2020-12-00; online 2020-12-11]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Network analysis reveals how lipids and other cofactors influence membrane protein allostery.

Westerlund AM, Fleetwood O, Pérez-Conesa S, Delemotte L

J Chem Phys 153 (14) 141103 [2020-10-14; online 2020-10-23]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Pulsed Electric Fields Can Create Pores in the Voltage Sensors of Voltage-Gated Ion Channels.

Rems L, Kasimova MA, Testa I, Delemotte L

Biophys. J. 119 (1) 190-205 [2020-07-07; online 2020-06-08]

Ilaria Testa Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Energy Landscapes Reveal Agonist Control of G Protein-Coupled Receptor Activation via Microswitches.

Fleetwood O, Matricon P, Carlsson J, Delemotte L

Biochemistry 59 (7) 880-891 [2020-02-25; online 2020-02-07]

Jens Carlsson Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Molecular Insights from Conformational Ensembles via Machine Learning.

Fleetwood O, Kasimova MA, Westerlund AM, Delemotte L

Biophys. J. 118 (3) 765-780 [2020-02-04; online 2019-12-21]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

InfleCS: Clustering Free Energy Landscapes with Gaussian Mixtures.

Westerlund AM, Delemotte L

J Chem Theory Comput 15 (12) 6752-6759 [2019-12-10; online 2019-11-07]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating.

Kasimova MA, Tewari D, Cowgill JB, ..., Delemotte L, Chanda B

Elife 8 (-) - [2019-11-27; online 2019-11-27]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Sharing Data from Molecular Simulations.

Abraham M, Apostolov R, Barnoud J, ..., Woods C, Zhmurov A

J Chem Inf Model 59 (10) 4093-4099 [2019-10-28; online 2019-10-11]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Opening leads to closing: Allosteric crosstalk between the activation and inactivation gates in KcsA.

Delemotte L

J. Gen. Physiol. 150 (10) 1356-1359 [2018-10-01; online 2018-08-24]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Determining the molecular basis of voltage sensitivity in membrane proteins.

Kasimova MA, Lindahl E, Delemotte L

J. Gen. Physiol. 150 (10) 1444-1458 [2018-10-01; online 2018-08-27]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Exploring the Viral Channel KcvPBCV-1 Function via Computation.

Andersson AEV, Kasimova MA, Delemotte L

J. Membr. Biol. 251 (3) 419-430 [2018-06-00; online 2018-02-23]

Affiliated researcher Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Effect of Ca2+ on the promiscuous target-protein binding of calmodulin.

Westerlund AM, Delemotte L

PLoS Comput Biol 14 (4) e1006072 [2018-04-00; online 2018-04-03]

Affiliated researcher Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Inference of Calmodulin's Ca2+-Dependent Free Energy Landscapes via Gaussian Mixture Model Validation.

Westerlund AM, Harpole TJ, Blau C, Delemotte L

J Chem Theory Comput 14 (1) 63-71 [2018-01-09; online 2017-12-06]

Affiliated researcher Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

Molecular simulations and free-energy calculations suggest conformation-dependent anion binding to a cytoplasmic site as a mechanism for Na+/K+-ATPase ion selectivity.

Razavi AM, Delemotte L, Berlin JR, Carnevale V, Voelz VA

J Biol Chem 292 (30) 12412-12423 [2017-07-28; online 2017-06-06]

Affiliated researcher Lucie Delemotte SciLifeLab Fellow

Delemotte L

35 publications