Daniel Globisch

Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites.

Lin W, Conway LP, Vujasinovic M, Löhr JM, Globisch D

Angew. Chem. Int. Ed. Engl. 60 (43) 23232-23240 [2021-10-18; online 2021-09-17]

Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines.

Lin W, Yang Z, Kaur A, ..., Löhr JM, Globisch D

RSC Chem Biol 2 (5) 1479-1483 [2021-10-07; online 2021-08-12]

Enterotoxigenic Escherichia coli display a distinct growth phase before entry into stationary phase with shifts in tryptophan- fucose- and putrescine metabolism and degradation of neurotransmitter precursors

Joffré E, Xiao X, Correia MSP, ..., Zhu B, Sjöling Å

- - (-) - [2021-08-26; online 2021-08-26]

Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep.

Vallianatou T, Lin W, Bèchet NB, ..., Lundgaard I, Globisch D

J. Cereb. Blood Flow Metab. - (-) 271678X211033358 [2021-07-22; online 2021-07-22]

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis.

Kundu S, Ali MA, Handin N, ..., Globisch D, Sjöblom T

J. Exp. Clin. Cancer Res. 40 (1) 225 [2021-07-07; online 2021-07-07]

Comparison of two arylsulfatases for targeted mass spectrometric analysis of microbiota-derived metabolites

Jain A, Correia MSP, Meistermann H, ..., Löhr JM, Globisch D

J Pharm Biomed Anal 195 (-) 113818 [2021-02-00; online 2021-02-00]

Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency

Correia MSP, Thapa B, Vujasinovic M, Löhr JM, Globisch D

RSC Adv. 11 (55) 34788-34794 [2021-00-00; online 2021-00-00]

Year 2020

Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host.

Correia MSP, Jain A, Alotaibi W, ..., Rodriguez-Mateos A, Globisch D

Free Radic. Biol. Med. 160 (-) 745-754 [2020-11-20; online 2020-09-11]

Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World.

Nainytė M, Müller F, Ganazzoli G, ..., Globisch D, Carell T

Chemistry 26 (65) 14856-14860 [2020-11-20; online 2020-10-14]

Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples.

Correia MSP, Lin W, Aria AJ, Jain A, Globisch D

Metabolites 10 (10) 415 [2020-10-16; online 2020-10-16]

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2.

Conway LP, Rendo V, Correia MSP, ..., Sjöblom T, Globisch D

Angew. Chem. Int. Ed. Engl. 59 (34) 14342-14346 [2020-08-17; online 2020-07-08]

DNA surface exploration and operator bypassing during target search.

Marklund E, van Oosten B, Mao G, ..., Elf J, Deindl S

Nature 583 (7818) 858-861 [2020-07-00; online 2020-06-24]

Daniel Globisch SciLifeLab Fellow Sebastian Deindl

Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification.

Lin W, Conway LP, Block A, ..., Löhr JM, Globisch D

Analyst 145 (11) 3822-3831 [2020-06-07; online 2020-05-12]

Year 2019

Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples.

Conway LP, Garg N, Lin W, ..., Löhr JM, Globisch D

Chem. Commun. (Camb.) 55 (62) 9080-9083 [2019-08-11; online 2019-07-09]

Coupled Enzymatic Treatment and Mass Spectrometric Analysis for Identification of Glucuronidated Metabolites in Human Samples.

Correia MSP, Rao M, Ballet C, Globisch D

Chembiochem 20 (13) 1678-1683 [2019-07-01; online 2019-05-08]

Comprehensive kinetic and substrate specificity analysis of an arylsulfatase from Helix pomatia using mass spectrometry.

Correia MSP, Ballet C, Meistermann H, Conway LP, Globisch D

Bioorg. Med. Chem. 27 (6) 955-962 [2019-03-15; online 2019-01-30]

Year 2018

Chemoselective Probe Containing a Unique Bioorthogonal Cleavage Site for Investigation of Gut Microbiota Metabolism.

Garg N, Conway LP, Ballet C, ..., Löhr JM, Globisch D

Angew. Chem. Int. Ed. Engl. 57 (42) 13805-13809 [2018-10-15; online 2018-09-20]

Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis.

Shirey RJ, Globisch D, Eubanks LM, Hixon MS, Janda KD

ACS Infect Dis 4 (10) 1423-1431 [2018-10-12; online 2018-09-21]

New enzymatic and mass spectrometric methodology for the selective investigation of gut microbiota-derived metabolites.

Ballet C, Correia MSP, Conway LP, ..., Löhr JM, Globisch D

Chem Sci 9 (29) 6233-6239 [2018-08-07; online 2018-06-28]

Affiliated researcher Daniel Globisch SciLifeLab Fellow Sebastian Deindl

Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control.

Garg N, Hansson A, Knych HK, ..., Hedeland M, Globisch D

Org. Biomol. Chem. 16 (5) 698-702 [2018-01-31; online 2018-01-11]

Affiliated researcher Daniel Globisch SciLifeLab Fellow

Year 2017

Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG).

Globisch D, Eubanks LM, Shirey RJ, ..., Hoerauf A, Janda KD

Bioorg. Med. Chem. Lett. 27 (15) 3436-3440 [2017-08-01; online 2017-05-29]

Affiliated researcher Daniel Globisch SciLifeLab Fellow

Year 2016

Glycation Reactivity of a Quorum-Sensing Signaling Molecule.

Tsuchikama K, Gooyit M, Harris TL, ..., Kaufmann GF, Janda KD

Angew. Chem. Int. Ed. Engl. 55 (12) 4002-4006 [2016-03-14; online 2016-02-17]

Year 2015

Litomosoides sigmodontis: a jird urine metabolome study.

Globisch D, Specht S, Pfarr KM, ..., Hoerauf A, Janda KD

Bioorg. Med. Chem. Lett. 25 (24) 5804-5807 [2015-12-15; online 2015-10-23]

A chemoenzymatic approach toward the preparation of site-specific antibody–drug conjugates

Cai X, Janda KD

Tetrahedron Letters 56 (23) 3172-3175 [2015-06-00; online 2015-06-00]

Flagellin as carrier and adjuvant in cocaine vaccine development.

Lockner JW, Eubanks LM, Choi JL, ..., Wilson IA, Janda KD

Mol. Pharm. 12 (2) 653-662 [2015-02-02; online 2015-01-07]

Year 2013

Mechanistic Insights into the LsrK Kinase Required for Autoinducer-2 Quorum Sensing Activation

Zhu J, Hixon MS, Globisch D, Kaufmann GF, Janda KD

J. Am. Chem. Soc. 135 (21) 7827-7830 [2013-05-29; online 2013-05-16]

Onchocerca volvulus-neurotransmitter tyramine is a biomarker for river blindness

Globisch D, Moreno AY, Hixon MS, ..., Hoerauf A, Janda KD

Proceedings of the National Academy of Sciences 110 (11) 4218-4223 [2013-03-12; online 2013-02-25]

Year 2012

Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency

Brandmayr C, Wagner M, Brückl T, ..., Biel M, Carell T

Angewandte Chemie International Edition 51 (44) 11162-11165 [2012-10-29; online 2012-10-04]

Low values of 5-hydroxymethylcytosine (5hmC), the “sixth base,” are associated with anaplasia in human brain tumors

Kraus TFJ, Globisch D, Wagner M, ..., Carell T, Kretzschmar HA

Int. J. Cancer 131 (7) 1577-1590 [2012-10-01; online 2012-03-02]

The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA

Reiter V, Matschkal DMS, Wagner M, ..., Müller M, Carell T

Nucleic Acids Res. 40 (13) 6235-6240 [2012-07-00; online 2012-03-15]

Uncharacterized 4,5-Dihydroxy-2,3-Pentanedione (DPD) Molecules Revealed Through NMR Spectroscopy: Implications for a Greater Signaling Diversity in Bacterial Species

Globisch D, Lowery CA, McCague KC, Janda KD

Angewandte Chemie International Edition 51 (17) 4204-4208 [2012-04-23; online 2012-02-29]

Year 2011

Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization

Zakhari JS, Kinoyama I, Hixon MS, ..., Globisch D, Janda KD

Bioorganic & Medicinal Chemistry 19 (21) 6203-6209 [2011-11-00; online 2011-11-00]

Systems-Based Analysis of Modified tRNA Bases

Globisch D, Pearson D, Hienzsch A, ..., Sieber SA, Carell T

Angewandte Chemie International Edition 50 (41) 9739-9742 [2011-10-04; online 2011-08-31]

5-Hydroxymethylcytosine, the Sixth Base of the Genome

Münzel M, Globisch D, Carell T

Angewandte Chemie International Edition 50 (29) 6460-6468 [2011-07-11; online 2011-06-17]

Discovery and Synthesis of New UV-Induced Intrastrand C(4−8)G and G(8−4)C Photolesions

Münzel M, Szeibert C, Glas AF, Globisch D, Carell T

J. Am. Chem. Soc. 133 (14) 5186-5189 [2011-04-13; online 2011-04-13]

LC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA

Pearson D, Hienzsch A, Wagner M, ..., Özden D, Carell T

Chem. Commun. 47 (18) 5196 [2011-00-00; online 2011-00-00]

Year 2010

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

Globisch D, Münzel M, Müller M, ..., Biel M, Carell T

PLoS ONE 5 (12) e15367 [2010-12-23; online 2010-12-23]

Efficient Synthesis of 5-Hydroxymethylcytosine Containing DNA

Münzel M, Globisch D, Trindler C, Carell T

Org. Lett. 12 (24) 5671-5673 [2010-12-17; online 2010-12-17]

A Novel Synthetic Route for the Anti-HIV Drug MC-1220 and its Analogues

Loksha YM, Globisch D, Loddo R, ..., La Colla P, Pedersen EB

ChemMedChem 5 (11) 1847-1849 [2010-11-08; online 2010-08-16]

Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain

Münzel M, Globisch D, Brückl T, ..., Biel M, Carell T

Angewandte Chemie International Edition 49 (31) 5375-5377 [2010-06-25; online 2010-06-25]

Year 2009

Parallel isotope-based quantification of modified tRNA nucleosides.

Brückl T, Globisch D, Wagner M, Müller M, Carell T

Angew. Chem. Int. Ed. Engl. 48 (42) 7932-7934 [2009-09-12; online 2009-09-12]

Synthesis and anti‐HIV‐1 evaluation of 1,5‐disubstituted pyrimidine‐2,4‐diones

Loksha YM, Globisch D, Pedersen EB, ..., Collu G, Loddo R

J. Heterocyclic Chem. 45 (-) 1161-1166 [2009-03-13; online 2009-03-13]

Year 2008

Stability ofHoogsteen-Type Triplexes – Electrostatic Attraction between Duplex Backbone and Triplex-Forming Oligonucleotide (TFO) Using an Intercalating Conjugate

Globisch D, Bomholt N, Filichev VV, Pedersen EB

HCA 91 (5) 805-818 [2008-05-00; online 2008-05-00]