Schwenk JM

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Family name Schwenk
Given name Jochen M
Initials JM
ORCID

ORCID 0000-0001-8141-8449
Affiliations Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden.

70 publications

PubMed DOI Crossref
A human pan-disease blood atlas of the circulating proteome.
Álvez MB, Bergström S, Kenrick J, ..., Edfors F, Uhlén M
Science (New York, N.Y.) 390 (6779) eadx2678 [2025-12-18; online 2025-12-18]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
A standardized framework for circulating blood proteomics.
Cai X, Geyer PE, Perez-Riverol Y, ..., Völker U, Guo T
Nat. Genet. 57 (10) 2371-2380 [2025-10-00; online 2025-09-23]
PubMed DOI Crossref
Frequent longitudinal blood microsampling and proteome monitoring identify disease markers and enable timely intervention in a mouse model of type 1 diabetes.
Parajuli A, Bendes A, Byvald F, ..., Schwenk JM, Flodström-Tullberg M
Diabetologia 68 (10) 2277-2289 [2025-10-00; online 2025-08-04]
PubMed DOI Crossref
A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study.
Atabaki NN, Coral DE, Pomares-Millan H, ..., Viñuela A, Franks PW
medRxiv - (-) - [2025-06-02; online 2025-06-02]
PubMed DOI Crossref
Genetically Determined Inflammation-Related Proteins in Asthma and Type-2 Signatures.
Hernandez-Pacheco N, Björkander S, Merid SK, ..., Schwenk JM, Melén E
Allergy 80 (6) 1702-1714 [2025-06-00; online 2025-06-04]
PubMed DOI Crossref
Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare.
Kämpe A, Gudmundsson S, Walsh CP, ..., Lindstrand A, Lappalainen T
Nat. Med. 31 (6) 1730-1732 [2025-06-00; online 2025-04-05]
PubMed DOI Crossref
The Circulating Proteome─Technological Developments, Current Challenges, and Future Trends.
Geyer PE, Hornburg D, Pernemalm M, ..., Deutsch EW, Schwenk JM
J. Proteome Res. 23 (12) 5279-5295 [2024-12-06; online 2024-10-31]
DDLS Fellow Fredrik Edfors
PubMed DOI Crossref
A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes.
Halama A, Zaghlool S, Thareja G, ..., Schmidt F, Suhre K
Nat Commun 15 (1) 7111 [2024-08-19; online 2024-08-19]
PubMed DOI Crossref
Multiplexed mapping of the interactome of GPCRs with receptor activity-modifying proteins.
Kotliar IB, Bendes A, Dahl L, ..., Schwenk JM, Sakmar TP
Sci Adv 10 (31) eado9959 [2024-08-02; online 2024-07-31]
DOI Crossref
The Effect of Metformin Treatment on the Circulating Proteome
Connolly B, McCreight L, Slieker RC, ..., Gummesson A, Pearson ER
- - (-) - [2024-06-08; online 2024-06-08]
PubMed DOI Crossref
Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections.
Fredolini C, Dodig-Crnković T, Bendes A, ..., Roxhed N, Schwenk JM
Commun Med (Lond) 4 (1) 55 [2024-04-02; online 2024-04-02]
PubMed DOI Crossref
The impact of circulating protein levels identified by affinity proteomics on short-term, overall breast cancer risk.
Grassmann F, Mälarstig A, Dahl L, ..., Schwenk JM, Czene K
Br. J. Cancer 130 (4) 620-627 [2024-03-00; online 2023-12-22]
PubMed DOI Crossref
Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, ..., Trégouët DA, Odeberg J
Nat Commun 14 (1) 7752 [2023-11-27; online 2023-11-27]
DDLS Fellow Fredrik Edfors
PubMed DOI Crossref
Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation.
Mälarstig A, Grassmann F, Dahl L, ..., Czene K, Hedman ÅK
Nat Commun 14 (1) 7680 [2023-11-24; online 2023-11-24]
PubMed DOI Crossref
Expanding the GPCR-RAMP interactome.
Kotliar IB, Bendes A, Dahl L, ..., Schwenk JM, Sakmar TP
bioRxiv - (-) - [2023-11-23; online 2023-11-23]
PubMed DOI Crossref
Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis.
FitzGerald O, Behrens F, Barton A, ..., Vivekanantham A, Pennington SR
Ther Adv Musculoskelet Dis 15 (-) 1759720X231192315 [2023-09-08; online 2023-09-08]
PubMed DOI Crossref
Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.
Brown AA, Fernandez-Tajes JJ, Hong MG, ..., Dermitzakis ET, Viñuela A
Nat Commun 14 (1) 5062 [2023-08-21; online 2023-08-21]
PubMed DOI Crossref
Author Correction: Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
Allesøe RL, Lundgaard AT, Hernández Medina R, ..., Brunak S, IMI DIRECT Consortium
Nat. Biotechnol. 41 (7) 1026 [2023-07-00; online 2023-05-03]
PubMed DOI Crossref
Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, ..., Trégouët DA, Odeberg J
Nat Commun 14 (1) 3280 [2023-06-07; online 2023-06-07]
DDLS Fellow Fredrik Edfors
PubMed DOI Crossref
A Longitudinal Study of Individual Radiation Responses in Pediatric Patients Treated with Proton and Photon Radiotherapy, and Interventional Cardiology: Rationale and Research Protocol of the HARMONIC Project.
Andreassi MG, Haddy N, Harms-Ringdahl M, ..., Fuentes M, Haghdoost S
Int J Mol Sci 24 (9) - [2023-05-08; online 2023-05-08]
PubMed DOI Crossref
Multiplexed selectivity screening of anti-GPCR antibodies.
Dahl L, Kotliar IB, Bendes A, ..., Sakmar TP, Schwenk JM
Sci Adv 9 (18) eadf9297 [2023-05-03; online 2023-05-03]
DOI Crossref
Evaluation of Circulating Plasma Proteins in Breast Cancer: A Mendelian Randomization Analysis
Malarstig A, Grassman F, Dahl L, ..., Czene K, Hedman A
- - (-) - [2023-04-04; online 2023-04-04]
PubMed DOI Crossref
Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
Allesøe RL, Lundgaard AT, Hernández Medina R, ..., Brunak S, IMI DIRECT Consortium
Nat. Biotechnol. 41 (3) 399-408 [2023-03-00; online 2023-01-02]
PubMed DOI Crossref
Microfluidic Device for Patient-Centric Multiplexed Assays with Readout in Centralized Laboratories.
Hauser J, Dale M, Beck O, ..., Fredolini C, Roxhed N
Anal. Chem. 95 (2) 1350-1358 [2023-01-17; online 2022-12-22]
PubMed DOI Crossref
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins.
Kotliar IB, Lorenzen E, Schwenk JM, Hay DL, Sakmar TP
Pharmacol Rev 75 (1) 1-34 [2023-01-00; online 2022-12-08]
DOI Crossref
Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs)
Kotliar IB, Ceraudo E, Kemelmakher-Liben K, ..., Schwenk JM, Sakmar TP
- - (-) - [2022-12-06; online 2022-12-06]
DOI Crossref
Multiplexed selectivity screening of anti-GPCR antibodies
Dahl L, Kotliar IB, Bendes A, ..., Sakmar TP, Schwenk JM
- - (-) - [2022-11-24; online 2022-11-24]
PubMed DOI Crossref
Advances in plasma proteomics: Moving from technology to precision medicine.
Yu X, Schwenk JM, Xu P, LaBaer J
Proteomics Clin Appl 16 (6) e2200083 [2022-11-00; online 2022-11-16]
PubMed DOI Crossref
Omics and Multi-Omics Analysis for the Early Identification and Improved Outcome of Patients with Psoriatic Arthritis.
Gurke R, Bendes A, Bowes J, ..., Pennington SR, HIPPOCRATES Consortium
Biomedicines 10 (10) - [2022-09-24; online 2022-09-24]
PubMed DOI Crossref
Genetic Landscape of the ACE2 Coronavirus Receptor.
Yang Z, Macdonald-Dunlop E, Chen J, ..., Wilson JF, Shen X
Circulation 145 (18) 1398-1411 [2022-05-03; online 2022-04-07]
DOI Crossref
Elevated plasma Complement Factor H Regulating Protein 5 is associated with venous thromboembolism and COVID-19 severity
Sanchez-Rivera L, Iglesias MJ, Ibrahim-Kosta M, ..., Trégouët DA, Odeberg J
- - (-) - [2022-04-21; online 2022-04-21]
PubMed DOI Crossref
Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection.
Bauer W, Weber M, Diehl-Wiesenecker E, ..., Micke P, Kappert K
Viruses 13 (12) - [2021-12-07; online 2021-12-07]
PubMed DOI Crossref
Advances and Utility of the Human Plasma Proteome.
Deutsch EW, Omenn GS, Sun Z, ..., Moritz RL, Schwenk JM
J. Proteome Res. 20 (12) 5241-5263 [2021-12-03; online 2021-10-21]
DOI Crossref
Precise blood proteome profiling in an undiagnosed population with COVID-19
Fredolini C, Dodig-Crnković T, Bendes A, ..., Roxhed N, Schwenk JM
- - (-) - [2021-11-16; online 2021-11-16]
PubMed DOI Crossref
Elevated circulating follistatin associates with an increased risk of type 2 diabetes.
Wu C, Borné Y, Gao R, ..., Groop L, De Marinis Y
Nat Commun 12 (1) 6486 [2021-11-10; online 2021-11-10]
PubMed DOI Crossref
Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients.
Zeybel M, Altay O, Arif M, ..., Borén J, Mardinoglu A
Mol Syst Biol 17 (10) e10459 [2021-10-00; online 2021-10-26]
Adil Mardinoglu DDLS Fellow Muhammad Arif Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.
Roxhed N, Bendes A, Dale M, ..., Fredolini C, Schwenk JM
Nat Commun 12 (1) 3695 [2021-06-17; online 2021-06-17]
SciLifeLab Fellow Simon Elsässer
DOI Crossref
Combined Metabolic Activators Reduces Liver Fat in Nonalcoholic Fatty Liver Disease Patients
Zeybel M, Altay O, Arif M, ..., Borén J, Mardinoglu A
- - (-) - [2021-05-23; online 2021-05-23]
Adil Mardinoglu DDLS Fellow Muhammad Arif Saeed Shoaie SciLifeLab Fellow
DOI Crossref
Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer
Thomas CE, Dahl L, Byström S, ..., Schwenk JM, Gabrielson M
- - (-) - [2021-05-22; online 2021-05-22]
DOI Crossref
Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study
Viñuela A, Brown AA, Fernandez J, ..., Pearson ER, Dermitzakis ET
- - (-) - [2021-03-29; online 2021-03-29]
DOI Crossref
Identification of endothelial-derived proteins in plasma associated with cardiovascular risk factors
Iglesias M, Kruse L, Sanchez-Rivera L, ..., Odeberg J, Butler L
- - (-) - [2021-02-09; online 2021-02-09]
PubMed DOI Crossref
Genetics meets proteomics: perspectives for large population-based studies.
Suhre K, McCarthy MI, Schwenk JM
Nat. Rev. Genet. 22 (1) 19-37 [2021-01-00; online 2020-08-28]
PubMed DOI Crossref
Enhanced Validation of Antibodies Enables the Discovery of Missing Proteins.
Sivertsson Å, Lindström E, Oksvold P, ..., Uhlén M, Lindskog C
J. Proteome Res. 19 (12) 4766-4781 [2020-12-04; online 2020-11-10]
PubMed DOI Crossref
Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study.
Obura M, Beulens JWJ, Slieker R, ..., Rutters F, IMI-DIRECT Consortium
PLoS ONE 15 (11) e0242360 [2020-11-30; online 2020-11-30]
PubMed DOI Crossref
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality.
Hong MG, Dodig-Crnković T, Chen X, ..., Magnusson PK, Schwenk JM
Life Sci. Alliance 3 (10) - [2020-10-00; online 2020-07-31]
DDLS Fellow Fredrik Edfors
PubMed DOI Crossref
Integration of molecular profiles in a longitudinal wellness profiling cohort.
Tebani A, Gummesson A, Zhong W, ..., Uhlen M, Fagerberg L
Nat Commun 11 (1) 4487 [2020-09-08; online 2020-09-08]
Adil Mardinoglu DDLS Fellow Fredrik Edfors Muhammad Arif SciLifeLab Fellow
DOI Crossref
A translational multiplex serology approach to profile the prevalence of anti-SARS-CoV-2 antibodies in home-sampled blood
Roxhed N, Bendes A, Dale M, ..., Fredolini C, Schwenk JM
- - (-) - [2020-07-02; online 2020-07-02]
SciLifeLab Fellow Simon Elsässer
PubMed DOI Crossref
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts.
Atabaki-Pasdar N, Ohlsson M, Viñuela A, ..., Pavo I, Franks PW
PLoS Med. 17 (6) e1003149 [2020-06-00; online 2020-06-19]
PubMed DOI Crossref
Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer.
Drobin K, Marczyk M, Halle M, ..., Schwenk JM, Haghdoost S
Cancers (Basel) 12 (3) - [2020-03-22; online 2020-03-22]
DOI Crossref
Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling
Dodig-Crnković T, Hong MG, Thomas CE, ..., Uhlén M, Schwenk JM
- - (-) - [2020-03-15; online 2020-03-15]
DDLS Fellow Fredrik Edfors
DOI Crossref
Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study
Atabaki-Pasdar N, Ohlsson M, Viñuela A, ..., Pavo I, Franks PW
- - (-) - [2020-02-11; online 2020-02-11]
PubMed DOI Crossref
Progress on Identifying and Characterizing the Human Proteome: 2019 Metrics from the HUPO Human Proteome Project.
Omenn GS, Lane L, Overall CM, ..., Baker MS, Deutsch EW
J. Proteome Res. 18 (12) 4098-4107 [2019-12-06; online 2019-09-13]
PubMed DOI Crossref
Mass Spectrometry-Based Plasma Proteomics: Considerations from Sample Collection to Achieving Translational Data.
Ignjatovic V, Geyer PE, Palaniappan KK, ..., Deutsch EW, Schwenk JM
J. Proteome Res. 18 (12) 4085-4097 [2019-12-06; online 2019-10-11]
PubMed DOI Crossref
The human secretome.
Uhlén M, Karlsson MJ, Hober A, ..., Fagerberg L, Sivertsson Å
Sci Signal 12 (609) eaaz0274 [2019-11-26; online 2019-11-26]
Adil Mardinoglu DDLS Fellow Fredrik Edfors SciLifeLab Fellow
PubMed DOI Crossref
Multiplexed analysis of the secretin-like GPCR-RAMP interactome.
Lorenzen E, Dodig-Crnković T, Kotliar IB, ..., Schwenk JM, Sakmar TP
Sci Adv 5 (9) eaaw2778 [2019-09-00; online 2019-09-18]
DOI Crossref
Mass Spectrometry-Based Plasma Proteomics: Considerations from Sample Collection to Achieving Translational Data
Ignjatovic V, Geyer PE, Palaniappan KK, ..., Deutsch EW, Schwenk JM
- - (-) - [2019-07-26; online 2019-07-26]
PubMed DOI Crossref
Screening a Resource of Recombinant Protein Fragments for Targeted Proteomics.
Edfors F, Forsström B, Vunk H, ..., Schwenk JM, Uhlen M
J. Proteome Res. 18 (7) 2706-2718 [2019-07-05; online 2019-06-07]
DDLS Fellow Fredrik Edfors
PubMed DOI Crossref
Systematic assessment of antibody selectivity in plasma based on a resource of enrichment profiles.
Fredolini C, Byström S, Sanchez-Rivera L, ..., Lehtiö J, Schwenk JM
Sci Rep 9 (1) 8324 [2019-06-06; online 2019-06-06]
PubMed DOI Crossref
In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta.
Pernemalm M, Sandberg A, Zhu Y, ..., Westgren M, Lehtiö J
Elife 8 (-) - [2019-04-08; online 2019-04-08]
DOI Crossref
Multiplexed Analysis of the Secretin-like GPCR-RAMP Interactome
Lorenzen E, Dodig-Crnković T, Kotliar IB, ..., Schwenk JM, Sakmar TP
- - (-) - [2019-04-06; online 2019-04-06]
DOI Crossref
Author response: In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta
Pernemalm M, Sandberg A, Zhu Y, ..., Westgren M, Lehtiö J
- - (-) - [2019-02-13; online 2019-02-13]
DOI Crossref
Systematic Development of Sandwich Immunoassays for the Plasma Secretome
Häussler RS, Bendes A, Iglesias M, ..., Qundos U, Schwenk JM
- - (-) - [2019-01-08; online 2019-01-08]
DDLS Fellow Fredrik Edfors
PubMed DOI Crossref
Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project.
Omenn GS, Lane L, Overall CM, ..., Baker MS, Deutsch EW
J. Proteome Res. 17 (12) 4031-4041 [2018-12-07; online 2018-08-23]
DOI Crossref
Screening a Resource of Recombinant Protein Fragments for Targeted Proteomics
Edfors F, Forsström B, Vunk H, ..., Schwenk JM, Uhlen M
- - (-) - [2018-11-19; online 2018-11-19]
DDLS Fellow Fredrik Edfors
DOI Crossref
Profiles of circulating histidine-rich glycoprotein associate with chronological age and risk of all-cause mortality
Hong MG, Dodig-Crnković T, Chen X, ..., Magnusson PKE, Schwenk JM
- - (-) - [2018-11-09; online 2018-11-09]
DDLS Fellow Fredrik Edfors
DOI Crossref
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium
Koivula RW, Forgie IM, Kurbasic A, ..., Pearson E, Franks PW
- - (-) - [2018-04-16; online 2018-04-16]
PubMed DOI Crossref
A pathology atlas of the human cancer transcriptome.
Uhlen M, Zhang C, Lee S, ..., Mardinoglu A, Ponten F
Science (New York, N.Y.) 357 (6352) eaan2507 [2017-08-18; online 2017-08-19]
Adil Mardinoglu Affiliated researcher DDLS Fellow Fredrik Edfors Muhammad Arif SciLifeLab Fellow
PubMed DOI Crossref
A subcellular map of the human proteome.
Thul PJ, Åkesson L, Wiking M, ..., Uhlén M, Lundberg E
Science (New York, N.Y.) 356 (6340) eaal3321 [2017-05-26; online 2017-05-11]
Adil Mardinoglu Affiliated researcher SciLifeLab Fellow
PubMed DOI Crossref
Discovery of circulating proteins associated to knee radiographic osteoarthritis.
Lourido L, Ayoglu B, Fernández-Tajes J, ..., Nilsson P, Blanco FJ
Sci Rep 7 (1) 137 [2017-03-09; online 2017-03-09]
PubMed DOI Crossref
PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study.
Bruzelius M, Iglesias MJ, Hong MG, ..., Trégouët DA, Odeberg J
Blood 128 (23) e59-e66 [2016-12-08; online 2016-10-14]
SciLifeLab Data Centre
Publications 9.5.1