Pearce NM

Of problems and opportunities-How to treat and how to not treat crystallographic fragment screening data.

Weiss MS, Wollenhaupt J, Correy GJ, ..., Thunissen M, Pearce NM

Protein Sci. 31 (9) e4391 [2022-09-00; online 2022-08-31]

DDLS Fellow Nicholas Pearce

Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures.

Wood TM, Zeronian MR, Buijs N, ..., Janssen BJC, Martin NI

Chem Sci 13 (10) 2985-2991 [2022-03-09; online 2022-02-21]

DDLS Fellow Nicholas Pearce

Improving sampling of crystallographic disorder in ensemble refinement.

Ploscariu N, Burnley T, Gros P, Pearce NM

Acta Crystallogr D Struct Biol 77 (Pt 11) 1357-1364 [2021-11-01; online 2021-10-20]

DDLS Fellow Nicholas Pearce

A method for intuitively extracting macromolecular dynamics from structural disorder

Pearce NM, Gros P

Nat Commun 12 (1) - [2021-09-17; online 2021-09-17]

DDLS Fellow Nicholas Pearce

Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling.

Wendt M, Bellavita R, Gerber A, ..., Hennig S, Grossmann TN

Angew. Chem. Int. Ed. Engl. 60 (25) 13937-13944 [2021-06-14; online 2021-05-05]

DDLS Fellow Nicholas Pearce

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F

Oosterheert W, Xenaki KT, Neviani V, ..., van Bergen en Henegouwen PM, Gros P

Life Sci. Alliance 3 (11) e202000883 [2020-11-00; online 2020-09-21]

DDLS Fellow Nicholas Pearce

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.

Keedy DA, Hill ZB, Biel JT, ..., Wells JA, Fraser JS

Elife 7 (-) - [2018-06-07; online 2018-06-07]

DDLS Fellow Nicholas Pearce

Ten simple rules for surviving an interdisciplinary PhD.

Demharter S, Pearce N, Beattie K, ..., Deane CM, Knapp B

PLoS Comput Biol 13 (5) e1005512 [2017-05-00; online 2017-05-25]

DDLS Fellow Nicholas Pearce