Hardt W

Direct Salmonella injection into enteroid cells allows the study of host-pathogen interactions in the cytosol with high spatiotemporal resolution.

Ernst C, Andreassen PR, Giger GH, ..., Hardt WD, Vorholt JA

PLoS Biol. 22 (4) e3002597 [2024-04-00; online 2024-04-29]

Mikael Sellin SciLifeLab Fellow

Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice.

Fattinger SA, Maurer L, Geiser P, ..., Sellin ME, Hardt WD

Proc. Natl. Acad. Sci. U.S.A. 120 (48) e2315503120 [2023-11-28; online 2023-11-21]

Mikael Sellin SciLifeLab Fellow

Intraluminal neutrophils limit epithelium damage by reducing pathogen assault on intestinal epithelial cells during Salmonella gut infection.

Gül E, Enz U, Maurer L, ..., Sellin ME, Hardt WD

PLoS Pathog 19 (6) e1011235 [2023-06-00; online 2023-06-29]

Mikael Sellin SciLifeLab Fellow

A motile doublet form of Salmonella Typhimurium diversifies target search behavior at the epithelial surface.

Ek V, Fattinger SA, Florbrant A, ..., Eriksson J, Sellin ME

Mol. Microbiol. 117 (5) 1156-1172 [2022-05-00; online 2022-04-12]

Mikael Sellin SciLifeLab Fellow

Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF.

Hausmann A, Felmy B, Kunz L, ..., Sellin ME, Hardt WD

J. Exp. Med. 218 (11) - [2021-11-01; online 2021-09-16]

Mikael Sellin SciLifeLab Fellow

Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice.

Fattinger SA, Geiser P, Samperio Ventayol P, ..., Hardt WD, Sellin ME

Mucosal Immunol 14 (3) 615-629 [2021-05-00; online 2021-03-17]

Mikael Sellin SciLifeLab Fellow

Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers.

Samperio Ventayol P, Geiser P, Di Martino ML, ..., Eriksson J, Sellin ME

Proc. Natl. Acad. Sci. U.S.A. 118 (16) - [2021-04-20; online 2021-04-14]

Mikael Sellin SciLifeLab Fellow

Germ-free and microbiota-associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes.

Hausmann A, Russo G, Grossmann J, ..., Sellin ME, Hardt WD

Cell. Microbiol. 22 (6) e13191 [2020-06-00; online 2020-03-04]

Mikael Sellin SciLifeLab Fellow

Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium.

Fattinger SA, Böck D, Di Martino ML, ..., Hardt WD, Sellin ME

PLoS Pathog 16 (5) e1008503 [2020-05-00; online 2020-05-04]

Mikael Sellin SciLifeLab Fellow

Inflammation boosts bacteriophage transfer between Salmonella spp.

Diard M, Bakkeren E, Cornuault JK, ..., Slack E, Hardt WD

Science (New York, N.Y.) 355 (6330) 1211-1215 [2017-03-17; online 2017-03-16]

Affiliated researcher Mikael Sellin SciLifeLab Fellow