Spatially resolved transcriptomics and beyond.

Crosetto N, Bienko M, van Oudenaarden A

Nat. Rev. Genet. 16 (1) 57-66 [2015-01-00; online 2014-12-02]

Considerable progress in sequencing technologies makes it now possible to study the genomic and transcriptomic landscape of single cells. However, to better understand the complexity of multicellular organisms, we must devise ways to perform high-throughput measurements while preserving spatial information about the tissue context or subcellular localization of analysed nucleic acids. In this Innovation article, we summarize pioneering technologies that enable spatially resolved transcriptomics and discuss how these methods have the potential to extend beyond transcriptomics to encompass spatially resolved genomics, proteomics and possibly other omic disciplines.

Affiliated researcher

Fellows programme

Magda Bienko

PubMed 25446315

DOI 10.1038/nrg3832

Crossref 10.1038/nrg3832

pii: nrg3832