Organization and Regulation of Mitochondrial Protein Synthesis.

Ott M, Amunts A, Brown A

Annu. Rev. Biochem. 85 (1) 77-101 [2016-06-02; online 2016-01-18]

Mitochondria are essential organelles of endosymbiotic origin that are responsible for oxidative phosphorylation within eukaryotic cells. Independent evolution between species has generated mitochondrial genomes that are extremely diverse, with the composition of the vestigial genome determining their translational requirements. Typically, translation within mitochondria is restricted to a few key subunits of the oxidative phosphorylation complexes that are synthesized by dedicated ribosomes (mitoribosomes). The dramatically rearranged mitochondrial genomes, the limited set of transcripts, and the need for the synthesized proteins to coassemble with nuclear-encoded subunits have had substantial consequences for the translation machinery. Recent high-resolution cryo-electron microscopy has revealed the effect of coevolution on the mitoribosome with the mitochondrial genome. In this review, we place the new structural information in the context of the molecular mechanisms of mitochondrial translation and focus on the novel ways protein synthesis is organized and regulated in mitochondria.

Affiliated researcher

Alexey Amunts

SciLifeLab Fellow

PubMed 26789594

DOI 10.1146/annurev-biochem-060815-014334

Crossref 10.1146/annurev-biochem-060815-014334

Publications 9.5.0