Chemoselective probe for detailed analysis of ketones and aldehydes produced by gut microbiota in human samples.

Conway LP, Garg N, Lin W, Vujasinovic M, Löhr JM, Globisch D

Chem. Commun. (Camb.) 55 (62) 9080-9083 [2019-08-11; online 2019-07-09]

New strategies are required for the discovery of unknown bioactive molecules produced by gut microbiota in the human host. Herein, we utilize a chemoselective probe immobilized to magnetic beads for analysis of carbonyls in human fecal samples. We identified 112 metabolites due to femtomole analysis and an increased mass spectrometric sensitivity by up to six orders of magnitude.

Daniel Globisch

Fellows programme

PubMed 31287110

DOI 10.1039/c9cc04605d

Crossref 10.1039/c9cc04605d

Publications 7.1.2