Geng K

Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9-mediated genome engineering in HAP1 cells mimicking cancer profiles.

Geng K, Merino LG, Veiga RG, ..., Brinkman EK, Kutter C

Life Sci. Alliance 7 (2) - [2024-02-00; online 2023-11-20]

Claudia Kutter SciLifeLab Fellow

Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription.

Cameron DP, Grosser J, Ladigan S, ..., Hahn SA, Baranello L

Sci Adv 9 (41) eadg5109 [2023-10-13; online 2023-10-13]

Claudia Kutter SciLifeLab Fellow

Estrogen receptor activation remodelsTEAD1gene expression to alleviate nonalcoholic fatty liver disease

Sommerauer C, Gallardo-Dodd CJ, Savva C, ..., Williams C, Kutter C

- - (-) - [2023-09-08; online 2023-09-08]

Claudia Kutter SciLifeLab Fellow

CRISPR-Cas9-mediated genome engineering exaggerates genomic deletion at 10q23.31 including the<i>PTEN</i>gene locus mimicking cancer profiles

Geng K, Merino LG, Veiga RG, ..., Brinkman EK, Kutter C

- - (-) - [2023-04-06; online 2023-04-06]

Claudia Kutter SciLifeLab Fellow

Target-enriched nanopore sequencing and de novo assembly reveals co-occurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cells.

Geng K, Merino LG, Wedemann L, ..., White RJ, Kutter C

Genome Res 32 (10) 1876-1891 [2022-10-00; online 2022-09-30]

Claudia Kutter SciLifeLab Fellow

Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation.

Zhu K, Wang Y, Sarlus H, ..., Högberg B, Harris RA

EMBO Rep. 23 (7) e54499 [2022-07-05; online 2022-05-20]

Claudia Kutter SciLifeLab Fellow

CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism.

Søndergaard JN, Sommerauer C, Atanasoai I, ..., Barragan I, Kutter C

Gut 71 (10) 2081-2092 [2022-01-12; online 2022-01-12]

Claudia Kutter SciLifeLab Fellow

CRISPR/Cas9 deletions induce adverse on-target genomic effects leading to functional DNA in human cells

Geng K, Merino LG, Wedemann L, ..., White RJ, Kutter C

- - (-) - [2021-07-01; online 2021-07-01]