J Med Chem

ISSN	1520-4804
ISSN-L	0022-2623
IUID	7741c10bf77a4052bf534e8c8c1baabf
Modified	2020-11-27T13:12:54.662Z
Created	2020-11-06T09:01:34.307Z

Year 2025

PubMed DOI Crossref

Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches for DNA Repair Enzyme OGG1.

Varga M, Ortis F, Del Prado A, ..., Watson AJB, Michel M

J Med Chem 68 (21) 22455-22483 [2025-11-13; online 2025-10-15]

PubMed DOI Crossref

Sulfilimines: An Underexplored Bioisostere for Drug Design?

Arvidsson PI

J Med Chem 68 (4) 4056-4058 [2025-02-27; online 2025-01-31]

Year 2024

PubMed DOI Crossref

Discovery of a Series of Macrocycles as Potent Inhibitors of Leishmania Infantum.

Riu F, Ruppitsch LA, Duy Vo D, ..., Sjö P, Kihlberg J

J Med Chem 67 (20) 18170-18193 [2024-10-24; online 2024-10-08]

PubMed DOI Crossref

Discovery of 2-Aryl-4-aminoquinazolin-Based LSD1 Inhibitors to Activate Immune Response in Gastric Cancer.

Wang B, Wang SW, Zhou Y, ..., Chen XB, Dai XJ

J Med Chem 67 (18) 16165-16184 [2024-09-26; online 2024-09-12]

PubMed DOI Crossref

Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.

de Souza Gama FH, Dutra LA, Hawgood M, ..., Azevedo H, Couñago RM

J Med Chem 67 (11) 8609-8629 [2024-06-13; online 2024-05-23]

Year 2022

PubMed DOI Crossref

Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction.

Begnini F, Geschwindner S, Johansson P, ..., Schiesser S, Kihlberg J

J Med Chem 65 (4) 3473-3517 [2022-02-24; online 2022-02-02]

Jens Carlsson SciLifeLab Fellow

Year 2021

PubMed DOI Crossref

Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.

McCoull W, Boyd S, Brown MR, ..., Zhu Q, Smith PD

J Med Chem 64 (18) 13524-13539 [2021-09-23; online 2021-09-03]

SciLifeLab Fellow Yumeng Mao

Year 2020

PubMed DOI Crossref

Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase.

Degorce SL, Tavana O, Banks E, ..., Yang B, Edmondson SD

J Med Chem 63 (18) 10460-10473 [2020-09-24; online 2020-09-14]

SciLifeLab Fellow Yumeng Mao

PubMed DOI Crossref

Docking Finds GPCR Ligands in Dark Chemical Matter.

Ballante F, Rudling A, Zeifman A, ..., Loza MI, Carlsson J

J Med Chem 63 (2) 613-620 [2020-01-23; online 2020-01-13]

Jens Carlsson SciLifeLab Fellow

Year 2018

PubMed DOI Crossref

Docking Screens for Dual Inhibitors of Disparate Drug Targets for Parkinson's Disease.

Jaiteh M, Zeifman A, Saarinen M, ..., Loza MI, Carlsson J

J Med Chem 61 (12) 5269-5278 [2018-06-28; online 2018-06-15]

Affiliated researcher Jens Carlsson SciLifeLab Fellow

Year 2017

PubMed DOI Crossref

Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space.

Rudling A, Gustafsson R, Almlöf I, ..., Stenmark P, Carlsson J

J Med Chem 60 (19) 8160-8169 [2017-10-12; online 2017-10-03]

Affiliated researcher Jens Carlsson SciLifeLab Fellow

Year 2015

PubMed DOI Crossref

Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models.

Ranganathan A, Stoddart LA, Hill SJ, Carlsson J

J Med Chem 58 (24) 9578-9590 [2015-12-24; online 2015-12-08]

PubMed DOI Crossref

Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Chofor R, Sooriyaarachchi S, Risseeuw MD, ..., Mowbray SL, Van Calenbergh S

J Med Chem 58 (7) 2988-3001 [2015-04-09; online 2015-03-31]

Year 2014

PubMed DOI Crossref

Synthesis of P1'-functionalized macrocyclic transition-state mimicking HIV-1 protease inhibitors encompassing a tertiary alcohol.

De Rosa M, Unge J, Motwani HV, ..., Wallberg H, Larhed M

J Med Chem 57 (15) 6444-6457 [2014-08-14; online 2014-08-01]

PubMed DOI Crossref

A high-throughput cell-based method to predict the unbound drug fraction in the brain.

Mateus A, Matsson P, Artursson P

J Med Chem 57 (7) 3005-3010 [2014-04-10; online 2014-03-20]

PubMed DOI Crossref

Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties.

Over B, McCarren P, Artursson P, ..., Duvall JR, Kihlberg J

J Med Chem 57 (6) 2746-2754 [2014-03-27; online 2014-02-26]

Year 2013

PubMed DOI Crossref

Structure-guided design of novel thiazolidine inhibitors of O-acetyl serine sulfhydrylase from Mycobacterium tuberculosis.

Poyraz O, Jeankumar VU, Saxena S, ..., Sriram D, Schneider G

J Med Chem 56 (16) 6457-6466 [2013-08-22; online 2013-08-07]

PubMed DOI Crossref

Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability.

Fransson R, Sköld C, Kratz JM, ..., Hallberg M, Sandström A

J Med Chem 56 (12) 4953-4965 [2013-06-27; online 2013-06-17]