Pérez-Ortín JE

Proper 5'-3' cotranslational mRNA decay in yeast requires import of Xrn1 to the nucleus.

Jordán-Pla A, Zhang Y, García-Martínez J, ..., Pelechano V, Pérez-Ortín JE

PLoS ONE 20 (1) e0308195 [2025-01-22; online 2025-01-22]

SciLifeLab Fellow

Comparison of Xrn1 and Rat1 5' → 3' exoribonucleases in budding yeast supports the specific role of Xrn1 in cotranslational mRNA decay.

Pérez-Ortín JE, Jordán-Pla A, Zhang Y, ..., Pelechano V, García-Martínez J

Yeast 41 (7) 458-472 [2024-07-00; online 2024-06-14]

SciLifeLab Fellow

Rpb4 and Puf3 imprint and post-transcriptionally control the stability of a common set of mRNAs in yeast.

Garrido-Godino AI, Gupta I, Gutiérrez-Santiago F, ..., Pelechano V, Navarro F

RNA Biol 18 (8) 1206-1220 [2021-08-00; online 2020-11-01]

SciLifeLab Fellow

Homeostasis in the Central Dogma of molecular biology: the importance of mRNA instability.

Pérez-Ortín JE, Tordera V, Chávez S

RNA Biol 16 (12) 1659-1666 [2019-12-00; online 2019-09-02]

The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation.

Gómez-Herreros F, Margaritis T, Rodríguez-Galán O, ..., Holstege FCP, Chávez S

Nucleic Acids Res. 45 (16) 9302-9318 [2017-09-19; online 2017-06-24]

Affiliated researcher SciLifeLab Fellow

The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons.

García-Martínez J, Delgado-Ramos L, Ayala G, ..., Chávez S, Pérez-Ortín JE

Nucleic Acids Res. 44 (8) 3643-3658 [2016-05-05; online 2015-12-29]

SciLifeLab Fellow Vicente Pelechano