Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals.
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Yu T, Zhou YJ, Wenning L, Liu Q, Krivoruchko A, Siewers V, Nielsen J, David F
Nat Commun 8 (-) 15587 [2017-05-26; online 2017-05-26]
Production of chemicals and biofuels through microbial fermentation is an economical and sustainable alternative for traditional chemical synthesis. Here we present the construction of a Saccharomyces cerevisiae platform strain for high-level production of very-long-chain fatty acid (VLCFA)-derived chemicals. Through rewiring the native fatty acid elongation system and implementing a heterologous Mycobacteria FAS I system, we establish an increased biosynthesis of VLCFAs in S. cerevisiae. VLCFAs can be selectively modified towards the fatty alcohol docosanol (C
PubMed 28548095
DOI 10.1038/ncomms15587
Crossref 10.1038/ncomms15587
pii: ncomms15587
pmc: PMC5458556