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Llona-Minguez S, Fayezi S, Alihemmati A, Juárez-Jiménez J, Piedrafita FJ, Helleday T
Bioorg. Med. Chem. Lett. 27 (18) 4462-4466 [2017-09-15; online 2017-08-05]
A series of tetrahydrobenzothiophene carboxamides, inspired by structural features present in kinase and SCD1 inhibitors, are presented here. Prototype compound 8 (MMDD13) modulates fatty acid elongase and desaturase indexes, lipid accumulation, while preserving kinase inhibitory activity. This chemotype represents a stepping stone towards chemical probes to study the consequences of lipid metabolism modulation through non-redundant pathways.
PubMed 28807439
DOI 10.1016/j.bmcl.2017.08.006
Crossref 10.1016/j.bmcl.2017.08.006
pii: S0960-894X(17)30795-3