Sci Adv

ISSN	2375-2548
ISSN-L	2375-2548
IUID	0159a469b1eb4b45bc91da6212f8c685
Modified	2020-11-27T13:12:59.849Z
Created	2018-12-05T10:22:13.584Z

Year 2025

PubMed DOI Crossref

Near-infrared MINFLUX imaging enabled by suppression of fluorophore blinking.

Srambickal CV, Esmaeeli HM, Piguet J, ..., Egner A, Widengren J

Sci Adv 11 (49) eadw3149 [2025-12-05; online 2025-12-05]

PubMed DOI Crossref

Time-resolved Mendelian randomization detects substantial variation in the detrimental effect of obesity throughout life.

Karlsson T, Hadizadeh F, Rask-Andersen M, Schmitz D, Johansson Å

Sci Adv 11 (43) eadv0926 [2025-10-24; online 2025-10-24]

PubMed DOI Crossref

Ultrafast, remote-controlled protonation reaction enables structural changes in a phytochrome.

Shankar MK, Grunewald L, Wahlgren WY, ..., Ihalainen JA, Westenhoff S

Sci Adv 11 (42) eady0499 [2025-10-17; online 2025-10-17]

PubMed DOI Crossref

Uncovering the regulatory landscape of early human B cell lymphopoiesis and its implications in the pathogenesis of B-ALL.

Planell N, Martínez-de-Morentin X, Mouzo D, ..., Prosper F, Gomez-Cabrero D

Sci Adv 11 (41) eadw3110 [2025-10-10; online 2025-10-10]

PubMed DOI Crossref

The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis.

Cianfanelli V, Nanni M, Corrà S, ..., Ziviani E, Cecconi F

Sci Adv 11 (40) eadw7376 [2025-10-03; online 2025-10-03]

PubMed DOI Crossref

The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes.

Odai R, Leemann M, Al-Murad T, ..., Pereira J, Atkinson GC

Sci Adv 11 (40) eadz8560 [2025-10-03; online 2025-10-01]

PubMed DOI Crossref

Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer.

Kauko O, Turunen M, Pihlajamaa P, ..., Hautaniemi S, Taipale J

Sci Adv 11 (34) eadt1798 [2025-08-22; online 2025-08-20]

PubMed DOI Crossref

Isoform-level profiling of m6A epitranscriptomic signatures in human brain.

Gleeson J, Madugalle SU, Wan CY, ..., De Paoli-Iseppi R, Clark MB

Sci Adv 11 (32) eadp0783 [2025-08-08; online 2025-08-08]

PubMed DOI Crossref

Droplet microfluidics-based detection of rare antibiotic-resistant subpopulations in Escherichia coli from bloodstream infections.

Agnihotri SN, Fatsis-Kavalopoulos N, Windhager J, Tenje M, Andersson DI

Sci Adv 11 (27) eadv4558 [2025-07-04; online 2025-07-04]

PubMed DOI Crossref

Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT3A receptor.

Haloi N, Karlsson E, Delarue M, Howard RJ, Lindahl E

Sci Adv 11 (15) eadr0797 [2025-04-11; online 2025-04-11]

PubMed DOI Crossref

Sequence-dependent scale for translocon-mediated insertion of interfacial helices in membranes.

Grau B, Kormos R, Bañó-Polo M, ..., DeGrado WF, Mingarro I

Sci Adv 11 (8) eads6804 [2025-02-21; online 2025-02-19]

PubMed DOI Crossref

Adaptive sampling-based structural prediction reveals opening of a GABAA receptor through the αβ interface.

Haloi N, Eriksson Lidbrink S, Howard RJ, Lindahl E

Sci Adv 11 (2) eadq3788 [2025-01-10; online 2025-01-08]

PubMed DOI Crossref

A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity.

Burtscher V, Wang L, Cowgill J, ..., Evers AS, Chanda B

Sci Adv 11 (1) eadr7427 [2025-01-03; online 2025-01-03]

Lucie Delemotte SciLifeLab Fellow

Year 2024

PubMed DOI Crossref

Biologically inspired bioactive hydrogels for scarless corneal repair.

Huang J, Jiang T, Qie J, ..., Yao K, Han H

Sci Adv 10 (51) eadt1643 [2024-12-20; online 2024-12-18]

PubMed DOI Crossref

Five centuries of consanguinity, isolation, health, and conflict in Las Gobas: A Northern Medieval Iberian necropolis.

Rodríguez-Varela R, Yaka R, Pochon Z, ..., Azkarate A, Götherström A

Sci Adv 10 (35) eadp8625 [2024-08-30; online 2024-08-28]

PubMed DOI Crossref

Origin, structure, and composition of the spider major ampullate silk fiber revealed by genomics, proteomics, and single-cell and spatial transcriptomics.

Sonavane S, Hassan S, Chatterjee U, ..., Reimegård J, Rising A

Sci Adv 10 (33) eadn0597 [2024-08-16; online 2024-08-14]

PubMed DOI Crossref

AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1.

Díaz-Holguín A, Saarinen M, Vo DD, ..., Carlsson J, Svenningsson P

Sci Adv 10 (32) eadn1524 [2024-08-09; online 2024-08-07]

Jens Carlsson SciLifeLab Fellow

PubMed DOI Crossref

Multiplexed mapping of the interactome of GPCRs with receptor activity-modifying proteins.

Kotliar IB, Bendes A, Dahl L, ..., Schwenk JM, Sakmar TP

Sci Adv 10 (31) eado9959 [2024-08-02; online 2024-07-31]

PubMed DOI Crossref

How sex and gender shape functional brain networks.

Matte Bon G, Kraft D, Kaufmann T

Sci Adv 10 (28) eadq3079 [2024-07-12; online 2024-07-12]

Year 2023

PubMed DOI Crossref

Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR.

Manfredi F, Stasi L, Buonanno S, ..., Bonini C, Ruggiero E

Sci Adv 9 (48) eadg8014 [2023-12-00; online 2023-12-01]

PubMed DOI Crossref

XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes.

Chatzinikolaou G, Stratigi K, Siametis A, ..., Altmüller J, Garinis GA

Sci Adv 9 (45) eadi2095 [2023-11-10; online 2023-11-08]

PubMed DOI Crossref

Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription.

Cameron DP, Grosser J, Ladigan S, ..., Hahn SA, Baranello L

Sci Adv 9 (41) eadg5109 [2023-10-13; online 2023-10-13]

Claudia Kutter SciLifeLab Fellow

PubMed DOI Crossref

Digital assay for rapid electronic quantification of clinical pathogens using DNA nanoballs.

Tayyab M, Barrett D, van Riel G, ..., Javanmard M, Pelechano V

Sci Adv 9 (36) eadi4997 [2023-09-08; online 2023-09-06]

SciLifeLab Fellow

PubMed DOI Crossref

Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells.

Gallardo-Dodd CJ, Oertlin C, Record J, ..., Ponomarev SA, Westerberg LS

Sci Adv 9 (34) eadg1610 [2023-08-25; online 2023-08-25]

Claudia Kutter SciLifeLab Fellow

PubMed DOI Crossref

Control of protein synthesis through mRNA pseudouridylation by dyskerin.

Pederiva C, Trevisan DM, Peirasmaki D, ..., Agostini F, Farnebo M

Sci Adv 9 (30) eadg1805 [2023-07-28; online 2023-07-28]

PubMed DOI Crossref

Large-scale phylogenomics of aquatic bacteria reveal molecular mechanisms for adaptation to salinity.

Jurdzinski KT, Mehrshad M, Delgado LF, ..., Bertilsson S, Andersson AF

Sci Adv 9 (21) eadg2059 [2023-05-26; online 2023-05-26]

PubMed DOI Crossref

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis.

Thomas OG, Bronge M, Tengvall K, ..., Olsson T, Kockum I

Sci Adv 9 (20) eadg3032 [2023-05-19; online 2023-05-17]

PubMed DOI Crossref

Multiplexed selectivity screening of anti-GPCR antibodies.

Dahl L, Kotliar IB, Bendes A, ..., Sakmar TP, Schwenk JM

Sci Adv 9 (18) eadf9297 [2023-05-03; online 2023-05-03]

Year 2022

PubMed DOI Crossref

MicroRNAs are deeply linked to the emergence of the complex octopus brain.

Zolotarov G, Fromm B, Legnini I, ..., Peterson KJ, Rajewsky N

Sci Adv 8 (47) eadd9938 [2022-11-25; online 2022-11-25]

PubMed DOI Crossref

Orthologous microsatellites, transposable elements, and DNA deletions correlate with generation time and body mass in neoavian birds.

Ji Y, Feng S, Wu L, ..., Hackett SJ, Lei F

Sci Adv 8 (35) eabo0099 [2022-09-02; online 2022-08-31]

PubMed DOI Crossref

PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons.

Toskas K, Yaghmaeian-Salmani B, Skiteva O, ..., Perlmann T, Holmberg J

Sci Adv 8 (34) eabo1543 [2022-08-26; online 2022-08-26]

PubMed DOI Crossref

Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis.

Bronge M, Högelin KA, Thomas OG, ..., Olsson T, Grönlund H

Sci Adv 8 (17) eabn1823 [2022-04-29; online 2022-04-27]

PubMed DOI Crossref

Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.

Nakao T, Bick AG, Taub MA, ..., NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium , Natarajan P

Sci Adv 8 (14) eabl6579 [2022-04-08; online 2022-04-06]

Abhishek Niroula DDLS Fellow

PubMed DOI Crossref

Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow.

Le Duc D, Velluva A, Cassatt-Johnstone M, ..., Shapiro B, Schöneberg T

Sci Adv 8 (5) eabl6496 [2022-02-04; online 2022-02-04]

Year 2021

PubMed DOI Crossref

Causal effects of inflammatory protein biomarkers on inflammatory diseases.

Ek WE, Karlsson T, Höglund J, Rask-Andersen M, Johansson Å

Sci Adv 7 (50) eabl4359 [2021-12-10; online 2021-12-08]

PubMed DOI Crossref

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.

Kanellis DC, Espinoza JA, Zisi A, ..., Lindström MS, Bartek J

Sci Adv 7 (32) - [2021-08-00; online 2021-08-04]

SciLifeLab Fellow Simon Elsässer

PubMed DOI Crossref

A single-cell type transcriptomics map of human tissues.

Karlsson M, Zhang C, Méar L, ..., Uhlén M, Lindskog C

Sci Adv 7 (31) - [2021-07-00; online 2021-07-28]

Adil Mardinoglu DDLS Fellow Fredrik Edfors Muhammad Arif SciLifeLab Fellow

PubMed DOI Crossref

Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging.

Adori C, Daraio T, Kuiper R, ..., Bark C, Hökfelt T

Sci Adv 7 (30) - [2021-07-00; online 2021-07-21]

PubMed DOI Crossref

Metabolic control of nitrogen fixation in rhizobium-legume symbioses.

Schulte CCM, Borah K, Wheatley RM, ..., Papachristodoulou A, Poole PS

Sci Adv 7 (31) - [2021-07-00; online 2021-07-30]

PubMed DOI Crossref

Following spatial Aβ aggregation dynamics in evolving Alzheimer's disease pathology by imaging stable isotope labeling kinetics.

Michno W, Stringer KM, Enzlein T, ..., Edwards FA, Hanrieder J

Sci Adv 7 (25) - [2021-06-00; online 2021-06-16]

SciLifeLab Fellow Wojciech Michno

PubMed DOI Crossref

Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR.

Kaspar S, Oertlin C, Szczepanowska K, ..., Topisirovic I, Trifunovic A

Sci Adv 7 (22) - [2021-05-00; online 2021-05-26]

PubMed DOI Crossref

Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.

Leneva N, Kovtun O, Morado DR, Briggs JAG, Owen DJ

Sci Adv 7 (13) - [2021-03-00; online 2021-03-24]

PubMed DOI Crossref

Population collapse in Congo rainforest from 400 CE urges reassessment of the Bantu Expansion.

Seidensticker D, Hubau W, Verschuren D, ..., Schlebusch CM, Bostoen K

Sci Adv 7 (7) - [2021-02-00; online 2021-02-12]

PubMed DOI Crossref

The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters.

Rosenberger FA, Moore D, Atanassov I, ..., Freyer C, Wredenberg A

Sci Adv 7 (8) - [2021-02-00; online 2021-02-19]

PubMed DOI Crossref

JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality.

Stebbing J, Sánchez Nievas G, Falcone M, ..., Abizanda P, Lauschke VM

Sci Adv 7 (1) - [2021-01-00; online 2021-01-01]

Claudia Kutter SciLifeLab Fellow

PubMed DOI Crossref

Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA-induced dyskinesia.

Fridjonsdottir E, Shariatgorji R, Nilsson A, ..., Bezard E, Andrén PE

Sci Adv 7 (2) - [2021-01-00; online 2021-01-06]

Year 2020

PubMed DOI Crossref

Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening.

Kang PW, Westerlund AM, Shi J, ..., Delemotte L, Cui J

Sci Adv 6 (50) - [2020-12-00; online 2020-12-11]

Lucie Delemotte SciLifeLab Fellow

PubMed DOI Crossref

A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells.

Dias JM, Alekseenko Z, Jeggari A, ..., Iber D, Ericson J

Sci Adv 6 (38) - [2020-09-00; online 2020-09-16]

PubMed DOI Crossref

PhenoChip: A single-cell phenomic platform for high-throughput photophysiological analyses of microalgae.

Behrendt L, Salek MM, Trampe EL, ..., Kühl M, Stocker R

Sci Adv 6 (36) eabb2754 [2020-09-00; online 2020-09-02]

Lars Behrendt SciLifeLab Fellow

PubMed DOI Crossref

The past and future human impact on mammalian diversity.

Andermann T, Faurby S, Turvey ST, Antonelli A, Silvestro D

Sci Adv 6 (36) - [2020-09-00; online 2020-09-04]

DDLS Fellow Tobias Andermann

PubMed DOI Crossref

Chlamydial contribution to anaerobic metabolism during eukaryotic evolution.

Stairs CW, Dharamshi JE, Tamarit D, ..., Spang A, Ettema TJG

Sci Adv 6 (35) eabb7258 [2020-08-00; online 2020-08-26]

PubMed DOI Crossref

Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice.

Christoffersson G, Ratliff SS, von Herrath MG

Sci Adv 6 (35) eabb2878 [2020-08-00; online 2020-08-26]

Gustaf Christoffersson SciLifeLab Fellow

PubMed DOI Crossref

Molecular atlas of the adult mouse brain.

Ortiz C, Navarro JF, Jurek A, ..., Lundeberg J, Meletis K

Sci Adv 6 (26) eabb3446 [2020-06-00; online 2020-06-26]

PubMed DOI Crossref

No evidence for DNA N 6-methyladenine in mammals.

Douvlataniotis K, Bensberg M, Lentini A, Gylemo B, Nestor CE

Sci Adv 6 (12) eaay3335 [2020-03-00; online 2020-03-18]

Antonio Lentini DDLS Fellow

PubMed DOI Crossref

Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death.

Busker S, Qian W, Haraldsson M, ..., Tamm KP, Page BDG

Sci Adv 6 (12) eaax7945 [2020-03-00; online 2020-03-20]

Year 2019

PubMed DOI Crossref

Genomic architecture of parallel ecological divergence: Beyond a single environmental contrast.

Morales HE, Faria R, Johannesson K, ..., Westram AM, Butlin RK

Sci Adv 5 (12) eaav9963 [2019-12-00; online 2019-12-04]

PubMed DOI Crossref

Multiplexed analysis of the secretin-like GPCR-RAMP interactome.

Lorenzen E, Dodig-Crnković T, Kotliar IB, ..., Schwenk JM, Sakmar TP

Sci Adv 5 (9) eaaw2778 [2019-09-00; online 2019-09-18]

PubMed DOI Crossref

Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain.

Bigalke JM, Aibara S, Roth R, ..., Amunts A, Sandmark J

Sci Adv 5 (7) eaau4202 [2019-07-00; online 2019-07-31]

Alexey Amunts SciLifeLab Fellow

PubMed DOI Crossref

Pervasive hybridizations in the history of wheat relatives.

Glémin S, Scornavacca C, Dainat J, ..., David J, Ranwez V

Sci Adv 5 (5) eaav9188 [2019-05-00; online 2019-05-01]

PubMed DOI Crossref

Electrospray sample injection for single-particle imaging with x-ray lasers.

Bielecki J, Hantke MF, Daurer BJ, ..., Hajdu J, Maia FRNC

Sci Adv 5 (5) eaav8801 [2019-05-00; online 2019-05-03]

Year 2018

PubMed DOI Crossref

Ancient genomes suggest the eastern Pontic-Caspian steppe as the source of western Iron Age nomads.

Krzewińska M, Kılınç GM, Juras A, ..., Storå J, Götherström A

Sci Adv 4 (10) eaat4457 [2018-10-00; online 2018-10-03]

PubMed DOI Crossref

Molecular parallelism in fast-twitch muscle proteins in echolocating mammals.

Lee JH, Lewis KM, Moural TW, ..., Kang C, Hiller M

Sci Adv 4 (9) eaat9660 [2018-09-00; online 2018-09-26]

PubMed DOI Crossref

Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans.

Cedernaes J, Schönke M, Westholm JO, ..., Zierath JR, Benedict C

Sci Adv 4 (8) eaar8590 [2018-08-00; online 2018-08-22]

Year 2017

PubMed DOI Crossref

A drug pocket at the lipid bilayer-potassium channel interface.

Ottosson NE, Silverå Ejneby M, Wu X, ..., Lindahl E, Elinder F

Sci Adv 3 (10) e1701099 [2017-10-00; online 2017-10-25]

PubMed DOI Crossref

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.

Deville C, Carroni M, Franke KB, ..., Mogk A, Saibil HR

Sci Adv 3 (8) e1701726 [2017-08-00; online 2017-08-04]

Affiliated researcher

Year 2016

PubMed DOI Crossref

Analysis of neural crest-derived clones reveals novel aspects of facial development.

Kaucka M, Ivashkin E, Gyllborg D, ..., Hellander A, Adameyko I

Sci Adv 2 (8) e1600060 [2016-08-00; online 2016-08-03]