Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics.
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Velikyan I, Eriksson O
Theranostics 10 (1) 437-461 [2020-01-01; online 2020-01-01]
In the light of theranostics/radiotheranostics and prospective of personalized medicine in diabetes and oncology, this review presents prior and current advances in the development of radiolabeled imaging and radiotherapeutic exendin-based agents targeting glucagon-like peptide-1 receptor. The review covers chemistry, preclinical, and clinical evaluation. Such critical aspects as structure-activity-relationship, stability, physiological potency, kidney uptake, and dosimetry are discussed.
PubMed 31903131
DOI 10.7150/thno.38366
Crossref 10.7150/thno.38366
pmc: PMC6929622
pii: thnov10p0437