Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines.
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Lin W, Yang Z, Kaur A, Block A, Vujasinovic M, Löhr JM, Globisch D
RSC Chem Biol 2 (5) 1479-1483 [2021-10-07; online 2021-08-12]
The investigation of microbiome-derived metabolites is important to understand metabolic interactions with their human host. New methodologies for mass spectrometric discovery of undetected metabolites with unknown bioactivity are required. Herein, we introduce squaric acid as a new chemoselective moiety for amine metabolite analysis in human fecal samples.
PubMed 34704052
DOI 10.1039/d1cb00132a
Crossref 10.1039/d1cb00132a
pii: d1cb00132a
pmc: PMC8496035