Functional consequences of bidirectional promoters

Wei W, Pelechano V, Järvelin AI, Steinmetz LM

Trends in Genetics 27 (7) 267-276 [2011-07-00; online 2011-07-00]

Several studies have shown that promoters of protein-coding genes are origins of pervasive non-coding RNA transcription and can initiate transcription in both directions. However, only recently have researchers begun to elucidate the functional implications of this bidirectionality and non-coding RNA production. Increasing evidence indicates that non-coding transcription at promoters influences the expression of protein-coding genes, revealing a new layer of transcriptional regulation. This regulation acts at multiple levels, from modifying local chromatin to enabling regional signal spreading and more distal regulation. Moreover, the bidirectional activity of a promoter is regulated at multiple points during transcription, giving rise to diverse types of transcripts.

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PubMed 21601935

DOI 10.1016/j.tig.2011.04.002

Crossref 10.1016/j.tig.2011.04.002