Flipping a switch on BRD4: How to control the do-it-all.

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van Hout FAH, Vihervaara A

Mol. Cell 84 (22) 4257-4259 [2024-11-21; online 2024-11-23]

In this issue, Devaiah et al.1 identify JNK-catalyzed phosphorylation to convert bromodomain-containing protein 4 (BRD4) from a chromatin regulator to a transcription activator.

Anniina Vihervaara

SciLifeLab Fellow

PubMed 39577398

DOI 10.1016/j.molcel.2024.10.039

Crossref 10.1016/j.molcel.2024.10.039

pii: S1097-2765(24)00879-7