Genotype-covariate interaction effects and the heritability of adult body mass index.

Robinson MR, English G, Moser G, Lloyd-Jones LR, Triplett MA, Zhu Z, Nolte IM, van Vliet-Ostaptchouk JV, Snieder H, LifeLines Cohort Study , Esko T, Milani L, Mägi R, Metspalu A, Magnusson PKE, Pedersen NL, Ingelsson E, Johannesson M, Yang J, Cesarini D, Visscher PM

Nat. Genet. 49 (8) 1174-1181 [2017-08-00; online 2017-07-10]

Obesity is a worldwide epidemic, with major health and economic costs. Here we estimate heritability for body mass index (BMI) in 172,000 sibling pairs and 150,832 unrelated individuals and explore the contribution of genotype-covariate interaction effects at common SNP loci. We find evidence for genotype-age interaction (likelihood ratio test (LRT) = 73.58, degrees of freedom (df) = 1, P = 4.83 × 10

Affiliated researcher

PubMed 28692066

DOI 10.1038/ng.3912

Crossref 10.1038/ng.3912

pii: ng.3912

Publications 9.5.0