Sci Signal

An atlas of human metabolism.

Robinson JL, Kocabaş P, Wang H, ..., Uhlén M, Nielsen J

Sci Signal 13 (624) eaaz1482 [2020-03-24; online 2020-03-24]

Adil Mardinoglu SciLifeLab Fellow

The human secretome.

Uhlén M, Karlsson MJ, Hober A, ..., Fagerberg L, Sivertsson Å

Sci Signal 12 (609) eaaz0274 [2019-11-26; online 2019-11-26]

Adil Mardinoglu SciLifeLab Fellow

CD45 exclusion- and cross-linking-based receptor signaling together broaden FcεRI reactivity.

Felce JH, Sezgin E, Wane M, ..., Eggeling C, Davis SJ

Sci Signal 11 (561) - [2018-12-18; online 2018-12-18]

Erdinc Sezgin SciLifeLab Fellow

FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.

Wright SC, Cañizal MCA, Benkel T, ..., Schulte G, Hoffmann C

Sci Signal 11 (559) eaar5536 [2018-12-04; online 2018-12-04]

Jens Carlsson SciLifeLab Fellow

TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α.

Hamidi A, Song J, Thakur N, ..., Heldin CH, Landström M

Sci Signal 10 (486) - [2017-07-04; online 2017-07-04]

Affiliated researcher

The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.

Okita Y, Kimura M, Xie R, ..., Heldin CH, Kato M

Sci Signal 10 (474) - [2017-04-11; online 2017-04-11]

Affiliated researcher

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.

Morgado-Palacin I, Day A, Murga M, ..., Nussenzweig A, Fernandez-Capetillo O

Sci Signal 9 (445) ra91 [2016-09-13; online 2016-09-13]

Affiliated researcher

Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program.

Vasilaki E, Morikawa M, Koinuma D, ..., Miyazono K, Heldin CH

Sci Signal 9 (442) ra84 [2016-08-23; online 2016-08-23]

Affiliated researcher

Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

Zhang L, Kundu S, Feenstra T, ..., Dieterich LC, Dimberg A

Sci Signal 8 (406) ra125 [2015-12-08; online 2015-12-08]

Affiliated researcher

TRAF6 stimulates the tumor-promoting effects of TGFβ type I receptor through polyubiquitination and activation of presenilin 1.

Gudey SK, Sundar R, Mu Y, ..., Heldin CH, Landström M

Sci Signal 7 (307) ra2 [2014-01-07; online 2014-01-07]

Affiliated researcher