A myopic perspective on the future of protein diagnostics.

Landegren U, Al-Amin RA, Björkesten J

N Biotechnol 45 (-) 14-18 [2018-10-25; online 2018-01-05]

Plasma proteome analyses of the future promise invaluable insights into states of health, not only by measuring proteins whose role it is to ensure blood homeostasis, but increasingly also as a window into the health of practically any tissue in the body via so-called leakage protein biomarkers. Realizing more of this vast potential will require progress along many lines. Here we discuss the main ones, such as optimal selection of target proteins, affinity reagents, immunoassay formats, samples, and applications, with a view from ongoing work in our laboratory.

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PubMed 29309916

DOI 10.1016/j.nbt.2018.01.002

Crossref 10.1016/j.nbt.2018.01.002

S1871-6784(17)30547-2