From transcriptional complexity to cellular phenotypes: Lessons from yeast.

Pelechano V

Yeast 34 (12) 475-482 [2017-12-00; online 2017-10-11]

Pervasive transcription has been reported in many eukaryotic organisms, revealing a highly interleaved transcriptome organization that involves thousands of coding and non-coding RNAs. However, to date, the biological impact of transcriptome complexity is still poorly understood. Here I will review how subtle variations of the transcriptome can lead to divergent cellular phenotypes by fine-tuning both its coding potential and regulation. I will discuss strategies that can be used to link molecular variations with divergent biological outcomes. Finally, I will explore the implication of transcriptional complexity for our understanding of gene expression in the context of cell-to-cell phenotypic variability. Copyright © 2017 John Wiley & Sons, Ltd.

Affiliated researcher

SciLifeLab Fellow

Vicent Pelechano

PubMed 28866863

DOI 10.1002/yea.3277

Crossref 10.1002/yea.3277

Publications 9.5.0