Phenotypic co-receptor tropism and Maraviroc sensitivity in HIV-1 subtype C from East Africa.

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Siddik AB, Haas A, Rahman MS, Aralaguppe SG, Amogne W, Bader J, Klimkait T, Neogi U

Sci Rep 8 (1) 2363 [2018-02-05; online 2018-02-05]

Genotypic tropism testing (GTT) for co-receptor usage is a recommended tool for clinical practice before administration of the CCR5-antagonist maraviroc. For some isolates, phenotypic tropism testing (PTT) revealed discordant results with GTT. In this study, we performed a comparative study between GTT and PTT in HIV-1C from East Africa (HIV-1C

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PubMed 29403064

DOI 10.1038/s41598-018-20814-2

Crossref 10.1038/s41598-018-20814-2

pii: 10.1038/s41598-018-20814-2
pmc: PMC5799384