Altun M

A modular lentiviral system for multiplexed gene perturbation and functional analysis suggests interdependence of hormone receptors in breast cancer growth in vivo

Alam S, Matvienko D, Boström J, ..., Brisken C, Altun M

- - (-) - [2025-12-09; online 2025-12-09]

NUDT5 regulates the global efficacy of nucleoside analog drugs by coordinating purine synthesis and PRPP allocation

Valerie NCK, Alam S, Hormann FM, ..., Arvidsson PI, Altun M

- - (-) - [2025-11-20; online 2025-11-20]

A cell-based degrader assessment platform facilitates discovery of functional NUDT5 PROTACs

Alam S, Pires MJ, Tidestav G, ..., Valerie NCK, Altun M

- - (-) - [2025-06-19; online 2025-06-19]

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M

Nat Commun 15 (1) 10347 [2024-12-06; online 2024-12-06]

Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity

Pires MJ, Lovric A, Alam S, ..., Altun M, Valerie NCK

- - (-) - [2024-08-10; online 2024-08-10]

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M

- - (-) - [2022-09-19; online 2022-09-19]

Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound.

Giovannucci TA, Salomons FA, Haraldsson M, ..., Johnsen JI, Dantuma NP

Cell Death Dis 12 (10) 914 [2021-10-06; online 2021-10-06]

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.

Kanellis DC, Espinoza JA, Zisi A, ..., Lindström MS, Bartek J

Sci Adv 7 (32) - [2021-08-00; online 2021-08-04]

SciLifeLab Fellow Simon Elsässer

Development of a chemical probe against NUDT15.

Zhang SM, Desroses M, Hagenkort A, ..., Stenmark P, Helleday T

Nat. Chem. Biol. 16 (10) 1120-1128 [2020-10-00; online 2020-07-20]

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.

Azimi A, Caramuta S, Seashore-Ludlow B, ..., Uhlen M, Maddalo G

Mol Syst Biol 14 (3) e7858 [2018-03-05; online 2018-03-05]

DDLS Fellow Fredrik Edfors