Topisirovic I

Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics.

Papadopoli D, Palia R, Jovanovic P, ..., Pollak M, Topisirovic I

Elife 14 (-) - [2026-05-05; online 2026-05-05]

Translon: a single term for translated regions.

Świrski MI, Tierney JAS, Albà MM, ..., Valen E, Baranov PV

Nat. Methods 22 (10) 2002-2006 [2025-10-00; online 2025-09-02]

Plasticity of the mammalian integrated stress response.

Chen CW, Papadopoli D, Szkop KJ, ..., Topisirovic I, Hatzoglou M

Nature 641 (8065) 1319-1328 [2025-05-00; online 2025-03-26]

Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR).

Loughran G, Andreev DE, Terenin IM, ..., Dmitriev SE, Baranov PV

Nat. Struct. Mol. Biol. 32 (3) 418-430 [2025-03-00; online 2025-03-03]

SMYD5 methylation of rpL40 links ribosomal output to gastric cancer.

Park J, Wu J, Szkop KJ, ..., Gozani O, Mazur PK

Nature 632 (8025) 656-663 [2024-08-00; online 2024-07-24]

The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.

Ghaddar N, Wang S, Woodvine B, ..., Le Quesne J, Koromilas AE

Nat Commun 12 (1) 4651 [2021-07-30; online 2021-07-30]

Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR.

Kaspar S, Oertlin C, Szczepanowska K, ..., Topisirovic I, Trifunovic A

Sci Adv 7 (22) - [2021-05-00; online 2021-05-26]

SPANX Control of Lamin A/C Modulates Nuclear Architecture and Promotes Melanoma Growth.

Lazar I, Fabre B, Feng Y, ..., Dummer R, Ronai ZA

Mol. Cancer Res. 18 (10) 1560-1573 [2020-10-00; online 2020-06-22]

RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity.

Ristau J, van Hoef V, Peuget S, ..., Selivanova G, Larsson O

Cell Death Dis 10 (11) 845 [2019-11-07; online 2019-11-07]

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis.

Smith HW, Hirukawa A, Sanguin-Gendreau V, ..., Topisirovic I, Muller WJ

Nat Commun 10 (1) 2901 [2019-07-01; online 2019-07-01]