Valerie NCK

A modular lentiviral system for multiplexed gene perturbation and functional analysis suggests interdependence of hormone receptors in breast cancer growth in vivo

Alam S, Matvienko D, Boström J, ..., Brisken C, Altun M

- - (-) - [2025-12-09; online 2025-12-09]

NUDT5 regulates the global efficacy of nucleoside analog drugs by coordinating purine synthesis and PRPP allocation

Valerie NCK, Alam S, Hormann FM, ..., Arvidsson PI, Altun M

- - (-) - [2025-11-20; online 2025-11-20]

A cell-based degrader assessment platform facilitates discovery of functional NUDT5 PROTACs

Alam S, Pires MJ, Tidestav G, ..., Valerie NCK, Altun M

- - (-) - [2025-06-19; online 2025-06-19]

Uridine cytidine kinases dictate the therapeutic response of molnupiravir via its bioactivation

Shu H, Sharm S, Alam S, ..., Rudd SG, Zhang SM

- - (-) - [2025-05-14; online 2025-05-14]

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M

Nat Commun 15 (1) 10347 [2024-12-06; online 2024-12-06]

Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity

Pires MJ, Lovric A, Alam S, ..., Altun M, Valerie NCK

- - (-) - [2024-08-10; online 2024-08-10]

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M

- - (-) - [2022-09-19; online 2022-09-19]

Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.

Page BDG, Valerie NCK, Wright RHG, ..., Beato M, Helleday T

Nat Commun 10 (1) 5050 [2019-11-01; online 2019-11-01]

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.

Page BDG, Valerie NCK, Wright RHG, ..., Beato M, Helleday T

Nat Commun 9 (1) 250 [2018-01-17; online 2018-01-17]

Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.

Llona-Minguez S, Höglund A, Ghassemian A, ..., Scobie M, Helleday T

J Med Chem 60 (10) 4279-4292 [2017-05-25; online 2017-05-16]

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.

Herold N, Rudd SG, Ljungblad L, ..., Helleday T, Schaller T

Nat. Med. 23 (2) 256-263 [2017-02-00; online 2017-01-09]