den Hoed M

Common genetic variants near SLC2A2 and glycemic response to glimepiride in the GRADE comparative effectiveness clinical trial.

Li JH, Szczerbinski L, Tripputi M, ..., Mercader JM, Florez JC

medRxiv - (-) - [2025-10-08; online 2025-10-08]

Accurate characterization of CRISPR-Cas9 genome editing outcomes and mosaicism with near-perfect long reads

Höijer I, van Schendel R, Emmanouilidou A, ..., den Hoed M, Ameur A

- - (-) - [2025-09-09; online 2025-09-09]

Mosaic loss of chromosome Y and coronary atherosclerosis in men: insights into sex differences in cardiovascular risk from the SCAPIS study

Bjurling J, Malinovschi A, Jernberg T, ..., Halvardson J, Forsberg LA

- - (-) - [2025-07-14; online 2025-07-14]

Distilling causality between physical activity traits and obesity via Mendelian randomization.

Wang Z, Davey Smith G, Loos RJF, den Hoed M

Commun Med (Lond) 3 (1) 173 [2023-11-30; online 2023-11-30]

Investigating the role of lipid genes in liver disease using models of steatotic liver disease in zebrafish (Danio rerio).

Mujica E, den Hoed M

Liver Int. 43 (11) 2348-2350 [2023-11-00; online 2023-10-17]

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.

Lagou V, Jiang L, Ulrich A, ..., Prokopenko I, Meta-Analysis of Glucose and Insulin-Related Traits Consortium (MAGIC)

Nat. Genet. 55 (9) 1448-1461 [2023-09-00; online 2023-09-07]

Kita crispants for systematic image-based genetic screens of complex traits in zebrafish larvae

Mazzaferro E, Metzendorf C, Zhang H, ..., Allalou A, den Hoed M

- - (-) - [2023-07-24; online 2023-07-24]

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

Mathieson I, Day FR, Barban N, ..., Mills MC, Perry JRB

Nat Hum Behav 7 (5) 790-801 [2023-05-00; online 2023-03-02]

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression.

Mattis KK, Krentz NAJ, Metzendorf C, ..., den Hoed M, Gloyn AL

Diabetologia 66 (4) 674-694 [2023-04-00; online 2023-01-12]

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.

Wang Z, Emmerich A, Pillon NJ, ..., Loos RJF, Hoed MD

Nat. Genet. 54 (9) 1332-1344 [2022-09-00; online 2022-09-07]

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

Mattis KK, Krentz NA, Metzendorf C, ..., den Hoed M, Gloyn AL

- - (-) - [2022-06-05; online 2022-06-05]

Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance.

Pellegrinelli V, Rodriguez-Cuenca S, Rouault C, ..., Clément K, Vidal-Puig A

Nat Metab 4 (4) 476-494 [2022-04-00; online 2022-04-25]

CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations.

Höijer I, Emmanouilidou A, Östlund R, ..., den Hoed M, Ameur A

Nat Commun 13 (1) 627 [2022-02-02; online 2022-02-02]

Physical activity and sedentary behavior; mechanistic insights and role in disease prevention

Hoed Md, Wang Z, Emmerich A, ..., Thomis M, Loos R

- - (-) - [2021-12-16; online 2021-12-16]

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.

Mills MC, Tropf FC, Brazel DM, ..., Barban N, Day FR

Nat Hum Behav 5 (12) 1717-1730 [2021-12-00; online 2021-07-01]

CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations

Höijer I, Emmanouilidou A, Östlund R, ..., den Hoed M, Ameur A

- - (-) - [2021-10-05; online 2021-10-05]

Publisher Correction: Identification of 371 genetic variants for age at first sex and birth linked to externalising behavior.

Mills MC, Tropf FC, Brazel DM, ..., Barban N, Day FR

Nat Hum Behav 5 (8) 1111 [2021-08-00; online 2021-07-30]

Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.

Huang LO, Rauch A, Mazzaferro E, ..., Kilpeläinen TO, Loos RJF

Nat Metab 3 (2) 228-243 [2021-02-00; online 2021-02-22]

Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

Pellegrinelli V, Rodriguez-Cuenca S, Rouault C, ..., Clément K, Vidal-Puig A

- - (-) - [2020-08-24; online 2020-08-24]

Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach.

von der Heyde B, Emmanouilidou A, Mazzaferro E, ..., Brooke HL, den Hoed M

Sci Rep 10 (1) 11831 [2020-07-16; online 2020-07-16]

Identification of 370 genetic loci for age at first sex and birth linked to externalising behaviour

Mills MC, Tropf FC, Brazel DM, ..., Barban N, Day FR

- - (-) - [2020-05-07; online 2020-05-07]

Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Malik R, Chauhan G, Traylor M, ..., Debette S, Dichgans M

Nat. Genet. 51 (7) 1192-1193 [2019-07-00; online 2019-06-05]

Zebrafish larvae as a model system for systematic characterization of drugs and genes in dyslipidemia and atherosclerosis

Bandaru MK, Emmanouilidou A, Ranefall P, ..., Ingelsson E, den Hoed M

- - (-) - [2018-12-20; online 2018-12-20]

Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach

von der Heyde B, Emmanouilidou A, Mazzaferro E, ..., Brooke HL, den Hoed M

- - (-) - [2018-08-09; online 2018-08-09]

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Malik R, Chauhan G, Traylor M, ..., Debette S, Dichgans M

Nat. Genet. 50 (4) 524-537 [2018-04-00; online 2018-03-12]