Scharf MM

In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7.

Scharf MM, Kinsolving J, Grätz L, ..., Kolb P, Schulte G

Nat Commun 16 (1) 11138 [2025-12-14; online 2025-12-14]

Björn Forsberg DDLS Fellow

In silico docking yields small molecule compounds targeting the core of Frizzled 7 as negative allosteric modulators

Schulte G, Scharf M, Grätz L, ..., Forsberg B, Kolb P

- - (-) - [2025-08-15; online 2025-08-15]

Björn Forsberg DDLS Fellow

In silico docking yields small molecule compounds targeting the core of Frizzled 7 as negative allosteric modulators

Schulte G, Scharf M, Grätz L, ..., Forsberg B, Kolb P

- - (-) - [2025-07-17; online 2025-07-17]

Björn Forsberg DDLS Fellow

SAG1.3-derived Frizzled-targeting negative allosteric modulators

Schulte G, Grätz L, Turku A, ..., Löber S, Gmeiner P

- - (-) - [2024-02-20; online 2024-02-20]

Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations.

Grätz L, Kowalski-Jahn M, Scharf MM, ..., Gloriam DE, Schulte G

Nat Commun 14 (1) 4573 [2023-07-29; online 2023-07-29]