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Zinzula L, Beck F, Camasta M, Bohn S, Liu C, Morado D, Bracher A, Plitzko JM, Baumeister W
Nat Commun 15 (1) 10307 [2024-11-27; online 2024-11-27]
Marburg virus (MARV) causes lethal hemorrhagic fever in humans, posing a threat to global health. We determined by cryogenic electron microscopy (cryo-EM) the MARV helical ribonucleoprotein (RNP) complex structure in single-layered conformation, which differs from the previously reported structure of a double-layered helix. Our findings illuminate novel RNP interactions and expand knowledge on MARV genome packaging and nucleocapsid assembly, both processes representing attractive targets for the development of antiviral therapeutics against MARV disease.
PubMed 39604358
DOI 10.1038/s41467-024-54431-7
Crossref 10.1038/s41467-024-54431-7
pmc: PMC11603049
pii: 10.1038/s41467-024-54431-7
PDB: 9FVD
PDB: 5F5M
PDB: 5F5O
PDB: 5XSQ
PDB: 5Z9W
PDB: 6C54
PDB: 6NUT
PDB: 7F1M
PDB: 7YPW
PDB: 7YR8