Mortusewicz O

The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation.

Marttila P, Bonagas N, Chalkiadaki C, ..., Mortusewicz O, Helleday T

Mol Oncol 18 (9) 2179-2195 [2024-09-00; online 2024-03-27]

NUDT22 promotes cancer growth through pyrimidine salvage.

Walter M, Mayr F, Hanna BMF, ..., Helleday T, Herr P

Oncogene 42 (16) 1282-1293 [2023-04-00; online 2023-03-04]

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M

- - (-) - [2022-09-19; online 2022-09-19]

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.

Michel M, Benítez-Buelga C, Calvo PA, ..., de Vega M, Helleday T

Science (New York, N.Y.) 376 (6600) 1471-1476 [2022-06-24; online 2022-06-23]

NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487.

Hanna BMF, Michel M, Helleday T, Mortusewicz O

Int J Mol Sci 22 (9) - [2021-04-27; online 2021-04-27]

MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG.

Rudd SG, Gad H, Sanjiv K, ..., Berglund UW, Helleday T

Cancer Res. 80 (17) 3530-3541 [2020-09-01; online 2020-04-20]