Lappalainen T

Family name	Lappalainen
Given name	Tuuli
Initials	T
ORCID	ORCID 0000-0002-7746-8109
Affiliations	Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Solna, 17165, Sweden. New York Genome Center, New York, NY 10013, USA.

18 publications

PubMed DOI Crossref

Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

Domingo J, Minaeva M, Morris JA, ..., Sanjana NE, Lappalainen T

Elife 13 (-) - [2026-01-14; online 2026-01-14]

PubMed DOI Crossref

LIPA, a risk locus for coronary artery disease: decoding the variant-to-function relationship.

Li F, Flynn E, Ha P, ..., Lappalainen T, Zhang H

Eur. Heart J. 46 (48) 5273-5288 [2025-12-22; online 2025-08-19]

PubMed DOI Crossref

Improved Identification of Large-effect Rare Genetic Variants using Haplotype Aggregated Allele-specific Expression Data.

Ganapathy KR, Broly M, Silverstein S, ..., Lappalainen T, Mohammadi P

medRxiv - (-) - [2025-12-18; online 2025-12-18]

Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

Domingo J, Minaeva M, Morris JA, ..., Sanjana NE, Lappalainen T

- - (-) - [2025-11-25; online 2025-11-25]

PubMed DOI Crossref

Large-scale causal discovery using interventional data sheds light on gene network structure in k562 cells.

Brown BC, Tokolyi A, Morris JA, Lappalainen T, Knowles DA

Nat Commun 16 (1) 9628 [2025-10-31; online 2025-10-31]

PubMed DOI Crossref

Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database.

Gudmundsson S, Singer-Berk M, Stenton SL, ..., MacArthur DG, O'Donnell-Luria A

Nat Commun 16 (1) 9623 [2025-10-31; online 2025-10-31]

PubMed DOI Crossref

Recalibrating differential gene expression by genetic dosage variance prioritizes functionally relevant genes.

Rentzsch P, Kollotzek A, Ganapathy KR, Mohammadi P, Lappalainen T

Genome Res 35 (10) 2316-2325 [2025-10-01; online 2025-10-01]

PubMed DOI Crossref

Nonlinear transcriptional responses to gradual modulation of transcription factor dosage.

Domingo J, Minaeva M, Morris JA, ..., Sanjana NE, Lappalainen T

bioRxiv - (-) - [2025-08-07; online 2025-08-07]

Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traits

Kvastad L, Kollotzek A, Saghaleyni R, ..., Cao T, Lappalainen T

- - (-) - [2025-05-02; online 2025-05-02]

PubMed DOI Crossref

Specifying cellular context of transcription factor regulons for exploring context-specific gene regulation programs.

Minaeva M, Domingo J, Rentzsch P, Lappalainen T

NAR Genomics and Bioinformatics 7 (1) lqae178 [2025-03-00; online 2025-01-07]

Non-linear transcriptional responses to gradual modulation of transcription factor dosage

Domingo J, Minaeva M, Morris JA, ..., Sanjana NE, Lappalainen T

- - (-) - [2024-12-17; online 2024-12-17]

PubMed DOI Crossref

Recalibrating differential gene expression by genetic dosage variance prioritizes functionally relevant genes.

Rentzsch P, Kollotzek A, Mohammadi P, Lappalainen T

bioRxiv - (-) - [2024-04-10; online 2024-04-10]

PubMed DOI Crossref

The impact of genetically controlled splicing on exon inclusion and protein structure.

Einson J, Minaeva M, Rafi F, Lappalainen T

PLoS ONE 19 (3) e0291960 [2024-03-13; online 2024-03-13]

PubMed DOI Crossref

Specifying cellular context of transcription factor regulons for exploring context-specific gene regulation programs.

Minaeva M, Domingo J, Rentzsch P, Lappalainen T

bioRxiv - (-) - [2024-01-01; online 2024-01-01]

The impact of genetically controlled splicing on exon inclusion and protein structure

Einson J, Minaeva M, Rafi F, Lappalainen T

- - (-) - [2022-12-07; online 2022-12-07]

PubMed DOI Crossref

Transcriptome variation in human tissues revealed by long-read sequencing.

Glinos DA, Garborcauskas G, Hoffman P, ..., Lappalainen T, Cummings BB

Nature 608 (7922) 353-359 [2022-08-00; online 2022-08-03]

Multiset correlation and factor analysis enables exploration of multi-omic data

Brown BC, Wang C, Kasela S, ..., Knowles DA, Lappalainen T

- - (-) - [2022-07-20; online 2022-07-20]

PubMed DOI Crossref

From variant to function in human disease genetics.

Lappalainen T, MacArthur DG

Science (New York, N.Y.) 373 (6562) 1464-1468 [2021-09-24; online 2021-09-23]

SciLifeLab Data Centre

Publications 9.5.1