Lehtiö J

Family name	Lehtiö
Given name	Janne
Initials	J
ORCID	ORCID 0000-0002-8100-9562
Affiliations	Clinical Proteomics Mass Spectrometry, Department of Oncology-Pathology, Karolinska Institutet, Science for Life Laboratory, Solna, Sweden.

52 publications

PubMed DOI Crossref

Comparative evaluation of Olink Explore 3072 and mass spectrometry with peptide fractionation for plasma proteomics.

Sissala N, Babačić H, Leo IR, ..., Åberg M, Pernemalm M

Commun Chem 8 (1) 327 [2025-11-04; online 2025-11-04]

PubMed DOI Crossref

Pathway activation model for personalized prediction of drug synergy.

Trac QT, Huang Y, Erkers T, ..., Pawitan Y, Vu TN

Elife 13 (-) - [2025-06-03; online 2025-06-03]

DOI Crossref

Pathway activation model for personalized prediction of drug synergy

Trac QT, Huang Y, Erkers T, ..., Pawitan Y, Vu TN

Elife 13 (-) - [2025-06-03; online 2025-06-03]

PubMed DOI Crossref

Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare.

Kämpe A, Gudmundsson S, Walsh CP, ..., Lindstrand A, Lappalainen T

Nat. Med. 31 (6) 1730-1732 [2025-06-00; online 2025-04-05]

DOI Crossref

Pathway activation model for personalized prediction of drug synergy

Trac QT, Huang Y, Erkers T, ..., Pawitan Y, Vu TN

- - (-) - [2025-05-20; online 2025-05-20]

DOI Crossref

Pathway activation model for personalized prediction of drug synergy

Trac QT, Huang Y, Erkers T, ..., Pawitan Y, Vu TN

- - (-) - [2025-03-20; online 2025-03-20]

DOI Crossref

Author response: Pathway activation model for personalized prediction of drug synergy

Trac QT, Huang Y, Erkers T, ..., Pawitan Y, Vu TN

- - (-) - [2025-03-20; online 2025-03-20]

PubMed DOI Crossref

Functional proteoform group deconvolution reveals a broader spectrum of ibrutinib off-targets.

Leo IR, Kunold E, Audrey A, ..., Lehtiö J, Jafari R

Nat Commun 16 (1) 1948 [2025-02-25; online 2025-02-25]

PubMed DOI Crossref

The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia.

Hägerstrand D, Oder B, Cortese D, ..., Sutton LA, Rosenquist R

Leukemia 38 (11) 2429-2442 [2024-11-00; online 2024-09-11]

DOI Crossref

Pathway activation model for personalized prediction of drug synergy

Trac QT, Huang Y, Erkers T, ..., Pawitan Y, Vu TN

- - (-) - [2024-08-09; online 2024-08-09]

PubMed DOI Crossref

Cancer Core Europe: Leveraging Institutional Synergies to Advance Oncology Research and Care Globally.

Carmona J, Chavarria E, Donoghue K, ..., Zwart W, Tabernero J

Cancer Discov 14 (7) 1147-1153 [2024-07-01; online 2024-06-13]

DOI Crossref

Pathway activation model for personalized prediction of drug synergy

Trac QT, Huang Y, Erkers T, ..., Pawitan Y, Vu TN

- - (-) - [2024-06-08; online 2024-06-08]

PubMed DOI Crossref

Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer.

Wang K, Zerdes I, Johansson HJ, ..., Matikas A, Foukakis T

Nat Commun 15 (1) 3837 [2024-05-07; online 2024-05-07]

PubMed DOI Crossref

Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR.

Manfredi F, Stasi L, Buonanno S, ..., Bonini C, Ruggiero E

Sci Adv 9 (48) eadg8014 [2023-12-00; online 2023-12-01]

PubMed DOI Crossref

Development of mesothelioma-specific oncolytic immunotherapy enabled by immunopeptidomics of murine and human mesothelioma tumors.

Chiaro J, Antignani G, Feola S, ..., Lehtiö J, Cerullo V

Nat Commun 14 (1) 7056 [2023-11-03; online 2023-11-03]

PubMed DOI Crossref

Comprehensive proteomics and meta-analysis of COVID-19 host response.

Babačić H, Christ W, Araújo JE, ..., Klingström J, Pernemalm M

Nat Commun 14 (1) 5921 [2023-09-22; online 2023-09-22]

PubMed DOI Crossref

Proteogenomic analysis of acute myeloid leukemia associates relapsed disease with reprogrammed energy metabolism both in adults and children.

Stratmann S, Vesterlund M, Umer HM, ..., Lehtiö J, Holmfeldt L

Leukemia 37 (3) 550-559 [2023-03-00; online 2022-12-26]

DOI Crossref

Development of mesothelioma-specific oncolytic vaccine exploiting immunopeptidomic analysis of murine and human tumors

Chiaro J, Antignani G, Feola S, ..., Lehtiö J, Cerullo V

- - (-) - [2022-11-08; online 2022-11-08]

PubMed DOI Crossref

Proteogenomics refines the molecular classification of chronic lymphocytic leukemia.

Herbst SA, Vesterlund M, Helmboldt AJ, ..., Lehtiö J, Dietrich S

Nat Commun 13 (1) 6226 [2022-10-20; online 2022-10-20]

PubMed DOI Crossref

SubCellBarCode: integrated workflow for robust spatial proteomics by mass spectrometry.

Arslan T, Pan Y, Mermelekas G, ..., Orre LM, Lehtiö J

Nat Protoc 17 (8) 1832-1867 [2022-08-00; online 2022-06-22]

DOI Crossref

Integrative multi-omics analysis reveals molecular subtypes and tumor evolution of synovial sarcoma

Chen Y, Su Y, Leo IR, ..., Larsson O, Haglund de Flon F

- - (-) - [2022-05-10; online 2022-05-10]

PubMed DOI Crossref

Author Correction: The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Tamborero D, Dienstmann R, Rachid MH, ..., Rodon J, Lehtiö J

Nat Cancer 3 (5) 649 [2022-05-00; online 2022-04-23]

PubMed DOI Crossref

Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

Leo IR, Aswad L, Stahl M, ..., Vesterlund M, Jafari R

Nat Commun 13 (1) 1691 [2022-03-30; online 2022-03-30]

PubMed DOI Crossref

A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines.

Feola S, Chiaro J, Martins B, ..., Lehtiö J, Cerullo V

Elife 11 (-) - [2022-03-22; online 2022-03-22]

DOI Crossref

Author response: A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines

Feola S, Chiaro J, Martins B, ..., Lehtiö J, Cerullo V

- - (-) - [2022-02-22; online 2022-02-22]

DOI Crossref

Glioblastoma stem cells express non-canonical proteins and exclusive mesenchymal-like or non-mesenchymal-like protein signatures

Babačić H, Galardi S, Umer HM, ..., Ciafrè SA, Pernemalm M

- - (-) - [2022-02-10; online 2022-02-10]

PubMed DOI Crossref

The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Tamborero D, Dienstmann R, Rachid MH, ..., Rodon J, Lehtiö J

Nat Cancer 3 (2) 251-261 [2022-02-00; online 2022-02-24]

PubMed DOI Crossref

Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms.

Lehtiö J, Arslan T, Siavelis I, ..., Staaf J, Orre LM

Nat Cancer 2 (11) 1224-1242 [2021-11-00; online 2021-11-22]

DOI Crossref

Generation of ENSEMBL-based proteogenomics databases boosts the identification of non-canonical peptides

Umer HM, Zhu Y, Pfeuffer J, ..., Branca R, Perez-Riverol Y

- - (-) - [2021-06-09; online 2021-06-09]

PubMed DOI Crossref

Subcellular proteomics.

Christopher JA, Stadler C, Martin CE, ..., Emili A, Lilley KS

Nat Rev Methods Primers 1 (-) - [2021-04-29; online 2021-04-29]

PubMed DOI Crossref

PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer.

Brunner A, Suryo Rahmanto A, Johansson H, ..., Larsson LG, Sangfelt O

Elife 9 (-) - [2020-07-06; online 2020-07-06]

PubMed DOI Crossref

Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal.

Tamborero D, Dienstmann R, Rachid MH, ..., Rodon J, Lehtiö J

Nat. Med. 26 (7) 992-994 [2020-07-00; online 2020-07-08]

DOI Crossref

Author response: PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

Brunner A, Suryo Rahmanto A, Johansson H, ..., Larsson LG, Sangfelt O

- - (-) - [2020-06-22; online 2020-06-22]

PubMed DOI Crossref

Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.

Rudd SG, Tsesmetzis N, Sanjiv K, ..., Helleday T, Herold N

EMBO Mol Med 12 (3) e10419 [2020-03-06; online 2020-01-17]

PubMed DOI Crossref

A Mitochondrial LYR Protein Is Required for Complex I Assembly.

Ivanova A, Gill-Hille M, Huang S, ..., Whelan J, Murcha MW

Plant Physiol. 181 (4) 1632-1650 [2019-12-00; online 2019-10-10]

PubMed DOI Crossref

Early symptoms and sensations as predictors of lung cancer: a machine learning multivariate model.

Levitsky A, Pernemalm M, Bernhardson BM, ..., Tishelman C, Eriksson LE

Sci Rep 9 (1) 16504 [2019-11-11; online 2019-11-11]

PubMed DOI Crossref

Author Correction: Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin.

Johansson HJ, Vallhov H, Holm T, ..., Lehtiö J, Scheynius A

Sci Rep 9 (1) 15014 [2019-10-15; online 2019-10-15]

PubMed DOI Crossref

Ouabain-regulated phosphoproteome reveals molecular mechanisms for Na+, K+-ATPase control of cell adhesion, proliferation, and survival.

Panizza E, Zhang L, Fontana JM, ..., Lehtiö J, Aperia A

FASEB J. 33 (9) 10193-10206 [2019-09-00; online 2019-07-10]

PubMed DOI Crossref

The viral protein corona directs viral pathogenesis and amyloid aggregation.

Ezzat K, Pernemalm M, Pålsson S, ..., Spetz AL, El Andaloussi S

Nat Commun 10 (1) 2331 [2019-05-27; online 2019-05-27]

PubMed DOI Crossref

In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta.

Pernemalm M, Sandberg A, Zhu Y, ..., Westgren M, Lehtiö J

Elife 8 (-) - [2019-04-08; online 2019-04-08]

PubMed DOI Crossref

Breast cancer quantitative proteome and proteogenomic landscape.

Johansson HJ, Socciarelli F, Vacanti NM, ..., Børresen-Dale AL, Lehtiö J

Nat Commun 10 (1) 1600 [2019-04-08; online 2019-04-08]

PubMed DOI Crossref

Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.

Yang M, Vesterlund M, Siavelis I, ..., Lehtiö J, Paulsson K

Nat Commun 10 (1) 1519 [2019-04-03; online 2019-04-03]

DOI Crossref

Author response: In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

Pernemalm M, Sandberg A, Zhu Y, ..., Westgren M, Lehtiö J

- - (-) - [2019-02-13; online 2019-02-13]

PubMed DOI Crossref

Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis.

Järver P, Dondalska A, Poux C, ..., LeGrand R, Spetz AL

Sci Rep 8 (1) 15841 [2018-10-26; online 2018-10-26]

PubMed DOI Crossref

Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment.

Dyczynski M, Vesterlund M, Björklund AC, ..., Tamm KP, Nilsson R

Cell Death Dis 9 (9) 846 [2018-08-28; online 2018-08-28]

PubMed DOI Crossref

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome.

Sork H, Corso G, Krjutskov K, ..., Mäger I, El Andaloussi S

Sci Rep 8 (1) 10813 [2018-07-17; online 2018-07-17]

PubMed DOI Crossref

Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin.

Johansson HJ, Vallhov H, Holm T, ..., Lehtiö J, Scheynius A

Sci Rep 8 (1) 9182 [2018-06-15; online 2018-06-15]

PubMed DOI Crossref

Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications.

Nassa G, Giurato G, Cimmino G, ..., Weisz A, Tarallo R

Sci Rep 8 (1) 498 [2018-01-11; online 2018-01-11]

PubMed DOI Crossref

Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.

Egaña I, Kaito H, Nitzsche A, ..., Hellström M, German Mouse Clinic Consortium

Sci Rep 7 (1) 15453 [2017-11-13; online 2017-11-13]

PubMed DOI Crossref

Isoelectric point-based fractionation by HiRIEF coupled to LC-MS allows for in-depth quantitative analysis of the phosphoproteome.

Panizza E, Branca RMM, Oliviusson P, Orre LM, Lehtiö J

Sci Rep 7 (1) 4513 [2017-07-03; online 2017-07-03]

PubMed

Alterations in the membrane-associated proteome fraction of alveolar macrophages in sarcoidosis.

Kjellin H, Silva E, Branca RM, ..., Lehtiö J, Wheelock ÅM

Sarcoidosis Vasc Diffuse Lung Dis 33 (1) 17-28 [2016-03-29; online 2016-03-29]

Affiliated researcher

DOI Crossref

Comparative proteomics reveals signature metabolisms of exponentially growing and stationary phase marine bacteria

Muthusamy S, Lundin D, Branca RM, ..., Lehtiö J, Pinhassi J

- - (-) - [2016-03-01; online 2016-03-01]