Publications 2021

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1042 publications

PubMed DOI Crossref
Therapeutic Potential of Ferulic Acid in Alzheimer's Disease.
Turkez H, Arslan ME, Barboza JN, ..., de Sousa DP, Mardinoğlu A
Curr Drug Deliv 19 (8) 860-873 [2021-12-30; online 2021-12-30]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
Author response: Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity
Carrasquilla GD, García-Ureña M, Fall T, Sørensen TI, Kilpeläinen TO
- - (-) - [2021-12-30; online 2021-12-30]
DOI Crossref
An online atlas of human plasma metabolite signatures of gut microbiome composition
Dekkers KF, Sayols-Baixeras S, Baldanzi G, ..., Orho-Melander M, Fall T
- - (-) - [2021-12-30; online 2021-12-30]
PubMed DOI Crossref
Potential of [11C]UCB-J as a PET tracer for islets of Langerhans.
Puuvuori E, Rokka J, Carlsson PO, ..., Eriksson J, Eriksson O
Sci Rep 11 (1) 24466 [2021-12-28; online 2021-12-28]
Olof Eriksson SciLifeLab Fellow
PubMed DOI Crossref
Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle.
Vallianatou T, Bèchet NB, Correia MSP, Lundgaard I, Globisch D
Metabolites 12 (1) - [2021-12-27; online 2021-12-27]
Daniel Globisch SciLifeLab Fellow
DOI Crossref
Influenza A H1N1–mediated pre-existing immunity to SARS-CoV-2 predicts COVID-19 outbreak dynamics
Almazán NM, Rahbar A, Carlsson M, ..., Sörensen B, Söderberg-Nauclér C
- - (-) - [2021-12-25; online 2021-12-25]
DOI Crossref
Upstream charged and hydrophobic residues impact the timing of membrane insertion of transmembrane helices
Nicolaus F, Ibrahimi F, den Besten A, von Heijne G
- - (-) - [2021-12-24; online 2021-12-24]
PubMed DOI Crossref
Author Correction: The SEQC2 epigenomics quality control (EpiQC) study.
Foox J, Nordlund J, Lalancette C, ..., Deng Y, Mason CE
Genome Biol. 22 (1) 350 [2021-12-23; online 2021-12-23]
PubMed DOI Crossref
Amino Acid Sensing and Assimilation by the Fungal Pathogen Candida albicans in the Human Host.
Silao FGS, Ljungdahl PO
Pathogens 11 (1) - [2021-12-22; online 2021-12-22]
PubMed DOI Crossref
A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen.
Landegren N, Ishii N, Aranda-Guillén M, ..., Hashimoto T, Kämpe O
Proc. Natl. Acad. Sci. U.S.A. 118 (51) - [2021-12-21; online 2021-12-17]
DOI Crossref
Author response: ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the lamprey central canal
Jalalvand E, Alvelid J, Coceano G, ..., Grillner S, Testa I
- - (-) - [2021-12-20; online 2021-12-20]
PubMed DOI Crossref
Analysis of blood group antigens on MUC5AC in mucinous ovarian cancer tissues using in situ proximity ligation assay.
Mateoiu C, Vitiazeva V, Kristjansdottir B, ..., Sundfeldt K, Karlsson NG
Glycobiology 31 (11) 1464-1471 [2021-12-18; online 2021-08-31]
PubMed DOI Crossref
Treatment of Respiratory Distress Syndrome with Single Recombinant Polypeptides that Combine Features of SP-B and SP-C.
Basabe-Burgos O, Landreh M, Rising A, Curstedt T
ACS chemical biology 16 (12) 2864-2873 [2021-12-17; online 2021-12-08]
PubMed DOI Crossref
Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases.
Paloschi V, Sabater-Lleal M, Middelkamp H, ..., Tenje M, Maegdefessel L
Cardiovasc Res 117 (14) 2742-2754 [2021-12-17; online 2021-03-18]
PubMed DOI Crossref
Nuclear receptors: from molecular mechanisms to therapeutics.
Frigo DE, Bondesson M, Williams C
Essays Biochem. 65 (6) 847-856 [2021-12-17; online 2021-11-27]
PubMed DOI Crossref
Generation of RNA sequencing libraries for transcriptome analysis of globin-rich tissues of the domestic dog.
Ezer S, Yoshihara M, Katayama S, ..., Krjutskov K, Kere J
STAR Protoc 2 (4) 100995 [2021-12-17; online 2021-12-12]
PubMed DOI Crossref
Computational methods to study enveloped viral entry.
Tuerkova A, Kasson PM
Biochem. Soc. Trans. 49 (6) 2527-2537 [2021-12-17; online 2021-11-17]
PubMed DOI Crossref
Chemical Mapping Exposes the Importance of Active Site Interactions in Governing the Temperature Dependence of Enzyme Turnover.
Winter SD, Jones HBL, Răsădean DM, ..., van der Kamp MW, Pudney CR
ACS Catal 11 (24) 14854-14863 [2021-12-17; online 2021-11-29]
DOI Crossref
Towards a structurally resolved human protein interaction network
Elofsson A, Burke D, Bryant P, ..., Kundrotas P, Beltrao P
- - (-) - [2021-12-16; online 2021-12-16]
DOI Crossref
Physical activity and sedentary behavior; mechanistic insights and role in disease prevention
Hoed Md, Wang Z, Emmerich A, ..., Thomis M, Loos R
- - (-) - [2021-12-16; online 2021-12-16]
PubMed DOI Crossref
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.
Zhang SM, Rehling D, Jemth AS, ..., Stenmark P, Helleday T
Cell Chem Biol 28 (12) 1693-1702.e6 [2021-12-16; online 2021-06-29]
PubMed DOI Crossref
Reply to Guo's commentary on: "Immune cells lacking Y chromosome show dysregulation of autosomal gene expression".
Forsberg LA
Cell. Mol. Life Sci. 79 (1) 30 [2021-12-15; online 2021-12-15]
DOI Crossref
PTEN inhibits AMPK to control collective migration
Peglion F, Capuana L, Perfettini I, ..., Llense F, Etienne-Manneville S
- - (-) - [2021-12-14; online 2021-12-14]
DOI Crossref
Cell transcriptomic atlas of the non-human primate Macaca fascicularis
Han L, Wei X, Liu C, ..., Esteban MA, Liu L
- - (-) - [2021-12-13; online 2021-12-13]
PubMed DOI Crossref
Accurate spliced alignment of long RNA sequencing reads
Sahlin K, Mäkinen V
Bioinformatics 37 (24) 4643-4651 [2021-12-11; online 2021-07-24]
Kristoffer Sahlin SciLifeLab Fellow
DOI Crossref
Ancient DNA from a 2,700-year-old goitered gazelle ( Gazella subgutturosa ) confirms gazelle hunting in Iron Age Central Asia
Rodrigues Soares AE, Boroffka N, Schröder O, ..., Benecke N, Günther T
- - (-) - [2021-12-10; online 2021-12-10]
DOI Crossref
Linked-read whole-genome sequencing resolves common and private structural variants in multiple myeloma
Peña-Pérez L, Frengen N, Hauenstein J, ..., Lindstrand A, Månsson R
- - (-) - [2021-12-09; online 2021-12-09]
PubMed DOI Crossref
Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the CDKN2A/B Gene Locus as a Major Risk Locus.
Letko A, Minor KM, Norton EM, ..., Mickelson JR, Drögemüller C
Genes (Basel) 12 (12) - [2021-12-09; online 2021-12-09]
PubMed DOI Crossref
Systems Biology Approaches to Decipher the Underlying Molecular Mechanisms of Glioblastoma Multiforme.
Kaynar A, Altay O, Li X, ..., Shoaie S, Mardinoglu A
Int J Mol Sci 22 (24) 13213 [2021-12-08; online 2021-12-08]
Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow
PubMed DOI Crossref
Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells.
Elksnis A, Cen J, Wikström P, Carlsson PO, Welsh N
Biomedicines 9 (12) - [2021-12-08; online 2021-12-08]
PubMed DOI Crossref
Long-term STED imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes.
Carravilla P, Dasgupta A, Zhurgenbayeva G, ..., Sezgin E, Eggeling C
Biophys Rep (N Y) 1 (2) None [2021-12-08; online 2021-12-08]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
Genomic Signatures of Sexual Selection on Pollen-Expressed Genes in Arabis alpina.
Gutiérrez-Valencia J, Fracassetti M, Horvath R, ..., Kolář F, Slotte T
Mol. Biol. Evol. - (-) - [2021-12-08; online 2021-12-08]
SciLifeLab Fellow Tanja Slotte
DOI Crossref
FRET-FISH probes chromatin compaction at individual genomic loci in single cells
Mota A, Wernersson E, Li-Wang X, ..., Crosetto N, Bienko M
- - (-) - [2021-12-08; online 2021-12-08]
PubMed DOI Crossref
What Is the Role of the Environment in the Emergence of Novel Antibiotic Resistance Genes? A Modeling Approach.
Bengtsson-Palme J, Jonsson V, Heß S
Environ. Sci. Technol. 55 (23) 15734-15743 [2021-12-07; online 2021-11-18]
DDLS Fellow Johan Bengtsson-Palme
PubMed DOI Crossref
FLT3-ITD allelic ratio and HLF expression predict FLT3 inhibitor efficacy in adult AML.
Kivioja J, Malani D, Kumar A, ..., Kallioniemi O, Heckman CA
Sci Rep 11 (1) 23565 [2021-12-07; online 2021-12-07]
DOI Crossref
Proactive autoscaling for edge computing systems with kubernetes
Ju L, Singh P, Toor S
- - (-) - [2021-12-06; online 2022-02-07]
Prashant Singh SciLifeLab Fellow
DOI Crossref
Monitoring Drug-Target Interactions through Target Engagement-Mediated Amplification on Arrays and in situ
Al-Amin R, Johansson L, Abdurakhmanov E, ..., Lundbäck T, Landegren U
- - (-) - [2021-12-06; online 2021-12-06]
PubMed DOI Crossref
Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis.
Kim PG, Niroula A, Shkolnik V, ..., Natarajan P, Ebert BL
J. Exp. Med. 218 (12) - [2021-12-06; online 2021-10-26]
Abhishek Niroula DDLS Fellow
PubMed DOI Crossref
An efficient, non-invasive approach for in-vivo sampling of hair follicles: design and applications in monitoring DNA damage and aging.
Kudlova N, Slavik H, Duskova P, ..., Mistrik M, Hajduch M
Aging (Albany NY) 13 (23) 25004-25024 [2021-12-06; online 2021-12-06]
DOI Crossref
What can cold-induced transcriptomes of Arctic Brassicaceae tell us about the evolution of cold tolerance?
Birkeland S, Slotte T, Brysting AK, ..., Brochmann C, Nowak MD
- - (-) - [2021-12-05; online 2021-12-05]
PubMed DOI Crossref
The Current State of Beta-Cell-Mass PET Imaging for Diabetes Research and Therapies.
Cheung P, Eriksson O
Biomedicines 9 (12) - [2021-12-03; online 2021-12-03]
Olof Eriksson SciLifeLab Fellow
DOI Crossref
Smart3-ATAC: a highly sensitive method for joint accessibility and full-length transcriptome analysis in single cells
Cheng H, Pui Hp, Lentini A, ..., Deng Q, Enge M
- - (-) - [2021-12-03; online 2021-12-03]
Antonio Lentini DDLS Fellow
PubMed DOI Crossref
Advances and Utility of the Human Plasma Proteome.
Deutsch EW, Omenn GS, Sun Z, ..., Moritz RL, Schwenk JM
J. Proteome Res. 20 (12) 5241-5263 [2021-12-03; online 2021-10-21]
PubMed DOI Crossref
FACT-seq: profiling histone modifications in formalin-fixed paraffin-embedded samples with low cell numbers.
Zhao L, Xing P, Polavarapu VK, ..., Uhrbom L, Chen X
Nucleic Acids Res. 49 (21) e125 [2021-12-02; online 2021-09-18]
PubMed DOI Crossref
A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization.
Zampetidis CP, Galanos P, Angelopoulou A, ..., Papantonis A, Gorgoulis VG
Mol. Cell 81 (23) 4907-4923.e8 [2021-12-02; online 2021-11-17]
PubMed DOI Crossref
Genome Stability Is in the Eye of the Beholder: CR1 Retrotransposon Activity Varies Significantly across Avian Diversity.
Galbraith JD, Kortschak RD, Suh A, Adelson DL
Genome Biol Evol 13 (12) - [2021-12-01; online 2021-12-12]
PubMed DOI Crossref
Esophageal Adenocarcinoma After Antireflux Surgery in a Cohort Study From the 5 Nordic Countries.
Maret-Ouda J, Santoni G, Wahlin K, ..., von Euler-Chelpin M, Lagergren J
Ann Surg 274 (6) e535-e540 [2021-12-01; online 2019-12-05]
PubMed DOI Crossref
A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens.
Liu W, Johansson Å, Rask-Andersen H, Rask-Andersen M
BMC Med 19 (1) 302 [2021-12-01; online 2021-12-01]
PubMed DOI Crossref
eIF4A3 regulates the TFEB-mediated transcriptional response via GSK3B to control autophagy.
Sakellariou D, Tiberti M, Kleiber TH, ..., Papaleo E, Frankel LB
Cell Death Differ. 28 (12) 3344-3356 [2021-12-00; online 2021-06-22]
PubMed DOI Crossref
Syndromic RNA polymerase II insufficiency: Generation of a human induced pluripotent stem cell line (UUIGPi002A-5) with a heterozygous disruption of POLR2A.
Schuster J, de Guidi C, Fatima A, Sobol M, Dahl N
Stem Cell Res 57 (-) 102577 [2021-12-00; online 2021-10-19]
PubMed DOI Crossref
Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire.
Fattinger SA, Sellin ME, Hardt WD
Curr Opin Microbiol 64 (-) 9-18 [2021-12-00; online 2021-09-06]
Mikael Sellin SciLifeLab Fellow
PubMed DOI Crossref
Protein sequence-to-structure learning: Is this the end(-to-end revolution)?
Laine E, Eismann S, Elofsson A, Grudinin S
Proteins 89 (12) 1770-1786 [2021-12-00; online 2021-09-22]
PubMed DOI Crossref
Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR.
Baatallah N, Elbahnsi A, Mornon JP, ..., Callebaut I, Hinzpeter A
Cell. Mol. Life Sci. 78 (23) 7813-7829 [2021-12-00; online 2021-10-29]
PubMed DOI Crossref
Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms.
Zhong W, Altay O, Arif M, ..., Uhlen M, Fagerberg L
EBioMedicine 74 (-) 103723 [2021-12-00; online 2021-11-27]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse in Childhood Acute Myeloid Leukemia.
Skou AS, Juul-Dam KL, Hansen M, ..., Ommen HB, Hasle H
J Mol Diagn 23 (12) 1787-1799 [2021-12-00; online 2021-09-29]
PubMed DOI Crossref
Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro.
Garcia-Alonso L, Handfield LF, Roberts K, ..., Turco MY, Vento-Tormo R
Nat. Genet. 53 (12) 1698-1711 [2021-12-00; online 2021-12-02]
PubMed DOI Crossref
In vitro transcriptome response to propolis in differentiated SH-SY5Y neurons.
Turkez H, Arslan ME, Yilmaz A, ..., Abd El-Aty AM, Mardinoglu A
J Food Biochem 45 (12) e13990 [2021-12-00; online 2021-11-03]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
In silico prediction of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models.
Fagerholm U, Hellberg S, Alvarsson J, Arvidsson McShane S, Spjuth O
Xenobiotica 51 (12) 1366-1371 [2021-12-00; online 2021-12-08]
PubMed DOI Crossref
Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines.
Nencetti S, Cuffaro D, Nuti E, ..., Marshall GR, Orlandini E
J Enzyme Inhib Med Chem 36 (1) 34-47 [2021-12-00; online 2020-10-27]
PubMed DOI Crossref
Identification of a novel variant in GPR56/ADGRG1 gene through whole exome sequencing in a consanguineous Pakistani family.
Zulfiqar S, Tariq M, Ramzan S, ..., Abdullah U, Mahmood Baig S
J Clin Neurosci 94 (-) 8-12 [2021-12-00; online 2021-09-30]
PubMed DOI Crossref
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.
Mills MC, Tropf FC, Brazel DM, ..., Barban N, Day FR
Nat Hum Behav 5 (12) 1717-1730 [2021-12-00; online 2021-07-01]
PubMed DOI Crossref
High resolution and rapid separation of bacteria from blood using elasto-inertial microfluidics.
Narayana Iyengar S, Kumar T, Mårtensson G, Russom A
Electrophoresis 42 (23) 2538-2551 [2021-12-00; online 2021-09-23]
PubMed DOI Crossref
Comparative genome sequencing reveals insights into the dynamics of Wolbachia in native and invasive cherry fruit flies.
Wolfe TM, Bruzzese DJ, Klasson L, ..., Feder JL, Schuler H
Mol. Ecol. 30 (23) 6259-6272 [2021-12-00; online 2021-05-07]
PubMed DOI Crossref
COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study.
Chatzikonstantinou T, Kapetanakis A, Scarfò L, ..., Stamatopoulos K, Ghia P
Leukemia 35 (12) 3444-3454 [2021-12-00; online 2021-11-01]
PubMed DOI Crossref
Author Correction: RecA finds homologous DNA by reduced dimensionality search.
Wiktor J, Gynnå AH, Leroy P, ..., Testa I, Elf J
Nature 600 (7887) E11 [2021-12-00; online 2021-11-14]
PubMed DOI Crossref
A bioinformatic platform to integrate target capture and whole genome sequences of various read depths for phylogenomics.
G Ribeiro P, Torres Jiménez MF, Andermann T, ..., Bacon CD, Matos-Maraví P
Mol. Ecol. 30 (23) 6021-6035 [2021-12-00; online 2021-10-31]
DDLS Fellow Tobias Andermann
PubMed DOI Crossref
Safety in multi-assembly via paths appearing in all path covers of a DAG.
Caceres M, Mumey B, Husic E, ..., Sahlin K, Tomescu AII
IEEE/ACM Trans Comput Biol Bioinform PP (-) - [2021-11-30; online 2021-11-30]
Kristoffer Sahlin SciLifeLab Fellow
PubMed DOI Crossref
Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells.
Luo Z, Lundin S, Mejia-Cordova M, ..., Sandler S, Singh K
Int J Mol Sci 22 (23) - [2021-11-30; online 2021-11-30]
PubMed DOI Crossref
A Detailed Gene Expression Map of Giardia Encystation.
Rojas-López L, Krakovka S, Einarsson E, ..., Jerlström-Hultqvist J, Svärd SG
Genes (Basel) 12 (12) - [2021-11-30; online 2021-11-30]
DOI Crossref
Genomic and niche divergence in an Amazonian palm species complex
Bacon CD, Roncal J, Andermann T, ..., Tunarosa N, Antonelli A
- 197 (4) 498-512 [2021-11-29; online 2021-05-10]
DDLS Fellow Tobias Andermann
PubMed DOI Crossref
Editorial: Methanotrophs: Diversity, Environmental Relevance and Applications.
Cervantes FJ, Garcia SL, Peura S, Balagurusamy N
Front Microbiol 12 (-) 796861 [2021-11-29; online 2021-11-29]
PubMed DOI Crossref
Biology and Treatment of High-Risk CLL: Significance of Complex Karyotype.
Chatzikonstantinou T, Demosthenous C, Baliakas P
Front Oncol 11 (-) 788761 [2021-11-29; online 2021-11-29]
PubMed DOI Crossref
Training algorithm matters for the performance of neural network potential: A case study of Adam and the Kalman filter optimizers.
Shao Y, Dietrich FM, Nettelblad C, Zhang C
J Chem Phys 155 (20) 204108 [2021-11-28; online 2021-12-03]
PubMed DOI Crossref
A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study.
Bergström S, Öijerstedt L, Remnestål J, ..., Nilsson P, Genetic Frontotemporal Dementia Initiative (GENFI)
Mol Neurodegener 16 (1) 79 [2021-11-27; online 2021-11-27]
PubMed DOI Crossref
Point-of-care testing in a high-income country paediatric emergency department: a qualitative study in Sweden.
Rasti R, Brännström J, Mårtensson A, ..., Alvesson HM, Alfvén T
BMJ Open 11 (11) e054234 [2021-11-25; online 2021-11-25]
DOI Crossref
HSFs drive stress type-specific transcription of genes and enhancers
Himanen SV, Puustinen MC, Da Silva AJ, Vihervaara A, Sistonen L
- - (-) - [2021-11-23; online 2021-11-23]
DOI Crossref
STK11 pathway in vitro validation
Lehtiö J, Arslan T, Siavelis I, ..., Staaf J, Orre LM
- - (-) - [2021-11-22; online 2021-11-22]
PubMed DOI Crossref
Pinene-Based Oxidative Synthetic Toolbox for Scalable Polyester Synthesis.
Stamm A, Öhlin J, Mosbech C, ..., Malmström E, Syrén PO
JACS Au 1 (11) 1949-1960 [2021-11-22; online 2021-10-08]
DOI Crossref
Mass spectrometry-based proteomic analysis of NSCLC tumor and biopsy samples
Lehtiö J, Arslan T, Siavelis I, ..., Staaf J, Orre LM
- - (-) - [2021-11-22; online 2021-11-22]
DOI Crossref
Immune landscape evaluation of NSCLC clinical samples
Lehtiö J, Arslan T, Siavelis I, ..., Staaf J, Orre LM
- - (-) - [2021-11-22; online 2021-11-22]
DOI Crossref
Bioinformatics analysis of NSCLC multi-omics data
Lehtiö J, Arslan T, Siavelis I, ..., Staaf J, Orre LM
- - (-) - [2021-11-22; online 2021-11-22]
PubMed DOI Crossref
The Influence of Domain Permutations of an Albumin-Binding Domain-Fused HER2-Targeting Affibody-Based Drug Conjugate on Tumor Cell Proliferation and Therapy Efficacy.
Yin W, Xu T, Altai M, ..., Gräslund T, Orlova A
Pharmaceutics 13 (11) - [2021-11-21; online 2021-11-21]
DOI Crossref
High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue
Crosetto N, Zhang N, Harbers L, ..., Marchiò C, Bienko M
- - (-) - [2021-11-19; online 2021-11-19]
PubMed DOI Crossref
Fragment-based design of selective GPCR ligands guided by free energy simulations.
Matricon P, Vo DD, Gao ZG, ..., Jacobson KA, Carlsson J
Chem. Commun. (Camb.) 57 (92) 12305-12308 [2021-11-19; online 2021-11-19]
Jens Carlsson SciLifeLab Fellow
PubMed DOI Crossref
FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation.
Gultekin O, Gonzalez-Molina J, Hardell E, ..., Lehti K, Carlson JW
NPJ Precis Oncol 5 (1) 97 [2021-11-19; online 2021-11-19]
PubMed DOI Crossref
A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease.
Yang H, Arif M, Yuan M, ..., Zhang C, Mardinoglu A
iScience 24 (11) 103222 [2021-11-19; online 2021-10-05]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by exposing ssDNA gaps.
Paes Dias M, Tripathi V, van der Heijden I, ..., Ray Chaudhuri A, Jonkers J
Mol. Cell 81 (22) 4692-4708.e9 [2021-11-18; online 2021-09-22]
PubMed DOI Crossref
Single cell genomics reveals plastid-lacking Picozoa are close relatives of red algae.
Schön ME, Zlatogursky VV, Singh RP, ..., Wideman JG, Burki F
Nat Commun 12 (1) 6651 [2021-11-17; online 2021-11-17]
Fabien Burki SciLifeLab Fellow
DOI Crossref
NUDT18 catalyzes the hydrolysis of active metabolites of the antivirals Remdesivir, Ribavirin and Molnupiravir
Jemth AS, Scaletti ER, Homan E, ..., Helleday T, Michel M
- - (-) - [2021-11-17; online 2021-11-17]
PubMed DOI Crossref
CD93 Signaling via Rho Proteins Drives Cytoskeletal Remodeling in Spreading Endothelial Cells.
Barbera S, Raucci L, Lugano R, ..., Galvagni F, Orlandini M
Int J Mol Sci 22 (22) - [2021-11-17; online 2021-11-17]
PubMed DOI Crossref
Boron-based hybrids as novel scaffolds for the development of drugs with neuroprotective properties.
Cacciatore I, Turkez H, Di Rienzo A, ..., Mardinoglu A, Di Stefano A
RSC Med Chem 12 (11) 1944-1949 [2021-11-17; online 2021-08-13]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Using High-Sensitivity Lipidomics To Assess Microscale Heterogeneity in Oceanic Sinking Particles and Single Phytoplankton Cells.
Hunter JE, Fredricks HF, Behrendt L, ..., Stocker R, Van Mooy BAS
Environ. Sci. Technol. 55 (22) 15456-15465 [2021-11-16; online 2021-11-01]
Lars Behrendt SciLifeLab Fellow
DOI Crossref
Precise blood proteome profiling in an undiagnosed population with COVID-19
Fredolini C, Dodig-Crnković T, Bendes A, ..., Roxhed N, Schwenk JM
- - (-) - [2021-11-16; online 2021-11-16]
PubMed DOI Crossref
MapToCleave: High-throughput profiling of microRNA biogenesis in living cells.
Kang W, Fromm B, Houben AJ, ..., Biryukova I, Friedländer MR
Cell Reports 37 (7) 110015 [2021-11-16; online 2021-11-18]
Marc Friedländer SciLifeLab Fellow
DOI Crossref
Influence of the extracellular domain size on the dynamic behavior of membrane proteins
Gurdap CO, Wedemann L, Sych T, Sezgin E
- - (-) - [2021-11-16; online 2021-11-16]
PubMed DOI Crossref
Engineered Human Induced Pluripotent Cells Enable Genetic Code Expansion in Brain Organoids.
van Husen LS, Katsori AM, Meineke B, ..., Schedin-Weiss S, Elsässer SJ
Chembiochem 22 (22) 3208-3213 [2021-11-16; online 2021-09-13]
SciLifeLab Fellow Simon Elsässer
DOI Crossref
Cover Feature: Engineered Human Induced Pluripotent Cells Enable Genetic Code Expansion in Brain Organoids (ChemBioChem 22/2021)
van Husen LS, Katsori A, Meineke B, ..., Schedin‐Weiss S, Elsässer SJ
Chembiochem 22 (22) 3108-3108 [2021-11-16; online 2021-09-28]
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Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation.
Benediktsdottir A, Lu L, Cao S, ..., Hughes D, Sandström A
Eur J Med Chem 224 (-) 113699 [2021-11-15; online 2021-07-13]
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Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor.
Chen Y, Fleetwood O, Pérez-Conesa S, Delemotte L
J Chem Inf Model - (-) - [2021-11-15; online 2021-11-15]
Lucie Delemotte SciLifeLab Fellow
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Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking.
Andersson L, Cinato M, Mardani I, ..., Borén J, Levin MC
Eur. Heart J. 42 (43) 4481-4492 [2021-11-14; online 2021-07-24]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
A Landmark-based Common Coordinate Framework for Spatial Transcriptomics Data
Andersson A, Andrusivová Ž, Czarnewski P, ..., Sundström E, Lundeberg J
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Image-based high-throughput mapping of TGF-β-induced phosphocomplexes at a single-cell level.
Lönn P, Al-Amin RA, Doulabi EM, ..., Kamali-Moghaddam M, Landegren U
Commun Biol 4 (1) 1284 [2021-11-12; online 2021-11-12]
DOI Crossref
GutMicroNet: an interactive platform for gut microbiome interaction exploration
Arif M, Portlock T, Güngör C, ..., Mardinoglu A, Shoaie S
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PubMed DOI Crossref
A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling.
Meineke B, Heimgärtner J, Craig AJ, ..., Moodie LWK, Elsässer SJ
Front Chem 9 (-) 768535 [2021-11-11; online 2021-11-11]
SciLifeLab Fellow Simon Elsässer
PubMed DOI Crossref
Association between proton-pump inhibitors and the risk of gastric cancer: a systematic review with meta-analysis.
Segna D, Brusselaers N, Glaus D, Krupka N, Misselwitz B
Ther Adv Gastroenterol 14 (-) 17562848211051463 [2021-11-10; online 2021-11-10]
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Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis.
Tebani A, Jotanovic J, Hekmati N, ..., Casar-Borota O, Pontén F
Acta Neuropathol Commun 9 (1) 181 [2021-11-10; online 2021-11-10]
DOI Crossref
Towards a structurally resolved human protein interaction network
Burke DF, Bryant P, Barrio-Hernandez I, ..., Beltrao P, Elofsson A
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PubMed DOI Crossref
Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation.
Erdélyi K, Ditrói T, Johansson HJ, ..., Lehtiö J, Nagy P
Proc. Natl. Acad. Sci. U.S.A. 118 (45) - [2021-11-09; online 2021-11-06]
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Large-scale identification of RBP-RNA interactions by RAPseq refines essentials of post-transcriptional gene regulation
Atanasoai I, Papavasileiou S, Preiß N, Kutter C
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Claudia Kutter SciLifeLab Fellow
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Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis.
Hober A, Tran-Minh KH, Foley D, ..., Engstrand L, Edfors F
Elife 10 (-) - [2021-11-08; online 2021-11-08]
PubMed DOI Crossref
NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFN-α production in patients with SLE.
Georgakis S, Gkirtzimanaki K, Papadaki G, ..., Verginis P, Bertsias G
JCI Insight 6 (21) - [2021-11-08; online 2021-11-08]
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ELIXIR and Toxicology: a community in development
Martens M, Stierum R, Schymanski EL, ..., Županič A, Willighagen EL
F1000Res 10 (-) 1129 [2021-11-08; online 2021-11-08]
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CRISPRi as a Tool to Repress Multiple Copies of Extracellular Polymeric Substances (EPS)-Related Genes in the Cyanobacterium Synechocystis sp. PCC 6803.
Santos M, Pacheco CC, Yao L, Hudson EP, Tamagnini P
Life (Basel) 11 (11) - [2021-11-06; online 2021-11-06]
PubMed DOI Crossref
pyconsFold: a fast and easy tool for modeling and docking using distance predictions.
Lamb J, Elofsson A
Bioinformatics 37 (21) 3959-3960 [2021-11-05; online 2021-07-10]
DOI Crossref
Specific T Cell Receptor Gene Repertoire Profiles in Subgroups of CLL Patients with Distinct Genomic Aberrations
Vlachonikola E, Sofou E, Gkoliou G, ..., Baliakas P, Chatzidimitriou A
Blood 138 (Supplement 1) 3749-3749 [2021-11-05; online 2021-11-05]
PubMed DOI Crossref
OpenPhi: an interface to access Philips iSyntax whole slide images for computational pathology.
Mulliqi N, Kartasalo K, Olsson H, ..., Eklund M, Ruusuvuori P
Bioinformatics 37 (21) 3995-3997 [2021-11-05; online 2021-08-07]
DDLS Fellow Kimmo Kartasalo
DOI Crossref
Different Prognostic Impact of Recurrent Gene Mutations in IGHV-Mutated and IGHV-Unmutated Chronic Lymphocytic Leukemia: A Retrospective, Multi-Center Cohort Study By Eric, the European Research Initiative on CLL, in Harmony
Mansouri L, Thorvaldsdottir B, Sutton LA, ..., Stamatopoulos K, Rosenquist R
Blood 138 (Supplement 1) 2617-2617 [2021-11-05; online 2021-11-05]
PubMed DOI Crossref
Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion.
Hansel C, Hlouschek J, Xiang K, ..., Jendrossek V, Matschke J
Cells 10 (11) - [2021-11-05; online 2021-11-05]
DOI Crossref
A Novel CD34-Specific T-Cell Engager Efficiently Depletes Stem Cells and Acute Myeloid Leukemia Cells in Vitro and In Vivo
Arruda LCM, Jin L, Lambert M, ..., Carlsten M, Uhlin M
Blood 138 (Supplement 1) 2861-2861 [2021-11-05; online 2021-11-05]
DOI Crossref
Testing for association with rare variants in the coding and non-coding genome: RAVA-FIRST, a new approach based on CADD deleteriousness score
Bocher O, Ludwig TE, Marenne G, ..., Perdry H, Génin E
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PubMed DOI Crossref
Vesicle Viewer: Online visualization and analysis of small-angle scattering from lipid vesicles.
Lewis-Laurent A, Doktorova M, Heberle FA, Marquardt D
Biophys. J. 120 (21) 4639-4648 [2021-11-02; online 2021-09-24]
DDLS Fellow Milka Doktorova
PubMed DOI Crossref
Rolling Circle Amplification in Integrated Microsystems: An Uncut Gem toward Massively Multiplexed Pathogen Diagnostics and Genotyping.
Soares RRG, Madaboosi N, Nilsson M
Acc. Chem. Res. 54 (21) 3979-3990 [2021-11-02; online 2021-10-12]
PubMed DOI Crossref
Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis.
Matias MI, Yong CS, Foroushani A, ..., Taylor N, Dardalhon V
Cell Reports 37 (5) 109911 [2021-11-02; online 2021-11-04]
PubMed DOI Crossref
Mining the Protein Data Bank to improve prediction of changes in protein-protein binding.
Flores SC, Alexiou A, Glaros A
PLoS ONE 16 (11) e0257614 [2021-11-02; online 2021-11-02]
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Protein allocation and utilization in the versatile chemolithoautotroph Cupriavidus necator.
Jahn M, Crang N, Janasch M, ..., Asplund-Samuelsson J, Hudson EP
Elife 10 (-) - [2021-11-01; online 2021-11-01]
PubMed DOI Crossref
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF.
Hausmann A, Felmy B, Kunz L, ..., Sellin ME, Hardt WD
J. Exp. Med. 218 (11) - [2021-11-01; online 2021-09-16]
Mikael Sellin SciLifeLab Fellow
PubMed DOI Crossref
Improving sampling of crystallographic disorder in ensemble refinement.
Ploscariu N, Burnley T, Gros P, Pearce NM
Acta Crystallogr D Struct Biol 77 (Pt 11) 1357-1364 [2021-11-01; online 2021-10-20]
DDLS Fellow Nicholas Pearce
PubMed DOI Crossref
Characterization of the human ABO genotypes and their association to common inflammatory and cardiovascular diseases in the UK Biobank.
Höglund J, Karlsson T, Johansson T, Ek WE, Johansson Å
Am. J. Hematol. 96 (11) 1350-1362 [2021-11-01; online 2021-08-18]
PubMed DOI Crossref
The stress-immunity axis in shellfish.
Coates CJ, Söderhäll K
J Invertebr Pathol 186 (-) 107492 [2021-11-00; online 2020-10-18]
PubMed DOI Crossref
The role of CDHR3 in susceptibility to otitis media.
Hirsch SD, Elling CL, Bootpetch TC, ..., Ryan AF, Santos-Cortez RLP
J. Mol. Med. 99 (11) 1571-1583 [2021-11-00; online 2021-07-28]
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The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus.
Schwochow D, Bornelöv S, Jiang T, ..., Tixier-Boichard M, Andersson L
Pigment Cell Melanoma Res 34 (6) 1015-1028 [2021-11-00; online 2021-05-04]
PubMed DOI Crossref
Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis.
Akbar M, MacDonald L, Crowe LAN, ..., McInnes IB, Millar NL
Ann. Rheum. Dis. 80 (11) 1494-1497 [2021-11-00; online 2021-05-17]
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Safety and Efficacy Assessments to Take Antioxidants in Glioblastoma Therapy: From In Vitro Experiences to Animal and Clinical Studies.
Turkez H, Tozlu OO, Arslan ME, Mardinoglu A
Neurochem Int 150 (-) 105168 [2021-11-00; online 2021-08-25]
Adil Mardinoglu SciLifeLab Fellow
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SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation.
Adolphe C, Millar A, Kojic M, ..., Genovesi LA, Wainwright BJ
Mol. Cancer Res. 19 (11) 1831-1839 [2021-11-00; online 2021-07-30]
PubMed DOI Crossref
Protein kinase C family evolution in jawed vertebrates.
Garcia-Concejo A, Larhammar D
Dev. Biol. 479 (-) 77-90 [2021-11-00; online 2021-07-28]
PubMed DOI Crossref
Intratumoral immunostimulatory AdCD40L gene therapy in patients with advanced solid tumors.
Irenaeus S, Hellström V, Wenthe J, ..., Loskog A, Ullenhag GJ
Cancer Gene Ther. 28 (10-11) 1188-1197 [2021-11-00; online 2020-12-14]
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GRK3 deficiency elicits brain immune activation and psychosis.
Sellgren CM, Imbeault S, Larsson MK, ..., Engberg G, Erhardt S
Mol. Psychiatry 26 (11) 6820-6832 [2021-11-00; online 2021-05-12]
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Effective sequence similarity detection with strobemers
Sahlin K
Genome Res. 31 (11) 2080-2094 [2021-11-00; online 2021-10-19]
Kristoffer Sahlin SciLifeLab Fellow
PubMed DOI Crossref
Distinction of lymphoid and myeloid clonal hematopoiesis.
Niroula A, Sekar A, Murakami MA, ..., Natarajan P, Ebert BL
Nat. Med. 27 (11) 1921-1927 [2021-11-00; online 2021-10-18]
Abhishek Niroula DDLS Fellow
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Discordant Reporting of a Previously Undescribed Pathogenic Germline BRCA2 Variant in Blood and Tumor Tissue in a Patient With Pancreatic Adenocarcinoma.
Kordes M, Tamborero D, Lagerstedt-Robinson K, ..., Löhr JM, Gustafsson Liljefors M
JCO Precis Oncol 5 (-) 974-980 [2021-11-00; online 2022-01-08]
PubMed DOI Crossref
Deep learning and alignment of spatially resolved single-cell transcriptomes with Tangram.
Biancalani T, Scalia G, Buffoni L, ..., Macosko EZ, Regev A
Nat. Methods 18 (11) 1352-1362 [2021-11-00; online 2021-10-28]
Sanja Vickovic SciLifeLab Fellow
PubMed DOI Crossref
Deciphering conformational selectivity in the A2A adenosine G protein-coupled receptor by free energy simulations.
Jespers W, Heitman LH, IJzerman AP, ..., Åqvist J, Gutiérrez-de-Terán H
PLoS Comput Biol 17 (11) e1009152 [2021-11-00; online 2021-11-24]
PubMed DOI Crossref
Cycling between growth and production phases increases cyanobacteria bioproduction of lactate.
Shabestary K, Hernández HP, Miao R, ..., Branco Dos Santos F, Hudson EP
Metab. Eng. 68 (-) 131-141 [2021-11-00; online 2021-10-01]
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Correction to: IL‑15 superagonist N‑803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor‑derived NK cells.
Van der Meer JMR, Maas RJA, Guldevall K, ..., Hobo W, Dolstra H
Cancer Immunol. Immunother. 70 (11) 3367 [2021-11-00; online 2021-09-16]
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Combined RNA/tissue profiling identifies novel Cancer/testis genes.
Jamin SP, Hikmet F, Mathieu R, ..., Chalmel F, Primig M
Mol Oncol 15 (11) 3003-3023 [2021-11-00; online 2021-06-23]
PubMed DOI Crossref
Colistin resistance in Escherichia coli confers protection of the cytoplasmic but not outer membrane from the polymyxin antibiotic.
Humphrey M, Larrouy-Maumus GJ, Furniss RCD, ..., Sabnis A, Edwards AM
Microbiology (Reading, Engl.) 167 (11) - [2021-11-00; online 2021-11-02]
PubMed DOI Crossref
Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.
Lee BJ, Boyer JA, Burnett GL, ..., Smith JAM, Rosen N
Nat. Chem. Biol. 17 (11) 1209 [2021-11-00; online 2021-10-08]
PubMed DOI Crossref
Advances in plasma proteomics: Call for papers for an upcoming special issue.
Yu X, Schwenk J, Xu P, LaBaer J
Proteomics Clin Appl 15 (6) e2100084 [2021-11-00; online 2021-11-12]
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Stratification of the Gut Microbiota Composition Landscape Across the Alzheimer’s Disease Continuum in a Turkish Cohort
Yıldırım S, Nalbantoğlu ÖU, Bayraktar A, ..., Köseoğlu E, Hanoğlu L
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Gene Expression Profiling of Early Acute Febrile Stage of Dengue Infection and Its Comparative Analysis With Streptococcus pneumoniae Infection.
Bajrai LH, Sohrab SS, Alandijany TA, ..., Parveen S, Azhar EI
Front. Cell. Infect. Microbiol. 11 (-) 707905 [2021-10-28; online 2021-10-28]
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Event-triggered STED imaging
Alvelid J, Damenti M, Testa I
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DOI Crossref
Comprehensive analysis of chemical and biological problems associated with browning agents used in aquatic studies
Scharnweber K, Peura S, Attermeyer K, ..., Tranvik LJ, Székely AJ
Limnol Oceanogr Methods - (-) - [2021-10-28; online 2021-10-28]
Sarahi Garcia SciLifeLab Fellow
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Revealing the Molecular Mechanisms of Alzheimer's Disease Based on Network Analysis.
Bayraktar A, Lam S, Altay O, ..., Shoaie S, Mardinoglu A
Int J Mol Sci 22 (21) 11556 [2021-10-26; online 2021-10-26]
Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow
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Europe and the world: boosting international academic cooperation in a time of geopolitical tension and polarization.
Vallin M, Gaunt A, Tomson G, Ottersen OP
Eur J Public Health 31 (5) 929-930 [2021-10-26; online 2021-08-27]
PubMed DOI Crossref
The Lon protease temporally restricts polar cell differentiation events during the Caulobacter cell cycle.
Omnus DJ, Fink MJ, Szwedo K, Jonas K
Elife 10 (-) - [2021-10-25; online 2021-10-25]
PubMed DOI Crossref
Inferring the experimental design for accurate gene regulatory network inference.
Seçilmiş D, Hillerton T, Nelander S, Sonnhammer ELL
Bioinformatics 37 (20) 3553-3559 [2021-10-25; online 2021-05-13]
PubMed DOI Crossref
Virtual reality for 3D histology: multi-scale visualization of organs with interactive feature exploration.
Liimatainen K, Latonen L, Valkonen M, Kartasalo K, Ruusuvuori P
BMC Cancer 21 (1) 1133 [2021-10-22; online 2021-10-22]
DDLS Fellow Kimmo Kartasalo
PubMed DOI Crossref
Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density.
Schmitz D, Ek WE, Berggren E, ..., Karlsson T, Johansson Å
J. Clin. Endocrinol. Metab. 106 (11) e4471-e4486 [2021-10-21; online 2021-07-14]
PubMed DOI Crossref
Dopaminergic and Cholinergic Modulation of Large Scale Networks in silico Using Snudda.
Frost Nylen J, Hjorth JJJ, Grillner S, Hellgren Kotaleski J
Front Neural Circuits 15 (-) 748989 [2021-10-21; online 2021-10-21]
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Simulation of jet printing of solder paste for surface mounted technology
Mårtensson GE, Göhl J, Mark A
SSMT 33 (5) 266-273 [2021-10-19; online 2021-05-13]
DOI Crossref
Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time
Havervall S, Marking U, Greilert-Norin N, ..., Åberg M, Thålin C
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PubMed DOI Crossref
Drug repurposing improves disease targeting 11-fold and can be augmented by network module targeting, applied to COVID-19.
Rivero-García I, Castresana-Aguirre M, Guglielmo L, Guala D, Sonnhammer ELL
Sci Rep 11 (1) 20687 [2021-10-19; online 2021-10-19]
DOI Crossref
Author response: Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis
Hober A, Tran-Minh KH, Foley D, ..., Engstrand L, Edfors F
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PubMed DOI Crossref
Monitoring the Microevolution of Salmonella enterica in Healthy Dairy Cattle Populations at the Individual Farm Level Using Whole-Genome Sequencing.
Carroll LM, Buehler AJ, Gaballa A, ..., Cheng RA, Wiedmann M
Front Microbiol 12 (-) 763669 [2021-10-18; online 2021-10-18]
DDLS Fellow Laura Carroll
PubMed DOI Crossref
Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites.
Lin W, Conway LP, Vujasinovic M, Löhr JM, Globisch D
Angew. Chem. Int. Ed. Engl. 60 (43) 23232-23240 [2021-10-18; online 2021-09-17]
Daniel Globisch SciLifeLab Fellow
DOI Crossref
Revisiting the demographic history of Central African populations from a genetic perspective
Breton G, Fortes-Lima C, Schlebusch CM
Hum Popul Genet Genom - (-) 1-29 [2021-10-16; online 2021-10-16]
DOI Crossref
Identification of electroporation sites in the complex lipid organization of the plasma membrane
Rems L, Tang X, Zhao F, ..., Testa I, Delemotte L
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DOI Crossref
scSPLAT, a scalable plate-based protocol for single cell WGBS library preparation
Raine A, Lundmark A, Annett A, ..., Bergin C, Nordlund J
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PubMed DOI Crossref
Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel.
Bergh C, Heusser SA, Howard R, Lindahl E
Elife 10 (-) - [2021-10-15; online 2021-10-15]
PubMed DOI Crossref
Integrative Analysis to Identify Genes Associated with Stemness and Immune Infiltration in Glioblastoma.
Warrier NM, Agarwal P, Kumar P
Cells 10 (10) - [2021-10-15; online 2021-10-15]
PubMed DOI Crossref
Functional Proteomic Profiling of Triple-Negative Breast Cancer.
Gromova I, Espinoza JA, Grauslund M, ..., van Oostrum J, Moreira JMA
Cells 10 (10) - [2021-10-15; online 2021-10-15]
PubMed DOI Crossref
Recent Evolution and Genomic Profile of Salmonella enterica Serovar Heidelberg Isolates from Poultry Flocks in Brazil.
Kipper D, Orsi RH, Carroll LM, ..., Wiedmann M, Lunge VR
Applied and environmental microbiology 87 (21) e0103621 [2021-10-14; online 2021-08-18]
DDLS Fellow Laura Carroll
DOI Crossref
PoSTcode: Probabilistic image-based spatial transcriptomics decoder
Gataric M, Park JS, Li T, ..., Bayraktar O, Gerstung M
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PubMed DOI Crossref
Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK.
Elksnis A, Schiffer TA, Palm F, ..., Welsh N, Wang X
Clin. Sci. 135 (19) 2243-2263 [2021-10-14; online 2021-09-28]
PubMed DOI Crossref
Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical Neurons.
Bergström P, Trybala E, Eriksson CE, ..., Zetterberg H, Bergström T
Viruses 13 (10) - [2021-10-14; online 2021-10-14]
SciLifeLab Fellow Wojciech Michno
PubMed DOI Crossref
The Assessment of Selected miRNA Profile in Familial Mediterranean Fever.
Kahraman CY, Egin ME, Tatar A, Turkez H, Mardinoglu A
Biomed Res Int 2021 (-) 6495700 [2021-10-13; online 2021-10-13]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Characterization of Basal Transcriptomes Identifies Potential Metabolic and Virulence-Associated Adaptations Among Diverse Nontyphoidal Salmonella enterica Serovars.
Cohn AR, Orsi RH, Carroll LM, ..., Wiedmann M, Cheng RA
Front Microbiol 12 (-) 730411 [2021-10-13; online 2021-10-13]
DDLS Fellow Laura Carroll
PubMed DOI Crossref
USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork.
Franz A, Valledor P, Ubieto-Capella P, ..., Fernandez-Capetillo O, Lecona E
Cell Reports 37 (2) 109819 [2021-10-12; online 2021-10-14]
PubMed DOI Crossref
The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma.
Dadras MS, Caja L, Mezheyeuski A, ..., Heldin CH, Moustakas A
Cell Death Dis 12 (10) 932 [2021-10-12; online 2021-10-12]
PubMed DOI Crossref
Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective.
Zhang P, Carlsten C, Chaleckis R, ..., Wright RO, Wheelock CE
Environ Sci Technol Lett 8 (10) 839-852 [2021-10-12; online 2021-09-07]
DOI Crossref
The coordination of replication initiation with growth rate in Escherichia coli
Knöppel A, Broström O, Gras K, Fange D, Elf J
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Diversity and ecology of protists revealed by metabarcoding.
Burki F, Sandin MM, Jamy M
Curr. Biol. 31 (19) R1267-R1280 [2021-10-11; online 2021-10-13]
Fabien Burki SciLifeLab Fellow
PubMed DOI Crossref
Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet.
Yang H, Mayneris-Perxachs J, Boqué N, ..., Mardinoglu A, Caimari A
Biomedicines 9 (10) - [2021-10-11; online 2021-10-11]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines.
Lin W, Yang Z, Kaur A, ..., Löhr JM, Globisch D
RSC Chem Biol 2 (5) 1479-1483 [2021-10-07; online 2021-08-12]
Daniel Globisch SciLifeLab Fellow
DOI Crossref
PatientMatcher: a customizable Python-based open-source tool for matching undiagnosed rare disease patients via the MatchMaker Exchange network
Rasi C, Nilsson D, Magnusson M, ..., Wirta V, Stranneheim H
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Membrane-assisted assembly and selective autophagy of enteroviruses
Dahmane S, Kerviel A, Morado DR, ..., Altan-Bonnet N, Carlson LA
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PubMed DOI Crossref
AKAP79 enables calcineurin to directly suppress protein kinase A activity.
Church TW, Tewatia P, Hannan S, ..., Hellgren Kotaleski J, Gold MG
Elife 10 (-) - [2021-10-06; online 2021-10-06]
PubMed DOI Crossref
Progress and Future Directions with Peptide-Drug Conjugates for Targeted Cancer Therapy.
Lindberg J, Nilvebrant J, Nygren PÅ, Lehmann F
Molecules 26 (19) - [2021-10-05; online 2021-10-05]
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CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations
Höijer I, Emmanouilidou A, Östlund R, ..., den Hoed M, Ameur A
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PubMed DOI Crossref
Biocatalysis in the Recycling Landscape for Synthetic Polymers and Plastics towards Circular Textiles.
Jönsson C, Wei R, Biundo A, ..., Bornscheuer UT, Syrén PO
ChemSusChem 14 (19) 4028-4040 [2021-10-05; online 2021-02-12]
DOI Crossref
Nanoengineered DNA origami with repurposed TOP1 inhibitors targeting myeloid cells for the mitigation of neuroinflammation
Zhu K, Wang Y, Sarlus H, ..., Högberg B, Harris RA
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PubMed DOI Crossref
Genomic Characterization of Endemic and Ecdemic Non-typhoidal Salmonella enterica Lineages Circulating Among Animals and Animal Products in South Africa.
Carroll LM, Pierneef R, Mathole M, Matle I
Front Microbiol 12 (-) 748611 [2021-10-04; online 2021-10-04]
DDLS Fellow Laura Carroll
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Brain microvasculature endothelial cell orientation on micropatterned hydrogels is affected by glucose level variations.
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Qasim MS, Lampi M, Heinonen MK, ..., Roine E, Sarin LP
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Clinical Experience of Proteasome Inhibitor Bortezomib Regarding Efficacy and Safety in Severe Systemic Lupus Erythematosus: A Nationwide Study.
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Eur Neuropsychopharmacol 51 (-) e165-e166 [2021-10-00; online 2021-10-00]
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The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver.
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Ballante F, Kooistra AJ, Kampen S, de Graaf C, Carlsson J
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Jens Carlsson SciLifeLab Fellow
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Lars Behrendt SciLifeLab Fellow
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Michno W, Blennow K, Zetterberg H, Brinkmalm G
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EFSA Panel on Biological Hazards (BIOHAZ) , Koutsoumanis K, Allende A, ..., Stella P, Peixe L
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EFSA J 19 (10) e06858 [2021-10-00; online 2021-10-26]
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EFSA J 19 (10) e06856 [2021-10-00; online 2021-10-26]
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EFSA J 19 (10) e06855 [2021-10-00; online 2021-10-26]
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EFSA J 19 (10) e06854 [2021-10-00; online 2021-10-26]
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EFSA J 19 (10) e06853 [2021-10-00; online 2021-10-26]
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EFSA J 19 (10) e06852 [2021-10-00; online 2021-10-26]
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EFSA J 19 (10) e06865 [2021-10-00; online 2021-10-26]
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EFSA J 19 (10) e06864 [2021-10-00; online 2021-10-26]
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EFSA J 19 (10) e06863 [2021-10-00; online 2021-10-26]
DDLS Fellow Johan Bengtsson-Palme
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EFSA J 19 (10) e06862 [2021-10-00; online 2021-10-26]
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Pinto IF, Mikkonen S, Josefsson L, ..., Emmer Å, Chotteau V
Curr. Opin. Biotechnol. 71 (-) 55-64 [2021-10-00; online 2021-07-07]
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Environ Int 155 (-) 106601 [2021-10-00; online 2021-05-04]
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van Zuydam NR, Stiby A, Abdalla M, ..., Kullo IJ, GoLEAD Consortium, SUMMIT Consortium†
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Espes D, Liljebäck H, Hill H, ..., Caballero-Corbalan J, Carlsson PO
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Öman A, Dicksved J, Engstrand L, Berntson L
J Rheumatol 48 (10) 1589-1595 [2021-10-00; online 2020-12-01]
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Journal of Thoracic Oncology 16 (10) S974 [2021-10-00; online 2021-10-00]
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Nat Ecol Evol 5 (10) 1415-1423 [2021-10-00; online 2021-08-12]
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DeepImageJ: A user-friendly environment to run deep learning models in ImageJ.
Gómez-de-Mariscal E, García-López-de-Haro C, Ouyang W, ..., Muñoz-Barrutia A, Sage D
Nat. Methods 18 (10) 1192-1195 [2021-10-00; online 2021-09-30]
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Fernandes SJ, Ericsson M, Khademi M, ..., Kockum I, Tegnér J
Epigenomics 13 (20) 1607-1618 [2021-10-00; online 2021-10-22]
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Fromm B, Tarbier M, Smith O, ..., Gilbert MTP, Friedländer MR
RNA 27 (10) 1291 [2021-10-00; online 2021-09-18]
Marc Friedländer SciLifeLab Fellow
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Xenobiotica 51 (10) 1095-1100 [2021-10-00; online 2021-08-13]
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Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients.
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Mol Syst Biol 17 (10) e10459 [2021-10-00; online 2021-10-26]
Adil Mardinoglu Saeed Shoaie SciLifeLab Fellow
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Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy.
Wenthe J, Naseri S, Labani-Motlagh A, ..., Loskog A, Lövgren T
Cancer Immunol. Immunother. 70 (10) 2851-2865 [2021-10-00; online 2021-03-05]
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Association of levonorgestrel intrauterine devices with stress reactivity, mental health, quality of life and sexual functioning: A systematic review.
Bürger Z, Bucher AM, Comasco E, ..., Kogler L, Derntl B
Front Neuroendocrinol 63 (-) 100943 [2021-10-00; online 2021-08-20]
Erika Comasco SciLifeLab Fellow
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A practical guide to large-scale docking.
Bender BJ, Gahbauer S, Luttens A, ..., Irwin JJ, Shoichet BK
Nat Protoc 16 (10) 4799-4832 [2021-10-00; online 2021-09-24]
Jens Carlsson SciLifeLab Fellow
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A microfluidic chip carrier including temperature control and perfusion system for long-term cell imaging.
Cantoni F, Werr G, Barbe L, Porras AM, Tenje M
HardwareX 10 (-) e00245 [2021-10-00; online 2021-11-06]
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Mangsbo SM, Havervall S, Laurén I, ..., Klingström J, Thålin C
PLoS ONE 16 (9) e0258041 [2021-09-30; online 2021-09-30]
Gustaf Christoffersson SciLifeLab Fellow
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Janßen R, Beck AJ, Werner J, ..., Andersson AF, Labrenz M
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Chelebian E, Avenel C, Kartasalo K, ..., Lundeberg J, Wählby C
Cancers (Basel) 13 (19) - [2021-09-28; online 2021-09-28]
DDLS Fellow Kimmo Kartasalo
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Velikyan I, Rosenström U, Rosestedt M, Eriksson O, Antoni G
Pharmaceuticals (Basel, Switzerland) 14 (10) - [2021-09-28; online 2021-09-28]
Olof Eriksson SciLifeLab Fellow
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Inferring Genome-Wide Correlations of Mutation Fitness Effects between Populations.
Huang X, Fortier AL, Coffman AJ, ..., Ragsdale AP, Gutenkunst RN
Mol. Biol. Evol. 38 (10) 4588-4602 [2021-09-27; online 2021-05-28]
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High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing
Kostecka A, Nowikiewicz T, Olszewski P, ..., Dumanski JP, Piotrowski A
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Persson J, Puuvuori E, Zhang B, ..., Eriksson O, Löfblom J
Sci Rep 11 (1) 19151 [2021-09-27; online 2021-09-27]
Olof Eriksson SciLifeLab Fellow
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A Chromosome-Level Assembly of Blunt Snout Bream (Megalobrama amblycephala) Genome Reveals an Expansion of Olfactory Receptor Genes in Freshwater Fish.
Liu H, Chen C, Lv M, ..., Andersson L, Wang W
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A structural biology community assessment of AlphaFold 2 applications
Akdel M, Pires DEV, Porta Pardo E, ..., Croll TI, Beltrao P
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Toward Rapid Detection of Viable Bacteria in Whole Blood for Early Sepsis Diagnostics and Susceptibility Testing.
Narayana Iyengar S, Dietvorst J, Ferrer-Vilanova A, ..., Muñoz-Berbel X, Russom A
ACS Sens 6 (9) 3357-3366 [2021-09-24; online 2021-08-19]
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Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases.
Lam S, Hartmann N, Benfeitas R, ..., Knight R, Mardinoglu A
Biomedicines 9 (10) - [2021-09-24; online 2021-09-24]
Adil Mardinoglu SciLifeLab Fellow
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HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers.
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From variant to function in human disease genetics.
Lappalainen T, MacArthur DG
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Editorial: The Role of Biomembranes and Biophysics in Immune Cell Signaling.
Shi Y, Sezgin E, Chen W
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Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.
McCoull W, Boyd S, Brown MR, ..., Zhu Q, Smith PD
J Med Chem 64 (18) 13524-13539 [2021-09-23; online 2021-09-03]
SciLifeLab Fellow Yumeng Mao
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Microfluidic Synthesis of Indomethacin-Loaded PLGA Microparticles Optimized by Machine Learning.
Damiati SA, Damiati S
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Using informative features in machine learning based method for COVID-19 drug repurposing.
Aghdam R, Habibi M, Taheri G
J Cheminform 13 (1) 70 [2021-09-20; online 2021-09-20]
DDLS Fellow Golnaz Taheri
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Structural basis of l-tryptophan-dependent inhibition of release factor 2 by the TnaC arrest peptide.
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Nucleic Acids Res. 49 (16) 9539-9547 [2021-09-20; online 2021-08-18]
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A method for intuitively extracting macromolecular dynamics from structural disorder
Pearce NM, Gros P
Nat Commun 12 (1) 5493 [2021-09-17; online 2021-09-17]
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The shared risk of diabetes between dog and cat owners and their pets: register based cohort study
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Secondary ossification center induces and protects growth plate structure
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Purkinje cells located in the adult zebrafish valvula cerebelli exhibit variable functional responses.
Chang W, Pedroni A, Köster RW, Giacomello S, Ampatzis K
Sci Rep 11 (1) 18408 [2021-09-15; online 2021-09-15]
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Potential of brain mast cells for therapeutic application in the immune response to bacterial and viral infections.
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Improved prediction of protein-protein interactions using AlphaFold2
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A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability.
Felletti M, Romilly C, Wagner EGH, Jonas K
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Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering.
Lycksell M, Rovšnik U, Bergh C, ..., Howard RJ, Lindahl E
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Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types.
Chisari A, Golán I, Campisano S, ..., Sancho P, Caja L
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Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial
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Protein-lipid interaction at low pH induces oligomerisation of the MakA cytotoxin from Vibrio cholerae
Nadeem A, Berg A, Pace H, ..., Uhlin BE, Wai SN
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sepal: identifying transcript profiles with spatial patterns by diffusion-based modeling.
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Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study.
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Phosphorus Regulation of Methane Oxidation in Water From Ice‐Covered Lakes
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A brief review of vertebrate sex evolution with a pledge for integrative research: towards 'sexomics'.
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Integrating multi-taxon palaeogenomes and sedimentary ancient DNA to study past ecosystem dynamics.
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High definition DIC imaging uncovers transient stages of pathogen infection cycles on the surface of human adult stem cell-derived intestinal epithelium
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Polycomb Repressive Complex 2 shields naïve human pluripotent cells from trophectoderm differentiation
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Ion Channels: Intersection of Structure, Function, and Pharmacology.
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The ABCC4 gene is associated with pyometra in golden retriever dogs.
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Functional cross-talk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5.
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ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the central canal
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Coordinating DNA Replication and Mitosis through Ubiquitin/SUMO and CDK1.
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Advances in the Relationships Between Cow's Milk Protein Allergy and Gut Microbiota in Infants.
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Neutralization of VOCs including Delta one year post COVID-19 or vaccine
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Candidatus Methylumidiphilus Drives Peaks in Methanotrophic Relative Abundance in Stratified Lakes and Ponds Across Northern Landscapes.
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The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation.
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Neuronal mimicry generates an ecosystem critical for brain metastatic growth of SCLC
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Structure‐Guided Design of G‐Protein‐Coupled Receptor Polypharmacology
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Structure-Guided Design of G-Protein-Coupled Receptor Polypharmacology.
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Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing.
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Integrated annotation and analysis of genomic features reveal new types of functional elements and large-scale epigenetic phenomena in the developing zebrafish
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Integrated Single Cell and Spatial Transcriptomics Reveal Autoreactive Differentiated B Cells in Joints of Early Rheumatoid Arthritis
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Sample-to-answer COVID-19 nucleic acid testing using a low-cost centrifugal microfluidic platform with bead-based signal enhancement and smartphone read-out.
Soares RRG, Akhtar AS, Pinto IF, ..., Pelechano V, Russom A
Lab Chip 21 (15) 2932-2944 [2021-08-07; online 2021-06-11]
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Genome assemblies of three closely related leaf beetle species (Galerucella spp.).
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Quantifying RNA Synthesis at Rate-Limiting Steps of Transcription Using Nascent RNA-Sequencing Data
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Canine oral melanoma genomic and transcriptomic study defines two molecular subgroups with different therapeutical targets
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MapToCleave: high-throughput profiling of microRNA biogenesis in living cells
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Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness.
Zhao LJ, Li YY, Zhang YT, ..., Zheng YC, Liu HM
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Adil Mardinoglu SciLifeLab Fellow
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Imaging-Guided Therapy Simultaneously Targeting HER2 and EpCAM with Trastuzumab and EpCAM-Directed Toxin Provides Additive Effect in Ovarian Cancer Model.
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Combined Metabolic Activators Improve Cognitive Functions without Altering Motor Scores in Parkinson’s Disease
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Microbial retention and resistances in stormwater quality improvement devices treating road runoff
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A phenomics approach for antiviral drug discovery.
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Wang QL, Lagergren J
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NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis.
Zhao Z, Gad H, Benitez-Buelga C, ..., Xia Q, Helleday T
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Co-occurrence of cohesin complex and Ras signaling mutations during progression from myelodysplastic syndromes to secondary acute myeloid leukemia.
Martín-Izquierdo M, Abáigar M, Hernández-Sánchez JM, ..., Díez-Campelo M, Hernández-Rivas JM
Haematologica 106 (8) 2215-2223 [2021-08-01; online 2021-08-01]
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Theoretical studies on 1,4-dihydropyridine derivatives as P-glycoprotein allosteric inhibitors: insights on symmetry and stereochemistry.
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The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.
Kanellis DC, Espinoza JA, Zisi A, ..., Lindström MS, Bartek J
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SciLifeLab Fellow Simon Elsässer
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The evolutionary history of topological variations in the CPA/AT transporters.
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The emerging role of artificial intelligence in the reporting of prostate pathology.
Egevad L, Delahunt B, Samaratunga H, ..., Kartasalo K, Eklund M
Pathology 53 (5) 565-567 [2021-08-00; online 2021-06-06]
DDLS Fellow Kimmo Kartasalo
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Structure and Interdigitation of Chain-Asymmetric Phosphatidylcholines and Milk Sphingomyelin in the Fluid Phase.
Frewein MPK, Doktorova M, Heberle FA, ..., Porcar L, Pabst G
Symmetry (Basel) 13 (8) - [2021-08-00; online 2021-08-05]
DDLS Fellow Milka Doktorova
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Rpb4 and Puf3 imprint and post-transcriptionally control the stability of a common set of mRNAs in yeast.
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MTH1 Inhibitors for the Treatment of Psoriasis.
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Vrettou M, Yan L, Nilsson KW, ..., Nylander I, Comasco E
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Machine Learning Strategies When Transitioning between Biological Assays.
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Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning.
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Cotranslational Translocation and Folding of a Periplasmic Protein Domain in Escherichia coli.
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Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia.
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Developmental landscape of human forebrain at a single-cell level unveils early waves of oligodendrogenesis
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Combined Metabolic Activators Improves Cognitive Functions in Alzheimer’s Disease
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Author response: Vision, challenges and opportunities for a Plant Cell Atlas
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PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair.
Ninou AH, Lehto J, Chioureas D, ..., Seashore-Ludlow B, Gustafsson NMS
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Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1.
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The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin
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Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells.
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Association of Protective HLA-A With HLA-B Positive Ankylosing Spondylitis.∗27
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The Healthy Female Microbiome Across Body Sites: Effect of Hormonal Contraceptives and the Menstrual Cycle
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Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity.
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Benchmarking ultra-high molecular weight DNA preservation methods for long-read and long-range sequencing
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In-Line Analysis of Organ-on-Chip Systems with Sensors: Integration, Fabrication, Challenges, and Potential.
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De novo spatiotemporal modelling of cell-type signatures identifies novel cell populations in the developmental human heart
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Allosteric effect of nanobody binding on ligand-specific active states of the β2-Adrenergic Receptor
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Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples
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COVseq is a cost-effective workflow for mass-scale SARS-CoV-2 genomic surveillance
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Serglycin-Deficiency Causes Reduced Weight Gain and Changed Intestinal Cytokine Responses in Mice Infected With Giardia intestinalis.
Li Z, Peirasmaki D, Svärd S, Åbrink M
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Recent Progress in the Molecular Imaging of Nonalcoholic Fatty Liver Disease.
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Olof Eriksson SciLifeLab Fellow
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Identification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition.
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Sci Rep 11 (1) 14171 [2021-07-08; online 2021-07-08]
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Circadian Genes as Exploratory Biomarkers in DMD: Results From Both the mdx Mouse Model and Patients.
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Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide.
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Interpretable Machine Learning Identifies Paediatric Systemic Lupus Erythematosus Subtypes Based On Gene Expression Data
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Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis.
Kundu S, Ali MA, Handin N, ..., Globisch D, Sjöblom T
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An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism.
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A Novel mRNA-Mediated and MicroRNA-Guided Approach to Specifically Eradicate Drug-Resistant Hepatocellular Carcinoma Cell Lines by Se-Methylselenocysteine.
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Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure.
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Indolylbenzothiadiazoles as highly tunable fluorophores for imaging lipid droplet accumulation in astrocytes and glioblastoma cells.
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Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential.
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NUAK1 and NUAK2 Fine-Tune TGF-β Signaling.
van de Vis RAJ, Moustakas A, van der Heide LP
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Genome-Wide Association Study of Estradiol Levels, and the Causal Effect of Estradiol on Bone Mineral Density
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Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma.
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The spatial transcriptomic landscape of the healing intestine following damage
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iNetModels 2.0: an interactive visualization and database of multi-omics data.
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Nucleic Acids Res. 49 (W1) W271-W276 [2021-07-02; online 2021-04-14]
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DIAproteomics: A Multifunctional Data Analysis Pipeline for Data-Independent Acquisition Proteomics and Peptidomics.
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CeLaVi: an interactive cell lineage visualization tool.
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Nucleic Acids Res. 49 (W1) W80-W85 [2021-07-02; online 2021-05-07]
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Widespread displacement of DNA- and RNA-binding factors underlies toxicity of arginine-rich cell-penetrating peptides.
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The N-terminal Helix-Turn-Helix Motif of Transcription Factors MarA and Rob Drives DNA Recognition.
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The Effect of the Molecular Weight of Polyvinylpyrrolidone and the Model Drug on Laser-Induced In Situ Amorphization.
Hempel NJ, Merkl P, Knopp MM, ..., Sotiriou GA, Löbmann K
Molecules 26 (13) 4035 [2021-07-01; online 2021-07-01]
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Tafazzin Deficiency Reduces Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets From Male Mice.
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PathBIX-a web server for network-based pathway annotation with adaptive null models.
Castresana-Aguirre M, Persson E, Sonnhammer ELL
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Editorial: NK-Myeloid Cell Interactions in the Tumor Microenvironment: Implications for Cancer Immunotherapy.
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Front Immunol 12 (-) 718844 [2021-07-01; online 2021-07-01]
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CRISPR/Cas9 deletions induce adverse on-target genomic effects leading to functional DNA in human cells
Geng K, Merino LG, Wedemann L, ..., White RJ, Kutter C
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The emerging role of radionuclide molecular imaging of HER2 expression in breast cancer.
Tolmachev V, Orlova A, Sörensen J
Semin. Cancer Biol. 72 (-) 185-197 [2021-07-00; online 2021-01-16]
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Simultaneous detection of SARS-CoV-2 and pandemic (H1N1) 2009 virus with real-time isothermal platform.
Yu L, Wang J, Li X, ..., Guo X, Yin X
Heliyon 7 (7) e07584 [2021-07-00; online 2021-07-15]
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Same data, different conclusions: Radical dispersion in empirical results when independent analysts operationalize and test the same hypothesis
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Organizational Behavior and Human Decision Processes 165 (-) 228-249 [2021-07-00; online 2021-07-00]
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Safety Assessments of Nickel Boride Nanoparticles on the Human Pulmonary Alveolar Cells by Using Cell Viability and Gene Expression Analyses.
Türkez H, Arslan ME, Sönmez E, ..., Açikyildiz M, Mardinoğlu A
Biol Trace Elem Res 199 (7) 2602-2611 [2021-07-00; online 2020-09-09]
Adil Mardinoglu SciLifeLab Fellow
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STED and parallelized RESOLFT optical nanoscopy of the tubular endoplasmic reticulum and its mitochondrial contacts in neuronal cells.
Damenti M, Coceano G, Pennacchietti F, Bodén A, Testa I
Neurobiol. Dis. 155 (-) 105361 [2021-07-00; online 2021-04-12]
Ilaria Testa SciLifeLab Fellow
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Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling.
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Neurotherapeutics 18 (3) 1963-1979 [2021-07-00; online 2021-04-15]
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Recommendations for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples.
Kubik S, Marques AC, Xing X, ..., Willig A, Xu Z
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Modification of Heritability for Educational Attainment and Fluid Intelligence by Socioeconomic Deprivation in the UK Biobank.
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Increased levels of inflammatory markers in the subscapularis tendon and joint capsule in patients with subacromial impingement.
Farfaras S, Roshani L, Mulder J, ..., Hallström EK, Kartus JT
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Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes.
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Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State.
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Effects of 6 weeks of treatment with dapagliflozin, a sodium-glucose co-transporter-2 inhibitor, on myocardial function and metabolism in patients with type 2 diabetes: A randomized, placebo-controlled, exploratory study.
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Diabetes Obes Metab 23 (7) 1505-1517 [2021-07-00; online 2021-03-12]
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Distinct genetic regions are associated with differential population susceptibility to chemical exposures.
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Environ Int 152 (-) 106488 [2021-07-00; online 2021-03-10]
Oskar Karlsson SciLifeLab Fellow
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Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging.
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DNA Origami Penetration in Cell Spheroid Tissue Models is Enhanced by Wireframe Design.
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Erik Benson SciLifeLab Fellow
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Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator.
Kaltsouni E, Fisher PM, Dubol M, ..., Comasco E, Sundström-Poromaa I
Neuropsychopharmacology 46 (8) 1460-1467 [2021-07-00; online 2021-04-29]
Erika Comasco SciLifeLab Fellow
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Artificial Intelligence for Diagnosis and Gleason Grading of Prostate Cancer in Biopsies-Current Status and Next Steps.
Kartasalo K, Bulten W, Delahunt B, ..., Egevad L, Eklund M
Eur Urol Focus 7 (4) 687-691 [2021-07-00; online 2021-08-12]
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Analogue tuning of particle focusing in elasto-inertial flow
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A single-cell type transcriptomics map of human tissues.
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Adil Mardinoglu SciLifeLab Fellow
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Developing an Electrochemical Biosensor for the Detection of Hemagglutinin Protein of Influenza A Virus Subtype H1N1 in Artificial Saliva
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DNA Blocks the Lethal Effect of Human Beta-Defensin 2 Against Neisseria meningitidis.
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Front Microbiol 12 (-) 697232 [2021-06-30; online 2021-06-30]
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A Multi-omics Study of Circulating Phospholipid Markers of Blood Pressure
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The Lon protease temporally restricts polar cell differentiation events during the Caulobacter cell cycle
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DeepMP: a deep learning tool to detect DNA base modifications on Nanopore sequencing data
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Data-Driven Ensemble Docking to Map Molecular Interactions of Steroid Analogs with Hepatic Organic Anion Transporting Polypeptides.
Tuerkova A, Ungvári O, Laczkó-Rigó R, ..., Özvegy-Laczka C, Zdrazil B
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Analysis at single-cell resolution identifies a stable mammalian tRNA-mRNA interface and increased translation efficiency in neurons
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Cisplatin inhibits frequency and suppressive activity of monocytic myeloid-derived suppressor cells in cancer patients.
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Oncoimmunology 10 (1) 1935557 [2021-06-27; online 2021-06-27]
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Pesticide-induced multigenerational effects on amphibian reproduction and metabolism.
Karlsson O, Svanholm S, Eriksson A, ..., Jernerén F, Berg C
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Oskar Karlsson SciLifeLab Fellow
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Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus.
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Mol Ther Oncolytics 21 (-) 356-366 [2021-06-25; online 2021-05-05]
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Chemical mapping exposes the importance of active site interactions in governing the temperature dependence of enzyme turnover
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The human nucleoporin Tpr protects cells from RNA-mediated replication stress.
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Engineered human induced pluripotent cells enable genetic code expansion in brain organoids
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An Open-Source Modular Framework for Automated Pipetting and Imaging Applications
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COVseq is a cost-effective workflow for mass-scale SARS-CoV-2 genomic surveillance.
Simonetti M, Zhang N, Harbers L, ..., Ghisetti V, Crosetto N
Nat Commun 12 (1) 3903 [2021-06-23; online 2021-06-23]
Magda Bienko SciLifeLab Fellow
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Accelerated regression-based summary statistics for discrete stochastic systems via approximate simulators.
Jiang RM, Wrede F, Singh P, Hellander A, Petzold LR
BMC Bioinformatics 22 (1) 339 [2021-06-23; online 2021-06-23]
Prashant Singh SciLifeLab Fellow
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Probing interplays between human XBP1u translational arrest peptide and 80S ribosome
Palma FD, Decherchi S, Pardo-Avila F, ..., Heijne Gv, Cavalli A
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Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade.
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Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin α5.
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A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells
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The contribution of rare whole genome sequencing variants to plasma protein levels and to the missing heritability
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The Influence of Drug–Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles
Hempel NJ, Merkl P, Knopp MM, ..., Sotiriou GA, Löbmann K
Pharmaceutics 13 (6) 917 [2021-06-21; online 2021-06-21]
Alexandra Teleki SciLifeLab Fellow
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Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms
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Digital droplet microfluidic integrated Lab-in-a-fiber detection of SARS-CoV2 viral RNA
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CLEO®/Europe-EQEC 2021, One Page Summary Template Volumetric RESOLFT fluorescence nanoscopy
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App-based COVID-19 syndromic surveillance and prediction of hospital admissions: The COVID Symptom Study Sweden
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Flexible seed size enables ultra-fast and accurate read alignment
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Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and obesity
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Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome
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Stable IgG-antibody levels in patients with mild SARS-CoV-2 infection
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Application of high-throughput 5'P sequencing for the study of co-translational mRNA decay.
Zhang Y, Pelechano V
STAR Protoc 2 (2) 100447 [2021-06-18; online 2021-03-31]
SciLifeLab Fellow Vicent Pelechano
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A combination of genetic and phenotypic characterization of spring- and autumn-spawning herring suggests gene flow between populations
Berg F, Østgaard HD, Slotte A, Andersson L, Folkvord A
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Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.
Roxhed N, Bendes A, Dale M, ..., Fredolini C, Schwenk JM
Nat Commun 12 (1) 3695 [2021-06-17; online 2021-06-17]
SciLifeLab Fellow Simon Elsässer
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flexiMAP: a regression-based method for discovering differential alternative polyadenylation events in standard RNA-seq data.
Szkop KJ, Moss DS, Nobeli I
Bioinformatics 37 (10) 1461-1464 [2021-06-16; online 2020-10-15]
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Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?
Rodriguez-Calvo T, Christoffersson G, Bender C, ..., Kent SC, James EA
Front Immunol 12 (-) 683091 [2021-06-16; online 2021-06-16]
Gustaf Christoffersson SciLifeLab Fellow
PubMed DOI Crossref
Early Changes in Crayfish Hemocyte Proteins after Injection with a β-1,3-glucan, Compared to Saline Injected and Naive Animals.
Ekblom C, Söderhäll K, Söderhäll I
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Cooperativity of α-Synuclein Binding to Lipid Membranes.
Makasewicz K, Wennmalm S, Stenqvist B, ..., Linse S, Sparr E
ACS Chem Neurosci 12 (12) 2099-2109 [2021-06-16; online 2021-06-02]
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Insights into the Role of the Discontinuous TM7 Helix of Human Ferroportin through the Prism of the Asp325 Residue.
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Flex Printed Circuit Board Implemented Graphene-Based DNA Sensor for Detection of SARS-CoV-2.
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IEEE Sens J 21 (12) 13060-13067 [2021-06-15; online 2021-03-24]
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Comparison of vaginal self-sampling and cervical sampling by medical professionals for the detection of HPV and CIN2+: A randomized study.
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Cell scientist to watch – Alexey Amunts
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Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology.
Shakur R, Ochoa JP, Robinson AJ, ..., Vihinen M, Monserrat L
NPJ Genom Med 6 (1) 47 [2021-06-14; online 2021-06-14]
Abhishek Niroula DDLS Fellow
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Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling.
Wendt M, Bellavita R, Gerber A, ..., Hennig S, Grossmann TN
Angew. Chem. Int. Ed. Engl. 60 (25) 13937-13944 [2021-06-14; online 2021-05-05]
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Newly synthesized RNA Sequencing Characterizes Transcription Dynamics in Three Pluripotent States
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Leveraging breeding programs and genomic data in Norway spruce (Picea abies L. Karst) for GWAS analysis.
Chen ZQ, Zan Y, Milesi P, ..., Lascoux M, Wu HX
Genome Biol. 22 (1) 179 [2021-06-13; online 2021-06-13]
Pascal Milesi SciLifeLab Fellow
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Affinity Proteomics Assays for Cardiovascular and Atherosclerotic Disease Biomarkers.
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Author response: NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1
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A Blueprint for High Affinity SARS-CoV-2 Mpro Inhibitors from Activity-Based Compound Library Screening Guided by Analysis of Protein Dynamics.
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Systems analysis reveals ageing-related perturbations in retinoids and sex hormones in Alzheimer’s and Parkinson’s diseases
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SignalP 6.0 achieves signal peptide prediction across all types using protein language models
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Learning the Regulatory Code of Gene Expression.
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A porcine brain-wide RNA editing landscape.
Huang J, Lin L, Dong Z, ..., Bolund L, Luo Y
Commun Biol 4 (1) 717 [2021-06-10; online 2021-06-10]
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Generation of ENSEMBL-based proteogenomics databases boosts the identification of non-canonical peptides
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A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines
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New Perspectives on the Evolution of Within-Individual Genome Variation and Germline/Soma Distinction.
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Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet
Hempel NJ, Merkl P, Asad S, ..., Sotiriou GA, Löbmann K
Mol. Pharmaceutics 18 (6) 2254-2262 [2021-06-07; online 2021-05-05]
Alexandra Teleki SciLifeLab Fellow
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SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
Sancho-Shimizu V, Brodin P, Cobat A, ..., Casanova JL, Zhang SY
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Limits and potential of combined folding and docking using PconsDock
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Spatial cell type mapping of the oligodendrocyte lineage in the mouse juvenile and adult CNS with in situ sequencing
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STED super-resolution imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes
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Interpretable machine learning identifies paediatric Systemic Lupus Erythematosus subtypes based on gene expression data
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Rapid and Sensitive Detection of SARS-CoV-2 Infection Using Quantitative Peptide Enrichment LC-MS Analysis
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The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function.
Oftedal BE, Maio S, Handel AE, ..., Maizels RM, Holländer GA
Commun Biol 4 (1) 681 [2021-06-03; online 2021-06-03]
Erdinc Sezgin SciLifeLab Fellow
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Interpretable machine learning identifies paediatric Systemic Lupus Erythematosus subtypes based on gene expression data
Younes S, Annett A, Stoll P, ..., Meadows J, Komorowski J
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Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network.
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Nat Commun 12 (1) 3297 [2021-06-02; online 2021-06-02]
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USP7 limits CDK1 activity throughout the cell cycle.
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Imaging of the Glucagon Receptor in Subjects with Type 2 Diabetes.
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine 62 (6) 833-838 [2021-06-01; online 2020-10-23]
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EMBR-07. MYC BUT NOT MYCN GENERATES AGGRESSIVE GROUP 3 MEDULLOBLASTOMA BY ARF PATHWAY SUPPRESSION
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Neuro-oncology 23 (Supplement_1) i7-i7 [2021-06-01; online 2021-06-01]
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Unboxing mutations: Connecting mutation types with evolutionary consequences.
Berdan EL, Blanckaert A, Slotte T, ..., Westram AM, Fragata I
Mol. Ecol. 30 (12) 2710-2723 [2021-06-00; online 2021-05-19]
SciLifeLab Fellow Tanja Slotte
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Towards policies that capture the expected value of biomolecular diversity for drug discovery, human health, and well-being.
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Biol Futur 72 (2) 119-125 [2021-06-00; online 2020-09-07]
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Nat Cancer 2 (6) 581-583 [2021-06-00; online 2022-02-06]
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POS0392 PRESENCE OF FOUR SERUM AUTOANTIBODIES ASSOCIATES WITH THE ACPA STATUS IN EARLY RHEUMATOID ARTHRITIS
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Ann Rheum Dis 80 (-) 425-426 [2021-06-00; online 2021-06-00]
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POS0008 IDENTIFICATION AND CHARACTERIZATION OF HISRS+ CD4+ T CELLS PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES
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Ann Rheum Dis 80 (-) 206 [2021-06-00; online 2021-06-00]
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More Than Just Letters and Chemistry: Genomics Goes Mechanics.
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Trends Biochem. Sci. 46 (6) 431-432 [2021-06-00; online 2021-04-12]
SciLifeLab Fellow Sebastian Deindl
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Lynch syndrome and Muir-Torre phenotype associated with a recurrent variant in the 3'UTR of the MSH6 gene.
Cini G, Carnevali I, Sahnane N, ..., Viel A, Tibiletti MG
Cancer Genet 254-255 (-) 1-10 [2021-06-00; online 2021-01-19]
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Inhibition of RPS6K reveals context-dependent Akt activity in luminal breast cancer cells.
Erdem C, Lee AV, Taylor DL, Lezon TR
PLoS Comput Biol 17 (6) e1009125 [2021-06-00; online 2021-06-30]
Cemal Erdem DDLS Fellow
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Human origins in Southern African palaeo-wetlands? Strong claims from weak evidence
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Journal of Archaeological Science 130 (-) 105374 [2021-06-00; online 2021-06-00]
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From Prehistory to Precision Medicine: Are Genetic Risk Scores Our Next Step?
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Following spatial Aβ aggregation dynamics in evolving Alzheimer's disease pathology by imaging stable isotope labeling kinetics.
Michno W, Stringer KM, Enzlein T, ..., Edwards FA, Hanrieder J
Sci Adv 7 (25) - [2021-06-00; online 2021-06-16]
SciLifeLab Fellow Wojciech Michno
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Extracellular Vesicle Capture by AnTibody of CHoice and Enzymatic Release (EV-CATCHER): A customizable purification assay designed for small-RNA biomarker identification and evaluation of circulating small-EVs.
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Robert A, Peona V, Ottenburghs J
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Correction to: Towards policies that capture the expected value of biomolecular diversity for drug discovery, human health, and well-being.
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Circle-to-circle amplification coupled with microfluidic affinity chromatography enrichment for in vitro molecular diagnostics of Zika fever and analysis of anti-flaviviral drug efficacy
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Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides.
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Acta Physiol 232 (2) e13655 [2021-06-00; online 2021-05-06]
Gustaf Christoffersson SciLifeLab Fellow
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A microfluidics-based method for culturing osteoblasts on biomimetic hydroxyapatite.
Atif AR, Pujari-Palmer M, Tenje M, Mestres G
Acta Biomater 127 (-) 327-337 [2021-06-00; online 2021-03-27]
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Distinct microbial community along the chronic oil pollution continuum of the Persian Gulf converge with oil spill accidents.
Rezaei Somee M, Dastgheib SMM, Shavandi M, ..., Amoozegar MA, Mehrshad M
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Synthetic antigen-presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses
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Revisiting the Role of γδ T Cells in Anti-CMV Immune Response after Transplantation.
Gaballa A, Alagrafi F, Uhlin M, Stikvoort A
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Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source.
Douangamath A, Powell A, Fearon D, ..., Gorrie-Stone T, von Delft F
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DDLS Fellow Nicholas Pearce
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Using TIF-Seq2 to investigate association between 5´ and 3´mRNA ends.
Li B, Marques S, Wang J, Pelechano V
Meth. Enzymol. 655 (-) 85-118 [2021-05-28; online 2021-05-28]
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The accelerated weight histogram method for alchemical free energy calculations.
Lundborg M, Lidmar J, Hess B
J Chem Phys 154 (20) 204103 [2021-05-28; online 2021-07-10]
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Perivascular Macrophages Regulate Blood Flow Following Tissue Damage.
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Multi-Parametric Field Experiment Links Explosive Activity and Persistent Degassing at Stromboli
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Integration of the Microbiome, Metabolome and Transcriptomics Data Identified Novel Metabolic Pathway Regulation in Colorectal Cancer.
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FunCoup 5: Functional Association Networks in All Domains of Life, Supporting Directed Links and Tissue-Specificity.
Persson E, Castresana-Aguirre M, Buzzao D, Guala D, Sonnhammer ELL
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Editorial: Application of Systems Biology in Molecular Characterization and Diagnosis of Cancer.
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Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor.
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3D genomics across the tree of life reveals condensin II as a determinant of architecture type.
Hoencamp C, Dudchenko O, Elbatsh AMO, ..., Lieberman Aiden E, Rowland BD
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Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers.
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Molecular programming in utero modulates hepatic lipid metabolism and adult metabolic risk in obese mother offspring in a sex-specific manner
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Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5
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COVseq is a cost-effective workflow for mass-scale SARS-CoV-2 genomic surveillance
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Author response: Single-cell analysis of mosquito hemocytes identifies signatures of immune cell subtypes and cell differentiation
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Phagocytosis and Efferocytosis by Resident Macrophages in the Mouse Pancreas.
Parv K, Westerlund N, Merchant K, ..., Lindsay RS, Christoffersson G
Front Endocrinol (Lausanne) 12 (-) 606175 [2021-05-25; online 2021-05-25]
Gustaf Christoffersson SciLifeLab Fellow
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Integrative functional analysis uncovers metabolic differences between Candida species
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Genomic basis of parallel adaptation varies with divergence in Arabidopsis and its relatives.
Bohutínská M, Vlček J, Yair S, ..., Slotte T, Kolář F
Proc. Natl. Acad. Sci. U.S.A. 118 (21) - [2021-05-25; online 2021-05-19]
SciLifeLab Fellow Tanja Slotte
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A combined approach for single-cell mRNA and intracellular protein expression analysis.
Reimegård J, Tarbier M, Danielsson M, ..., Friedländer MR, Gallant CJ
Commun Biol 4 (1) 624 [2021-05-25; online 2021-05-25]
DDLS Fellow Marc Friedländer Marcel Tarbier SciLifeLab Fellow
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Digging into bivalve miRNAomes: between conservation and innovation.
Rosani U, Bortoletto E, Bai CM, ..., Venier P, Fromm B
Philos. Trans. R. Soc. Lond., B, Biol. Sci. 376 (1825) 20200165 [2021-05-24; online 2021-04-05]
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Multi-omics analysis reveals the impact of microbiota on host metabolism in hepatic steatosis
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Combined Metabolic Activators Reduces Liver Fat in Nonalcoholic Fatty Liver Disease Patients
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Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer
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What Is Abnormal in Normal Karyotype Acute Myeloid Leukemia in Children? Analysis of the Mutational Landscape and Prognosis of the TARGET-AML Cohort.
Herlin MK, Yones SA, Kjeldsen E, Holmfeldt L, Hasle H
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Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice.
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Microbial Community Interactions Are Sensitive to Small Changes in Temperature.
Burman E, Bengtsson-Palme J
Front Microbiol 12 (-) 672910 [2021-05-21; online 2021-05-21]
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Faculty Opinions recommendation of Replication timing maintains the global epigenetic state in human cells.
Elsässer S, Lafranchi L
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DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance.
Zhang J, Terán G, Popa M, ..., Laín S, Darekar S
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Survival analysis of pathway activity as a prognostic determinant in breast cancer
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Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance.
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Mol. Cell 81 (10) 2216-2230.e10 [2021-05-20; online 2021-04-12]
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Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain.
Vallianatou T, Shariatgorji R, Nilsson A, ..., Svenningsson P, Andrén PE
ACS Chem Neurosci 12 (10) 1811-1823 [2021-05-19; online 2021-05-03]
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The evolution and changing ecology of the African hominid oral microbiome.
Fellows Yates JA, Velsko IM, Aron F, ..., Herbig A, Warinner C
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The Effect of Chemical Structure of OEG Ligand Shells with Quaternary Ammonium Moiety on the Colloidal Stabilization, Cellular Uptake and Photothermal Stability of Gold Nanorods.
Salajkova S, Havel F, Sramek M, ..., Zarska M, Hodny Z
Int J Nanomedicine 16 (-) 3407-3427 [2021-05-18; online 2021-05-18]
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Reply to Nagle et al.: The universal stiffening effects of cholesterol on lipid membranes.
Ashkar R, Doktorova M, Heberle FA, ..., Khelashvili G, Brown MF
Proc. Natl. Acad. Sci. U.S.A. 118 (20) - [2021-05-18; online 2021-05-07]
DDLS Fellow Milka Doktorova
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The human exposome and health in the Anthropocene.
Karlsson O, Rocklöv J, Lehoux AP, ..., Blunt MJ, Birnbaum LS
Int J Epidemiol 50 (2) 378-389 [2021-05-17; online 2020-12-23]
Oskar Karlsson SciLifeLab Fellow
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MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.
Kaiser K, Jang A, Kompanikova P, ..., Lehtinen MK, Bryja V
Development 148 (10) - [2021-05-15; online 2021-05-25]
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Phylogenomic Insights into the Origin of Primary Plastids.
Irisarri I, Strassert JFH, Burki F
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Fabien Burki SciLifeLab Fellow
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Comprehensive dataset of shotgun metagenomes from oxygen stratified freshwater lakes and ponds.
Buck M, Garcia SL, Fernandez L, ..., Bertilsson S, Peura S
Sci Data 8 (1) 131 [2021-05-14; online 2021-05-14]
Sarahi Garcia SciLifeLab Fellow
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Using patients' own knowledge of early sensations and symptoms to develop an interactive, individualized e-questionnaire to facilitate early diagnosis of lung cancer.
Levitsky A, Bernhardson BM, Henoch I, ..., Tishelman C, Eriksson LE
BMC Cancer 21 (1) 544 [2021-05-13; online 2021-05-13]
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Molecular Characterization of Multidrug-Resistant Yersinia enterocolitica From Foodborne Outbreaks in Sweden.
Karlsson PA, Tano E, Jernberg C, ..., Järhult JD, Wang H
Front Microbiol 12 (-) 664665 [2021-05-13; online 2021-05-13]
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Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans.
Bosley JR, Björnson E, Zhang C, ..., Borén J, Mardinoglu A
Front. Pharmacol. 12 (-) 643179 [2021-05-13; online 2021-05-13]
Adil Mardinoglu SciLifeLab Fellow
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Correcting for Naturally Occurring Mass Isotopologue Abundances in Stable-Isotope Tracing Experiments with PolyMID.
Jeong H, Yu Y, Johansson HJ, ..., Lehtiö J, Vacanti NM
Metabolites 11 (5) - [2021-05-12; online 2021-05-12]
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Comparative Genomics Analysis of Keratin-Degrading Chryseobacterium Species Reveals Their Keratinolytic Potential for Secondary Metabolite Production
Kang D, Shoaie S, Jacquiod S, Sørensen SJ, Ledesma-Amaro R
Microorganisms 9 (5) 1042 [2021-05-12; online 2021-05-12]
Saeed Shoaie SciLifeLab Fellow
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Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction.
Arif M, Klevstig M, Benfeitas R, ..., Mardinoglu A, Boren J
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Freshwater Chlorobia Exhibit Metabolic Specialization among Cosmopolitan and Endemic Populations.
Garcia SL, Mehrshad M, Buck M, ..., Greening C, Peura S
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Antibody Responses After a Single Dose of ChAdOx1 nCoV-19 Vaccine in Healthcare Workers Previously Infected with SARS-CoV-2
Havervall S, Marking U, Greilert-Norin N, ..., Nilsson P, Thålin C
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Accurate absolute free energies for ligand-protein binding based on non-equilibrium approaches.
Gapsys V, Yildirim A, Aldeghi M, ..., van der Spoel D, de Groot BL
Commun Chem 4 (1) 61 [2021-05-11; online 2021-05-11]
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Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes and normal tissues
Diamanti K, Cavalli M, Pereira MJ, ..., Eriksson JW, Wadelius C
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High-resolution targeted bisulfite sequencing reveals blood cell type-specific DNA methylation patterns in IL13 and ORMDL3.
Söderhäll C, Reinius LE, Salmenperä P, ..., Myllykangas S, Kere J
Clin Epigenetics 13 (1) 106 [2021-05-10; online 2021-05-10]
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Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer's disease.
Zhang X, O'Callaghan P, Li H, ..., Lindahl U, Li JP
Acta Neuropathol Commun 9 (1) 84 [2021-05-10; online 2021-05-10]
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The Genomic Architecture and Evolutionary Fates of Supergenes.
Gutiérrez-Valencia J, Hughes PW, Berdan EL, Slotte T
Genome Biol Evol 13 (5) - [2021-05-07; online 2021-03-20]
SciLifeLab Fellow Tanja Slotte
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The ribosome modulates folding inside the ribosomal exit tunnel.
Wruck F, Tian P, Kudva R, ..., Tans SJ, Katranidis A
Commun Biol 4 (1) 523 [2021-05-05; online 2021-05-05]
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Environmental Enrichment Induces Epigenomic and Genome Organization Changes Relevant for Cognition.
Espeso-Gil S, Holik AZ, Bonnin S, ..., Hor CN, Ossowski S
Front Mol Neurosci 14 (-) 664912 [2021-05-05; online 2021-05-05]
Marc Friedländer SciLifeLab Fellow
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Correction to: A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence.
Komseli ES, Pateras IS, Krejsgaard T, ..., Bartek J, Gorgoulis VG
BMC Genomics 22 (1) 327 [2021-05-05; online 2021-05-05]
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The Chaperonin GroESL Facilitates Caulobacter crescentus Cell Division by Supporting the Functions of the Z-Ring Regulators FtsA and FzlA.
Schroeder K, Heinrich K, Neuwirth I, Jonas K
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Accuratede novoidentification of biosynthetic gene clusters with GECCO
Carroll LM, Larralde M, Fleck JS, ..., Cappio E, Zeller G
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DDLS Fellow Laura Carroll
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A microscopy-compatible temperature regulation system for single-cell phenotype analysis - demonstrated by thermoresponse mapping of microalgae.
Andersson M, Johansson S, Bergman H, ..., Behrendt L, Tenje M
Lab Chip 21 (9) 1694-1705 [2021-05-04; online 2021-05-06]
Lars Behrendt SciLifeLab Fellow
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A MicroRNA Gene Panel Predicts the Vaginal Microbiota Composition.
Cheng L, Kaźmierczak D, Norenhag J, ..., Hydbring P, Du J
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Synthetic Biology in Cyanobacteria and Applications for Biotechnology
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Next generation plasma proteome profiling to monitor health and disease.
Zhong W, Edfors F, Gummesson A, ..., Fagerberg L, Uhlén M
Nat Commun 12 (1) 2493 [2021-05-03; online 2021-05-03]
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Keeping up with the Bacillus cereus group: taxonomy through the genomics era and beyond.
Carroll LM, Cheng RA, Wiedmann M, Kovac J
Crit Rev Food Sci Nutr 62 (28) 7677-7702 [2021-05-03; online 2021-05-03]
DDLS Fellow Laura Carroll
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Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.
Ghovanloo MR, Choudhury K, Bandaru TS, ..., Goodchild SJ, Ruben PC
J. Gen. Physiol. 153 (5) - [2021-05-03; online 2021-04-10]
Lucie Delemotte SciLifeLab Fellow
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Inflammation and Apolipoproteins Are Potential Biomarkers for Stratification of Cutaneous Melanoma Patients for Immunotherapy and Targeted Therapy.
Karlsson MJ, Costa Svedman F, Tebani A, ..., Egyhazi Brage S, Maddalo G
Cancer Res. 81 (9) 2545-2555 [2021-05-01; online 2021-02-11]
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Volumetric live cell imaging with three-dimensional parallelized RESOLFT microscopy.
Bodén A, Pennacchietti F, Coceano G, ..., Ratz M, Testa I
Nat. Biotechnol. 39 (5) 609-618 [2021-05-00; online 2021-01-11]
Ilaria Testa SciLifeLab Fellow
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The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling.
Papoutsoglou P, Rodrigues-Junior DM, Morén A, ..., Heldin CH, Moustakas A
Oncogene 40 (21) 3748-3765 [2021-05-00; online 2021-05-04]
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The C-type lectin CD93 controls endothelial cell migration via activation of the Rho family of small GTPases.
Barbera S, Lugano R, Pedalina A, ..., Galvagni F, Orlandini M
Matrix Biol. 99 (-) 1-17 [2021-05-00; online 2021-05-29]
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Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation.
Moreno-Ruiz P, Corvigno S, Te Grootenhuis NC, ..., Micke P, Östman A
Lung Cancer 155 (-) 10-19 [2021-05-00; online 2021-02-25]
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Strategies for Constructing and Operating DNA Origami Linear Actuators.
Benson E, Carrascosa Marzo R, Bath J, Turberfield AJ
Small 17 (20) e2007704 [2021-05-00; online 2021-05-04]
Erik Benson SciLifeLab Fellow
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Quick Systemic Lupus Activity Questionnaire (Q-SLAQ): a simplified version of SLAQ for patient-reported disease activity.
Svenungsson E, Gunnarsson I, Illescas-Bäckelin V, ..., Sjöwall C, Pettersson S
Lupus Sci Med 8 (1) - [2021-05-00; online 2021-05-12]
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Pancreatic cancer cachexia: three dimensions of a complex syndrome.
Kordes M, Larsson L, Engstrand L, Löhr JM
Br. J. Cancer 124 (10) 1623-1636 [2021-05-00; online 2021-03-19]
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Molecular Reorganization during the Formation of the Human Skin Barrier Studied In Situ.
Narangifard A, Wennberg CL, den Hollander L, ..., Daneholt B, Norlén L
J. Invest. Dermatol. 141 (5) 1243-1253.e6 [2021-05-00; online 2020-10-22]
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Involvement of Autophagy in Levodopa-Induced Dyskinesia.
Feyder M, Plewnia C, Lieberman OJ, ..., Borgkvist A, Fisone G
Mov Disord 36 (5) 1137-1146 [2021-05-00; online 2021-01-18]
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IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells.
Van der Meer JMR, Maas RJA, Guldevall K, ..., Hobo W, Dolstra H
Cancer Immunol. Immunother. 70 (5) 1305-1321 [2021-05-00; online 2020-11-03]
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High-throughput 5′P sequencing enables the study of degradation-associated ribosome stalls
Zhang Y, Pelechano V
Cell Rep Methods 1 (1) 100001 [2021-05-00; online 2021-05-00]
SciLifeLab Fellow Vicent Pelechano
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Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions.
Kim JH, Megquier K, Thomas R, ..., Lindblad-Toh K, Modiano JF
Mol. Cancer Res. 19 (5) 847-861 [2021-05-00; online 2021-03-01]
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Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice.
Fattinger SA, Geiser P, Samperio Ventayol P, ..., Hardt WD, Sellin ME
Mucosal Immunol 14 (3) 615-629 [2021-05-00; online 2021-03-17]
Mikael Sellin SciLifeLab Fellow
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Distinct whole-blood transcriptome profile of children with metabolic healthy overweight/obesity compared to metabolic unhealthy overweight/obesity.
Plaza-Florido A, Altmäe S, Esteban FJ, ..., Radom-Aizik S, Ortega FB
Pediatr. Res. 89 (7) 1687-1694 [2021-05-00; online 2020-11-23]
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DLG4-related synaptopathy: a new rare brain disorder.
Rodríguez-Palmero A, Boerrigter MM, Gómez-Andrés D, ..., Pujol A, Tümer Z
Genet Med 23 (5) 888-899 [2021-05-00; online 2021-02-17]
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The Protein Quality Control Network in Caulobacter crescentus.
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How Does Liquid-Liquid Phase Separation in Model Membranes Reflect Cell Membrane Heterogeneity?
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Advances in Predictions of Oral Bioavailability of Candidate Drugs in Man with New Machine Learning Methodology.
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NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487.
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Clustering of Major Histocompatibility Complex-Class I Molecules in Healthy and Cancer Colon Cells Revealed from Their Nanomechanical Properties.
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The deep population history in Africa.
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Ptychographic wavefront characterization for single-particle imaging at x-ray lasers
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GraphQA: protein model quality assessment using graph convolutional networks.
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Scalable machine learning-assisted model exploration and inference using Sciope.
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Bioinformatics 37 (2) 279-281 [2021-04-19; online 2020-07-25]
Prashant Singh SciLifeLab Fellow
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High throughput viscoelastic particle focusing and separation in spiral microchannels.
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Germline variants at SOHLH2 influence multiple myeloma risk.
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PET Imaging of GPR44 by Antagonist [11C]MK-7246 in Pigs.
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Olof Eriksson SciLifeLab Fellow
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A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1.
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Optofluidic Fiber Component for Separation and counting of Micron-Sized Particles
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In-Silico Study of Immune System Associated Genes in Case of Type-2 Diabetes With Insulin Action and Resistance, and/or Obesity.
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DNA methylation in cord blood in association with prenatal depressive symptoms.
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Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering
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Genetic substructure and complex demographic history of South African Bantu speakers.
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Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes.
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The genome of Draba nivalis shows signatures of adaptation to the extreme environmental stresses of the Arctic.
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The evolving landscape of biomarker testing for non-small cell lung cancer in Europe.
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The International Association for the Study of Lung Cancer Global Survey on Programmed Death-Ligand 1 Testing for NSCLC.
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STRN-ALK rearranged pediatric malignant peritoneal mesothelioma - Functional testing of 527 cancer drugs in patient-derived cancer cells.
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Predicting complex spikes in striatal projection neurons of the direct pathway following neuromodulation by acetylcholine and dopamine.
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Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.
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PD-L1 and IDO1 are potential targets for treatment in patients with primary diffuse large B-cell lymphoma of the CNS.
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Nasal upregulation of CST1 in dog-sensitised children with severe allergic airway disease.
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Longitudinal Assessment of 11C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes.
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Diabetes 70 (4) 966-975 [2021-04-00; online 2021-01-21]
Olof Eriksson SciLifeLab Fellow
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Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens.
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Exploring the GLP-1-GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography.
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Effects of prenatal exposure and co-exposure to metallic or metalloid elements on early infant neurodevelopmental outcomes in areas with small-scale gold mining activities in Northern Tanzania.
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Drug Occupancy Assessment at the Glucose-Dependent Insulinotropic Polypeptide Receptor by Positron Emission Tomography.
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Olof Eriksson SciLifeLab Fellow
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Differential expression of microRNAs and tRNA fragments mediate the adaptation of the liver fluke Fasciola gigantica to its intermediate snail and definitive mammalian hosts.
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Development and Validation of a Risk Prediction Model for Esophageal Squamous Cell Carcinoma Using Cohort Studies.
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Colorimetric isothermal nucleic acid detection of SARS-CoV-2 with dye combination.
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Autoantibody profiles are associated with specific clinical features in psychotic disorders
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Apoptotic effect of berberine via Bcl-2, ROR1, and mir-21 in patients with B-chronic lymphocytic leukemia.
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Altered perivascular fibroblast activity precedes ALS disease onset.
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Accurate detection of Newcastle disease virus using proximity-dependent DNA aptamer ligation assays.
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Accurate contact-based modelling of repeat proteins predicts the structure of new repeats protein families.
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AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.
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The GenTree Platform: growth traits and tree-level environmental data in 12 European forest tree species.
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Serum Proteomic Profiling in Rheumatoid Arthritis by Antibody Suspension Bead Arrays.
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In Situ Transforming RNA Nanovaccines from Polyethylenimine Functionalized Graphene Oxide Hydrogel for Durable Cancer Immunotherapy.
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Systematic Assessment of Safety Threshold for Donor Age in Cadaveric Liver Transplantation.
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STATegra: Multi-Omics Data Integration - A Conceptual Scheme With a Bioinformatics Pipeline.
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HIV-Exposed Seronegative Sex Workers Express Low T-Cell Activation and an Intact Ectocervical Tissue Microenvironment.
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Comparative fungal community analyses using metatranscriptomics and ITS-amplicon sequencing from Norway spruce
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Plasma Proteins and Cancer.
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Electrochemical Genosensing of E. coli Based on Padlock Probes and Rolling Circle Amplification.
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Endothelial Cell Orientation and Polarity Are Controlled by Shear Stress and VEGF Through Distinct Signaling Pathways.
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Ulipristal Acetate for Treatment of Premenstrual Dysphoric Disorder: A Proof-of-Concept Randomized Controlled Trial.
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Assessment of Cesarean Delivery and Neurodevelopmental and Psychiatric Disorders in the Children of a Population-Based Swedish Birth Cohort.
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The GenTree Leaf Collection: Inter‐ and intraspecific leaf variation in seven forest tree species in Europe
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Global Ecol. Biogeogr. 30 (3) 590-597 [2021-03-00; online 2021-01-06]
Pascal Milesi SciLifeLab Fellow
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Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson’s disease
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Cell Reports 34 (9) 108807 [2021-03-00; online 2021-03-00]
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Spage2vec: Unsupervised representation of localized spatial gene expression signatures.
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Revisiting old lessons from classic literature on persistent global pollutants : This article belongs to Ambio's 50th Anniversary Collection. Theme: Environmental contaminants.
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Pycro-Manager: open-source software for customized and reproducible microscope control.
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Plasma Proteomics to Predict Insulin-mediated Glucose Disposal/Uptake
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No evidence for a placental microbiome in human pregnancies at term.
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Localized reconstruction in Scipion expedites the analysis of symmetry mismatches in cryo-EM data.
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Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma.
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Nature 591 (7851) E27 [2021-03-00; online 2021-03-13]
Abhishek Niroula DDLS Fellow
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Assembly of a Rieske non-heme iron oxygenase multicomponent system from Phenylobacterium immobile E DSM 1986 enables pyrazon cis-dihydroxylation in E. coli.
Hunold A, Escobedo-Hinojosa W, Potoudis E, ..., Syrén PO, Hauer B
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Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.
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A unique bipartite Polycomb signature regulates stimulus-response transcription during development.
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A loss-of-function mutation in RORB disrupts saltatorial locomotion in rabbits.
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3D-printing of solid lipid tablets from emulsion gels
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Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis
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Whole Genome and Exome Sequencing Reference Datasets from A Multi-center and Cross-platform Benchmark Study
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Machine learning for cell classification and neighborhood analysis in glioma tissue
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Comprehensive analysis of chemical and biological problems associated with browning agents used in aquatic studies
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Antibiotic Resistance in Shiga Toxigenic Escherichia coli Isolates from Surface Waters and Sediments in a Mixed Use Urban Agricultural Landscape.
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Intra-helical salt bridge contribution to membrane protein insertion
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Interpretable Machine Learning Reveals Dissimilarities Between Subtypes of Autism Spectrum Disorder.
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The Organelle in the Ointment: cryptic mitochondria account for many unknown sequences in cross-species microbiome comparisons
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Interactive biomedical segmentation tool powered by deep learning and ImJoy
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Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing.
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Spatial Regulation of T-Cell Signaling by Programmed Death-Ligand 1 on Wireframe DNA Origami Flat Sheets.
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ACS Nano 15 (2) 3441-3452 [2021-02-23; online 2021-02-08]
Ilaria Testa SciLifeLab Fellow
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High-Definition DIC Imaging Uncovers Transient Stages of Pathogen Infection Cycles on the Surface of Human Adult Stem Cell-Derived Intestinal Epithelium.
van Rijn JM, Eriksson J, Grüttner J, ..., Svärd SG, Sellin ME
MBio 13 (1) e0002222 [2021-02-22; online 2022-02-01]
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Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes.
Johansson H, Søndergaard JN, Jorns C, Kutter C, Ellis ECS
Front Endocrinol (Lausanne) 11 (-) 554922 [2021-02-22; online 2021-02-22]
Claudia Kutter SciLifeLab Fellow
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Mechanism of membrane-tethered mitochondrial protein synthesis.
Itoh Y, Andréll J, Choi A, ..., Battersby BJ, Amunts A
Science (New York, N.Y.) 371 (6531) 846-849 [2021-02-19; online 2021-02-20]
Alexey Amunts SciLifeLab Fellow
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Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma.
Ruiz-Pérez MV, Sainero-Alcolado L, Oliynyk G, ..., Schulze A, Arsenian-Henriksson M
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Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy.
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Ion Binding to a Mammalian Sodium/Proton Exchanger Membrane Protein from Molecular Dynamics Simulations
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Interplay of Nav1.5 Disease-Causing Mutations and Phosphorylation Revealed by Protein Semi-Synthesis and Molecular Dynamics Simulations
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High-throughput proteomics of breast cancer interstitial fluid: identification of tumor subtype-specific serologically relevant biomarkers.
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Balancing Stereochemistry and Goodness-of-Fit for Automated Simulation-Based Refinement into Cryo-EM Maps
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Antibiotics should not be used for back/leg pain.
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Development of Small Molecule NUDT22 Inhibitors for Uses in Cancer
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Colonization and genetic diversification processes of Leishmania infantum in the Americas.
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Targeting MYCN in Molecularly Defined Malignant Brain Tumors.
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Can we put Humpty Dumpty back together again? What does protein quantification mean in bottom-up proteomics?
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Rolling Circle Amplification in Bead-Based Microfluidic Device with Integrated Photodiode for Fluorescence Signal Transduction
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Multicohort Metabolomics Analysis Discloses 9-Decenoylcarnitine to Be Associated With Incident Atrial Fibrillation.
Lind L, Salihovic S, Sundström J, ..., Fall T, Ärnlöv J
J Am Heart Assoc 10 (2) e017579 [2021-01-19; online 2021-01-05]
DOI Crossref
High resolution bacterial separation from blood using elasto-inertial microfluidics
Iyengar SN, Kumar T, Måertensson G, Russom A
- - (-) - [2021-01-19; online 2021-01-19]
PubMed DOI Crossref
Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer's Disease.
Turkez H, Cacciatore I, Marinelli L, ..., Di Stefano A, Mardinoglu A
Biomolecules 11 (1) - [2021-01-19; online 2021-01-19]
PubMed DOI Crossref
Drug synergy scoring using minimal dose response matrices.
Mäkelä P, Zhang SM, Rudd SG
BMC Res Notes 14 (1) 27 [2021-01-19; online 2021-01-19]
PubMed DOI Crossref
Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers.
Li X, Kim W, Arif M, ..., Zhang C, Mardinoglu A
Cancers (Basel) 13 (2) - [2021-01-19; online 2021-01-19]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples.
Alekseenko A, Barrett D, Pareja-Sanchez Y, ..., Yin X, Pelechano V
Sci Rep 11 (1) 1820 [2021-01-19; online 2021-01-19]
SciLifeLab Fellow Simon Elsässer Vicent Pelechano
DOI Crossref
COVseq is a cost-effective workflow for mass-scale SARS-CoV-2 genomic surveillance
Simonetti M, Zhang N, Harbers L, ..., Ghisetti V, Crosetto N
- - (-) - [2021-01-19; online 2021-01-19]
PubMed DOI Crossref
Single-Molecule, Super-Resolution, and Functional Analysis of G Protein-Coupled Receptor Behavior Within the T Cell Immunological Synapse.
Felce JH, Parolini L, Sezgin E, ..., Frater J, Dustin ML
Front Cell Dev Biol 8 (-) 608484 [2021-01-18; online 2021-01-18]
Erdinc Sezgin SciLifeLab Fellow
DOI Crossref
A genomic perspective across Earth’s microbiomes reveals that genome size in Archaea and Bacteria is linked to ecosystem type and trophic strategy
Rodríguez-Gijón A, Nuy JK, Mehrshad M, ..., Woyke T, Garcia SL
- - (-) - [2021-01-18; online 2021-01-18]
PubMed DOI Crossref
Soluble and Exosome-Bound α-Galactosylceramide Mediate Preferential Proliferation of Educated NK Cells with Increased Anti-Tumor Capacity.
Wagner AK, Gehrmann U, Hiltbrunner S, ..., Kärre K, Gabrielsson S
Cancers (Basel) 13 (2) - [2021-01-15; online 2021-01-15]
PubMed DOI Crossref
Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase.
Gamiz-Arco G, Gutierrez-Rus LI, Risso VA, ..., Gaucher EA, Sanchez-Ruiz JM
Nat Commun 12 (1) 380 [2021-01-15; online 2021-01-15]
PubMed DOI Crossref
Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis.
Ozalp O, Cark O, Azbazdar Y, ..., Sezgin E, Ozhan G
Biomolecules 11 (1) - [2021-01-14; online 2021-01-14]
Erdinc Sezgin SciLifeLab Fellow
PubMed DOI Crossref
High-resolution analysis of cell-state transitions in yeast suggests widespread transcriptional tuning by alternative starts.
Chia M, Li C, Marques S, ..., Luscombe NM, van Werven FJ
Genome Biol. 22 (1) 34 [2021-01-14; online 2021-01-14]
DOI Crossref
FOXO1 and FOXO3 cooperatively regulate innate lymphoid cell development
Luu TT, Søndergaard JN, Peña-Pérez L, ..., Månsson R, Kadri N
- - (-) - [2021-01-14; online 2021-01-14]
PubMed DOI Crossref
DNA Methylation Levels in Mononuclear Leukocytes from the Mother and Her Child Are Associated with IgE Sensitization to Allergens in Early Life.
Acevedo N, Scala G, Merid SK, ..., Greco D, Scheynius A
Int J Mol Sci 22 (2) - [2021-01-14; online 2021-01-14]
PubMed DOI Crossref
Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy.
Zhang X, Sjöblom T
Pharmaceuticals (Basel, Switzerland) 14 (1) - [2021-01-13; online 2021-01-13]
DOI Crossref
A phenomics approach for in vitro antiviral drug discovery
Rietdijk J, Tampere M, Pettke A, ..., Puumalainen MR, Carreras-Puigvert J
- - (-) - [2021-01-13; online 2021-01-13]
DOI Crossref
Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the liver
Hildebrandt F, Andersson A, Saarenpää S, ..., Lundeberg J, Ankarklev J
- - (-) - [2021-01-12; online 2021-01-12]
PubMed DOI Crossref
Salmonella enterica Serovar Typhimurium Exploits Cycling through Epithelial Cells To Colonize Human and Murine Enteroids.
Geiser P, Di Martino ML, Samperio Ventayol P, ..., Hellström PM, Sellin ME
MBio 12 (1) - [2021-01-12; online 2021-01-12]
PubMed DOI Crossref
UPLC-ESI-MRM/MS for Absolute Quantification and MS/MS Structural Elucidation of Six Specialized Pyranonaphthoquinone Metabolites From Ventilago harmandiana.
Limjiasahapong S, Kaewnarin K, Jariyasopit N, ..., Reutrakul V, Khoomrung S
Front Plant Sci 11 (-) 602993 [2021-01-11; online 2021-01-11]
PubMed DOI Crossref
A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae.
Rodríguez-Galán O, García-Gómez JJ, Rosado IV, ..., Kressler D, de la Cruz J
Nucleic Acids Res. 49 (1) 206-220 [2021-01-11; online 2020-12-18]
SciLifeLab Fellow Vicent Pelechano
DOI Crossref
Graph-based image decoding for multiplexed in situ RNA detection
Partel G, Wahlby C
- - (-) 3783-3790 [2021-01-10; online 2021-01-10]
PubMed DOI Crossref
Universal and taxon-specific trends in protein sequences as a function of age.
James JE, Willis SM, Nelson PG, ..., Kosinski LJ, Masel J
Elife 10 (-) - [2021-01-08; online 2021-01-08]
DDLS Fellow Jennifer James
PubMed DOI Crossref
The spatial RNA integrity number assay for in situ evaluation of transcriptome quality.
Kvastad L, Carlberg K, Larsson L, ..., Nistér M, Lundeberg J
Commun Biol 4 (1) 57 [2021-01-08; online 2021-01-08]
PubMed DOI Crossref
RNAcentral 2021: secondary structure integration, improved sequence search and new member databases.
RNAcentral Consortium
Nucleic Acids Res. 49 (D1) D212-D220 [2021-01-08; online 2020-10-28]
PubMed DOI Crossref
Pfam: The protein families database in 2021.
Mistry J, Chuguransky S, Williams L, ..., Finn RD, Bateman A
Nucleic Acids Res. 49 (D1) D412-D419 [2021-01-08; online 2020-10-31]
PubMed DOI Crossref
Colistin Dependence in Extensively Drug-Resistant Acinetobacter baumannii Strain Is Associated with ISAjo2 and ISAba13 Insertions and Multiple Cellular Responses.
Chamoun S, Welander J, Martis-Thiele MM, ..., Vikström E, Turkina MV
Int J Mol Sci 22 (2) - [2021-01-08; online 2021-01-08]
PubMed DOI Crossref
Bayesian genome scale modelling identifies thermal determinants of yeast metabolism.
Li G, Hu Y, Luo H, ..., Ji B, Nielsen J
Nat Commun 12 (1) 190 [2021-01-08; online 2021-01-08]
DOI Crossref
Agonistic CD40 antibody therapy induces tertiary lymphoid structures but impairs the response to immune checkpoint blockade in glioma
van Hooren L, Vaccaro A, Ramachandran M, ..., Essand M, Dimberg A
- - (-) - [2021-01-06; online 2021-01-06]
PubMed DOI Crossref
Evolutionarily related small viral fusogens hijack distinct but modular actin nucleation pathways to drive cell-cell fusion.
Chan KMC, Arthur AL, Morstein J, ..., Drubin DG, Fletcher DA
Proc. Natl. Acad. Sci. U.S.A. 118 (1) - [2021-01-05; online 2021-01-15]
DOI Crossref
Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations
Rovšnik U, Zhuang Y, Forsberg BO, ..., Howard RJ, Lindahl E
- - (-) - [2021-01-05; online 2021-01-05]
PubMed DOI Crossref
ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria.
Mühleip A, Kock Flygaard R, Ovciarikova J, ..., Sheiner L, Amunts A
Nat Commun 12 (1) 120 [2021-01-05; online 2021-01-05]
DOI Crossref
SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection
Havervall S, Falk AJ, Klingström J, ..., Nilsson P, Thålin C
- - (-) - [2021-01-04; online 2021-01-04]
PubMed DOI Crossref
Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer.
Paczkowski M, Kretzschmar WW, Markelc B, ..., Byrne HM, Kannan P
Commun Biol 4 (1) 6 [2021-01-04; online 2021-01-04]
PubMed DOI Crossref
Obese mother offspring have hepatic lipidic modulation that contributes to sex-dependent metabolic adaptation later in life.
Savva C, Helguero LA, González-Granillo M, ..., Kutter C, Korach-André M
Commun Biol 4 (1) 14 [2021-01-04; online 2021-01-04]
Claudia Kutter SciLifeLab Fellow
PubMed DOI Crossref
Error correction enables use of Oxford Nanopore technology for reference-free transcriptome analysis.
Sahlin K, Medvedev P
Nat Commun 12 (1) 2 [2021-01-04; online 2021-01-04]
Kristoffer Sahlin SciLifeLab Fellow
PubMed DOI Crossref
CAFE: a software suite for analysis of paired-sample transposon insertion sequencing data.
Abramova A, Osińska A, Kunche H, Burman E, Bengtsson-Palme J
Bioinformatics - (-) - [2021-01-04; online 2021-01-04]
DDLS Fellow Johan Bengtsson-Palme
PubMed DOI Crossref
Nontarget analysis reveals gut microbiome-dependent differences in the fecal PCB metabolite profiles of germ-free and conventional mice.
Li X, Liu Y, Martin JW, Cui JY, Lehmler HJ
Environ Pollut 268 (Pt A) 115726 [2021-01-01; online 2020-09-25]
PubMed DOI Crossref
Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multi-center study.
Leeksma AC, Baliakas P, Moysiadis T, ..., Mellink C, Kater AP
Haematologica 106 (1) 87-97 [2021-01-01; online 2021-01-01]
PubMed DOI Crossref
Diversity of electron transport chains in anaerobic protists.
Gawryluk RMR, Stairs CW
Biochim Biophys Acta Bioenerg 1862 (1) 148334 [2021-01-01; online 2020-11-04]
PubMed DOI Crossref
Actin networks regulate the cell membrane permeability during electroporation.
Muralidharan A, Rems L, Kreutzer MT, Boukany PE
Biochim Biophys Acta Biomembr 1863 (1) 183468 [2021-01-01; online 2020-08-31]
PubMed DOI Crossref
Vibrio areninigrae as a pathogenic bacterium in a crustacean.
Hernández-Pérez A, Söderhäll K, Sirikharin R, Jiravanichpaisal P, Söderhäll I
J Invertebr Pathol 178 (-) 107517 [2021-01-00; online 2020-12-24]
PubMed DOI Crossref
Ultrasound image analysis using deep neural networks for discriminating between benign and malignant ovarian tumors: comparison with expert subjective assessment.
Christiansen F, Epstein EL, Smedberg E, ..., Smith K, Epstein E
Ultrasound Obstet Gynecol 57 (1) 155-163 [2021-01-00; online 2020-11-04]
PubMed DOI Crossref
The effect of Toll-like receptor stimulation on the motility of regulatory T cells.
Chodaczek G, Pagni PP, Christoffersson G, ..., Wegrzyn AS, von Herrath M
J. Autoimmun. 116 (-) 102563 [2021-01-00; online 2020-11-12]
Gustaf Christoffersson SciLifeLab Fellow
PubMed DOI Crossref
TSLP as druggable target - a silver-lining for atopic diseases?
Adhikary PP, Tan Z, Page BDG, Hedtrich S
Pharmacol Ther 217 (-) 107648 [2021-01-00; online 2020-08-03]
PubMed DOI Crossref
Systems biology based drug repositioning for development of cancer therapy.
Turanli B, Altay O, Borén J, ..., Arga KY, Mardinoglu A
Semin. Cancer Biol. 68 (-) 47-58 [2021-01-00; online 2019-09-27]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Surgery of metastatic melanoma after systemic therapy - the SUMMIST trial: study protocol for a randomized controlled trial.
Holmberg CJ, Katsarelias D, Jespersen H, ..., Ny L, Olofsson Bagge R
Acta Oncol 60 (1) 52-55 [2021-01-00; online 2020-11-30]
PubMed DOI Crossref
Spatially resolved transcriptomics adds a new dimension to genomics.
Larsson L, Frisén J, Lundeberg J
Nat. Methods 18 (1) 15-18 [2021-01-00; online 2021-01-08]
PubMed DOI Crossref
Serious Transport Accidents in Tourette Syndrome or Chronic Tic Disorder.
Mataix-Cols D, Brander G, Chang Z, ..., Sidorchuk A, Fernández de la Cruz L
Mov Disord 36 (1) 188-195 [2021-01-00; online 2020-09-24]
DOI Crossref
Radionuclide therapy using ABD-fused ADAPT scaffold protein: Proof of Principle
Garousi J, von Witting E, Borin J, ..., Tolmachev V, Hober S
Biomaterials 266 (-) 120381 [2021-01-00; online 2021-01-00]
PubMed DOI Crossref
Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease.
Asad S, Wegler C, Ahl D, ..., Artursson P, Teleki A
J Pharm Sci 110 (1) 239-250 [2021-01-00; online 2020-11-04]
Alexandra Teleki SciLifeLab Fellow
PubMed DOI Crossref
Profiling of donor-specific immune effector signatures in response to rituximab in a human whole blood loop assay using blood from CLL patients.
Eltahir M, Fletcher E, Dynesius L, ..., Mattsson M, Mangsbo SM
Int. Immunopharmacol. 90 (-) 107226 [2021-01-00; online 2020-12-11]
PubMed DOI Crossref
Predicting With Confidence: Using Conformal Prediction in Drug Discovery.
Alvarsson J, Arvidsson McShane S, Norinder U, Spjuth O
J Pharm Sci 110 (1) 42-49 [2021-01-00; online 2020-10-17]
PubMed DOI Crossref
Null association between serum 25-hydroxyvitamin D levels with allergic rhinitis, allergic sensitization and non-allergic rhinitis: A Mendelian randomization study.
Feng Q, Bønnelykke K, Ek WE, ..., Leung RY, Cheung BM
Clin. Exp. Allergy 51 (1) 78-86 [2021-01-00; online 2020-09-28]
PubMed DOI Crossref
News ways of understanding the complex biology of diabetes using PET.
Eriksson O, Långström B, Antoni G
Nucl. Med. Biol. 92 (-) 65-71 [2021-01-00; online 2020-04-27]
Olof Eriksson SciLifeLab Fellow
PubMed DOI Crossref
Neuroimaging the menstrual cycle: A multimodal systematic review.
Dubol M, Epperson CN, Sacher J, ..., Sundström-Poromaa I, Comasco E
Front Neuroendocrinol 60 (-) 100878 [2021-01-00; online 2020-10-22]
Erika Comasco SciLifeLab Fellow
PubMed DOI Crossref
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality.
Stebbing J, Sánchez Nievas G, Falcone M, ..., Abizanda P, Lauschke VM
Sci Adv 7 (1) - [2021-01-00; online 2021-01-01]
Claudia Kutter SciLifeLab Fellow
PubMed DOI Crossref
Generation of human induced pluripotent stem cell (iPSC) lines (UUMCBi001-A, UUMCBi002-A) from two healthy donors.
Vasylovska S, Schuster J, Brboric A, ..., Dahl N, Lau J
Stem Cell Res 50 (-) 102114 [2021-01-00; online 2020-12-09]
PubMed DOI Crossref
Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study.
Koivula RW, Atabaki-Pasdar N, Giordano GN, ..., Franks PW, IMI DIRECT Consortium
Diabetologia 64 (1) 260-261 [2021-01-00; online 2020-11-14]
PubMed DOI Crossref
Contributions of de novo variants to systemic lupus erythematosus.
Almlöf JC, Nystedt S, Mechtidou A, ..., Sandling JK, Syvänen AC
Eur. J. Hum. Genet. 29 (1) 184-193 [2021-01-00; online 2020-07-28]
PubMed DOI Crossref
Cancer and Risk of COVID-19 Through a General Community Survey.
Lee KA, Ma W, Sikavi DR, ..., Chan AT, COPE consortium
Oncologist 26 (1) e182-e185 [2021-01-00; online 2020-09-07]
PubMed DOI Crossref
Adhesion molecule cross-linking and cytokine exposure modulate IgE- and non-IgE-dependent basophil activation.
Kalm F, Mansouri L, Russom A, Lundahl J, Nopp A
Immunology 162 (1) 92-104 [2021-01-00; online 2020-10-29]
DOI Crossref
Proteoglycans in Stem Cells
- - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Orthogonal Mixture of Hidden Markov Models
Safinianaini N, de Souza CPE, Boström H, Lagergren J
- - (-) 509-525 [2021-00-00; online 2021-02-25]
DOI Crossref
Organ-Specific Metabolic Pathways Distinguish Prediabetes, Type 2 Diabetes and Normal Tissues
Diamanti K, Cavalli M, Pereira MJ, ..., Eriksson JW, Wadelius C
- - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Network Analyses Links Epicardial Fat Metabolism to Human Coronary Heart Disease
Doran S, Arif M, Clausen M, ..., Mardinoglu A, Boren J
- - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Multiomics Personalized Network Analyses Highlight Progressive Immune Disruption of Central Metabolism Associated with COVID-19 Severity
Ambikan AT, Yang H, Krishnan S, ..., Benfeitas R, Neogi U
- - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Molecular Imaging of Diabetes
Joosten L, Boss M, Jansen T, ..., de Galan B, Gotthardt M
- - (-) 1415-1431 [2021-00-00; online 2021-00-00]
DOI Crossref
Mitochondrial Metabolism Drives Triacylglycerol Synthesis to Control Regulatory T Cell Differentiation
Matias MI, Yong C, Foroushani A, ..., Dardalhon V, Taylor N
SSRN Journal - (-) - [2021-00-00; online 2021-00-00]
PubMed DOI Crossref
Ligand design by targeting a binding site water
Matricon P, Suresh RR, Gao ZG, ..., Jacobson KA, Carlsson J
Chem Sci 12 (3) 960-968 [2021-00-00; online 2021-00-00]
Jens Carlsson SciLifeLab Fellow
PubMed DOI Crossref
Investigation of the individual human sulfatome in plasma and urine samples reveals an age-dependency
Correia MSP, Thapa B, Vujasinovic M, Löhr JM, Globisch D
RSC Adv. 11 (55) 34788-34794 [2021-00-00; online 2021-00-00]
Daniel Globisch SciLifeLab Fellow
DOI Crossref
Heparan Sulfate in Normal and Cancer Stem Cells of the Brain
Xiong A, Roy A, Spyrou A, Forsberg-Nilsson K
- - (-) 205-236 [2021-00-00; online 2021-06-08]
DOI Crossref
Genome-Scale Metabolic Modelling of the Human Gut Microbiome Reveals Changes of the Glyoxylate and Dicarboxylate Metabolism in Metabolic Disorders
Proffitt C, Bidkhori G, Lee S, ..., Moyes DL, Shoaie S
SSRN Journal - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Explainable Artificial Neural Network for Recurrent Venous Thromboembolism Based on Plasma Proteomics
Razzaq M, Goumidi L, Iglesias MJ, ..., Morange PE, Tregouet DA
- - (-) 108-121 [2021-00-00; online 2021-09-13]
DOI Crossref
Drug Repositioning for Clear Cell Renal Cell Carcinoma Based on Stratification of Patients
Li X, Kim W, Juszczak K, ..., Zhang C, Mardinoglu A
- - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Combined Metabolic Cofactor Supplementation Reduces Liver Fat in Nonalcoholic Fatty Liver Disease
Zeybel M, Altay O, Arif M, ..., Boren J, Mardinoglu A
SSRN Journal - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Combined Metabolic Activators Improves Cognitive Functions in Alzheimer's Disease
Yulug B, Altay O, Li X, ..., Uhlen M, Mardinoglu A
SSRN Journal - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in a Golden Syrian Hamster Study
Yang H, Mayneris-Perxachs J, Boqué N, ..., Mardinoglu A, Caimari A
SSRN Journal - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in a Golden Syrian Hamster Study
Yang H, Mayneris-Perxachs J, Boqué N, ..., Mardinoglu A, Caimari A
- - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
B Cell Expansion Hinders the Stroma-Epithelium Regenerative Crosstalk During Mucosal Healing
Frede A, Tripathi KP, Czarnewski P, ..., Saez-Rodriguez J, Villablanca EJ
- - (-) - [2021-00-00; online 2021-00-00]
DOI Crossref
Analysis of Population Structure
Sjödin P, Gattepaille L, Skoglund P, Schlebusch C, Jakobsson M
- - (-) 47-68 [2021-00-00; online 2021-03-14]
DOI Crossref
A Network-Based Approach Reveals the Dysregulated Transcriptional Regulation in Non- Alcohol Fatty Liver Disease
Yang H, Arif M, Yuan M, ..., Zhang C, Mardinoglu A
- - (-) - [2021-00-00; online 2021-00-00]
SciLifeLab Data Centre
Publications 9.5.1