Publications 2020

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874 publications

PubMed DOI Crossref
The serine protease HtrA plays a key role in heat-induced dispersal of pneumococcal biofilms.
Chao Y, Bergenfelz C, Sun R, ..., Achour A, Hakansson AP
Sci Rep 10 (1) 22455 [2020-12-31; online 2020-12-31]
PubMed DOI Crossref
TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue.
Sjöstedt E, Kolnes AJ, Olarescu NC, ..., Bollerslev J, Casar-Borota O
Cancers (Basel) 13 (1) - [2020-12-31; online 2020-12-31]
PubMed DOI Crossref
5´XP sRNA-seq: efficient identification of transcripts with and without 5´ phosphorylation reveals evolutionary conserved small RNA.
Kugelberg U, Nätt D, Skog S, Kutter C, Öst A
RNA Biol - (-) 1-12 [2020-12-31; online 2020-12-31]
Claudia Kutter SciLifeLab Fellow
PubMed DOI Crossref
Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids.
Pettke A, Tampere M, Pronk R, ..., Mirazimi A, Puumalainen MR
Viruses 13 (1) - [2020-12-29; online 2020-12-29]
PubMed DOI Crossref
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.
Ladds MJGW, Popova G, Pastor-Fernández A, ..., Lane DP, Laín S
J Biol Chem 295 (52) 17935-17949 [2020-12-25; online 2020-09-08]
PubMed DOI Crossref
Development and external validation of a COVID-19 mortality risk prediction algorithm: a multicentre retrospective cohort study.
Mei J, Hu W, Chen Q, ..., Yue J, Wang QL
BMJ Open 10 (12) e044028 [2020-12-24; online 2020-12-24]
DDLS Fellow Qiaoli Wang
DOI Crossref
Multiplexed experimental strategies for fragment library screening using SPR biosensors
FitzGerald EA, Vagrys D, Opassi G, ..., de Esch IJP, Danielson UH
- - (-) - [2020-12-23; online 2020-12-23]
PubMed DOI Crossref
Erratum for Hugerth et al., "Assessment of In Vitro and In Silico Protocols for Sequence-Based Characterization of the Human Vaginal Microbiome".
Hugerth LW, Pereira M, Zha Y, ..., Schuppe-Koistinen I, Engstrand L
mSphere 5 (6) - [2020-12-23; online 2020-12-23]
DOI Crossref
Author response: Identification of ligand-specific G protein-coupled receptor states and prediction of downstream efficacy via data-driven modeling
Fleetwood O, Carlsson J, Delemotte L
- - (-) - [2020-12-23; online 2020-12-23]
DOI Crossref
SARS-CoV-2 infections among personnel providing home care services for the elderly in Stockholm, Sweden
Hassan SS, Seigerud Å, Mühr LSA, ..., Lundgren KC, Dillner J
- - (-) - [2020-12-22; online 2020-12-22]
PubMed DOI Crossref
Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
Lehmann LC, Bacic L, Hewitt G, ..., Boulton SJ, Deindl S
Cell Reports 33 (12) 108529 [2020-12-22; online 2020-12-29]
SciLifeLab Fellow Sebastian Deindl
PubMed DOI Crossref
Ileocolonic Histopathological and Microbial Alterations in the Irritable Bowel Syndrome: A Nested Community Case-Control Study.
Talley NJ, Alexander JL, Walker MM, ..., Powell N, Andreasson A
Clin Transl Gastroenterol 12 (1) e00296 [2020-12-22; online 2020-12-22]
DDLS Fellow Luisa Hugerth
PubMed DOI Crossref
Complex subsurface hydrothermal fluid mixing at a submarine arc volcano supports distinct and highly diverse microbial communities.
Reysenbach AL, St John E, Meneghin J, ..., Diehl A, Bach W
Proc. Natl. Acad. Sci. U.S.A. 117 (51) 32627-32638 [2020-12-22; online 2020-12-04]
DOI Crossref
Aggregation and immobilisation of membrane proteins interplay with local lipid order in the plasma membrane of T cells
Urbančič I, Schiffelers L, Jenkins E, ..., Sezgin E, Eggeling C
- - (-) - [2020-12-22; online 2020-12-22]
DOI Crossref
Genomic instability is an early event driving chromatin reorganization and escape from oncogene-induced senescence
Zampetidis C, Galanos P, Angelopoulou A, ..., Papantonis A, Gorgoulis V
- - (-) - [2020-12-20; online 2020-12-20]
DOI Crossref
The chaperonin GroESL facilitates Caulobacter crescentus cell division by supporting the function of the actin homologue FtsA
Schroeder K, Heinrich K, Neuwirth I, Jonas K
- - (-) - [2020-12-18; online 2020-12-18]
PubMed DOI Crossref
Preclinical Evaluation of the Copper-64 Labeled GRPR-Antagonist RM26 in Comparison with the Cobalt-55 Labeled Counterpart for PET-Imaging of Prostate Cancer.
Baun C, Mitran B, Rinne SS, ..., Orlova A, Thisgaard H
Molecules 25 (24) - [2020-12-18; online 2020-12-18]
PubMed DOI Crossref
MuscleAtlasExplorer: a web service for studying gene expression in human skeletal muscle.
Asplund O, Rung J, Groop L, Prasad B R, Hansson O
Database (Oxford) 2020 (-) - [2020-12-18; online 2020-12-19]
PubMed DOI Crossref
Editorial: Redox Homeostasis and Cancer.
Sinha M, Mardinoglu A, Ghose J, Singh K
Oxid Med Cell Longev 2020 (-) 5487381 [2020-12-18; online 2020-12-18]
DOI Crossref
SOCIODEMOGRAPHIC CHARACTERISTICS AND COVID-19 TESTING RATES: SPATIO-TEMPORAL PATTERNS AND IMPACT OF TEST ACCESSIBILITY IN SWEDEN
Kennedy B, Varotsis G, Hammar U, ..., Björk J, Fall T
- - (-) - [2020-12-16; online 2020-12-16]
PubMed DOI Crossref
Revamping Space-omics in Europe.
Madrigal P, Gabel A, Villacampa A, ..., da Silveira WA, Herranz R
Cell Syst 11 (6) 555-556 [2020-12-16; online 2020-11-25]
DOI Crossref
The evolutionary history of topological variations in the CPA/AT superfamily
Govindarajan S, Bassot C, Lamb J, ..., Huang Y, Elofsson A
- - (-) - [2020-12-15; online 2020-12-15]
PubMed DOI Crossref
The developmental relationship between teeth and dermal odontodes in the most primitive bony fish Lophosteus.
Chen D, Blom H, Sanchez S, ..., Märss T, Ahlberg PE
Elife 9 (-) - [2020-12-15; online 2020-12-15]
PubMed DOI Crossref
Screening of Multiple Biomarkers Associated With Ischemic Stroke in Atrial Fibrillation.
Hijazi Z, Wallentin L, Lindbäck J, ..., Oldgren J, Siegbahn A
J Am Heart Assoc 9 (24) e018984 [2020-12-15; online 2020-12-09]
PubMed DOI Crossref
Managing Coronavirus Disease 2019 Spread With Voluntary Public Health Measures: Sweden as a Case Study for Pandemic Control.
Kamerlin SCL, Kasson PM
Clin Infect Dis 71 (12) 3174-3181 [2020-12-15; online 2020-07-02]
DOI Crossref
Informing NMR experiments with molecular dynamics simulations to characterize the dominant activated state of the KcsA ion channel
Pérez-Conesa S, Keeler EG, Zhang D, Delemotte L, McDermott AE
- - (-) - [2020-12-15; online 2020-12-15]
PubMed DOI Crossref
Ancient microRNA profiles of a 14,300-year-old canid samples confirm taxonomic origin and give glimpses into tissue-specific gene regulation from the Pleistocene.
Fromm B, Tarbier M, Smith O, ..., Gilbert TP, Friedlander MR
RNA - (-) - [2020-12-15; online 2020-12-15]
Marc Friedländer SciLifeLab Fellow
PubMed DOI Crossref
An angular motion of a conserved four-helix bundle facilitates alternating access transport in the TtNapA and EcNhaA transporters.
Masrati G, Mondal R, Rimon A, ..., Lindahl E, Ben-Tal N
Proc. Natl. Acad. Sci. U.S.A. 117 (50) 31850-31860 [2020-12-15; online 2020-11-30]
DOI Crossref
A blueprint for high affinity SARS-CoV-2 Mpro inhibitors from activity-based compound library screening guided by analysis of protein dynamics
Gossen J, Albani S, Hanke A, ..., Kokh DB, Rossetti G
- - (-) - [2020-12-15; online 2020-12-15]
DOI Crossref
The SEQC2 Epigenomics Quality Control (EpiQC) Study: Comprehensive Characterization of Epigenetic Methods, Reproducibility, and Quantification
Foox J, Nordlund J, Lalancette C, ..., Deng Y, Mason CE
- - (-) - [2020-12-14; online 2020-12-14]
DOI Crossref
Screening for high amounts of SARS-CoV-2 identifies pre-symptomatic subjects among healthy healthcare workers
Dillner J, Elfström KM, Blomqvist J, ..., Mühr LSA, Lundgren KC
- - (-) - [2020-12-14; online 2020-12-14]
DOI Crossref
Three-dimensional spatial transcriptomics uncovers cell type dynamics in the rheumatoid arthritis synovium
Vickovic S, Schapiro D, Carlberg K, ..., Regev A, Ståhl PL
- - (-) - [2020-12-11; online 2020-12-11]
DOI Crossref
Functional crosstalk between phosphorylation and disease-causing mutations in the cardiac sodium channel Na v 1.5
Galleano I, Harms H, Choudhury K, ..., Delemotte L, Pless SA
- - (-) - [2020-12-11; online 2020-12-11]
DOI Crossref
A porcine brain-wide RNA editing landscape
Huang J, Lin L, Dong Z, ..., Bolund L, Luo Y
- - (-) - [2020-12-11; online 2020-12-11]
DOI Crossref
A multi-omics study of circulating phospholipid markers of blood pressure
Liu J, de Vries PS, Greco M. FD, ..., Dehghan A, Demirkan A
- - (-) - [2020-12-11; online 2020-12-11]
PubMed DOI Crossref
A New Era for Space Life Science: International Standards for Space Omics Processing.
Rutter L, Barker R, Bezdan D, ..., Herranz R, Muratani M
Patterns (N Y) 1 (9) 100148 [2020-12-11; online 2020-11-25]
PubMed DOI Crossref
The shared risk of diabetes between dog and cat owners and their pets: register based cohort study.
Delicano RA, Hammar U, Egenvall A, ..., Fall T, Kennedy B
BMJ 371 (-) m4337 [2020-12-10; online 2020-12-10]
PubMed DOI Crossref
Cell-cell fusion of mesenchymal cells with distinct differentiations triggers genomic and transcriptomic remodelling toward tumour aggressiveness.
Delespaul L, Gélabert C, Lesluyes T, ..., Lartigue L, Chibon F
Sci Rep 10 (1) 21634 [2020-12-10; online 2020-12-10]
PubMed DOI Crossref
Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease.
Hiltunen AE, Kangas SM, Ohlmeier S, ..., Uusimaa J, Hinttala R
Mol. Med. 26 (1) 123 [2020-12-09; online 2020-12-09]
PubMed DOI Crossref
Precise Triggering and Chemical Control of Single-Virus Fusion within Endosomes.
Haldar S, Okamoto K, Dunning RA, Kasson PM
J. Virol. 95 (1) - [2020-12-09; online 2020-12-09]
PubMed DOI Crossref
Automated Removal of Non-homologous Sequence Stretches with PREQUAL.
Irisarri I, Burki F, Whelan S
Methods in molecular biology (Clifton, N.J.) 2231 (-) 147-162 [2020-12-09; online 2020-12-09]
Fabien Burki SciLifeLab Fellow
PubMed DOI Crossref
Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection.
Pålsson SA, Dondalska A, Bergenstråhle J, ..., Galloux M, Spetz AL
Front Immunol 11 (-) 580547 [2020-12-08; online 2020-12-08]
PubMed DOI Crossref
Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development.
Malkani S, Chin CR, Cekanaviciute E, ..., Mason CE, Beheshti A
Cell Reports 33 (10) 108448 [2020-12-08; online 2020-11-25]
DDLS Fellow Marc Friedländer Marcel Tarbier SciLifeLab Fellow
PubMed DOI Crossref
Mitochondrial DNA Sequence Diversity in Mammals: A Correlation between the Effective and Census Population Sizes.
James J, Eyre-Walker A
Genome Biol Evol 12 (12) 2441-2449 [2020-12-06; online 2020-10-24]
DDLS Fellow Jennifer James
PubMed DOI Crossref
The Role of Intratumor Heterogeneity in the Response of Metastatic Non-Small Cell Lung Cancer to Immune Checkpoint Inhibitors.
Nicoś M, Krawczyk P, Crosetto N, Milanowski J
Front Oncol 10 (-) 569202 [2020-12-04; online 2020-12-04]
DOI Crossref
NGSpeciesID: DNA barcode and amplicon consensus generation from long-read sequencing data
Sahlin K, Lim M, Prost S
- - (-) - [2020-12-04; online 2020-12-04]
PubMed DOI Crossref
Longitudinal Plasma Protein Profiling Using Targeted Proteomics and Recombinant Protein Standards.
Kotol D, Hunt H, Hober A, ..., Uhlén M, Edfors F
J. Proteome Res. 19 (12) 4815-4825 [2020-12-04; online 2020-09-04]
PubMed DOI Crossref
Enhanced Validation of Antibodies Enables the Discovery of Missing Proteins.
Sivertsson Å, Lindström E, Oksvold P, ..., Uhlén M, Lindskog C
J. Proteome Res. 19 (12) 4766-4781 [2020-12-04; online 2020-11-10]
PubMed DOI Crossref
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.
Visnes T, Benítez-Buelga C, Cázares-Körner A, ..., Berglund UW, Helleday T
Nucleic Acids Res. 48 (21) 12234-12251 [2020-12-02; online 2020-11-20]
PubMed DOI Crossref
Microbial model communities: To understand complexity, harness the power of simplicity.
Bengtsson-Palme J
Comput Struct Biotechnol J 18 (-) 3987-4001 [2020-12-02; online 2020-12-02]
DDLS Fellow Johan Bengtsson-Palme
DOI Crossref
Direct RNA targeted transcriptomic profiling in tissue using Hybridization-based RNA In Situ Sequencing (HybRISS)
Lee H, Salas SM, Gyllborg D, Nilsson M
- - (-) - [2020-12-02; online 2020-12-02]
PubMed DOI Crossref
Bromopyrylium Derivatization Facilitates Identification by Mass Spectrometry Imaging of Monoamine Neurotransmitters and Small Molecule Neuroactive Compounds.
Shariatgorji R, Nilsson A, Strittmatter N, ..., Goodwin RJA, Andrén PE
J. Am. Soc. Mass Spectrom. 31 (12) 2553-2557 [2020-12-02; online 2020-07-21]
PubMed DOI Crossref
Unravelling the mechanism of pH-regulation in dinoflagellate luciferase.
Kamerlin N, Delcey MG, Lindh R
Int J Biol Macromol 164 (-) 2671-2680 [2020-12-01; online 2020-08-19]
DOI Crossref
Guidelines for accurate genotyping of SARS-CoV-2 using amplicon-based sequencing of clinical samples
Kubik S, Marques AC, Xing X, ..., Willig A, Xu Z
- - (-) - [2020-12-01; online 2020-12-01]
PubMed DOI Crossref
Expression of the stem cell marker CD133 in malignant meningioma.
Maier AD, Mirian C, Bartek J, ..., Broholm H, Mathiesen TI
Clin Neuropathol 40 (3) 151-159 [2020-12-01; online 2020-12-01]
PubMed DOI Crossref
Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure.
Zrimec J, Börlin CS, Buric F, ..., Töpel M, Zelezniak A
Nat Commun 11 (1) 6141 [2020-12-01; online 2020-12-01]
PubMed DOI Crossref
Assessment of Posttraumatic Stress Disorder and Educational Achievement in Sweden.
Vilaplana-Pérez A, Sidorchuk A, Pérez-Vigil A, ..., Mataix-Cols D, Fernández de la Cruz L
JAMA Netw Open 3 (12) e2028477 [2020-12-01; online 2020-12-01]
DOI Crossref
Understanding effects of enhancer variants in coronary artery disease using allele specific promoter-enhancer interaction
Pradhananga S, Sahlen P
Atherosclerosis 315 (-) e189 [2020-12-00; online 2020-12-00]
PubMed DOI Crossref
The environment drives microbial trait variability in aquatic habitats.
Beier S, Andersson AF, Galand PE, ..., McMahon K, Bertilsson S
Mol. Ecol. 29 (23) 4605-4617 [2020-12-00; online 2020-10-18]
PubMed DOI Crossref
The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling.
Chen B, Dragomir MP, Fabris L, ..., Ajani JA, Calin GA
Gastroenterology 159 (6) 2146-2162.e33 [2020-12-00; online 2020-08-15]
PubMed DOI Crossref
Structural and functional consequences of reversible lipid asymmetry in living membranes.
Doktorova M, Symons JL, Levental I
Nat. Chem. Biol. 16 (12) 1321-1330 [2020-12-00; online 2020-11-16]
DDLS Fellow Milka Doktorova
PubMed DOI Crossref
Spatial Characterization of the Human Centrosome Proteome Opens Up New Horizons for a Small but Versatile Organelle.
Danielsson F, Mahdessian D, Axelsson U, ..., Thul PJ, Lundberg E
Proteomics 20 (23) e1900361 [2020-12-00; online 2020-08-26]
PubMed DOI Crossref
S100A6 is a critical regulator of hematopoietic stem cells.
Grahn THM, Niroula A, Végvári Á, ..., Zubarev RA, Karlsson S
Leukemia 34 (12) 3323-3337 [2020-12-00; online 2020-06-19]
Abhishek Niroula DDLS Fellow
PubMed DOI Crossref
Recent advances in single-molecule fluorescence microscopy render structural biology dynamic
Bacic L, Sabantsev A, Deindl S
Current Opinion in Structural Biology 65 (-) 61-68 [2020-12-00; online 2020-12-00]
SciLifeLab Fellow Sebastian Deindl
DOI Crossref
Proceedings of the EuBIC-MS 2020 Developers’ Meeting
Ashwood C, Bittremieux W, Deutsch EW, ..., Webel H, Willems S
EuPA Open Proteom 24 (-) 1-6 [2020-12-00; online 2020-12-00]
DOI Crossref
PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
Carter SSD, Atif AR, Kadekar S, ..., Tenje M, Mestres G
Organs-on-a-Chip 2 (-) 100004 [2020-12-00; online 2020-12-00]
PubMed DOI Crossref
Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy.
van Westering TLE, Johansson HJ, Hanson B, ..., Aoki Y, Roberts TC
Mol. Cell Proteomics 19 (12) 2047-2068 [2020-12-00; online 2020-09-29]
PubMed DOI Crossref
Metabolomic Profile in HFpEF vs HFrEF Patients.
Hage C, Löfgren L, Michopoulos F, ..., Persson H, Linde C
J Card Fail 26 (12) 1050-1059 [2020-12-00; online 2020-08-01]
PubMed DOI Crossref
Increased sperm production linked to competition in the maternal social environment.
Hobson L, Hurst JL, Stockley P
R Soc Open Sci 7 (12) 201171 [2020-12-00; online 2020-12-16]
PubMed DOI Crossref
Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40.
Wenthe J, Naseri S, Hellström AC, ..., Eriksson E, Loskog A
Cancer Gene Ther. 27 (12) 948-959 [2020-12-00; online 2020-05-01]
PubMed DOI Crossref
Identification of areas of grading difficulties in prostate cancer and comparison with artificial intelligence assisted grading.
Egevad L, Swanberg D, Delahunt B, ..., Clements M, Eklund M
Virchows Arch. 477 (6) 777-786 [2020-12-00; online 2020-06-15]
DDLS Fellow Kimmo Kartasalo
PubMed DOI Crossref
IL-16 processing in sentinel node regulatory T cells is a factor in bladder cancer immunity.
Krantz D, Mints M, Winerdal M, ..., Sherif A, Winqvist O
Scand. J. Immunol. 92 (6) e12926 [2020-12-00; online 2020-08-30]
PubMed DOI Crossref
Genomic insights on the contribution of balancing selection and local adaptation to the long-term survival of a widespread living fossil tree, Cercidiphyllum japonicum.
Zhu S, Chen J, Zhao J, ..., Lascoux M, Qiu Y
New Phytol. 228 (5) 1674-1689 [2020-12-00; online 2020-08-17]
PubMed DOI Crossref
Genome-wide detection of DNA double-strand breaks by in-suspension BLISS.
Bouwman BAM, Agostini F, Garnerone S, ..., Roukos V, Crosetto N
Nat Protoc 15 (12) 3894-3941 [2020-12-00; online 2020-11-02]
Magda Bienko SciLifeLab Fellow
PubMed DOI Crossref
Generation of two human iPSC lines (UUIGPi013-A and UUIPGi014-A) from cases with Down syndrome and full trisomy for chromosome 21 (T21).
Schuster J, Hoeber J, Sobol M, ..., Annerén G, Dahl N
Stem Cell Res 49 (-) 102081 [2020-12-00; online 2020-11-07]
PubMed DOI Crossref
Distinct pre-initiation steps in human mitochondrial translation
Khawaja A, Itoh Y, Remes C, ..., Amunts A, Rorbach J
Nat Commun 11 (1) - [2020-12-00; online 2020-06-10]
Alexey Amunts SciLifeLab Fellow
PubMed DOI Crossref
Comprehensive Investigation of Circulating Biomarkers and Their Causal Role in Atherosclerosis-Related Risk Factors and Clinical Events.
Zanetti D, Gustafsson S, Assimes TL, Ingelsson E
Circ Genom Precis Med 13 (6) e002996 [2020-12-00; online 2020-10-30]
PubMed DOI Crossref
Colonization factor CS30 from enterotoxigenic Escherichia coli binds to sulfatide in human and porcine small intestine.
Von Mentzer A, Zalem D, Chrienova Z, Teneberg S
Virulence 11 (1) 381-390 [2020-12-00; online 2020-04-05]
Astrid von Mentzer DDLS Fellow
PubMed DOI Crossref
Clear mortality gap caused by graft macrosteatosis in Chinese patients after cadaveric liver transplantation.
Liu Z, Wang W, Zhuang L, ..., Zhou L, Zheng S
Hepatobiliary Surg Nutr 9 (6) 739-758 [2020-12-00; online 2020-12-11]
PubMed DOI Crossref
Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening.
Kang PW, Westerlund AM, Shi J, ..., Delemotte L, Cui J
Sci Adv 6 (50) - [2020-12-00; online 2020-12-11]
Lucie Delemotte SciLifeLab Fellow
PubMed DOI Crossref
Association and Familial Coaggregation of Idiopathic Dystonia With Psychiatric Outcomes.
Martino D, Brander G, Svenningsson P, Larsson H, de la Cruz LF
Mov Disord 35 (12) 2270-2278 [2020-12-00; online 2020-09-17]
PubMed DOI Crossref
Antibiotic use and risk of colorectal cancer: a systematic review and dose-response meta-analysis.
Simin J, Fornes R, Liu Q, ..., Engstrand L, Brusselaers N
Br. J. Cancer 123 (12) 1825-1832 [2020-12-00; online 2020-09-24]
PubMed DOI Crossref
Aniridia with PAX6 mutations and narcolepsy.
Berntsson SG, Kristoffersson A, Daniilidou M, ..., Hallböök F, Landtblom AM
J Sleep Res 29 (6) e12982 [2020-12-00; online 2020-01-14]
PubMed DOI Crossref
Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi
Itoh Y, Naschberger A, Mortezaei N, Herrmann JM, Amunts A
Nat Commun 11 (1) - [2020-12-00; online 2020-10-14]
Alexey Amunts SciLifeLab Fellow
PubMed DOI Crossref
Aberrant splicing due to a novel RPS7 variant causes Diamond-Blackfan Anemia associated with spontaneous remission and meningocele.
Akram T, Fatima A, Klar J, ..., Schuster J, Dahl N
Int J Hematol 112 (6) 894-899 [2020-12-00; online 2020-08-09]
PubMed DOI Crossref
A transcription factor glial cell missing (Gcm) in the freshwater crayfish Pacifastacus leniusculus.
Junkunlo K, Söderhäll K, Söderhäll I
Dev. Comp. Immunol. 113 (-) 103782 [2020-12-00; online 2020-07-15]
PubMed DOI Crossref
A reference map of potential determinants for the human serum metabolome.
Bar N, Korem T, Weissbrod O, ..., Pedersen O, Segal E
Nature 588 (7836) 135-140 [2020-12-00; online 2020-11-11]
DOI Crossref
A practical guide to microfabrication and patterning of hydrogels for biomimetic cell culture scaffolds
Tenje M, Cantoni F, Porras Hernández AM, ..., Antfolk M, Pohlit H
Organs-on-a-Chip 2 (-) 100003 [2020-12-00; online 2020-12-00]
PubMed DOI Crossref
Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study.
Obura M, Beulens JWJ, Slieker R, ..., Rutters F, IMI-DIRECT Consortium
PLoS ONE 15 (11) e0242360 [2020-11-30; online 2020-11-30]
DOI Crossref
Phenotypic plasticity, population structure and adaptation in a young weed species with a worldwide distribution
Cornille A, Tiret M, Salcedo A, ..., Wright SI, Lascoux M
- - (-) - [2020-11-28; online 2020-11-28]
PubMed DOI Crossref
Maturation of Monocyte-Derived DCs Leads to Increased Cellular Stiffness, Higher Membrane Fluidity, and Changed Lipid Composition.
Lühr JJ, Alex N, Amon L, ..., Guck J, Dudziak D
Front Immunol 11 (-) 590121 [2020-11-27; online 2020-11-27]
PubMed DOI Crossref
Universal Single-Residue Terminal Labels for Fluorescent Live Cell Imaging of Microproteins.
Lafranchi L, Schlesinger D, Kimler KJ, Elsässer SJ
Journal of the American Chemical Society 142 (47) 20080-20087 [2020-11-25; online 2020-11-11]
SciLifeLab Fellow Simon Elsässer
DOI Crossref
Faculty Opinions recommendation of Genome-wide Nucleotide-Resolution Mapping of DNA Replication Patterns, Single-Strand Breaks, and Lesions by GLOE-Seq.
Elsässer S
- - (-) - [2020-11-25; online 2020-11-13]
DOI Crossref
The anti-inflammatory peptide Catestatin blocks chemotaxis
Muntjewerff EM, Parv K, Mahata SK, ..., Christoffersson G, van den Bogaart G
- - (-) - [2020-11-24; online 2020-11-24]
PubMed DOI Crossref
Improved computational analysis of ribosome dynamics from 5′P degradome data using fivepseq
Nersisyan L, Ropat M, Pelechano V
NAR Genomics and Bioinformatics 2 (4) - [2020-11-24; online 2020-11-24]
SciLifeLab Fellow Vicent Pelechano
PubMed DOI Crossref
Comparative interactomes of HSF1 in stress and disease reveal a role for CTCF in HSF1-mediated gene regulation.
Burchfiel ET, Vihervaara A, Guertin MJ, Gomez-Pastor R, Thiele DJ
J Biol Chem 296 (-) 100097 [2020-11-24; online 2020-11-24]
Anniina Vihervaara SciLifeLab Fellow
PubMed DOI Crossref
Exploring microfluidics as a tool to evaluate the biological properties of a titanium alloy under dynamic conditions.
Carter SD, Barbe L, Tenje M, Mestres G
Biomater Sci 8 (22) 6309-6321 [2020-11-21; online 2020-10-06]
PubMed DOI Crossref
Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells.
Zhan C, Bidkhori G, Schwarz H, ..., Rockberg J, Chotteau V
iScience 23 (11) 101653 [2020-11-20; online 2020-10-07]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Comparative dietary sulfated metabolome analysis reveals unknown metabolic interactions of the gut microbiome and the human host.
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Lung Cancer Immunotherapy in Transplant Patients and in Patients With Autoimmune Diseases.
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Biochemistry 59 (45) 4421-4428 [2020-11-17; online 2020-11-04]
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Acta Vet Scand 62 (1) 59 [2020-11-10; online 2020-11-10]
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Uncovering cancer gene regulation by accurate regulatory network inference from uninformative data.
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Henriksson P, Lentini A, Altmäe S, ..., Nestor CE, Löf M
BMC Genomics 21 (1) 769 [2020-11-09; online 2020-11-09]
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Point-of-care detection of SARS-CoV-2 in nasopharyngeal swab samples using an integrated smartphone-based centrifugal microfluidic platform
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Proteogenomic Subtyping of Chronic Lymphocytic Leukemia Identifies a Novel Poor Outcome Subgroup with a Distinct Drug Response Profile
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Genomic and Transcriptomic Characterization of Adult and Pediatric Relapsed Acute Myeloid Leukemia Reveals Novel Therapeutic Targets
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Commonly used clinical chemistry tests as mortality predictors: Results from two large cohort studies.
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Novel Effective Bacillus cereus Group Species "Bacillus clarus" Is Represented by Antibiotic-Producing Strain ATCC 21929 Isolated from Soil.
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The meadow jumping mouse genome and transcriptome suggest mechanisms of hibernation
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Redesigning Solvatochromic Probe Laurdan for Imaging Lipid Order Selectively in Cell Plasma Membranes.
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MNK2 governs the macrophage antiinflammatory phenotype.
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Cross-validated Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Quantitation Protocol for a Pharmaceutical Drug and Its Drug-Target Effects in the Brain Using Time-of-Flight and Fourier Transform Ion Cyclotron Resonance Analyzers.
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Computational Analysis of Alzheimer Amyloid Plaque Composition in 2D- and Elastically Reconstructed 3D-MALDI MS Images.
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Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.
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Enhanced Collagen Deposition in the Duodenum of Patients with Hyaline Fibromatosis Syndrome and Protein Losing Enteropathy.
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Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes.
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Tracking the motion of the KV1.2 voltage sensor reveals the molecular perturbations caused by a de novo mutation in a case of epilepsy.
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Slight Deuterium Enrichment in Water Acts as an Antioxidant: Is Deuterium a Cell Growth Regulator?
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Significance of host heparanase in promoting tumor growth and metastasis.
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SCRINSHOT enables spatial mapping of cell states in tissue sections with single-cell resolution.
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Quantification of aromatase binding in the female human brain using [11 C]cetrozole positron emission tomography.
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J Neurosci Res 98 (11) 2208-2218 [2020-11-00; online 2020-08-06]
Erika Comasco SciLifeLab Fellow
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Progressive Cactus is a multiple-genome aligner for the thousand-genome era.
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Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) induce epigenetic alterations and promote human breast cell carcinogenesis in vitro.
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Oskar Karlsson SciLifeLab Fellow
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P.719 Investigation of long-term effects of ouabain administration in mice, and analysis of ouabain-induced gene expression changes in a neuronal culture
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Eur Neuropsychopharmacol 40 (-) S408-S409 [2020-11-00; online 2020-11-00]
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LifeTime and improving European healthcare through cell-based interceptive medicine.
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Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F
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Life Sci. Alliance 3 (11) e202000883 [2020-11-00; online 2020-09-21]
DDLS Fellow Nicholas Pearce
PubMed DOI Crossref
High-density lipoprotein characteristics and coronary artery disease: a Mendelian randomization study.
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Metabolism 112 (-) 154351 [2020-11-00; online 2020-09-04]
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Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia.
Rosa L, Lobos-González L, Muñoz-Durango N, ..., Espinoza JA, Roa JC
Mol Oncol 14 (11) 2834-2852 [2020-11-00; online 2020-09-17]
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Elevated protein expression levels of KRAS in Pancreatic Ductal Adenocarcinoma (PDAC) are associated with better prognosis
Stålberg S, Silwal-Pandit L, Hamfjord J, Lehtiö J, Kure E
Pancreatology 20 (-) S129-S130 [2020-11-00; online 2020-11-00]
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EV-transported microRNAs of Schistosoma mansoni and Fasciola hepatica: Potential targets in definitive hosts.
Ovchinnikov VY, Kashina EV, Mordvinov VA, Fromm B
Infect. Genet. Evol. 85 (-) 104528 [2020-11-00; online 2020-09-04]
PubMed DOI Crossref
Correction to: Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) induce epigenetic alterations and promote human breast cell carcinogenesis in vitro.
Pierozan P, Cattani D, Karlsson O
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Complete response with combined BRAF and MEK inhibition in BRAF mutated advanced low-grade serous ovarian carcinoma.
Tholander B, Koliadi A, Botling J, ..., Öberg K, Ullenhag GJ
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Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
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Matrix Biol. 93 (-) 43-59 [2020-11-00; online 2020-03-20]
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Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson's Disease.
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Mov Disord 35 (11) 2101-2106 [2020-11-00; online 2020-08-15]
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A freshwater radiation of diplonemids.
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Drug synergy scoring using minimal dose response matrices
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Docking finds GPCR ligands in dark chemical matter
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Hikarchaeia demonstrate an intermediate stage in the methanogen-to-halophile transition.
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Nat Commun 11 (1) 5490 [2020-10-30; online 2020-10-30]
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Differences in structure and hibernation mechanism highlight diversification of the microsporidian ribosome
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PLoS Biol. 18 (10) e3000958 [2020-10-30; online 2020-10-30]
Jonas Barandun SciLifeLab Fellow
PubMed DOI Crossref
Potential Anticancer Effect of Carvacrol Codrugs on Human Glioblastoma Cells.
Yazici A, Marinelli L, Cacciatore I, ..., Mardinoğlu A, Türkez H
Curr Drug Deliv 18 (3) 350-356 [2020-10-29; online 2020-10-29]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations.
Cismaru AL, Rudin D, Ibañez L, ..., Wadelius M, Amstutz U
Genes (Basel) 11 (11) - [2020-10-29; online 2020-10-29]
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Fluidity and Lipid Composition of Membranes of Peroxisomes, Mitochondria and the ER From Oleic Acid-Induced Saccharomyces cerevisiae
Reglinski K, Steinfort-Effelsberg L, Sezgin E, ..., Eggeling C, Erdmann R
Front Cell Dev Biol 8 (-) 574363 [2020-10-29; online 2020-10-29]
Erdinc Sezgin SciLifeLab Fellow
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Fluid Proteomics of CSF and Serum Reveal Important Neuroinflammatory Proteins in Blood-Brain Barrier Disruption and Outcome Prediction Following Severe Traumatic Brain Injury: A Prospective, Observational Study
Lindblad C, Pin E, Just D, ..., Piehl F, Thelin EP
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Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells.
Tarbier M, Mackowiak SD, Frade J, ..., Gallant CJ, Friedländer MR
Nat Commun 11 (1) 5445 [2020-10-28; online 2020-10-28]
Magda Bienko Marc Friedländer SciLifeLab Fellow
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OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions.
Hanna BMF, Helleday T, Mortusewicz O
Biomolecules 10 (11) - [2020-10-26; online 2020-10-26]
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Hippocampal neural stem cells are more susceptible to the neurotoxin BMAA than primary neurons: effects on apoptosis, cellular differentiation, neurite outgrowth, and DNA methylation.
Pierozan P, Cattani D, Karlsson O
Cell Death Dis 11 (10) 910 [2020-10-24; online 2020-10-24]
Oskar Karlsson SciLifeLab Fellow
PubMed DOI Crossref
Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease.
Navarro JF, Croteau DL, Jurek A, ..., Lundeberg J, Bohr VA
iScience 23 (10) 101556 [2020-10-23; online 2020-09-15]
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Single Cell RNA Expression Analysis Using Flow Cytometry Based on Specific Probe Ligation and Rolling Circle Amplification.
Zhao Y, Lin C, Wu P, ..., Nilsson M, Ke R
ACS Sens 5 (10) 3031-3036 [2020-10-23; online 2020-09-24]
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Increasing thermal stability and improving biodistribution of VEGFR2-binding affibody molecules by a combination of in silico and directed evolution approaches.
Güler R, Svedmark SF, Abouzayed A, Orlova A, Löfblom J
Sci Rep 10 (1) 18148 [2020-10-23; online 2020-10-23]
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Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Bastard P, Rosen LB, Zhang Q, ..., Su HC, Casanova JL
Science (New York, N.Y.) 370 (6515) - [2020-10-23; online 2020-09-24]
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Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization.
Flygaard RK, Mühleip A, Tobiasson V, Amunts A
Nat Commun 11 (1) 5342 [2020-10-22; online 2020-10-22]
Alexey Amunts SciLifeLab Fellow
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OmicLoupe: Facilitating biological discovery by interactive exploration of multiple omic datasets and statistical comparisons
Willforss J, Siino V, Levander F
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Modelling the dispersion of SARS-CoV-2 on a dynamic network graph
Bryant P, Elofsson A
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Longitudinal plasma inflammatory proteome profiling during pregnancy in the Born into Life study.
Hedman AM, Lundholm C, Andolf E, ..., Fall T, Almqvist C
Sci Rep 10 (1) 17819 [2020-10-20; online 2020-10-20]
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Inhibiting insulin and mTOR signaling by afatinib and crizotinib combination fosters broad cytotoxic effects in cutaneous malignant melanoma.
Das I, Chen H, Maddalo G, ..., Davies MA, Egyházi Brage S
Cell Death Dis 11 (10) 882 [2020-10-20; online 2020-10-20]
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Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.
Liess AKL, Kucerova A, Schweimer K, ..., Mansfeld J, Lorenz S
Sci Signal 13 (654) - [2020-10-20; online 2020-10-20]
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High resolution and high throughput bacteria separation from blood using elasto-inertial microfluidics
Iyengar SN, Kumar T, Mårtensson G, Russom A
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Secondary ossification center induces and protects growth plate structure.
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Elife 9 (-) - [2020-10-16; online 2020-10-16]
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Rapid Preparation of a Large Sulfated Metabolite Library for Structure Validation in Human Samples.
Correia MSP, Lin W, Aria AJ, Jain A, Globisch D
Metabolites 10 (10) 415 [2020-10-16; online 2020-10-16]
Daniel Globisch SciLifeLab Fellow
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Preclinical Evaluation of the GRPR-Targeting Antagonist RM26 Conjugated to the Albumin-Binding Domain for GRPR-Targeting Therapy of Cancer.
Abouzayed A, Tano H, Nagy Á, ..., Eriksson Karlström A, Orlova A
Pharmaceutics 12 (10) - [2020-10-16; online 2020-10-16]
PubMed
[11C]5-Hydroxy-tryptophan model for quantitative assessment of in vivo serotonin biosynthesis, retention and degradation in the endocrine pancreas.
Lubberink M, Eriksson O
American journal of nuclear medicine and molecular imaging 10 (5) 226-234 [2020-10-15; online 2020-10-15]
Olof Eriksson SciLifeLab Fellow
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Sub-attomole detection of HIV-1 using padlock probes and rolling circle amplification combined with microfluidic affinity chromatography.
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SM-Omics: An automated platform for high-throughput spatial multi-omics
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From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase.
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Androgen Receptor Signaling Positively Regulates Monocytic Development.
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Front Immunol 11 (-) 519383 [2020-10-15; online 2020-10-15]
Camila Consiglio DDLS Fellow
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SARS-CoV-2 (COVID-19) infection in pregnant women: characterization of symptoms and syndromes predictive of disease and severity through real-time, remote participatory epidemiology.
Molteni E, Astley CM, Ma W, ..., Chan AT, Modat M
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Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1.
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Network analysis reveals how lipids and other cofactors influence membrane protein allostery.
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J Chem Phys 153 (14) 141103 [2020-10-14; online 2020-10-23]
Lucie Delemotte SciLifeLab Fellow
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A simplified approach to control cell adherence on biologically derived in vitro cell culture scaffolds by direct UV-mediated RGD linkage.
Porras Hernández AM, Pohlit H, Sjögren F, ..., Antfolk M, Tenje M
J Mater Sci Mater Med 31 (10) 89 [2020-10-14; online 2020-10-14]
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NGSpeciesID: DNA barcode and amplicon consensus generation from long-read sequencing data
Sahlin K, Lim M, Prost S
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Belowground fungal community diversity, composition and ecological functionality associated with winter wheat in conventional and organic agricultural systems.
Garnica S, Rosenstein R, Schön ME
PeerJ 8 (-) e9732 [2020-10-13; online 2020-10-13]
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Compared with matched controls, patients with postoperative atrial fibrillation (POAF) have increased long-term AF after CABG, and POAF is further associated with increased ischemic stroke, heart failure and mortality even after adjustment for AF.
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Lorenc A, Hamilton-Shield J, Perry R, Stevens M, CTYA HSCT Adipose and Muscle Late Effects Working Group
J Cancer Surviv 14 (5) 624-642 [2020-10-00; online 2020-07-18]
Adil Mardinoglu SciLifeLab Fellow
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Assigned NMR backbone resonances of the ligand-binding region domain of the pneumococcal serine-rich repeat protein (PsrP-BR) reveal a rigid monomer in solution.
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ANHIR: Automatic Non-Rigid Histological Image Registration Challenge.
Borovec J, Kybic J, Arganda-Carreras I, ..., Zhao S, Munoz-Barrutia A
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Genomics of an avian neo-sex chromosome reveals the evolutionary dynamics of recombination suppression and sex-linked genes
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Smad7 Enhances TGF-β-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells.
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Effect of molecular phenotype based on Warburg effect pathway on the prognosis and the efficacy of postoperative radiation in cervical cancer
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Chinese Journal of Radiological Medicine and Protection 40 (9) 666-673 [2020-09-25]
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Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase.
Degorce SL, Tavana O, Banks E, ..., Yang B, Edmondson SD
J Med Chem 63 (18) 10460-10473 [2020-09-24; online 2020-09-14]
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Basal Ganglia-A Motion Perspective.
Grillner S, Robertson B, Kotaleski JH
Compr Physiol 10 (4) 1241-1275 [2020-09-24; online 2020-09-24]
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Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR.
Smyrlaki I, Ekman M, Lentini A, ..., Högberg B, Reinius B
Nat Commun 11 (1) 4812 [2020-09-23; online 2020-09-23]
Antonio Lentini DDLS Fellow
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Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness.
Karvonen H, Arjama M, Kaleva L, ..., Murumägi A, Ungureanu D
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No Assembly Required: Using BTyper3 to Assess the Congruency of a Proposed Taxonomic Framework for the Bacillus cereus Group With Historical Typing Methods.
Carroll LM, Cheng RA, Kovac J
Front Microbiol 11 (-) 580691 [2020-09-22; online 2020-09-22]
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Deltaproteobacteria and Spirochaetes-Like Bacteria Are Abundant Putative Mercury Methylators in Oxygen-Deficient Water and Marine Particles in the Baltic Sea.
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Complement Properdin Regulates the Metabolo-Inflammatory Response to a High Fat Diet.
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Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides
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FRET-Based Sorting of Live Cells Reveals Shifted Balance between PLK1 and CDK1 Activities During Checkpoint Recovery.
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SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells.
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Northstar enables automatic classification of known and novel cell types from tumor samples.
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Characterization of zika virus infection of human fetal cardiac mesenchymal stromal cells.
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Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex.
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Estimating the impact of mobility patterns on COVID-19 infection rates in 11 European countries.
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Rapid development of cloud-native intelligent data pipelines for scientific data streams using the HASTE Toolkit
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COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight
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The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model.
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Freshwater Chlorobia exhibit metabolic specialization among cosmopolitan and endemic populations
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Sci Rep 10 (1) 14977 [2020-09-11; online 2020-09-11]
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Disease, Drugs and Dysbiosis: Understanding Microbial Signatures in Metabolic Disease and Medical Interventions.
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Integration of molecular profiles in a longitudinal wellness profiling cohort.
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Adil Mardinoglu SciLifeLab Fellow
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How cholesterol stiffens unsaturated lipid membranes.
Chakraborty S, Doktorova M, Molugu TR, ..., Brown MF, Ashkar R
Proc. Natl. Acad. Sci. U.S.A. 117 (36) 21896-21905 [2020-09-08; online 2020-08-25]
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Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.
Damas J, Hughes GM, Keough KC, ..., Karlsson EK, Lewin HA
Proc. Natl. Acad. Sci. U.S.A. 117 (36) 22311-22322 [2020-09-08; online 2020-08-21]
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The RNA exosome shapes the expression of key protein-coding genes.
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Nucleic Acids Res. 48 (15) 8509-8528 [2020-09-04; online 2020-07-28]
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Genome sequence of segmented filamentous bacteria present in the human intestine.
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Commun Biol 3 (1) 485 [2020-09-04; online 2020-09-04]
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Author response: Secondary ossification center induces and protects growth plate structure
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Hybrid seed incompatibility in Capsella is connected to chromatin condensation defects in the endosperm
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Accurate spliced alignment of long RNA sequencing reads
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Twentieth-century emergence of antimicrobial resistant human- and bovine-associated Salmonella enterica serotype Typhimurium lineages in New York State.
Carroll LM, Huisman JS, Wiedmann M
Sci Rep 10 (1) 14428 [2020-09-02; online 2020-09-02]
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MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG.
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Corrigendum to "Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour" [Behav. Brain Res. 382 (2020) 112476].
Checknita D, Bendre M, Ekström TJ, ..., Hodgins S, Nilsson KW
Behav. Brain Res. 393 (-) 112721 [2020-09-01; online 2020-06-23]
Erika Comasco SciLifeLab Fellow
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Transglutaminase 1 and 2 are localized in different blood cells in the freshwater crayfish Pacifastacus leniusculus.
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Fish Shellfish Immunol. 104 (-) 83-91 [2020-09-00; online 2020-05-30]
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To inhibit TrxR1 is to inactivate STAT3-Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors.
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The past and future human impact on mammalian diversity.
Andermann T, Faurby S, Turvey ST, Antonelli A, Silvestro D
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DDLS Fellow Tobias Andermann
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The Promises and Challenges of Tumor Mutation Burden as an Immunotherapy Biomarker: A Perspective from the International Association for the Study of Lung Cancer Pathology Committee.
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Systems Biology: A Multi-Omics Integration Approach to Metabolism and the Microbiome.
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Endocrinol Metab (Seoul) 35 (3) 507-514 [2020-09-00; online 2020-09-22]
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Steady moving contact line of water over a no-slip substrate
Lācis U, Johansson P, Fullana T, ..., Bagheri S, Zaleski S
Eur. Phys. J. Spec. Top. 229 (10) 1897-1921 [2020-09-00; online 2020-09-14]
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Similar names, different results: Consistency of the associations between prenatal exposure to phthalates and parent-ratings of behavior problems in preschool children.
England-Mason G, Martin JW, MacDonald A, ..., Letourneau N, Dewey D
Environ Int 142 (-) 105892 [2020-09-00; online 2020-06-25]
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Shared structural mechanisms of general anaesthetics and benzodiazepines.
Kim JJ, Gharpure A, Teng J, ..., Lindahl E, Hibbs RE
Nature 585 (7824) 303-308 [2020-09-00; online 2020-09-02]
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SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity.
De Meo S, Dell'Oste V, Molfetta R, ..., Santoni A, Cerboni C
PLoS Pathog 16 (9) e1008855 [2020-09-00; online 2020-09-28]
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Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis.
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Using Micro- and Macro-Level Network Metrics Unveils Top Communicative Gene Modules in Psoriasis.
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Automated GMP-Compliant Production of [68Ga]Ga-DO3A-Tuna-2 for PET Microdosing Studies of the Glucagon Receptor in Humans.
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The Quest for Orthologs benchmark service and consensus calls in 2020.
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A translational multiplex serology approach to profile the prevalence of anti-SARS-CoV-2 antibodies in home-sampled blood
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The Binding of CD93 to Multimerin-2 Promotes Choroidal Neovascularization.
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Growth-Inhibitory Activity of Bone Morphogenetic Protein 4 in Human Glioblastoma Cell Lines Is Heterogeneous and Dependent on Reduced SOX2 Expression.
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Colibactin DNA-damage signature indicates mutational impact in colorectal cancer.
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Enhancing a de novo enzyme activity by computationally-focused ultra-low-throughput screening.
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Molecular Structure of Sphingomyelin in Fluid Phase Bilayers Determined by the Joint Analysis of Small-Angle Neutron and X-ray Scattering Data.
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Skeletal Muscle Transcriptomic Comparison between Long-Term Trained and Untrained Men and Women.
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SARS-CoV-2 exposure, symptoms and seroprevalence in health care workers
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High-throughput 5’P sequencing enables the study of degradation-associated ribosome stalls
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Author response: PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer
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Characterization of the dynamic resting state of a pentameric ligand-gated ion channel by cryo-electron microscopy and simulations
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Successful delivery of large-size CRISPR/Cas9 vectors in hard-to-transfect human cells using small plasmids.
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Regio- and Stereoselective Synthesis of Allylic Spiroethers (Spirobenzofuranes) via an Intramolecular Mizoroki-Heck Reaction.
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Inferring Tumor Progression in Large Datasets
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Adipose tissue morphology, imaging and metabolomics predicting cardiometabolic risk and family history of type 2 diabetes in non-obese men.
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Harmonization of quality metrics and power calculation in multi-omic studies.
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Ciliate mitoribosome illuminates evolutionary steps of mitochondrial translation.
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Theoretical insights on helix repacking as the origin of P-glycoprotein promiscuity.
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High frequency of intermediary alleles in the HTT gene in Northern Sweden - The Swedish Huntingtin Alleles and Phenotype (SHAPE) study.
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Point-of-Care Approaches for Meningitis Diagnosis in a Low-Resource Setting (Southwestern Uganda): Observational Cohort Study Protocol of the “PI-POC” Trial (Preprint)
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Gefitinib and Afatinib Show Potential Efficacy for Fanconi Anemia-Related Head and Neck Cancer.
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Evaluating the Therapeutic Efficacy of Mono- and Bivalent Affibody-Based Fusion Proteins Targeting HER3 in a Pancreatic Cancer Xenograft Model.
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Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Saker channel
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Influence of nanobody binding on fluorescence emission, mobility and organization of GFP-tagged proteins
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Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors
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Chaining with Overlaps Revisited
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Kristoffer Sahlin SciLifeLab Fellow
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Sensitive mass spectrometric analysis of carbonyl metabolites in human urine and fecal samples using chemoselective modification.
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An In-Silico Analysis of Drugs Potentially Modulating the Cytokine Storm Triggered by SARS-CoV-2 Infection<strong> </strong>
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Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression.
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Trial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapy.
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An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
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SAT0335 SERUM AND BALF-DERIVED ANTI-JO1 AUTOANTIBODIES EXHIBIT HIGH REACTIVITY TO DISTINCT HISRS DOMAINS AND ASSOCIATE WITH LUNG AND JOINT INVOLVEMENT IN PATIENTS WITH IIM/ASS
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SAT0288 CHARACTERIZATION OF ANTI-AMINOACYL TRNA SYNTHETASE AUTOANTIBODIES IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES
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No distinct microbiome signature of irritable bowel syndrome found in a Swedish random population.
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Nanomedicine for improvement of dendritic cell-based cancer immunotherapy.
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Molecular atlas of the adult mouse brain.
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Immediate Adaptation Analysis Implicates BCL6 as an EGFR-TKI Combination Therapy Target in NSCLC.
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Human papillomavirus prevalence and risk factors among HIV-negative and HIV-positive women residing in rural Eastern Cape, South Africa.
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Germ-free and microbiota-associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes.
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Evaluation of a Hybrid Capture-Based Pan-Cancer Panel for Analysis of Treatment Stratifying Oncogenic Aberrations and Processes.
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Effects of chemical fractions from an oil sands end-pit lake on reproduction of fathead minnows.
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Author Correction: Hitchhiking into the cell.
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African population history: an ancient DNA perspective.
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AB0206 CIRCULATING CENTROMERE PROTEIN F AUTOANTIBODIES FOR PREDICTING CLINICAL RESPONSE TO INFLIXIMAB IN RHEUMATOID ARTHRITIS
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A molecularly distinct subset of glioblastoma requires serum-containing media to establish sustainable bona fide glioblastoma stem cell cultures.
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Shift in ecological strategy helps marginal populations of shepherd's purse (Capsella bursa-pastoris) to overcome a high genetic load.
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GPSeq reveals the radial organization of chromatin in the cell nucleus
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Probing contacts of inhibitor locked in transition states in the catalytic triad of DENV2 type serine protease and its mutants by 1H, 19F and 15 N NMR spectroscopy.
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Energy efficiency and biological interactions define the core microbiome of deep oligotrophic groundwater
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LRIG1 gene copy number analysis by ddPCR and correlations to clinical factors in breast cancer.
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Transcript isoform sequencing reveals widespread promoter-proximal transcriptional termination in Arabidopsis.
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An embryonic stem cell-specific heterochromatin state allows core histone exchange in the absence of DNA accessibility
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nucleAIzer: A Parameter-free Deep Learning Framework for Nucleus Segmentation Using Image Style Transfer.
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Opposing spatial trends in methylmercury and total mercury along a peatland chronosequence trophic gradient.
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Integrating the "Immunome" in the Stratification of Myelodysplastic Syndromes and Future Clinical Trial Design.
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z-STED Imaging and Spectroscopy to Investigate Nanoscale Membrane Structure and Dynamics.
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The Archaeal Roots of the Eukaryotic Dynamic Actin Cytoskeleton.
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Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis.
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Molecular Docking Studies of Royleanone Diterpenoids from Plectranthus spp. as P-Glycoprotein Inhibitors.
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Targeting tumor vulnerabilities associated with loss of heterozygosity.
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Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention.
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Theoretical Infrared Spectra: Quantitative Similarity Measures and Force Fields.
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Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis.
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Blood-derived biomarkers correlate with clinical progression in Duchenne muscular dystrophy.
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A chemical screen identifies a link between lipid metabolism and mRNA translation
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Lactone monomers obtained by enzyme catalysis and their use in reversible thermoresponsive networks
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Histidyl-Proline Diketopiperazine Isomers as Multipotent Anti-Alzheimer Drug Candidates.
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Epoxylathyrane Derivatives as MDR-Selective Compounds for Disabling Multidrug Resistance in Cancer.
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“A Proteogenomic workflow reveals distinct molecular phenotypes related to breast cancer appearance”
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Optimal protocols for sequence-based characterization of the human vaginal microbiome
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Human proteins incorporated into tick-borne encephalitis virus revealed by in situ proximity ligation.
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Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1.
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Glycosylation Tunes Neuroserpin Physiological and Pathological Properties.
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Predicting resolution and image quality in RESOLFT and other point scanning microscopes [Invited].
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National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions.
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MaRe: Processing Big Data with application containers on Apache Spark.
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Differential Expression of Immune Genes between Two Closely Related Beetle Species with Different Immunocompetence following Attack by Asecodes parviclava.
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Genome Biol Evol 12 (5) 522-534 [2020-05-01; online 2020-04-14]
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Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination.
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Tumor angiogenesis: causes, consequences, challenges and opportunities.
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The utility of artificial intelligence in the assessment of prostate pathology.
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TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness.
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TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment.
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Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism.
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Serglycin activates pro-tumorigenic signaling and controls glioblastoma cell stemness, differentiation and invasive potential.
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Salmonella Typhimurium discreet-invasion of the murine gut absorptive epithelium.
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RNA at DNA Double-Strand Breaks: The Challenge of Dealing with DNA:RNA Hybrids.
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Managing COVID-19 in the oncology clinic and avoiding the distraction effect.
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Intestinal epithelial NAIP/NLRC4 restricts systemic dissemination of the adapted pathogen Salmonella Typhimurium due to site-specific bacterial PAMP expression.
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Increased iron absorption in patients with chronic heart failure and iron deficiency.
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Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes: A Nationwide Register-Based Study With Sibling Analysis.
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Duchenne Muscular Dystrophy: recent advances in protein biomarkers and the clinical application.
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Does browning‐induced light limitation reduce fish body growth through shifts in prey composition or reduced foraging rates?
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Active sulfur cycling in the terrestrial deep subsurface.
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SpatialCPie: an R/Bioconductor package for spatial transcriptomics cluster evaluation.
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Bistability in oxidative stress response determines the migration behavior of phytoplankton in turbulence
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The microcircuits of striatum in silico.
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The genetic variation of lactase persistence alleles in northeast Africa
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Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists.
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Tumor endothelial ELTD1 as a predictive marker for treatment of renal cancer patients with sunitinib.
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A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community).
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Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin.
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Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks.
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Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates.
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Genome-Scale Metabolic Modeling of Glioblastoma Reveals Promising Targets for Drug Development.
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Estimating the impact of mobility patterns on COVID-19 infection rates in 11 European countries
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Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2.
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The in vitro cytotoxic, genotoxic, and oxidative damage potentials of the oral artificial sweetener aspartame on cultured human blood cells
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Autophagy role(s) in response to oncogenes and DNA replication stress.
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A putative silencer variant in a spontaneous canine model of retinitis pigmentosa.
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PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling.
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Complete Range of the Universal mtDNA Gene Pool and High Genetic Diversity in the Thai Dog Population.
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A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma.
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Proposal of a Taxonomic Nomenclature for the Bacillus cereus Group Which Reconciles Genomic Definitions of Bacterial Species with Clinical and Industrial Phenotypes.
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Phenotypic Variability with SLURP1 Mutations and Diffuse Palmoplantar Keratoderma.
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Improved Synthesis and Isolation of Bedaquiline.
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Rapid colorimetric detection of COVID-19 coronavirus using a reverse transcriptional loop-mediated isothermal amplification (RT-LAMP) diagnostic platform: iLACO
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A Guide to Carrying Out a Phylogenomic Target Sequence Capture Project.
Andermann T, Torres Jiménez MF, Matos-Maraví P, ..., Bacon CD, Antonelli A
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DDLS Fellow Tobias Andermann
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In silico and In vitro Investigation of a Likely Pathway for Anti-Cancerous Effect of Thrombocidin-1 as a Novel Anticancer Peptide.
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Towards a European health research and innovation cloud (HRIC).
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Enhanced sampling and free energy calculations for protein simulations.
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A whole-genome sequenced control population in northern Sweden reveals subregional genetic differences
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Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway.
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Creating Supported Plasma Membrane Bilayers Using Acoustic Pressure.
Sezgin E, Carugo D, Levental I, Stride E, Eggeling C
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Biophysical Characterization of Epigallocatechin-3-Gallate Effect on the Cardiac Sodium Channel Nav1.5.
Amarouch MY, Kurt H, Delemotte L, Abriel H
Molecules 25 (4) 902 [2020-02-18; online 2020-02-18]
Lucie Delemotte SciLifeLab Fellow
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G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury.
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Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules.
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GLI1-induced mammary gland tumours are transplantable and maintain major molecular features.
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The irradiated brain microenvironment supports glioma stemness and survival via astrocyte-derived Transglutaminase 2
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Deriving disease modules from the compressed transcriptional space embedded in a deep autoencoder.
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Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study
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Lipidomic profiles, lipid trajectories and clinical biomarkers in female elite endurance athletes.
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CDX2: A Prognostic Marker in Metastatic Colorectal Cancer Defining a Better BRAF Mutated and a Worse KRAS Mutated Subgroup.
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Amplification-free long read sequencing reveals unforeseen CRISPR-Cas9 off-target activity
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Transcriptomic profiling of experimental arterial injury reveals new mechanisms and temporal dynamics in vascular healing response.
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The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome
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SCRINSHOT, a spatial method for single-cell resolution mapping of cell states in tissue sections
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The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty.
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Correction: A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma.
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Pathway and network analysis of more than 2500 whole cancer genomes.
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Combined burden and functional impact tests for cancer driver discovery using DriverPower.
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The evolutionary history of 2,658 cancers.
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Selective sweeps on novel and introgressed variation shape mimicry loci in a butterfly adaptive radiation.
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PLoS Biol. 18 (2) e3000597 [2020-02-00; online 2020-02-06]
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Season of birth, childhood asthma and allergy in a nationwide cohort-Mediation through lower respiratory infections.
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Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging.
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Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms.
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NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus.
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Mapping pH-Dependent State Transitions of a Pentameric Ligand-gated Ion Channel through Markov State Modeling
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Is evolution predictable? Quantitative genetics under complex genotype-phenotype maps.
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Increased risk of multiple myeloma in primary Sjögren's syndrome is limited to individuals with Ro/SSA and La/SSB autoantibodies.
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Stat Methods Med Res 29 (2) 437-454 [2020-02-00; online 2019-04-03]
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Growth differentiation factor 15 (GDF-15) is a potential biomarker of both diabetic kidney disease and future cardiovascular events in cohorts of individuals with type 2 diabetes: a proteomics approach.
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Genomic basis for RNA alterations in cancer.
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Environmental impacts and limitations of third‐generation biobutanol: Life cycle assessment of n ‐butanol produced by genetically engineered cyanobacteria
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Paul Hudson SciLifeLab Fellow
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Digital Rolling Circle Amplification-Based Detection of Ebola and Other Tropical Viruses.
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Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function.
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Arch. Toxicol. 94 (2) 469-484 [2020-02-00; online 2019-12-10]
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Comparison of a Deep Learning Risk Score and Standard Mammographic Density Score for Breast Cancer Risk Prediction.
Dembrower K, Liu Y, Azizpour H, ..., Lindholm P, Strand F
Radiology 294 (2) 265-272 [2020-02-00; online 2019-12-17]
PubMed DOI Crossref
Classification of clear cell renal cell carcinoma based on PKM alternative splicing.
Li X, Turanli B, Juszczak K, ..., Zhang C, Mardinoglu A
Heliyon 6 (2) e03440 [2020-02-00; online 2020-02-19]
Adil Mardinoglu SciLifeLab Fellow
DOI Crossref
Calmodulin Functionally Couples the KCNQ1 Channel Voltage-Sensing and Pore Domains
Kang PW, Westerlund AM, Shi J, ..., Delemotte L, Cui J
Biophysical Journal 118 (3) 332a-333a [2020-02-00; online 2020-02-00]
PubMed DOI Crossref
Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity.
Achour A, Broggini L, Han X, ..., Camilloni C, Ricagno S
FEBS J. 287 (3) 546-560 [2020-02-00; online 2019-08-28]
PubMed DOI Crossref
Artificial intelligence for diagnosis and grading of prostate cancer in biopsies: a population-based, diagnostic study.
Ström P, Kartasalo K, Olsson H, ..., Egevad L, Eklund M
Lancet Oncol 21 (2) 222-232 [2020-02-00; online 2020-01-08]
PubMed DOI Crossref
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.
Rheinbay E, Nielsen MM, Abascal F, ..., Getz G, PCAWG Consortium
Nature 578 (7793) 102-111 [2020-02-00; online 2020-02-05]
PubMed DOI Crossref
ALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors.
Kaipio K, Chen P, Roering P, ..., Hautaniemi S, Carpén O
J. Pathol. 250 (2) 159-169 [2020-02-00; online 2019-12-03]
PubMed DOI Crossref
A window into lysogeny: revealing temperate phage biology with transcriptomics.
Owen SV, Canals R, Wenner N, ..., Kröger C, Hinton JCD
Microb Genom 6 (2) - [2020-02-00; online 2020-02-05]
PubMed DOI Crossref
A Multi-Cohort Metabolomics Analysis Discloses Sphingomyelin (32:1) Levels to be Inversely Related to Incident Ischemic Stroke.
Lind L, Salihovic S, Ganna A, ..., Ingelsson E, Ärnlöv J
J Stroke Cerebrovasc Dis 29 (2) 104476 [2020-02-00; online 2019-12-02]
DOI Crossref
In situ sequencing for RNA analysis in tissue sections v2
Yokota C, Gyllborg D, Nilsson M
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DOI Crossref
CopyMix: Mixture Model Based Single-Cell Clustering and Copy Number Profiling using Variational Inference
Safinianaini N, P. E. de Souza C, Roth A, ..., Toosi H, Lagergren J
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DOI Crossref
Approaches for Containerized Scientific Workflows in Cloud Environments with Applications in Life Science
Spjuth O, Capuccini M, Carone M, ..., Kultima K, Lampa S
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DOI Crossref
Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA
Madru C, Raia P, Hugonneau-Beaufet I, ..., Carroni M, Sauguet L
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DOI Crossref
Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder
Stenström L, Mahdessian D, Gnann C, ..., Thul PJ, Lundberg E
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DOI Crossref
Evolution from adherent to suspension – systems biology of HEK293 cell line development
Malm M, Saghaleyni R, Lundqvist M, ..., Nielsen J, Rockberg J
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PubMed DOI Crossref
Phylogenomics and biogeography of the world's thrushes (Aves, Turdus): new evidence for a more parsimonious evolutionary history.
Batista R, Olsson U, Andermann T, ..., Ribas CC, Antonelli A
Proc. Biol. Sci. 287 (1919) 20192400 [2020-01-29; online 2020-01-22]
DDLS Fellow Tobias Andermann
DOI Crossref
Mechanism of DNA surface exploration and operator bypassing during target search
Marklund E, van Oosten B, Mao G, ..., Elf J, Deindl S
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PubMed DOI Crossref
Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival.
Brück O, Dufva O, Hohtari H, ..., Pellinen T, Mustjoki S
Blood Adv 4 (2) 274-286 [2020-01-28; online 2020-01-23]
PubMed DOI Crossref
Exploring the therapeutic potential of modern and ancestral phenylalanine/tyrosine ammonia-lyases as supplementary treatment of hereditary tyrosinemia.
Hendrikse NM, Holmberg Larsson A, Svensson Gelius S, ..., Nordling E, Syrén PO
Sci Rep 10 (1) 1315 [2020-01-28; online 2020-01-28]
PubMed DOI Crossref
Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D.
Sayitoglu EC, Georgoudaki AM, Chrobok M, ..., Sutlu T, Duru AD
Front Immunol 11 (-) 40 [2020-01-28; online 2020-01-28]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Making Soup: Preparing and Validating Models of the Bacterial Cytoplasm for Molecular Simulation.
Oliveira Bortot L, Bashardanesh Z, van der Spoel D
J Chem Inf Model 60 (1) 322-331 [2020-01-27; online 2019-12-19]
PubMed DOI Crossref
Population Genomics of Transitions to Selfing in Brassicaceae Model Systems.
Mattila TM, Laenen B, Slotte T
Methods in molecular biology (Clifton, N.J.) 2090 (-) 269-287 [2020-01-25; online 2020-01-25]
SciLifeLab Fellow Tanja Slotte
PubMed DOI Crossref
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Kennedy SA, Jarboui MA, Srihari S, ..., Lynn DJ, Kolch W
Nat Commun 11 (1) 499 [2020-01-24; online 2020-01-24]
PubMed DOI Crossref
An optochemical tool for light-induced dissociation of adherens junctions to control mechanical coupling between cells.
Ollech D, Pflästerer T, Shellard A, ..., Wombacher R, Cavalcanti-Adam EA
Nat Commun 11 (1) 472 [2020-01-24; online 2020-01-24]
DOI Crossref
Improved computational analysis of ribosome dynamics from 5’P degradome data using fivepeseq
Nersisyan L, Ropat M, Pelechano V
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DOI Crossref
Human immune system variation during one year
Lakshmikanth T, Muhammad SA, Olin A, ..., Uhlen M, Brodin P
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PubMed DOI Crossref
Effect of TOP2A and ERCC1 gene polymorphisms on the efficacy and toxicity of cisplatin and etoposide-based chemotherapy in small cell lung cancer patients.
Nicoś M, Rolska-Kopińska A, Krawczyk P, ..., Szczyrek M, Milanowski J
Arch Med Sci 17 (2) 474-480 [2020-01-23; online 2020-01-23]
PubMed DOI Crossref
Docking Finds GPCR Ligands in Dark Chemical Matter.
Ballante F, Rudling A, Zeifman A, ..., Loza MI, Carlsson J
J Med Chem 63 (2) 613-620 [2020-01-23; online 2020-01-13]
Jens Carlsson SciLifeLab Fellow
DOI Crossref
Cancer-associated HIF-2α impacts trunk neural crest stemness
Mohlin S, Persson CU, Fredlund E, ..., Hammarlund E, Bronner ME
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PubMed DOI Crossref
Structure-Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH).
Spillier Q, Ravez S, Unterlass J, ..., Feron O, Frédérick R
Pharmaceuticals (Basel, Switzerland) 13 (2) - [2020-01-22; online 2020-01-22]
PubMed DOI Crossref
Paenibacillus odorifer, the Predominant Paenibacillus Species Isolated from Milk in the United States, Demonstrates Genetic and Phenotypic Conservation of Psychrotolerance but Clade-Associated Differences in Nitrogen Metabolic Pathways.
Beno SM, Cheng RA, Orsi RH, ..., Martin NH, Wiedmann M
mSphere 5 (1) - [2020-01-22; online 2020-01-22]
DDLS Fellow Laura Carroll
PubMed DOI Crossref
Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer.
Ma J, Ramachandran M, Jin C, ..., Yu D, Essand M
Cell Death Dis 11 (1) 48 [2020-01-22; online 2020-01-22]
PubMed DOI Crossref
On the Long and Winding Road to a Perfect Membrane Model.
Doktorova M
Biophys. J. 118 (2) 273-275 [2020-01-21; online 2019-11-28]
DDLS Fellow Milka Doktorova
PubMed DOI Crossref
Fabrication of Silicon Microfluidic Chips for Acoustic Particle Focusing Using Direct Laser Writing.
Fornell A, Söderbäck P, Liu Z, De Albuquerque Moreira M, Tenje M
Micromachines (Basel) 11 (2) - [2020-01-21; online 2020-01-21]
DOI Crossref
Creating supported plasma membrane bilayers using acoustic pressure
Sezgin E, Carugo D, Levental I, Stride E, Eggeling C
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PubMed DOI Crossref
Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro.
Chen G, Andrade-Talavera Y, Tambaro S, ..., Abelein A, Johansson J
Commun Biol 3 (1) 32 [2020-01-20; online 2020-01-20]
PubMed DOI Crossref
Menstrual Hygiene Preparedness Among Schools in India: A Systematic Review and Meta-Analysis of System-and Policy-Level Actions.
Sharma S, Mehra D, Brusselaers N, Mehra S
Int J Environ Res Public Health 17 (2) - [2020-01-19; online 2020-01-19]
PubMed DOI Crossref
Evidence of altered mucosa-associated and fecal microbiota composition in patients with Irritable Bowel Syndrome.
Sundin J, Aziz I, Nordlander S, ..., Simrén M, Öhman L
Sci Rep 10 (1) 593 [2020-01-17; online 2020-01-17]
DDLS Fellow Luisa Hugerth
DOI Crossref
Impact of nanoscale hindrances on the relationship between lipid packing and diffusion in model membranes
Beckers D, Urbancic D, Sezgin E
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PubMed DOI Crossref
Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation.
Pagoni A, Marinelli L, Di Stefano A, ..., Vassiliou S, Cacciatore I
Eur J Med Chem 186 (-) 111880 [2020-01-15; online 2019-11-12]
Adil Mardinoglu SciLifeLab Fellow
PubMed DOI Crossref
Spatiotemporal mapping of RNA editing in the developing mouse brain using in situ sequencing reveals regional and cell-type-specific regulation.
Lundin E, Wu C, Widmark A, ..., Öhman M, Nilsson M
BMC Biol. 18 (1) 6 [2020-01-14; online 2020-01-14]
PubMed DOI Crossref
Identification and transfer of spatial transcriptomics signatures for cancer diagnosis.
Yoosuf N, Navarro JF, Salmén F, Ståhl PL, Daub CO
Breast Cancer Res. 22 (1) 6 [2020-01-13; online 2020-01-13]
PubMed DOI Crossref
A set of monomeric near-infrared fluorescent proteins for multicolor imaging across scales.
Matlashov ME, Shcherbakova DM, Alvelid J, ..., Testa I, Verkhusha VV
Nat Commun 11 (1) 239 [2020-01-13; online 2020-01-13]
Ilaria Testa SciLifeLab Fellow
DOI Crossref
Three dimensional parallelized RESOLFT nanoscopy for volumetric live cell imaging
Bodén A, Pennacchietti F, Testa I
- - (-) - [2020-01-09; online 2020-01-09]
DOI Crossref
Stable stimulated emission depletion imaging of extended sample regions
Alvelid J, Testa I
J. Phys. D: Appl. Phys. 53 (2) 024001 [2020-01-09; online 2019-10-25]
Ilaria Testa SciLifeLab Fellow
PubMed DOI Crossref
MirGeneDB 2.0: the metazoan microRNA complement.
Fromm B, Domanska D, Høye E, ..., Friedländer MR, Peterson KJ
Nucleic Acids Res. 48 (D1) D132-D141 [2020-01-08; online 2019-10-11]
Marc Friedländer SciLifeLab Fellow
PubMed DOI Crossref
DisProt: intrinsic protein disorder annotation in 2020.
Hatos A, Hajdu-Soltész B, Monzon AM, ..., Tosatto SCE, Piovesan D
Nucleic Acids Res. 48 (D1) D269-D276 [2020-01-08; online 2019-11-13]
PubMed DOI Crossref
The GenTree Dendroecological Collection, tree-ring and wood density data from seven tree species across Europe.
Martínez-Sancho E, Slámová L, Morganti S, ..., Westin J, Fonti P
Sci Data 7 (1) 1 [2020-01-02; online 2020-01-02]
Pascal Milesi SciLifeLab Fellow
PubMed DOI Crossref
Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants.
Korchynska S, Krassnitzer M, Malenczyk K, ..., Hökfelt TG, Harkany T
EMBO J. 39 (1) e100882 [2020-01-02; online 2019-11-21]
PubMed DOI Crossref
Protein aggregation in bacteria.
Schramm FD, Schroeder K, Jonas K
FEMS Microbiol Rev 44 (1) 54-72 [2020-01-01; online 2019-10-22]
Kristina Jonas SciLifeLab Fellow
PubMed DOI Crossref
Polymorphism Data Assist Estimation of the Nonsynonymous over Synonymous Fixation Rate Ratio ω for Closely Related Species.
Mugal CF, Kutschera VE, Botero-Castro F, Wolf JBW, Kaj I
Mol. Biol. Evol. 37 (1) 260-279 [2020-01-01; online 2019-09-11]
PubMed DOI Crossref
Correction to: In Situ Sequencing: A High-Throughput, Multi-Targeted Gene Expression Profiling Technique for Cell Typing in Tissue Sections.
Hilscher MM, Gyllborg D, Yokota C, Nilsson M
Methods in molecular biology (Clifton, N.J.) 2148 (-) C1 [2020-01-01; online 2020-01-01]
PubMed DOI Crossref
Advances in GLP-1 receptor targeting radiolabeled agent development and prospective of theranostics.
Velikyan I, Eriksson O
Theranostics 10 (1) 437-461 [2020-01-01; online 2020-01-01]
Olof Eriksson SciLifeLab Fellow
DOI Crossref
ATR expands embryonic stem cell fate potential in response to replication stress
Atashpaz S, Shams SS, Gonzalez JM, ..., López-Contreras AJ, Costanzo V
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PubMed DOI Crossref
Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero.
Hedlund M, Thorlacius GE, Ivanchenko M, ..., Eloranta ML, Wahren-Herlenius M
RMD Open 6 (1) - [2020-01-00; online 2020-01-21]
PubMed DOI Crossref
Time-resolved imaging-based CRISPRi screening.
Camsund D, Lawson MJ, Larsson J, ..., Fange D, Elf J
Nat. Methods 17 (1) 86-92 [2020-01-00; online 2019-11-18]
PubMed DOI Crossref
The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis.
Norenhag J, Du J, Olovsson M, ..., Engstrand L, Brusselaers N
BJOG 127 (2) 171-180 [2020-01-00; online 2019-07-17]
PubMed DOI Crossref
The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease.
Haytural H, Mermelekas G, Emre C, ..., Tjernberg LO, Frykman S
Mol. Cell Proteomics 19 (1) 128-141 [2020-01-00; online 2019-11-07]
PubMed DOI Crossref
The New Tree of Eukaryotes.
Burki F, Roger AJ, Brown MW, Simpson AGB
Trends in Ecology & Evolution 35 (1) 43-55 [2020-01-00; online 2019-10-09]
Fabien Burki SciLifeLab Fellow
PubMed DOI Crossref
The Neuropeptide Y Y2 Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y2 Activation Reduces Histaminergic and IL-31-Induced Itch.
Ma H, Gao T, Jakobsson JET, ..., Larhammar D, Lagerström MC
J. Pharmacol. Exp. Ther. 372 (1) 73-82 [2020-01-00; online 2019-11-26]
PubMed DOI Crossref
Publisher Correction: Analysis of the Human Protein Atlas Image Classification competition.
Ouyang W, Winsnes CF, Hjelmare M, ..., Kappel C, Lundberg E
Nat. Methods 17 (1) 115 [2020-01-00; online 2019-12-12]
PubMed DOI Crossref
Promoter polymorphisms of TOP2A and ERCC1 genes as predictive factors for chemotherapy in non-small cell lung cancer patients.
Grenda A, Błach J, Szczyrek M, ..., Sawicki M, Milanowski J
Cancer Med 9 (2) 605-614 [2020-01-00; online 2019-12-03]
PubMed DOI Crossref
Proinflammatory Histidyl-Transfer RNA Synthetase-Specific CD4+ T Cells in the Blood and Lungs of Patients With Idiopathic Inflammatory Myopathies.
Galindo-Feria AS, Albrecht I, Fernandes-Cerqueira C, ..., Malmström V, Lundberg IE
Arthritis & rheumatology (Hoboken, N.J.) 72 (1) 179-191 [2020-01-00; online 2019-11-26]
DOI Crossref
Ontogenic succession of thermokarst thaw ponds is linked to dissolved organic matter quality and microbial degradation potential
Peura S, Wauthy M, Simone D, ..., Rautio M, Bertilsson S
Limnol. Oceanogr. 65 (S1) - [2020-01-00; online 2020-01-00]
Sari Peura SciLifeLab Fellow
PubMed DOI Crossref
Nordic OCD & Related Disorders Consortium: Rationale, design, and methods.
Mataix-Cols D, Hansen B, Mattheisen M, ..., Rück C, Crowley JJ
Am. J. Med. Genet. B Neuropsychiatr. Genet. 183 (1) 38-50 [2020-01-00; online 2019-08-19]
DOI Crossref
Non‐cyanobacterial diazotrophs dominate nitrogen‐fixing communities in permafrost thaw ponds
Fernandez L, Bertilsson S, Peura S
Limnol. Oceanogr. 65 (S1) - [2020-01-00; online 2020-01-00]
Sari Peura SciLifeLab Fellow
PubMed DOI Crossref
Medulloblastomics revisited: biological and clinical insights from thousands of patients.
Hovestadt V, Ayrault O, Swartling FJ, ..., Pfister SM, Northcott PA
Nat. Rev. Cancer 20 (1) 42-56 [2020-01-00; online 2019-12-09]
PubMed DOI Crossref
Changes in Proteomic Profiles are Related to Changes in BMI and Fat Distribution During 10 Years of Aging.
Lind L, Figarska S, Sundström J, ..., Ärnlöv J, Ingelsson E
Obesity (Silver Spring) 28 (1) 178-186 [2020-01-00; online 2019-12-05]
PubMed DOI Crossref
Biophysics and the nonlinear dynamics instigated by a special hormone.
Javed S, Sohail A, Asif A, Nutini A
Prog. Biophys. Mol. Biol. 150 (-) 62-66 [2020-01-00; online 2019-05-20]
PubMed DOI Crossref
Biomarkers: to be or not to be.
Yavuz S, Rönnblom L
Ann. Rheum. Dis. 79 (1) e8 [2020-01-00; online 2018-11-10]
PubMed DOI Crossref
Association Between Metformin Use and Risk of Esophageal Squamous Cell Carcinoma in a Population-Based Cohort Study.
Wang QL, Santoni G, Ness-Jensen E, Lagergren J, Xie SH
Am J Gastroenterol 115 (1) 73-78 [2020-01-00; online 2019-12-11]
DDLS Fellow Qiaoli Wang
PubMed DOI Crossref
Acute wheeze-specific gene module shows correlation with vitamin D and asthma medication.
Katayama S, Stenberg Hammar K, Krjutškov K, ..., Kere J, Söderhäll C
Eur. Respir. J. 55 (1) - [2020-01-00; online 2020-01-23]
PubMed DOI Crossref
AI- modelling of molecular identification and feminization of wolbachia infected Aedes aegypti.
Iftikhar M, Iftikhar S, Sohail A, Javed S
Prog. Biophys. Mol. Biol. 150 (-) 104-111 [2020-01-00; online 2019-07-11]
PubMed DOI Crossref
A new opening for orally taken peptide drugs.
Artursson P, Lundquist P
Nat Biomed Eng 4 (1) 12-13 [2020-01-00; online 2020-01-16]
PubMed DOI Crossref
A fieldable electrostatic air sampler enabling tuberculosis detection in bioaerosols.
Rufino de Sousa N, Sandström N, Shen L, ..., Croda J, Rothfuchs AG
Tuberculosis (Edinb) 120 (-) 101896 [2020-01-00; online 2019-12-24]
DOI Crossref
Screening for High Amounts of SARS-CoV-2 Identifies Pre-Symptomatic Subjects Among Healthy Healthcare Workers
Dillner J, Elfström KM, Blomqvist J, ..., Mühr LSA, Conneryd Lundgren K
SSRN Journal - (-) - [2020-00-00; online 2020-00-00]
DOI Crossref
Proximal Deletion 12q with a New Insight to Growth Retardation
Sobol M, Thuresson AC, Palmberg N, Soussi Zander C
Mol Syndromol 11 (3) 115-124 [2020-00-00; online 2020-04-10]
DOI Crossref
Inhibition of the Ubiquitin-Proteasome System by a Bioactivatable Prodrug
Giovannucci TA, Salomons FA, Martin Haraldsson M, ..., Johnsen JI, Dantuma N
SSRN Journal - (-) - [2020-00-00; online 2020-00-00]
DOI Crossref
GROMEX: A Scalable and Versatile Fast Multipole Method for Biomolecular Simulation
Kohnke B, Ullmann TR, Beckmann A, ..., Dachsel H, Grubmüller H
- - (-) 517-543 [2020-00-00; online 2020-07-31]
DOI Crossref
Fiber Based Optofluidic Micro-Flow Cytometer Collecting Side-Scattered Light
Harish AV, Kumar T, Russom A, Margulis W, Laurell F
- - (-) AW3I.3 [2020-00-00; online 2020-00-00]
DOI Crossref
Divergent Clonal Differentiation Trajectories Establish CD8 <sup>+</sup> Memory T Cell Heterogeneity During Acute Viral Infections in Humans
Mold JE, Modolo L, Hård J, ..., Michaelsson J, Frisén J
SSRN Journal - (-) - [2020-00-00; online 2020-00-00]
DOI Crossref
Discovery of Functional Alternatively Spliced <i>PKM</i> Transcripts in Human Cancers
Li X, Zhang C, Kim W, ..., Uhlen M, Mardinoglu A
- - (-) - [2020-00-00; online 2020-00-00]
DOI Crossref
Decoupling Inherent Risk and Early Cancer Signs in Image-Based Breast Cancer Risk Models
Liu Y, Azizpour H, Strand F, Smith K
- - (-) 230-240 [2020-00-00; online 2020-09-29]
DOI Crossref
Circulating miRNA Signature Predicts and Rescues Spaceflight Associated Health Risks
Malkani S, Cekanaviciute E, Mortreux M, ..., Grabham P, Beheshti A
- - (-) - [2020-00-00; online 2020-00-00]
DOI Crossref
Chapter 7. Bridging the Gap Between Atomistic Molecular Dynamics Simulations and Wet-lab Experimental Techniques: Applications to Membrane Proteins
Delemotte L
- - (-) 247-286 [2020-00-00; online 2020-00-00]
Lucie Delemotte SciLifeLab Fellow
DOI Crossref
COVID-19 and Beyond: A Call for Action and Audacious Solidarity to All the Citizens and Nations, It Is Humanity’s Fight
Auffray C, Balling R, Blomberg N, ..., Wolkenhauer O, Wouters E
SSRN Journal - (-) - [2020-00-00; online 2020-00-00]
DOI Crossref
Advances in whole genome methylomic sequencing
Nordlund J
- - (-) 213-233 [2020-00-00; online 2020-00-00]
DOI Crossref
Acute Kidney Injury Leading to CKD is Associated with a Persistence of Metabolic Dysfunction and Hypertriglyceridemia
Harzandi A, Bidkhori G, Lee S, ..., Shoaie S, Sharpe C
SSRN Journal - (-) - [2020-00-00; online 2020-00-00]
SciLifeLab Data Centre
Publications 9.5.1