Zhou Y

Family name	Zhou
Given name	Yitian
Initials	Y
ORCID	ORCID 0000-0003-3066-5444
Affiliations	Department of Physiology and Pharmacology, Karolinska Institutet, 17177, Stockholm, Sweden.

18 publications

PubMed DOI Crossref

CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real-World Setting.

Park Y, Zhou Y, Lauschke VM

Clin. Pharmacol. Ther. 120 (2) 412-419 [2026-08-00; online 2026-04-14]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Prediction of drug hypersensitivity by comprehensive modeling of HLA-peptidomes.

Zhong Y, Lauschke VM, Wang Y, Zhou Y

Brief. Bioinformatics 27 (4) - [2026-07-03; online 2026-07-03]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Feed-Forward Deep Neural Networks Predict Substrate-Specific Effects of Transporter Variants to Explain Drug Response Variability.

Park Y, Zhou Y, Xiao M, Nies AT, Lauschke VM

Clin Transl Sci 19 (5) e70592 [2026-05-00; online 2026-05-09]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Substrate-specificity of pharmacogenomic variability - clinical relevance and emerging predictive strategies.

Zhou Y, Park Y, Lauschke VM

Expert Opin Drug Metab Toxicol 22 (3) 201-215 [2026-03-00; online 2026-04-02]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Integration of germline pharmacogenomic burden to predict fluoropyrimidine-related toxicity - A secondary analysis of the PREPARE trial.

De Mattia E, Park Y, Peruzzi E, ..., Lauschke VM, Cecchin E

Oncogene 44 (45) 4352-4362 [2025-11-00; online 2025-09-25]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account.

Johansson I, Xanthopoulou EM, Zhou Y, ..., Jukic MM, Ingelman-Sundberg M

Clin. Pharmacol. Ther. 118 (1) 218-231 [2025-07-00; online 2025-04-22]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Evaluating the synergistic use of advanced liver models and AI for the prediction of drug-induced liver injury.

Zhou Y, Zhong Y, Lauschke VM

Expert Opin Drug Metab Toxicol 21 (5) 563-577 [2025-05-00; online 2025-02-02]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Molecular docking to investigate HLA-associated idiosyncratic drug reactions.

Li K, Lauschke VM, Zhou Y

Drug Metab Rev 57 (1) 67-90 [2025-02-00; online 2025-01-20]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

PharmFreq: a comprehensive atlas of ethnogeographic allelic variation in clinically important pharmacogenes.

Tremmel R, Zhou Y, Camara MD, ..., Eliasson E, Lauschke VM

Nucleic Acids Res. 53 (D1) D1498-D1509 [2025-01-06; online 2024-11-14]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

APF2: an improved ensemble method for pharmacogenomic variant effect prediction.

Zhou Y, Pirmann S, Lauschke VM

Pharmacogenomics J. 24 (3) 17 [2024-05-27; online 2024-05-27]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Population-specific variations in KCNH2 predispose patients to delayed ventricular repolarization upon dihydroartemisinin-piperaquine therapy.

Camara MD, Zhou Y, Dara A, ..., Gil PJ, Lauschke VM

Antimicrob. Agents Chemother. 68 (5) e0139023 [2024-05-02; online 2024-03-28]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Next-generation sequencing in pharmacogenomics - fit for clinical decision support?

Zhou Y, Lauschke VM

Expert Rev Clin Pharmacol 17 (3) 213-223 [2024-03-00; online 2024-01-23]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations.

Khor CC, Winter S, Sutiman N, ..., Chowbay B, Schroth W

Clin. Pharmacol. Ther. 113 (3) 712-723 [2023-03-00; online 2023-01-31]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

A paradigm shift in pharmacogenomics: From candidate polymorphisms to comprehensive sequencing.

Zhou Y, Koutsilieri S, Eliasson E, Lauschke VM

Basic Clin. Pharmacol. Toxicol. 131 (6) 452-464 [2022-12-00; online 2022-08-22]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data.

Zhou Y, Lauschke VM

Pharmacogenomics J. 22 (5-6) 284-293 [2022-12-00; online 2022-09-06]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Cardiovascular Pharmacogenomics: An Update on Clinical Studies of Antithrombotic Drugs in Brazilian Patients.

Hirata TDC, Dagli-Hernandez C, Genvigir FDV, ..., Hirata MH, Hirata RDC

Mol Diagn Ther 25 (6) 735-755 [2021-11-00; online 2021-08-06]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine.

Zhou Y, Arribas GH, Turku A, ..., Gastaldello S, Lauschke VM

Sci Adv 7 (36) eabi6856 [2021-09-03; online 2021-09-01]

DDLS Fellow Yitian Zhou

PubMed DOI Crossref

Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier.

Zhou Y, Dagli Hernandez C, Lauschke VM

Br. J. Cancer 123 (12) 1782-1789 [2020-12-00; online 2020-09-25]

DDLS Fellow Yitian Zhou