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Álvez MB, Bergström S, Kenrick J, Johansson E, Åberg M, Akyildiz M, Altay O, Sköld H, Antonopoulos K, Apostolakis E, Balcioglu YH, Bergström A, Bergström G, Björkander S, Brage SE, Brodin P, Butler L, Cajander S, Danielsson H, Dayangac M, Dinler-Doganay G, Doğanay L, Enblad G, Enblad M, Fagerberg L, Falck-Jones S, Färnert A, Forsberg M, Gonzalez L, Gummesson A, Gunnarsson K, Gunnarsson I, Gyllensten U, Hesselager G, Hober A, Höglund M, Holmqvist M, Horuluoglu B, Hultgren R, Iglesias MJ, Janols H, Johansson F, Johnsson A, Klareskog L, Kotol D, Kull I, Kvarnström M, Lautenbach MJ, Liljedahl U, Lindman H, Lindskog C, Lipcsey M, Lundberg IE, Mardinoglu A, Melén E, Meng L, Merritt AS, Mulder J, Nguyen MT, Nordlund J, Norrby-Teglund A, Notarnicola A, Nowak P, Odeberg J, Oksvold P, Olsson T, Padyukov L, Pauksens K, Piehl F, Pin E, Pontén F, Rameika N, Reepalu A, Roy J, Schwenk JM, Sen M, Siika A, Simonson OE, Sivertsson Å, Sjöblom T, Sjöstedt E, Skoglund L, Smed-Sörensen A, Sondén K, Sönnerborg A, Stålberg K, Strålin K, Sundén-Cullberg J, Sundling C, Sutantiwanichkul T, Svedman FC, Svensson M, Svenungsson E, Lakshmikanth T, Tran-Minh KH, Türkez H, Unge C, Venge P, Wahren-Herlenius M, Woessmann J, Yang H, Yeşilkaya UH, Yuan M, Zeybel M, Zhang C, Zhong W, Zwahlen M, von Feilitzen K, Nilsson P, Edfors F, Uhlén M
Science (New York, N.Y.) 390 (6779) eadx2678 [2025-12-18; online 2025-12-18]
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and body mass index, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8262 individuals and up to 5416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research.
PubMed 41066540
DOI 10.1126/science.adx2678
Crossref 10.1126/science.adx2678