Helleday T

Family name	Helleday
Given name	Thomas
Initials	T
ORCID	ORCID 0000-0002-7384-092X
Affiliations	Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.

40 publications

PubMed DOI Crossref

Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches for DNA Repair Enzyme OGG1.

Varga M, Ortis F, Del Prado A, ..., Watson AJB, Michel M

J Med Chem 68 (21) 22455-22483 [2025-11-13; online 2025-10-15]

PubMed DOI Crossref

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1.

Scaletti Hutchinson E, Gustafsson Westergren R, Almlöf I, ..., Helleday T, Stenmark P

FEBS Lett. 599 (19) 2790-2801 [2025-10-00; online 2025-07-27]

DOI Crossref

Blind De Novo Design of Dual Cyclic Peptide Agonists Targeting GCGR and GLP1R

Li Q, Wiita E, Helleday T, Bryant P

- - (-) - [2025-06-08; online 2025-06-08]

DDLS Fellow Patrick Bryant

PubMed DOI Crossref

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M

Nat Commun 15 (1) 10347 [2024-12-06; online 2024-12-06]

PubMed DOI Crossref

Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis.

Scaletti ER, Unterlass JE, Almlöf I, ..., Stenmark P, Jemth AS

FEBS J. 291 (19) 4301-4322 [2024-10-00; online 2024-06-29]

PubMed DOI Crossref

The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation.

Marttila P, Bonagas N, Chalkiadaki C, ..., Mortusewicz O, Helleday T

Mol Oncol 18 (9) 2179-2195 [2024-09-00; online 2024-03-27]

PubMed DOI Crossref

Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway.

Shen J, Guillén Mancina E, Chen S, ..., Sanjiv K, Helleday T

Oncogenesis 13 (1) 17 [2024-05-25; online 2024-05-25]

PubMed DOI Crossref

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue.

Zhang N, Harbers L, Simonetti M, ..., Bienko M, Crosetto N

Nat Commun 15 (1) 3475 [2024-04-24; online 2024-04-24]

Magda Bienko SciLifeLab Fellow

PubMed DOI Crossref

Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence.

Fabbrizi MR, Nickson CM, Hughes JR, ..., Helleday T, Parsons JL

Cell Death Dis 15 (2) 150 [2024-02-17; online 2024-02-17]

PubMed DOI Crossref

Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response.

Ramos L, Henriksson M, Helleday T, Green AC

Cancer Res. 84 (1) 9-16 [2024-01-02; online 2023-11-03]

DOI Crossref

Kinetic and structural characterization of human NUDIX hydrolases NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis

Scaletti ER, Unterlass JE, Almlöf I, ..., Stenmark P, Jemth AS

- - (-) - [2023-11-29; online 2023-11-29]

DOI Crossref

Front Cover: Synthesis of Substituted Indazole Acetic Acids by N−N Bond Forming Reactions (Eur. J. Org. Chem. 29/2023)

Odell LR, Skillinghaug B, Matt C, ..., Helleday T, Scobie M

Eur. J. Org. Chem. 26 (29) - [2023-08-00; online 2023-07-27]

DOI Crossref

Synthesis of Substituted Indazole Acetic Acids by N−N Bond Forming Reactions

Odell LR, Skillinghaug B, Matt C, ..., Helleday T, Scobie M

Eur. J. Org. Chem. 26 (29) - [2023-08-00; online 2023-05-24]

PubMed DOI Crossref

Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.

Green AC, Marttila P, Kiweler N, ..., Henriksson M, Meiser J

Nat Metab 5 (4) 642-659 [2023-04-00; online 2023-04-03]

PubMed DOI Crossref

NUDT22 promotes cancer growth through pyrimidine salvage.

Walter M, Mayr F, Hanna BMF, ..., Helleday T, Herr P

Oncogene 42 (16) 1282-1293 [2023-04-00; online 2023-03-04]

PubMed DOI Crossref

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model.

Tanner L, Single AB, Bhongir RKV, ..., Kalderén C, Egesten A

Nat Commun 14 (1) 643 [2023-02-06; online 2023-02-06]

PubMed DOI Crossref

An Approach for Systems-Level Understanding of Prostate Cancer from High-Throughput Data Integration to Pathway Modeling and Simulation.

Mobashir M, Turunen SP, Izhari MA, ..., Helleday T, Lehti K

Cells 11 (24) - [2022-12-19; online 2022-12-19]

PubMed DOI Crossref

Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer.

Henriksson S, Calderón-Montaño JM, Solvie D, Warpman Berglund U, Helleday T

Biomolecules 12 (12) - [2022-11-29; online 2022-11-29]

PubMed DOI Crossref

Targeting the DNA damage response and repair in cancer through nucleotide metabolism.

Helleday T, Rudd SG

Mol Oncol 16 (21) 3792-3810 [2022-11-00; online 2022-05-28]

DOI Crossref

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M

- - (-) - [2022-09-19; online 2022-09-19]

PubMed DOI Crossref

Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones.

Marklund M, Schultz N, Friedrich S, ..., Sonnhammer E, Lundeberg J

Nat Commun 13 (1) 5475 [2022-09-17; online 2022-09-17]

DOI Crossref

Overexpressed C-Myc Sensitize Cells to TH1579, an Mitotic Arrest and Oxidative DNA Damage Inducer

Henriksson S, Calderón-Montaño JM, Solvie D, Warpman Berglund U, Helleday T

- - (-) - [2022-08-22; online 2022-08-22]

PubMed DOI Crossref

Spatially resolved clonal copy number alterations in benign and malignant tissue.

Erickson A, He M, Berglund E, ..., Lamb AD, Lundeberg J

Nature 608 (7922) 360-367 [2022-08-00; online 2022-08-10]

PubMed DOI Crossref

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.

Michel M, Benítez-Buelga C, Calvo PA, ..., de Vega M, Helleday T

Science (New York, N.Y.) 376 (6600) 1471-1476 [2022-06-24; online 2022-06-23]

DOI Crossref

OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice

Tanner L, Bergwik J, Bhongir RK, ..., Adner M, Egesten A

- - (-) - [2022-05-19; online 2022-05-19]

PubMed DOI Crossref

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.

Bonagas N, Gustafsson NMS, Henriksson M, ..., Homan EJ, Helleday T

Nat Cancer 3 (2) 156-172 [2022-02-00; online 2022-02-28]

PubMed DOI Crossref

MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells.

Karsten S, Fiskesund R, Zhang XM, ..., Helleday T, Warpman Berglund U

Cell Death Differ. 29 (1) 246-261 [2022-01-00; online 2021-08-29]

PubMed DOI Crossref

Adaptation to Chronic-Cycling Hypoxia Renders Cancer Cells Resistant to MTH1-Inhibitor Treatment Which Can Be Counteracted by Glutathione Depletion.

Hansel C, Hlouschek J, Xiang K, ..., Jendrossek V, Matschke J

Cells 10 (11) - [2021-11-05; online 2021-11-05]

PubMed DOI Crossref

Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma.

van den Boogaard ML, Oka R, Hakkert A, ..., Koster J, Molenaar JJ

Proc. Natl. Acad. Sci. U.S.A. 118 (36) - [2021-09-07; online 2021-09-05]

PubMed DOI Crossref

Polθ inhibitors unchained.

Helleday T

Nat Cancer 2 (6) 581-583 [2021-06-00; online 2022-02-06]

PubMed DOI Crossref

Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.

Rudd SG, Tsesmetzis N, Sanjiv K, ..., Helleday T, Herold N

EMBO Mol Med 12 (3) e10419 [2020-03-06; online 2020-01-17]

DOI Crossref

In Silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization

Michel M, Homan EJ, Wiita E, ..., Helleday T, Berglund UW

- - (-) - [2019-10-25; online 2019-10-25]

DOI Crossref

MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells

Gad H, Mortusewicz O, Rudd SG, ..., Berglund UW, Helleday T

- - (-) - [2019-03-12; online 2019-03-12]

DOI Crossref

MTH1 inhibitor TH588 induces mitosis-dependent accumulation of genomic 8-oxodG and disturbs mitotic progression

Rudd SG, Gad H, Amaral N, ..., Berglund UW, Helleday T

- - (-) - [2019-03-12; online 2019-03-12]

PubMed DOI Crossref

Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.

Jemth AS, Scaletti E, Carter M, Helleday T, Stenmark P

Biochemistry 58 (7) 887-899 [2019-02-19; online 2019-01-16]

PubMed DOI Crossref

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.

Visnes T, Cázares-Körner A, Hao W, ..., Boldogh I, Helleday T

Science (New York, N.Y.) 362 (6416) 834-839 [2018-11-16; online 2018-11-18]

PubMed DOI Crossref

Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis.

Mur P, Jemth AS, Bevc L, ..., Helleday T, Valle L

Hum. Mutat. 39 (9) 1214-1225 [2018-09-00; online 2018-07-04]

PubMed DOI Crossref

Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments.

Liao H, Ji F, Helleday T, Ying S

EMBO Rep. 19 (9) - [2018-09-00; online 2018-08-13]

PubMed DOI Crossref

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.

Narwal M, Jemth AS, Gustafsson R, ..., Helleday T, Stenmark P

Biochemistry 57 (5) 593-603 [2018-02-06; online 2018-01-16]

PubMed DOI Crossref

Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines.

Llona-Minguez S, Ghassemian A, Baranczewski P, ..., Scobie M, Helleday T

Med. Chem. Commun. 8 (7) 1553-1560 [2017-07-01; online 2017-07-04]