Stenmark P

Family name	Stenmark
Given name	Pål
Initials	P
ORCID	ORCID 0000-0003-4777-3417
Affiliations	Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.

22 publications

PubMed DOI Crossref

Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches for DNA Repair Enzyme OGG1.

Varga M, Ortis F, Del Prado A, ..., Watson AJB, Michel M

J Med Chem 68 (21) 22455-22483 [2025-11-13; online 2025-10-15]

PubMed DOI Crossref

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1.

Scaletti Hutchinson E, Gustafsson Westergren R, Almlöf I, ..., Helleday T, Stenmark P

FEBS Lett. 599 (19) 2790-2801 [2025-10-00; online 2025-07-27]

PubMed DOI Crossref

Bacterial transcriptional repressor NrdR - a flexible multifactorial nucleotide sensor.

Rozman Grinberg I, Bimaï O, Shahid S, ..., Sjöberg BM, Logan DT

FEBS J. 292 (12) 3091-3112 [2025-06-00; online 2025-03-03]

PubMed DOI Crossref

Virtual fragment screening for DNA repair inhibitors in vast chemical space.

Luttens A, Vo DD, Scaletti ER, ..., Helleday T, Carlsson J

Nat Commun 16 (1) 1741 [2025-02-18; online 2025-02-18]

Andreas Luttens DDLS Fellow Jens Carlsson SciLifeLab Fellow

PubMed DOI Crossref

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M

Nat Commun 15 (1) 10347 [2024-12-06; online 2024-12-06]

PubMed DOI Crossref

Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis.

Scaletti ER, Unterlass JE, Almlöf I, ..., Stenmark P, Jemth AS

FEBS J. 291 (19) 4301-4322 [2024-10-00; online 2024-06-29]

DOI Crossref

Bacterial transcriptional repressor NrdR – a flexible multifactorial nucleotide sensor

Rozman Grinberg I, Bimaï O, Shahid S, ..., Sjöberg BM, Logan DT

- - (-) - [2024-09-08; online 2024-09-08]

DOI Crossref

Kinetic and structural characterization of human NUDIX hydrolases NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis

Scaletti ER, Unterlass JE, Almlöf I, ..., Stenmark P, Jemth AS

- - (-) - [2023-11-29; online 2023-11-29]

DOI Crossref

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

Valerie NCK, Sanjiv K, Mortusewicz O, ..., Page BDG, Altun M

- - (-) - [2022-09-19; online 2022-09-19]

DOI Crossref

Front Cover: The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors (ChemMedChem 18/2022)

Scaletti ER, Gustafsson Westergren R, Andersson Y, ..., Helleday T, Stenmark P

ChemMedChem 17 (18) - [2022-09-16; online 2022-09-26]

PubMed DOI Crossref

The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors.

Scaletti ER, Gustafsson Westergren R, Andersson Y, ..., Helleday T, Stenmark P

ChemMedChem 17 (18) e202200274 [2022-09-16; online 2022-07-06]

PubMed DOI Crossref

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.

Michel M, Benítez-Buelga C, Calvo PA, ..., de Vega M, Helleday T

Science (New York, N.Y.) 376 (6600) 1471-1476 [2022-06-24; online 2022-06-23]

PubMed DOI Crossref

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.

Bonagas N, Gustafsson NMS, Henriksson M, ..., Homan EJ, Helleday T

Nat Cancer 3 (2) 156-172 [2022-02-00; online 2022-02-28]

PubMed DOI Crossref

Development of a chemical probe against NUDT15.

Zhang SM, Desroses M, Hagenkort A, ..., Stenmark P, Helleday T

Nat. Chem. Biol. 16 (10) 1120-1128 [2020-10-00; online 2020-07-20]

PubMed DOI Crossref

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.

Škerlová J, Unterlass J, Göttmann M, ..., Jemth AS, Stenmark P

J Biol Chem 295 (33) 11656-11668 [2020-08-14; online 2020-06-22]

PubMed DOI Crossref

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.

Scaletti ER, Vallin KS, Bräutigam L, ..., Stenmark P, Jemth AS

J Biol Chem 295 (15) 4761-4772 [2020-04-10; online 2020-03-06]

PubMed DOI Crossref

Structural basis for the interaction of the chaperone Cbp3 with newly synthesized cytochrome b during mitochondrial respiratory chain assembly.

Ndi M, Masuyer G, Dawitz H, ..., Stenmark P, Ott M

J Biol Chem 294 (45) 16663-16671 [2019-11-08; online 2019-09-19]

PubMed DOI Crossref

Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.

Jemth AS, Scaletti E, Carter M, Helleday T, Stenmark P

Biochemistry 58 (7) 887-899 [2019-02-19; online 2019-01-16]

PubMed DOI Crossref

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.

Visnes T, Cázares-Körner A, Hao W, ..., Boldogh I, Helleday T

Science (New York, N.Y.) 362 (6416) 834-839 [2018-11-16; online 2018-11-18]

PubMed DOI Crossref

Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis.

Mur P, Jemth AS, Bevc L, ..., Helleday T, Valle L

Hum. Mutat. 39 (9) 1214-1225 [2018-09-00; online 2018-07-04]

PubMed DOI Crossref

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.

Narwal M, Jemth AS, Gustafsson R, ..., Helleday T, Stenmark P

Biochemistry 57 (5) 593-603 [2018-02-06; online 2018-01-16]

PubMed DOI Crossref

The structure of the tetanus toxin reveals pH-mediated domain dynamics.

Masuyer G, Conrad J, Stenmark P

EMBO Rep. 18 (8) 1306-1317 [2017-08-00; online 2017-06-23]