Michel M

Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP-Lyase Function.

Kehler M, Zhou K, Kemas AM, ..., Lauschke VM, Michel M

Chemistry 31 (33) e202500382 [2025-06-12; online 2025-05-15]

Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1

Hank EC, D'Arcy-Evans N, Scaletti ER, ..., Helleday T, Michel M

- - (-) - [2025-01-01; online 2025-01-01]

Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1

Hank EC, D'Arcy-Evans N, Scaletti ER, ..., Helleday T, Michel M

- - (-) - [2024-05-10; online 2024-05-10]

Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1

Hank EC, D'Arcy-Evans N, Wallner O, ..., de Vega M, Michel M

- - (-) - [2023-07-26; online 2023-07-26]

Front Cover: Optimization of ‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1 (ChemMedChem 1/2023)

Wallner O, Cázares‐Körner A, Scaletti ER, ..., Helleday T, Michel M

ChemMedChem 18 (1) - [2023-01-03; online 2023-01-19]

Synthetic switches of OGG1 control initiation of base excision repair and offer new treatment strategies.

Benitéz-Buelga C, Helleday T, Michel M

Clin Transl Med 12 (8) e1035 [2022-08-00; online 2022-08-30]

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.

Michel M, Benítez-Buelga C, Calvo PA, ..., de Vega M, Helleday T

Science (New York, N.Y.) 376 (6600) 1471-1476 [2022-06-24; online 2022-06-23]

NUDT18 catalyzes the hydrolysis of active metabolites of the antivirals Remdesivir, Ribavirin and Molnupiravir

Jemth AS, Scaletti ER, Homan E, ..., Helleday T, Michel M

- - (-) - [2021-11-17; online 2021-11-17]

NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487.

Hanna BMF, Michel M, Helleday T, Mortusewicz O

Int J Mol Sci 22 (9) - [2021-04-27; online 2021-04-27]

In Silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization

Michel M, Homan EJ, Wiita E, ..., Helleday T, Berglund UW

- - (-) - [2019-10-25; online 2019-10-25]