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The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation.

Marttila P, Bonagas N, Chalkiadaki C, ..., Mortusewicz O, Helleday T

Mol Oncol 18 (9) 2179-2195 [2024-09-00; online 2024-03-27]

Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL.

Largeot A, Klapp V, Viry E, ..., Paggetti J, Moussay E

Blood 141 (26) 3166-3183 [2023-06-29; online 2023-04-21]

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.

Michel M, Benítez-Buelga C, Calvo PA, ..., de Vega M, Helleday T

Science (New York, N.Y.) 376 (6600) 1471-1476 [2022-06-24; online 2022-06-23]

MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells.

Karsten S, Fiskesund R, Zhang XM, ..., Helleday T, Warpman Berglund U

Cell Death Differ. 29 (1) 246-261 [2022-01-00; online 2021-08-29]

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.

Škerlová J, Unterlass J, Göttmann M, ..., Jemth AS, Stenmark P

J Biol Chem 295 (33) 11656-11668 [2020-08-14; online 2020-06-22]