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The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation.

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Mol Oncol 18 (9) 2179-2195 [2024-09-00; online 2024-03-27]

Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL.

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Blood 141 (26) 3166-3183 [2023-06-29; online 2023-04-21]

Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.

Green AC, Marttila P, Kiweler N, ..., Henriksson M, Meiser J

Nat Metab 5 (4) 642-659 [2023-04-00; online 2023-04-03]

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.

Michel M, Benítez-Buelga C, Calvo PA, ..., de Vega M, Helleday T

Science (New York, N.Y.) 376 (6600) 1471-1476 [2022-06-24; online 2022-06-23]

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.

Bonagas N, Gustafsson NMS, Henriksson M, ..., Homan EJ, Helleday T

Nat Cancer 3 (2) 156-172 [2022-02-00; online 2022-02-28]

MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells.

Karsten S, Fiskesund R, Zhang XM, ..., Helleday T, Warpman Berglund U

Cell Death Differ. 29 (1) 246-261 [2022-01-00; online 2021-08-29]

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.

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J Biol Chem 295 (33) 11656-11668 [2020-08-14; online 2020-06-22]

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.

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Nat Commun 9 (1) 3872 [2018-09-24; online 2018-09-24]