Matsson P

Conformational Dynamics in the Cell Membrane Interactions of Bispecific Targeted Degrader Therapeutics.

Inganäs E, Lavén H, Caraballo R, ..., Hilgendorf C, Matsson P

J Med Chem 68 (24) 25881-25898 [2025-12-25; online 2025-12-10]

Conformational dynamics in the membrane interactions of bispecific targeted degrader therapeutics

Inganäs E, Lavén H, Caraballo R, ..., Hilgendorf C, Matsson P

- - (-) - [2025-03-20; online 2025-03-20]

Structural dynamics of therapeutic nucleic acids with phosphorothioate backbone modifications.

Carlesso A, Hörberg J, Deganutti G, Reymer A, Matsson P

NAR Genomics and Bioinformatics 6 (2) lqae058 [2024-06-00; online 2024-05-25]

Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes.

Wegler C, Matsson P, Krogstad V, ..., Andersson TB, Artursson P

Mol. Pharm. 18 (4) 1792-1805 [2021-04-05; online 2021-03-19]

A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (fu,cell).

Treyer A, Walday S, Boriss H, Matsson P, Artursson P

Pharm. Res. 36 (12) 178 [2019-11-07; online 2019-11-07]

Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids.

Treyer A, Mateus A, Wiśniewski JR, ..., Matsson P, Artursson P

Mol. Pharm. 15 (6) 2224-2233 [2018-06-04; online 2018-05-11]

Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.

Rossi Sebastiano M, Doak BC, Backlund M, ..., Matsson P, Kihlberg J

J Med Chem 61 (9) 4189-4202 [2018-05-10; online 2018-04-16]

Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.

Mateus A, Gordon LJ, Wayne GJ, ..., Hann MM, Artursson P

Proc. Natl. Acad. Sci. U.S.A. 114 (30) E6231-E6239 [2017-07-25; online 2017-07-12]

Structural and conformational determinants of macrocycle cell permeability.

Over B, Matsson P, Tyrchan C, ..., Duvall JR, Kihlberg J

Nat. Chem. Biol. 12 (12) 1065-1074 [2016-12-00; online 2016-10-17]