Sulfilimines: An Underexplored Bioisostere for Drug Design?

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Arvidsson PI

J Med Chem 68 (4) 4056-4058 [2025-02-27; online 2025-01-31]

Sulfilimines have so far received little attention as a bioisostere for sulfoxides in the design of biologically active compounds. A recent study on physicochemical and in vitro drug-like properties shows that sulfilimines deserve a place in the medicinal chemist's toolbox.

PubMed 39887148

DOI 10.1021/acs.jmedchem.5c00195

Crossref 10.1021/acs.jmedchem.5c00195

pmc: PMC11874043