Gaetani M

Family name	Gaetani
Given name	Massimiliano
Initials	M
ORCID	ORCID 0000-0001-5610-0797
Affiliations	Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Science for Life Laboratory, Stockholm, Sweden.

21 publications

DOI Crossref

NUDT5 regulates the global efficacy of nucleoside analog drugs by coordinating purine synthesis and PRPP allocation

Valerie NCK, Alam S, Hormann FM, ..., Arvidsson PI, Altun M

- - (-) - [2025-11-20; online 2025-11-20]

PubMed DOI Crossref

Toward a Species Search Engine: KISSE Offers a Rigorous Statistical Framework for Bone Collagen Tandem Mass Spectrometry Data.

Gharibi H, Saei AA, Chernobrovkin AL, ..., Gaetani M, Zubarev RA

Adv Sci (Weinh) 12 (40) e03963 [2025-10-00; online 2025-08-11]

PubMed DOI Crossref

Diverse oncogenes use common mechanisms to drive growth of major forms of human cancer.

Kauko O, Turunen M, Pihlajamaa P, ..., Hautaniemi S, Taipale J

Sci Adv 11 (34) eadt1798 [2025-08-22; online 2025-08-20]

DOI Crossref

A cell-based degrader assessment platform facilitates discovery of functional NUDT5 PROTACs

Alam S, Pires MJ, Tidestav G, ..., Valerie NCK, Altun M

- - (-) - [2025-06-19; online 2025-06-19]

PubMed DOI Crossref

One-Pot Time-Induced Proteome Integral Solubility Alteration Assay for Automated and Sensitive Drug-Target Identification.

Meng Z, Saei AA, Lyu H, Gaetani M, Zubarev RA

Anal. Chem. 96 (48) 18917-18921 [2024-12-03; online 2024-11-20]

PubMed DOI Crossref

Gel-Assisted Proteome Position Integral Shift Assay Returns Molecular Weight to Shotgun Proteomics and Identifies Caspase 3 Substrates.

Meng Z, Saei AA, Gharibi H, ..., Gaetani M, Zubarev RA

Anal. Chem. 96 (33) 13533-13541 [2024-08-20; online 2024-08-07]

DOI Crossref

One-Pot Time-Induced Proteome Integral Solubility Alteration (OPTI-PISA) assay for automated and sensitive drug target identification

Meng Z, Saei AA, Lyu H, Gaetani M, Zubarev RA

- - (-) - [2024-08-13; online 2024-08-13]

DOI Crossref

ThermoTargetMiner as a proteome integral solubility alteration target database for prospective drugs against lung cancer

Lyu H, Gharibi H, Sokolova B, ..., Saei AA, Zubarev RA

- - (-) - [2024-08-06; online 2024-08-06]

PubMed DOI Crossref

A chemical inhibitor of IST1-CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation.

Knyazeva A, Li S, Corkery DP, ..., Waldmann H, Wu YW

Proc. Natl. Acad. Sci. U.S.A. 121 (17) e2317680121 [2024-04-23; online 2024-04-18]

DOI Crossref

Gel-Assisted Proteome Position Integral Shift (GAPPIS) Assay Returns Molecular Weight to Shotgun Proteomics and Identifies Novel Caspase 3 Substrates

Meng Z, Saei AA, Zhang X, ..., Gaetani M, Zubarev RA

- - (-) - [2024-02-15; online 2024-02-15]

DOI Crossref

Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes

Knyazeva A, Li S, Corkery DP, ..., Waldmann H, Wu YW

- - (-) - [2023-08-28; online 2023-08-28]

PubMed DOI Crossref

Proteome integral solubility alteration high-throughput proteomics assay identifies Collectin-12 as a non-apoptotic microglial caspase-3 substrate.

Grabert K, Engskog-Vlachos P, Škandík M, ..., Joseph B, Cheray M

Cell Death Dis 14 (3) 192 [2023-03-11; online 2023-03-11]

PubMed DOI Crossref

DAR 16-II Primes Endothelial Cells for Angiogenesis Improving Bone Ingrowth in 3D-Printed BCP Scaffolds and Regeneration of Critically Sized Bone Defects.

Alfayez E, Veschini L, Dettin M, ..., Coward T, Di Silvio L

Biomolecules 12 (11) - [2022-11-02; online 2022-11-02]

PubMed DOI Crossref

Proteomics-Compatible Fourier Transform Isotopic Ratio Mass Spectrometry of Polypeptides.

Gharibi H, Chernobrovkin AL, Saei AA, ..., Makarov AA, Zubarev RA

Anal. Chem. 94 (43) 15048-15056 [2022-11-01; online 2022-10-17]

PubMed DOI Crossref

An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation.

Sabatier P, Beusch CM, Saei AA, ..., Rodin S, Zubarev RA

Nat Commun 12 (1) 6558 [2021-11-12; online 2021-11-12]

PubMed DOI Crossref

System-wide identification and prioritization of enzyme substrates by thermal analysis.

Saei AA, Beusch CM, Sabatier P, ..., Schüler H, Zubarev RA

Nat Commun 12 (1) 1296 [2021-02-26; online 2021-02-26]

PubMed DOI Crossref

Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways.

Sender V, Hentrich K, Pathak A, ..., Normark S, Henriques-Normark B

Proc. Natl. Acad. Sci. U.S.A. 117 (49) 31386-31397 [2020-12-08; online 2020-11-23]

PubMed DOI Crossref

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds.

Peuget S, Zhu J, Sanz G, ..., Zubarev R, Selivanova G

Cancer Res. 80 (7) 1538-1550 [2020-04-01; online 2020-02-04]

PubMed DOI Crossref

ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery.

Saei AA, Beusch CM, Chernobrovkin A, ..., Végvári Á, Zubarev RA

Nat Commun 10 (1) 5715 [2019-12-16; online 2019-12-16]

PubMed DOI Crossref

Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution.

Gaetani M, Sabatier P, Saei AA, ..., Lundström SL, Zubarev RA

J. Proteome Res. 18 (11) 4027-4037 [2019-11-01; online 2019-10-14]

DOI Crossref

Proteome Integral Stability Alteration assay dramatically increases throughput and sensitivity in profiling factor-induced proteome changes

Gaetani M, Sabatier P, Saei AA, ..., Lundstrom S, Zubarev RA

- - (-) - [2018-12-13; online 2018-12-13]